Article
Radiology, Nuclear Medicine & Medical Imaging
E. Guedj, J. Y. Campion, P. Dudouet, E. Kaphan, F. Bregeon, H. Tissot-Dupont, S. Guis, F. Barthelemy, P. Habert, M. Ceccaldi, M. Million, D. Raoult, S. Cammilleri, C. Eldin
Summary: In long COVID patients, brain PET scans showed significant hypometabolism in areas including bilateral rectal/orbital gyrus, temporal lobe, brainstem, and cerebellum. These metabolic abnormalities were associated with more functional complaints such as hyposmia/anosmia, memory/cognitive impairment, pain, and insomnia. The study suggests a potential biomarker value in identifying and monitoring long COVID patients, with implications for the impact of ACE drugs and nasal decongestant spray on brain metabolism.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Gary A. Ulaner, Peter Giuliano
Summary: A 68-year-old man with right cheek melanoma underwent F-18-FDG PET/CT, which showed FDG-avid lymph nodes in the left axilla post COVID-19 vaccination. These nodes were considered reactive to the vaccination. Although uncommon in the past, this finding becomes important with the increasing number of COVID-19 vaccinations.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Chao Lu, Kailiang Wang, Fei Meng, Yihe Wang, Yongzhi Shan, Penghu Wei, Guoguang Zhao
Summary: Patients with epileptogenic hypothalamic hamartoma exhibit reduced glucose metabolism and gray matter volume predominantly in the ipsilateral neocortex, as well as overall metabolic reduction in the cerebellum. Hypometabolism in the neocortex is more distributed ipsilaterally than contralaterally to the hamartoma. The characteristics of glucose hypometabolism differ based on seizure type and sex, suggesting potential involvement of specific brain pathways in seizure propagation in these patients.
FRONTIERS OF MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yu-Chin Wu, Chia-Hung Kao, Chiung-Wei Liao, Shung Shung Sun, Te-Chun Hsieh
Summary: A 13-year-old boy was suspected of pericarditis after receiving a second booster dose of bivalent mRNA COVID-19 vaccine. The F-18-FDG PET/CT successfully revealed the simultaneous presence of vaccine-related axillary lymphadenopathy and pericarditis without interference from physiological myocardial uptake, after the patient underwent specific preparation with a carbohydrate-free, high-fat diet.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aurelie Morand, Jacques-Yves Campion, Anne Lepine, Emmanuelle Bosdure, Lea Luciani, Serge Cammilleri, Brigitte Chabrol, Eric Guedj
Summary: Despite lower initial severity at the acute stage of infection, pediatric patients with suspected long COVID showed a similar brain hypometabolic pattern as adult long COVID patients approximately 5 months later, involving bilateral medial temporal lobes, brainstem, cerebellum, and the right olfactory gyrus.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreia Rocha, Bruna Bellaver, Debora G. Souza, Guilherme Schu, Igor C. Fontana, Gianina T. Venturin, Samuel Greggio, Fernanda U. Fontella, Manoela L. Schiavenin, Luiza S. Machado, Diogo Miron, Jaderson C. da Costa, Pedro Rosa-Neto, Diogo O. Souza, Luc Pellerin, Eduardo R. Zimmer
Summary: This study used FDG-PET imaging to investigate the impact of the antipsychotic drug clozapine on brain glucose metabolism in rats, and found that downregulation of GLT-1 resulted in astrocyte-dependent cortical hypometabolism, resembling the hypometabolic signature observed in people developing dementia.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Virology
Thorsten Rudroff, Craig D. Workman, Laura L. Boles Ponto
Summary: Scientific evidence on the subacute and long-term effects of COVID-19 caused by SARS-CoV-2 infection is increasing. The infection is systemic and involves multiple organs, leading to diverse complications and long-term consequences. While a significant proportion of patients experience neurological manifestations, the exact brain and skeletal muscle changes from SARS-CoV-2 infection remain largely unknown.
