Article
Nutrition & Dietetics
Rajiv Rana, Jayakumar Manoharan, Anubhuti Gupta, Dheerendra Gupta, Ahmed Elwakiel, Hamzah Khawaja, Sameen Fatima, Silke Zimmermann, Kunal Singh, Saira Ambreen, Ihsan Gadi, Ronald Biemann, Shihai Jiang, Khurrum Shahzad, Shrey Kohli, Berend Isermann
Summary: Diabetic kidney disease (DKD) is a growing pandemic associated with obesity and diabetes mellitus. DKD is now the leading cause of end-stage renal disease and is linked to increased risk of cardiovascular morbidity and mortality. This study demonstrates that the cytoprotective coagulation protease activated protein C (aPC) reduces mitochondrial ROS generation in tubular cells and mitigates renal sterile inflammation in DKD, supporting the potential therapeutic use of aPC in DKD treatment.
Article
Pharmacology & Pharmacy
Bingbing Zhu, Ji Fang, Zhengcai Ju, Ying Chen, Li Wang, Hao Wang, Lina Xing, Aili Cao
Summary: The study demonstrates that Zuogui Wan can improve diabetic nephropathy by inhibiting oxidative stress and podocyte apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hai-Jian Sun, Si-Ping Xiong, Xu Cao, Lei Cao, Meng-Yuan Zhu, Zhi-Yuan Wu, Jin-Song Bian
Summary: Sodium tetrasulfide (Na2S4) treatment can ameliorate diabetic kidney disease by inhibiting inflammation cytokines and reducing oxidative stress, renal fibrosis, and cell apoptosis. Na2S4 acts through sulfhydrating SIRT1 to deactivate p65 NF-kappa B and STAT3 phosphorylation/acetylation, ultimately reducing oxidative stress, inflammation response, and EMT progression in renal tubular epithelial cells.
Review
Engineering, Biomedical
Yuan Xiong, Xiangyu Chu, Tao Yu, Samuel Knoedler, Andreas Schroeter, Li Lu, Kangkang Zha, Ze Lin, Dongsheng Jiang, Yuval Rinkevich, Adriana C. Panayi, Bobin Mi, Guohui Liu, Yanli Zhao
Summary: Diabetic wounds present challenges due to drug resistance, biofilm formation, impaired angiogenesis, and oxidative damage. Reactive oxygen species (ROS) play a crucial role in their pathogenesis. ROS-scavenging nanosystems have shown promise for treating diabetic wounds by reducing inflammation and promoting angiogenesis. However, their therapeutic applicability and efficacy need further investigation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Matthew Reily-Bell, Andrew Bahn, Rajesh Katare
Summary: Research shows that ROS is one of the main causes of diabetic heart disease, and miRNAs play a crucial role in treating the disease. However, since miRNAs have multiple targets and exhibit different functions in different environments, a thorough understanding of their mechanisms is needed for successful application.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Engineering, Biomedical
Chen Shi, Ying Zhang, Guanfu Wu, Zhangyu Zhu, Haiping Zheng, Ximeng Sun, Yongyuan Heng, Shaowei Pan, Haonan Xiu, Jing Zhang, Zhaowei Yin, Ziyi Yu, Bin Liang
Summary: This study developed a reactive oxygen species (ROS)-responsive multifunctional injectable hydrogel for diabetic wound healing. The hydrogel effectively loaded and released curcumin liposomes and silver nanoparticles (AgNPs), promoting wound healing through ROS scavenging, bactericidal activity, anti-inflammatory effects, and angiogenesis. The hydrogel demonstrated favorable biocompatibility, degradability, and injectivity.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Transplantation
Kelly L. Hudkins, Xianwu Li, Alexander L. Holland, Shreya Swaminathan, Charles E. Alpers
Summary: This study showed that empagliflozin treatment in a mouse model of diabetic nephropathy (DN) improved proteinuria and reversed pathologic alterations, including an increase in podocyte number and density, improvement in podocyte foot process effacement and parietal epithelial cell activation. The study also found that SGLT2 inhibition reduced renal oxidative stress. These findings provide insights into the potential long-term benefits of empagliflozin in humans with DN.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Shuangwen Li, Lisi Zheng, Jun Zhang, Xuejun Liu, Zhongming Wu
Summary: Our research demonstrated the involvement of ferroptosis in the development of DN, and up-regulating Nrf2 with fenofibrate treatment inhibited diabetes-related ferroptosis, delaying the progression of DN. This study provided a new perspective on the development mechanism of DN and offered a new approach to delay the progression of DN.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Eri Mukai, Shimpei Fujimoto, Nobuya Inagaki
Summary: The dysfunction of pancreatic beta-cells is crucial in the development of type 2 diabetes mellitus, characterized by impaired glucose stimulation and reduced ATP production. High glucose metabolism leads to the generation of reactive oxygen species in mitochondria, which affects beta-cells due to low expression of antioxidant enzymes. Activating the antioxidant defense factor Nrf2 may improve beta-cell dysfunction caused by ROS.
