Reduced Phenotypic Severity Following Adeno-Associated Virus-Mediated Fmr1 Gene Delivery in Fragile X Mice

CNS expression of murine fragile X protein (FMRP) as a function of CGG-repeat size

(2014) A. L. Ludwig et al.   HUMAN MOLECULAR GENETICS

Promoter-Bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome

(2014) D. Colak et al.   SCIENCE

Reorganization of Circuits Underlying Cerebellar Modulation of Prefrontal Cortical Dopamine in Mouse Models of Autism Spectrum Disorder

(2013) Tiffany D. Rogers et al.   CEREBELLUM

Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuitsin vivo

(2013) Ji-Yoen Kim et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Delayed myelination in a mouse model of fragile X syndrome

(2013) L. K. K. Pacey et al.   HUMAN MOLECULAR GENETICS

Fragile X Screening by Quantification of FMRP in Dried Blood Spots by a Luminex Immunoassay

(2013) Giuseppe LaFauci et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Transgene Expression in Target-Defined Neuron Populations Mediated by Retrograde Infection with Adeno-Associated Viral Vectors

(2013) M. Rothermel et al.   JOURNAL OF NEUROSCIENCE

Systemic Delivery of MeCP2 Rescues Behavioral and Cellular Deficits in Female Mouse Models of Rett Syndrome

(2013) S. K. Garg et al.   JOURNAL OF NEUROSCIENCE

Impaired Critical Period Plasticity in Primary Auditory Cortex of Fragile X Model Mice

(2013) H. Kim et al.   JOURNAL OF NEUROSCIENCE

Fmr1 Transcript Isoforms: Association with Polyribosomes; Regional and Developmental Expression in Mouse Brain

(2013) David M. Brackett et al.   PLoS One

Fragile X syndrome: a preclinical review on metabotropic glutamate receptor 5 (mGluR5) antagonists and drug development

(2013) Andreea S. Pop et al.   PSYCHOPHARMACOLOGY

Transduction of the Central Nervous System After Intracerebroventricular Injection of Adeno-Associated Viral Vectors in Neonatal and Juvenile Mice

(2013) Shervin Gholizadeh et al.   Human Gene Therapy Methods

Nuclear Fragile X Mental Retardation Protein Is localized to Cajal Bodies

(2013) Alain Y. Dury et al.   PLoS Genetics

Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome

(2012) Sarah E. Rotschafer et al.   BRAIN RESEARCH

Consensus Paper: Pathological Role of the Cerebellum in Autism

(2012) S. Hossein Fatemi et al.   CEREBELLUM

Systemic delivery of scAAV9 in fetal macaques facilitates neuronal transduction of the central and peripheral nervous systems

(2012) C N Mattar et al.   GENE THERAPY

Intracellular transport of recombinant adeno-associated virus vectors

(2012) M Nonnenmacher et al.   GENE THERAPY

Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics

(2012) Claudia Bagni et al.   JOURNAL OF CLINICAL INVESTIGATION

Treatment of Neurodevelopmental Disorders in Adulthood

(2012) E. Castren et al.   JOURNAL OF NEUROSCIENCE

Improved Survival and Reduced Phenotypic Severity Following AAV9/MECP2 Gene Transfer to Neonatal and Juvenile Male Mecp2 Knockout Mice

(2012) Kamal KE Gadalla et al.   MOLECULAR THERAPY

FMRP targets distinct mRNA sequence elements to regulate protein expression

(2012) Manuel Ascano et al.   NATURE

Gene therapy and neurodevelopmental disorders

(2012) Steven James Gray   NEUROPHARMACOLOGY

Fragile X syndrome: From targets to treatments

(2012) Lasani S. Wijetunge et al.   NEUROPHARMACOLOGY

Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic-like responses

(2011) Corinne M. Spencer et al.   Autism Research

Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome

(2011) Alexia M. Thomas et al.   BEHAVIOURAL BRAIN RESEARCH

Global gene transfer into the CNS across the BBB after neonatal systemic delivery of single-stranded AAV vectors

(2011) Noriko Miyake et al.   BRAIN RESEARCH

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Pathways to Drug Development for Autism Spectrum Disorders

(2011) D R Hampson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Adeno-Associated Virus Serotype 9 Transduction in the Central Nervous System of Nonhuman Primates

(2011) Lluis Samaranch et al.   HUMAN GENE THERAPY

Subchronic Administration and Combination Metabotropic Glutamate and GABAB Receptor Drug Therapy in Fragile X Syndrome

(2011) L. K. K. Pacey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse

(2011) Laura K.K. Pacey et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Adeno-Associated Virus-Mediated Rescue of the Cognitive Defects in a Mouse Model for Angelman Syndrome

(2011) Jennifer L. Daily et al.   PLoS One

Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome

(2011) D. D. Krueger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex

(2011) F. Wang et al.   SCIENCE

Key role of striatal cholinergic interneurons in processes leading to arrest of motor stereotypies

(2010) Verena Aliane et al.   BRAIN

Delayed Stabilization of Dendritic Spines in Fragile X Mice

(2010) A. Cruz-Martin et al.   JOURNAL OF NEUROSCIENCE

Anatomical phenotyping in a mouse model of fragile X syndrome with magnetic resonance imaging

(2010) Jacob Ellegood et al.   NEUROIMAGE

Critical Period Plasticity Is Disrupted in the Barrel Cortex of Fmr1 Knockout Mice

(2010) Emily G. Harlow et al.   NEURON

The role of fragile X mental retardation protein in major mental disorders

(2010) S. Hossein Fatemi et al.   NEUROPHARMACOLOGY

Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome

(2009) Z Zeier et al.   GENE THERAPY

Increased GABAB Receptor-Mediated Signaling Reduces the Susceptibility of Fragile X Knockout Mice to Audiogenic Seizures

(2009) L. K. K. Pacey et al.   MOLECULAR PHARMACOLOGY

Cerebellar Purkinje Cells are Reduced in a Subpopulation of Autistic Brains: A Stereological Experiment Using Calbindin-D28k

(2008) Elizabeth R. Whitney et al.   CEREBELLUM

Ultrasonic Vocalizations Induced by Sex and Amphetamine in M2, M4, M5 Muscarinic and D2 Dopamine Receptor Knockout Mice

(2008) Haoran Wang et al.   PLoS One