Article
Radiology, Nuclear Medicine & Medical Imaging
E. Guedj, M. Million, P. Dudouet, H. Tissot-Dupont, F. Bregeon, S. Cammilleri, D. Raoult
Summary: Several brain complications have been reported in COVID-19 patients, suggesting potential neurotropism and delayed outbreak of neuroinflammatory diseases. PET metabolism analysis showed hypometabolism in the olfactory/rectus gyrus and other brain regions, supporting the neurotropism hypothesis. Further post-viral cohort studies are needed to determine the exact relationship between these hypometabolisms and persistent disorders.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Microbiology
Tzu-Chuan Ho, Chin-Chuan Chang, Hung-Pin Chan, Ying-Fong Huang, Yi-Ming Arthur Chen, Kuo-Pin Chuang, Che-Hsin Lee, Cheng-Hui Yuan, Yu-Zhen Deng, Ming-Hui Yang, Yu-Chang Tyan
Summary: A systematic review analyzed the pulmonary findings of [F-18]FDG PET/CT on asymptomatic COVID-19 patients, revealing that multiple ground-glass opacities and [F-18]FDG-avid thoracic lymph nodes were common patterns in PET/CT of asymptomatic patients with COVID-19. Postoperative COVID-19 patients should also pay attention to positive tuberculous chain lymph node metastasis.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ayah Adel Nawwar, Julie Searle, Iain Douglas Lyburn
Summary: The rapid rollout of COVID-19 vaccination has led to incidental findings on F-18-FDG PET/CT, with most cases involving reactive axillary lymphadenopathy. This study reports a 46-year-old woman with a history of breast cancer who experienced intense uptake in axillary nodes, as well as diffuse uptake in the spleen and bone marrow, after receiving the COVID-19 vaccine. She developed fever and required hospitalization but recovered with supportive treatment. One month later, she remained in good health. The observed uptake sites are believed to be related to a systemic immune response.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Najeeb Ahmed, Samreen Muzaffar, Corinne Binns, Muhammad Waqas Ilyas, Sharjeel Usmani
Summary: A case of abnormal uptake on F-18-FDG PET scan after COVID-19 vaccination in an 86-year-old female patient was reported. This highlights the importance of documenting vaccination history during PET scans to prevent false positive results.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martina Sollini, Michele Ciccarelli, Maurizio Cecconi, Alessio Aghemo, Paola Morelli, Fabrizia Gelardi, Arturo Chiti
Summary: The study included 10 COVID-19 recovered patients with persistent symptoms, showing increased [F-18]FDG uptake in bone marrow and blood vessels. Compared to controls, the recovered patients had higher [F-18]FDG uptake ratios, indicating that SARS-CoV-2 may induce vascular inflammation leading to persisting symptoms.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Medicine, General & Internal
Eva Maria Trivino-Ibanez, Beatriz Maria Jimenez-Rodriguez, Teodoro Rudolphi-Solero, Encarnacion Yolanda Garcia-Rivero, Antonio Rodriguez-Fernandez, Jose Manuel Llamas-Elvira, Manuel Gomez-Rio, Concepcion Morales-Garcia
Summary: This prospective study evaluated the usefulness of [F-18]FDG-PET/CT in the short-term follow-up of patients with COVID-19 pneumonia, and found that the findings were associated with pulmonary function impairment.
Editorial Material
Medicine, General & Internal
Romain-David Seban, Laurence Champion, Nicolas Deleval, Capucine Richard, Claire Provost
Summary: The deployment of COVID-19 vaccines worldwide has led to immune activation, as evidenced by FDG-avid axillary lymph nodes and increased spleen glucose metabolism, reflecting regional and systemic immune responses. These findings suggest that immune response may be associated with increased glucose metabolism in lymphoid organs, emphasizing the importance for nuclear physicians to recognize such immune responses post-vaccination.
Article
Clinical Neurology
Anita Nitchingham, Jarett Vanz-Brian Pereira, Eva A. Wegner, Vincent Oxenham, Jacqueline Close, Gideon A. Caplan
Summary: In this study, using FDG-PET, researchers found that patients with delirium showed hypometabolism in the bilateral thalami and certain cortical regions. The hypometabolism was correlated with delirium severity and performance on neuropsychological testing.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Nicholas J. Ashton, Andrea L. Benedet, Tharick A. Pascoal, Thomas K. Karikari, Juan Lantero-Rodriguez, Wagner S. Brum, Sulantha Mathotaarachchi, Joseph Therriault, Melissa Savard, Mira Chamoun, Erik Stoops, Cindy Francois, Eugeen Vanmechelen, Serge Gauthier, Eduardo R. Zimmer, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
Summary: CSF p-tau epitopes increase early in the development of AD pathology and are a primary candidate for detecting incipient Aβ pathology.
