Pathways to Drug Development for Autism Spectrum Disorders

Autism spectrum disorders and autistic traits: A decade of new twin studies

(2011) Angelica Ronald et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The neurochemical basis for the treatment of autism spectrum disorders and Fragile X Syndrome

(2011) David R. Hampson et al.   BIOCHEMICAL PHARMACOLOGY

RETRACTED: Enhanced Polyubiquitination of Shank3 and NMDA Receptor in a Mouse Model of Autism

(2011) M Ali Bangash et al.   CELL

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Autism spectrum disorders—A genetics review

(2011) Judith H Miles   GENETICS IN MEDICINE

Mechanisms of GABA release from human astrocytes

(2011) Moonhee Lee et al.   GLIA

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model

(2011) Sara Ricciardi et al.   HUMAN MOLECULAR GENETICS

IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation

(2011) Hongen Wei et al.   Journal of Neuroinflammation

Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse

(2011) Laura K.K. Pacey et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration

(2011) R. Michelle Reith et al.   NEUROBIOLOGY OF DISEASE

Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links

(2011) D. K. Sokol et al.   NEUROLOGY

Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders

(2011) Dan Levy et al.   NEURON

Maternal Immune Activation and Autism Spectrum Disorder: Interleukin-6 Signaling as a Key Mechanistic Pathway

(2011) E. Carla Parker-Athill et al.   NEUROSIGNALS

Psychopharmacology of Autistic Spectrum Disorders in Children and Adolescents

(2011) Ahsan Nazeer   PEDIATRIC CLINICS OF NORTH AMERICA

Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056

(2011) S. Jacquemont et al.   Science Translational Medicine

Maternal infection and immune involvement in autism

(2011) Paul H. Patterson   TRENDS IN MOLECULAR MEDICINE

Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism

(2011) Sharifia Wills et al.   Molecular Autism

Review of neuroimaging in autism spectrum disorders: what have we learned and where we go from here

(2011) Evdokia Anagnostou et al.   Molecular Autism

Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome

(2011) Claudia M Greco et al.   Molecular Autism

Connecting Genes to Brain in the Autism Spectrum Disorders

(2010) Brett S. Abrahams et al.   ARCHIVES OF NEUROLOGY

Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome

(2010) Christopher J. Yuskaitis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Microglial Activation and Increased Microglial Density Observed in the Dorsolateral Prefrontal Cortex in Autism

(2010) John T. Morgan et al.   BIOLOGICAL PSYCHIATRY

Open-label add-on treatment trial of minocycline in fragile X syndrome

(2010) Carlo Paribello et al.   BMC Neurology

Plasma cytokine profiles in Fragile X subjects: Is there a role for cytokines in the pathogenesis?

(2010) Paul Ashwood et al.   BRAIN BEHAVIOR AND IMMUNITY

Altered white matter fractional anisotropy and social impairment in children with autism spectrum disorder

(2010) Madoka Noriuchi et al.   BRAIN RESEARCH

Bridging the gap between MRI and postmortem research in autism

(2010) Cynthia Mills Schumann et al.   BRAIN RESEARCH

Etiological heterogeneity in autism spectrum disorders: More than 100 genetic and genomic disorders and still counting

(2010) Catalina Betancur   BRAIN RESEARCH

Signaling mechanisms regulating synapse formation and function in mental retardation

(2010) Bernadett Boda et al.   CURRENT OPINION IN NEUROBIOLOGY

The immune systemʼs role in the biology of autism

(2010) Paula Goines et al.   CURRENT OPINION IN NEUROLOGY

Tuberous sclerosis: A primary pathology of astrocytes?

(2010) Alexander A. Sosunov et al.   EPILEPSIA

Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism

(2010) Loren A. Martin et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Viral vector-mediated gene transfer for CNS disease

(2010) Brooke R Snyder et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Mitochondrial Dysfunction in Autism

(2010) Cecilia Giulivi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Management of Symptoms in Children With Autism Spectrum Disorders: A Comprehensive Review of Pharmacologic and Complementary-Alternative Medicine Treatments

(2010) Lynne C. Huffman et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome

(2010) C. Gross et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome

(2010) E. K. Osterweil et al.   JOURNAL OF NEUROSCIENCE

Astrocytes Prevent Abnormal Neuronal Development in the Fragile X Mouse

(2010) S. Jacobs et al.   JOURNAL OF NEUROSCIENCE

Rett Syndrome Microglia Damage Dendrites and Synapses by the Elevated Release of Glutamate

(2010) I. Maezawa et al.   JOURNAL OF NEUROSCIENCE

Functional impact of global rare copy number variation in autism spectrum disorders

(2010) Dalila Pinto et al.   NATURE

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

(2010) Hsiao-Tuan Chao et al.   NATURE

hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies

(2010) Eun Kyung Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Immune dysfunction in autism: A pathway to treatment

(2010) Milo Careaga et al.   Neurotherapeutics

Changing Face of Microglia

(2010) M. B. Graeber   SCIENCE

Potential therapeutic interventions for fragile X syndrome

(2010) Josien Levenga et al.   TRENDS IN MOLECULAR MEDICINE

Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders

(2010) Dan Ehninger et al.   TRENDS IN MOLECULAR MEDICINE

Fragile X and autism: Intertwined at the molecular level leading to targeted treatments

(2010) Randi Hagerman et al.   Molecular Autism

Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study

(2009) Jane Yip et al.   Autism Research

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

(2009) Jeffrey J. Hutsler et al.   BRAIN RESEARCH

Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome

(2009) Z Zeier et al.   GENE THERAPY

Increased GABAB Receptor-Mediated Signaling Reduces the Susceptibility of Fragile X Knockout Mice to Audiogenic Seizures

(2009) L. K. K. Pacey et al.   MOLECULAR PHARMACOLOGY

Innate and Adaptive Autoimmunity Directed to the Central Nervous System

(2009) Roopa Bhat et al.   NEURON

Immune Proteins in Brain Development and Synaptic Plasticity

(2009) Lisa M. Boulanger   NEURON

Association of Family History of Autoimmune Diseases and Autism Spectrum Disorders

(2009) H. O. Atladottir et al.   PEDIATRICS

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

(2009) Daniela Tropea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early-phase ERK activation as a biomarker for metabolic status in fragile X syndrome

(2008) Ning Weng et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Expression of the GABAergic system in animal models for fragile X syndrome and fragile X associated tremor/ataxia syndrome (FXTAS)

(2008) Charlotte D'Hulst et al.   BRAIN RESEARCH

Antibodies against fetal brain in sera of mothers with autistic children

(2008) Harvey S. Singer et al.   JOURNAL OF NEUROIMMUNOLOGY

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

Immune transcriptome alterations in the temporal cortex of subjects with autism

(2008) Krassimira Garbett et al.   NEUROBIOLOGY OF DISEASE