Article
Chemistry, Multidisciplinary
Kui Fan, Shiyi Yuan, Mi Zhou, Yuan Yu, Jing Guo, Liang Fang, Chanjuan Zhou, Peijin Cui, Siliang Zhang, Rong Li, Zhigang Wang, Ling Zhong, Li Zeng
Summary: This study developed a multifunctional nanoplatform that specifically targets podocytes to release mTOR and ROS inhibitors, demonstrating its safe and effective strategy for treating diabetic nephropathy.
Article
Multidisciplinary Sciences
Nada H. Aljarba, Md Saquib Hasnain, Abdullah AlKahtane, Hamzah Algamdy, Saad Alkahtani
Summary: The study demonstrated that Lagerstroemia speciosa extract has a significant protective effect against streptozotocin-induced DN in rats, by lowering glucose, creatinine, and lipid levels, and reducing serum albumin levels. This suggests that LSE may serve as a potential adjuvant for DN therapy and warrants further investigation.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Takuya Koizumi, Masaya Watanabe, Takashi Yokota, Masumi Tsuda, Haruka Handa, Jiro Koya, Kotaro Nishino, Daishiro Tatsuta, Hiroyuki Natsui, Takahide Kadosaka, Taro Koya, Motoki Nakao, Hikaru Hagiwara, Rui Kamada, Taro Temma, Shinya Tanaka, Toshihisa Anzai
Summary: Recent studies have shown that sodium-glucose co-transporter-2 inhibitors (SGLT2-i) can reduce the risk of atrial fibrillation (AF) in patients with diabetes mellitus (DM) by reducing oxidative stress. This study aimed to further investigate the mechanisms behind this protective effect and found that empagliflozin, a type of SGLT2-i, can suppress mitochondrial ROS generation and mitigate fibrosis in diabetic rats. These findings suggest that empagliflozin may have a cardioprotective effect by reducing mitochondrial ROS through AMPK signaling pathways and potentially preventing the development of AF in patients with type 2 DM.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Prima Buranasin, Hiromi Kominato, Koji Mizutani, Risako Mikami, Natsumi Saito, Kohei Takeda, Takanori Iwata
Summary: Diabetes mellitus is associated with periodontal disease and affects the efficacy of periodontal treatment. Increased reactive oxygen species (ROS) production in periodontal tissues of diabetic patients contributes to insulin resistance and impairs wound healing and tissue repair. Antioxidants and insulin resistance ameliorants may improve wound healing by inhibiting ROS production. This review comprehensively examines the latest evidence on ROS generation in periodontal tissues, particularly related to microbial challenge and diabetes, and discusses the impact of oxidative stress on wound healing in periodontal and dental implant therapies, as well as the potential benefits of administering antioxidants and anti-insulin resistance medications to counteract ROS production and inflammation.
Article
Biochemistry & Molecular Biology
Fang-Yuan Liu, Guo Nan Yin, Jiyeon Ock, Fitri Rahma Fridayana, Lashkari Niloofar, Yan Huang, Minh Nhat Vo, Jun-Kyu Suh, Soon-Sun Hong, Ju-Hee Kang, Ji-Kan Ryu
Summary: Severe vascular and nerve damage from diabetes leads to erectile dysfunction and poor response to oral phosphodiesterase 5 inhibitors. The study showed that administration of Ago2 can effectively improve penile erection in diabetic mice by enhancing cavernous endothelial cell angiogenesis and survival. Ago2 administration reduces reactive oxygen species production and improves signaling pathways, leading to improved cellular functions and erectile function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Ting-Ting Chang, Chih-Hung Chiang, Ching Chen, Su-Chu Lin, Hsin-Jou Lee, Jaw-Wen Chen
Summary: Hydralazine can protect renal proximal tubular epithelial cells from high glucose insults and prevent renal damage through XO/NADPH oxidase inhibition and Nrf2/HO-1 activation, indicating comprehensive antioxidation and anti-inflammation mechanisms for managing DN.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Lingjuan Piao, Jiyeon Choi, Guideock Kwon, Hunjoo Ha
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2017)
Article
Medicine, Research & Experimental
Jin Joo Cha, Hye Sook Min, Ki Tae Kim, Jung Eun Kim, Jung Yeon Ghee, Hyun Wook Kim, Ji Eun Lee, Jee Young Han, Gayoung Lee, Hun Joo Ha, Yun Soo Bae, Sae Rom Lee, Sung Hwan Moon, Sung Chan Lee, Ganghyun Kim, Young Sun Kang, Dae Ryong Cha
LABORATORY INVESTIGATION
(2017)
Article
Pharmacology & Pharmacy
Kyung-Hee Song, Seung-Youn Jung, Seong-Ho Kho, Sang-Gu Hwang, Hunjoo Ha, Seon Young Nam, Jie-Young Song
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2017)
Article
Oncology
Kyung-Hee Song, Seung-Youn Jung, Jeong-In Park, Jiyeon Ahn, Jong-Kuk Park, Sang-Gu Hwang, Eun-Ho Kim, Seon Young Nam, Seungwoo Park, Hunjoo Ha, Jie-Young Song
Article
Biochemistry & Molecular Biology
Jin Seong Hyeon, Youngae Jung, Gayoung Lee, Hunjoo Ha, Geum-Sook Hwang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Songling Jiang, Lingjuan Piao, Eun Bi Ma, Hunjoo Ha, Joo Young Huh
Summary: This study investigated the regulation of FNDC5 expression and irisin in circulation in type 1 and type 2 diabetic mice, and their relationship with metabolic parameters. The results showed that circulating irisin and subcutaneous fat FNDC5 gene expression were downregulated in diabetic and obese mice. Plasma irisin levels correlated positively with subcutaneous fat FNDC5 expression and negatively with markers of insulin resistance.
