Personalized mice: modelling the molecular heterogeneity of medulloblastoma

Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups

(2011) David W. Ellison et al.   ACTA NEUROPATHOLOGICA

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists

(2011) C. Metcalfe et al.   CANCER RESEARCH

TP53 Mutations in Favorable-Risk Wnt/Wingless-Subtype Medulloblastomas

(2011) Janet C. Lindsey et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting the Hedgehog Pathway: The development of Cyclopamine and the Development of Anti-Cancer Drugs Targeting the Hedgehog Pathway

(2011) A. Gould et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Loss of Trp53 promotes medulloblastoma development but not skin tumorigenesis in Sufu heterozygous mutant mice

(2011) Karin Heby-Henricson et al.   MOLECULAR CARCINOGENESIS

Development and cancer of the cerebellum

(2011) Mary E. Hatten et al.   TRENDS IN NEUROSCIENCES

Hedgehog signaling update

(2010) M. Michael Cohen Jr.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

(2010) Gerrit J. P. Dijkgraaf et al.   CANCER RESEARCH

Pleiotropic role for MYCN in medulloblastoma

(2010) F. J. Swartling et al.   GENES & DEVELOPMENT

Clinical Experience With Hedgehog Pathway Inhibitors

(2010) Jennifer A. Low et al.   JOURNAL OF CLINICAL ONCOLOGY

TP53 Mutation Is Frequently Associated With CTNNB1 Mutation or MYCN Amplification and Is Compatible With Long-Term Survival in Medulloblastoma

(2010) Elke Pfaff et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome

(2010) Yoon-Jae Cho et al.   JOURNAL OF CLINICAL ONCOLOGY

Medulloblastoma Comprises Four Distinct Molecular Variants

(2010) Paul A. Northcott et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular Therapy Targeting Sonic Hedgehog and Hepatocyte Growth Factor Signaling in a Mouse Model of Medulloblastoma

(2010) V. Coon et al.   MOLECULAR CANCER THERAPEUTICS

Subtypes of medulloblastoma have distinct developmental origins

(2010) Paul Gibson et al.   NATURE

Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas

(2010) R Sutter et al.   ONCOGENE

Cognitive Consequences of the Treatment of Medulloblastoma Among Children

(2010) Jean-Michel G. Saury et al.   PEDIATRIC NEUROLOGY

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

(2010) S. Buonamici et al.   Science Translational Medicine

Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma

(2009) Tracy-Ann Read et al.   CANCER CELL

Multipotent CD15+ Cancer Stem Cells in Patched-1-Deficient Mouse Medulloblastoma

(2009) R. J. Ward et al.   CANCER RESEARCH

Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy

(2009) Martin R Tremblay et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma

(2009) J. D. Kessler et al.   GENES & DEVELOPMENT

Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics

(2009) Sarah Fattet et al.   JOURNAL OF PATHOLOGY

Two Tumor Suppressors, p27Kip1and Patched-1, Collaborate to Prevent Medulloblastoma

(2009) Olivier Ayrault et al.   MOLECULAR CANCER RESEARCH

Dual and opposing roles of primary cilia in medulloblastoma development

(2009) Young-Goo Han et al.   NATURE MEDICINE

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Large cell/anaplastic medulloblastoma: Outcome according to myc status, histopathological, and clinical risk factors

(2009) Katja von Hoff et al.   PEDIATRIC BLOOD & CANCER

ThemiR-17∼92cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma

(2009) Tamar Uziel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency

(2009) Pierre-Olivier Frappart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma

(2008) Ulrich Schüller et al.   CANCER CELL

Medulloblastoma Can Be Initiated by Deletion of Patched in Lineage-Restricted Progenitors or Stem Cells

(2008) Zeng-Jie Yang et al.   CANCER CELL

Hepatocyte Growth Factor and Sonic Hedgehog Expression in Cerebellar Neural Progenitor Cells Costimulate Medulloblastoma Initiation and Growth

(2008) M. J. Binning et al.   CANCER RESEARCH

The Smo/Smo Model: Hedgehog-Induced Medulloblastoma with 90% Incidence and Leptomeningeal Spread

(2008) B. A. Hatton et al.   CANCER RESEARCH

Medulloblastoma: From Molecular Pathology to Therapy

(2008) A. Rossi et al.   CLINICAL CANCER RESEARCH

Pathological and molecular heterogeneity of medulloblastoma

(2008) Alberto Gulino et al.   CURRENT OPINION IN ONCOLOGY

Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma

(2008) K. J. Briggs et al.   GENES & DEVELOPMENT

Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development

(2008) H. Zhao et al.   GENES & DEVELOPMENT

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

(2008) D. Hambardzumyan et al.   GENES & DEVELOPMENT

c-Myc and β-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice

(2008) H Momota et al.   ONCOGENE

Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features

(2008) Marcel Kool et al.   PLoS One