Article
Biochemistry & Molecular Biology
Ingrid Del Castilo, Arthur S. Neumann, Felipe S. Lemos, Marco A. De Bastiani, Felipe L. Oliveira, Eduardo R. Zimmer, Amanda M. Rego, Cristiane C. P. Hardoim, Luis Caetano M. Antunes, Flavio A. Lara, Claudia P. Figueiredo, Julia R. Clarke
Summary: This study investigated the effects of long-term exposure to GBH-RUp on the gut environment in mice and found that it caused morphological and functional changes in the gut, which correlated with behavioral changes similar to those observed in patients with neurodevelopmental disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Bessem Mornagui, Raja Rezg, Cendrine Repond, Luc Pellerin
Summary: Bisphenol S (BPS), a substitute for bisphenol A (BPA), may act as an obesogenic endocrine disruptor and affect monocarboxylate transporters and mitochondrial respiratory system in the liver, leading to the development of hepatic steatosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Geriatrics & Gerontology
Wyllians Vendramini Borelli, Priscylla Nunes de Senna, Wagner Scheeren Brum, Artur Francisco Schumacher-Schuh, Eduardo R. Zimmer, Marcia Lorena Fagundes Chaves, Raphael Machado Castilhos
Summary: This study investigated the frequency of Functional Cognitive Disorder (FCD) among individuals with low education and found that FCD was the most common diagnosis in this population. Compared to Neurodegenerative Disorders (NDD), individuals with FCD were younger, had higher cognitive test scores, and higher levels of depression. Therefore, strategies to identify and manage FCD in primary care settings can benefit both patients and healthcare systems.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Editorial Material
Cell Biology
Eduardo R. Zimmer, Tharick A. Pascoal, Pedro Rosa-Neto, Agneta Nordberg, Luc Pellerin
Summary: This statement suggests that astrocytes play a major role in the microglia-dependent modulation of FDG-PET.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Letter
Gastroenterology & Hepatology
Anna Hadjihambi, Luc Pellerin
JOURNAL OF HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Douglas T. Leffa, Joao Pedro Ferrari-Souza, Bruna Bellaver, Cecile Tissot, Pamela C. L. Ferreira, Wagner S. Brum, Arthur Caye, Jodie Lord, Petroula Proitsi, Thais Martins-Silva, Luciana Tovo-Rodrigues, Dana L. Tudorascu, Victor L. Villemagne, Ann D. Cohen, Oscar L. Lopez, William E. Klunk, Thomas K. Karikari, Pedro Rosa-Neto, Eduardo R. Zimmer, Brooke S. G. Molina, Luis Augusto Rohde, Tharick A. Pascoal
Summary: The genetic liability for attention-deficit/hyperactivity disorder (ADHD) is associated with cognitive decline and the development of Alzheimer's Disease (AD) pathology, especially in individuals with increased amyloid-beta (Aβ) deposition.
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Joseph Therriault, Marie Vermeiren, Stijn Servaes, Cecile Tissot, Nicholas J. Ashton, Andrea Lessa Benedet, Thomas K. Karikari, Juan Lantero-Rodriguez, Wagner S. Brum, Firoza Z. Lussier, Gleb Bezgin, Jenna Stevenson, Nesrine Rahmouni, Peter Kunach, Yi-Ting Wang, Jaime Fernandez-Arias, Kely Quispialaya Socualaya, Arthur C. Macedo, Joao Pedro Ferrari-Souza, Pamela C. L. Ferreira, Bruna Bellaver, Douglas T. Leffa, Eduardo R. Zimmer, Paolo Vitali, Jean-Paul Soucy, Gallen Triana-Baltzer, Hartmuth C. Kolb, Tharick A. Pascoal, Paramita Saha-Chaudhuri, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
Summary: This study investigates the association between cerebrospinal fluid (CSF) and plasma p-tau biomarkers and the hallmark pathologies of Alzheimer's disease (AD): amyloid-beta plaques and tau neurofibrillary tangles. The results suggest that p-tau is mainly associated with amyloid-beta accumulation, indicating that p-tau abnormalities may be an early event in the pathogenesis of AD.
Article
Neurosciences
Marina Tedeschi Dauar, Tharick Ali Pascoal, Joseph Therriault, Jared Rowley, Sara Mohaddes, Monica Shin, Eduardo R. Zimmer, Simon Fristed Eskildsen, Vladimir S. Fonov, Serge Gauthier, Judes Poirier, Pedro Rosa-Neto
Summary: This study assessed the association between cognitive measures and pathophysiological events in Alzheimer's disease patients, specifically focusing on delayed episodic memory tests. The findings revealed correlations between memory scores and regional amyloid deposition and brain metabolism across different stages of the disease.