Review
Biochemistry & Molecular Biology
Md Jamal Uddin, Ee Hyun Kim, Md. Abdul Hannan, Hunjoo Ha
Summary: Oxidative stress is crucial in the pathophysiology of chronic kidney disease (CKD), and targeting the Nrf2-HO-1 signaling pathway may offer a potential approach for the treatment of CKD. Research has shown the beneficial effects of small molecule natural products in protecting against CKD.
Review
Chemistry, Medicinal
Md Ataur Rahman, Raju Dash, Abdullah Al Mamun Sohag, Mahboob Alam, Hunjoo Ha, Il Soo Moon, Md Jamal Uddin, Md Abdul Hannan, Hyewhon Rhim
Summary: Marine sterols have shown potential in combating Alzheimer's disease, with their anti-inflammatory and antioxidant properties providing various health benefits, including anti-aging and anti-cancer effects. Through interactions with different proteins and enzymes, marine sterols participate in regulating multiple cellular systems.
Article
Biochemistry & Molecular Biology
Eun Seon Pak, Lak Shin Jeong, Xiyan Hou, Sushil K. Tripathi, Jiyoun Lee, Hunjoo Ha
Summary: The synthesized dual-acting ligand LJ-4459, functioning as an A(2A)AR agonist and an A(3)AR antagonist, exhibits potential in preventing the progression of tubulointerstitial fibrosis. LJ-4459 showed improvements in kidney morphology, reductions in tubular injury markers, and attenuation of fibrosis. Additionally, LJ-4459 inhibited inflammation, oxidative stress, and macrophage infiltration in the obstructed kidney tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Md Jamal Uddin, Mithila Farjana, Akhi Moni, Khandkar Shaharina Hossain, Md Abdul Hannan, Hunjoo Ha
Summary: As we age, our kidneys become more susceptible to damage, making natural compound resveratrol an attractive potential anti-aging agent. Researchers are actively investigating the mechanisms by which resveratrol delays kidney aging and minimizes side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Md Abdul Hannan, Md Sarwar Zahan, Partha Protim Sarker, Akhi Moni, Hunjoo Ha, Md Jamal Uddin
Summary: Black cumin and its vital compound, thymoquinone, have shown protective effects against kidney injury caused by various xenobiotics through antioxidation, anti-inflammation, anti-apoptosis, and antifibrosis mechanisms. Clinical trials have demonstrated improvements in blood and urine parameters in advanced CKD patients. However, further research is needed to explore targeted delivery mechanisms and to gather more clinical evidence for recommending black cumin to CKD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Weiwei Zhu, Namood E. Sahar, Hafiz Muhammad Ahmad Javaid, Eun Seon Pak, Guang Liang, Yi Wang, Hunjoo Ha, Joo Young Huh
Summary: The study showed that long-term exercise can improve high-fat diet-induced fatty liver by promoting repair and anti-inflammatory effects of irisin. Irisin can regulate the MD2-TLR4 pathway by competitively binding with MD2, thereby reducing the inflammatory response of NAFLD.
Article
Biochemistry & Molecular Biology
Eun Seon Pak, Md Jamal Uddin, Hunjoo Ha
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Joo Young Huh, Inji Jung, Lingjuan Piao, Hunjoo Ha, Myung-Hee Chung
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Physiology
Minji Sohn, Keumji Kim, Md Jamal Uddin, Gayoung Lee, Inah Hwang, Hyeji Kang, Hyunji Kim, Jung Hwa Lee, Hunjoo Ha
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2017)