Article
Clinical Neurology
Bruna Bellaver, Albert Puig-Pijoan, Joao Pedro Ferrari-Souza, Douglas T. Leffa, Firoza Z. Lussier, Pamela C. L. Ferreira, Cecile Tissot, Guilherme Povala, Joseph Therriault, Andrea L. Benedet, Nicholas J. Ashton, Stijn Servaes, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Marie Vermeiren, Arthur C. Macedo, Aida Fernandez-Lebrero, Greta Garcia-Escobar, Irene Navalpotro-Gomez, Oscar Lopez, Dana L. Tudorascu, Ann Cohen, Victor L. Villemagne, William E. Klunk, Serge Gauthier, Eduardo R. Zimmer, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Marc Suarez-Calvet, Pedro Rosa-Neto, Tharick A. Pascoal
Summary: The permeability of the blood-brain barrier (BBB) may affect the levels of brain-derived proteins in the blood, which in turn can impact the relationship between brain and blood biomarkers. The study found that BBB permeability influenced the relationship between plasma A beta(42/40) and CSF A beta(42/40) as well as A beta-PET positivity, but did not significantly impact the relationship between brain and plasma p-tau levels.
ALZHEIMERS & DEMENTIA
(2023)
Article
Chemistry, Medicinal
Igor C. Fontana, Debora G. Souza, Diogo O. Souza, Antony Gee, Eduardo R. Zimmer, Salvatore Bongarzone
Summary: The excitatory amino acid transporter 2 (EAAT2) is crucial for the clearance and recycling of glutamate, the major excitatory neurotransmitter in the brain. Dysfunctions in EAAT2 can lead to neurodegenerative diseases, such as ALS and AD. Detecting EAAT2 in the living human brain is important for improving diagnosis and therapy for these diseases. This article discusses the role of EAAT2 and presents potential activators for therapy and molecular imaging tools for diagnosis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Aline Rigon Zimmer, Bianca Franco Leonardi, Eduardo Rigon Zimmer, Alexandre Pastoris Muller, Grace Gosmann, Luis Valmor Cruz Portela
Summary: This study evaluated the protective effects of Capsicum baccatum red pepper on metabolic syndrome induced by an ultra-processed diet in rats. The results showed that oral administration of C. baccatum along with the ultra-processed diet prevented adipose tissue accumulation, reduced total cholesterol and LDL levels, and improved glucose metabolism, all commonly associated with metabolic syndrome. The study suggests that C. baccatum red pepper is a secure and enriched source of bioactive compounds promising to protect against pathological processes associated with metabolic syndrome.
Article
Clinical Neurology
Wyllians Vendramini Borelli, Carolina Rodrigues Formoso, Andrei Bieger, Pamela Lukasewicz Ferreira, Eduardo R. Zimmer, Tharick Ali Pascoal, Marcia Lorena Fagundes Chaves, Raphael Machado Castilhos
Summary: Risk factors for dementia vary among different races, and hearing loss is the most important contributor to overall population attributable fraction in all races. Public policies aimed at reducing preventable risk factors for dementia should consider the race of the target populations.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2023)
Article
Clinical Neurology
Mychael V. Lourenco, Wyllians Vendramini Borelli, Claudia Duran-Aniotz, Eduardo R. Zimmer, Shamyr Sulyvan de Castro
Summary: Alzheimer's disease (AD) is a global health issue, with immense socioeconomic burden on low- and middle-income countries (LMIC) as well as high-income countries. However, LMICs face disparities in resources and barriers to publishing in international journals, including funding constraints, language barriers, and high article processing charges. The equalization of publication fees by publishing companies could help reduce scientific inequality and improve AD research capacity in LMICs.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2023)
Article
Pharmacology & Pharmacy
Pamela C. L. Ferreira, Bruna Bellaver, Guilherme Povala, Wagner S. Brum, Cecile Tissot, Atef Badji, Matthew E. Sloan, Andrea L. Benedet, Pedro Rosa-Neto, Nicholas J. Ashton, Tharick A. Pascoal, Antoine Leuzy, Eduardo R. Zimmer
Summary: Endocannabinoid system biomarkers are associated with the progression and pathological features of Alzheimer's disease. Although not specific enough for diagnosis, they hold promise for prognosis, drug-target engagement, and a better understanding of the disease.
CANNABIS AND CANNABINOID RESEARCH
(2023)
