Review
Cardiac & Cardiovascular Systems
Dongbo Yu, James K. Liao
Summary: This review discusses the development of statins, their non-lipid-lowering benefits, and proposes future research directions in this field.
CARDIOVASCULAR RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Anna Pierzchlinska, Marek Drozdzik, Monika Bialecka
Summary: Parkinson's disease is a neurodegenerative disorder with unclear etiology and treatment options. Studies suggest that statins may have neuroprotective effects, but the data on this are conflicting. Cholesterol is essential for brain function and may also play a role in protecting against Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Sandip Rahangdale, Rajshree Fating, Mona Gajbhiye, Mona Kapse, Nazma Inamdar, Nandkishor Kotagale, Milind Umekar, Brijesh Taksande
Summary: Statins have antidepressant-like effects, potentially through promoting the release of agmatine and interacting with imidazoline receptors. These drugs also increase the levels of agmatine in the brain, presenting a new direction for potential treatment of depression.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Oliver J. Liakopoulos, Elmar W. Kuhn, Martin Hellmich, Markus Schloemicher, Justus Strauch, Wilko Reents, Anno Diegeler, Matthias Thielmann, Daniel Wendt, Jochen Boergermann, Jan F. Gummert, Christian Stoppe, Andreas Goetzenich, Sven Martens, Hermann Reichenspurner, Jens Wippermann, Hannes Reuter, Yeong-Hoon Choi, Thorsten Wahlers
Summary: This study aimed to analyze the effects of high-dose statin therapy before surgical revascularization. The results showed that additional statin loading before surgery did not reduce the rate of major adverse cardiac and cerebrovascular events (MACCE) occurring within 30 days.
EUROPEAN HEART JOURNAL
(2023)
Article
Clinical Neurology
Hyo Jeong Lee, Kyungdo Han, Yong Wook Kim, Seung Nam Yang, Seo Yeon Yoon
Summary: This study aimed to examine the association between lipid levels and the risk of Parkinson's disease (PD) in individuals with diabetes mellitus (DM) and evaluate whether the association changes with the use of statins. The results showed an inverse association between lipid levels and PD development in patients with DM, which was influenced by statin use.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Bradley S. Guidry, Katherine A. Kelly, Aaron M. Yengo-Kahn, Matthews Lan, Alan R. Tang, Silky Chotai, Peter Morone, Patrick D. Kelly
Summary: This study found that concurrent use of statin drugs after surgical treatment for cSDH can help reduce the size of hematoma, potentially serving as a low-cost, low-risk supplement to surgical management for cSDH patients.
WORLD NEUROSURGERY
(2021)
Review
Pharmacology & Pharmacy
David M. Dolivo, Charlotte R. Reed, Kristine A. Gargiulo, Adrian E. Rodrigues, Robert D. Galiano, Thomas A. Mustoe, Seok Jong Hong
Summary: Fibrosis is a common pathological repair process in organs, but there is a lack of effective therapeutic methods. Repurposing existing drugs, such as statins, can be a complementary strategy to treat tissue fibrosis. Statins have been found to have anti-fibrotic effects through various mechanisms, and a better understanding of these effects can aid in the development of novel therapeutic agents.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Andrea Beyerle, Brandon Greene, Barbara Dietrich, Bronwyn A. Kingwell, Priya Panjwani, Samuel D. Wright, Eva Herzog
Summary: The investigational drug CSL112 is being developed for reducing the risk of early recurrent cardiovascular events after an acute myocardial infarction. A study in rats showed that combining CSL112 with alirocumab and/or atorvastatin did not have significant additive liver toxicity effects, with minimal impact on exposure levels and lipid profiles.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Man K. S. Lee, Olivia D. Cooney, Xuzhu Lin, Shaktypreya Nadarajah, Dragana Dragoljevic, Kevin Huynh, Danise-Ann Onda, Sandra Galic, Peter J. Meikle, Thomas Edlund, Morgan D. Fullerton, Bruce E. Kemp, Andrew J. Murphy, Kim Loh
Summary: The study revealed that the AMPK/HMGCR axis plays a crucial role in the development of atherosclerosis. Defects in AMPK regulation of HMGCR lead to increased aortic lesions, plaque-associated macrophages, lipid accumulation, and atherogenic monocytes.
MOLECULAR METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Nicholas B. Alana, William A. Ciurylo, Natalie Hurlock
Summary: This study suggests that moderate and high intensity statin medications may reduce the frequency of DIC in critically ill patients with severe sepsis or septic shock.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Cardiac & Cardiovascular Systems
Genki Ichihara, Yoshinori Katsumata, Yuki Sugiura, Yuta Matsuoka, Rae Maeda, Jin Endo, Atsushi Anzai, Kohsuke Shirakawa, Hidenori Moriyama, Hiroki Kitakata, Takahiro Hiraide, Shinichi Goto, Seien Ko, Yuji Iwasawa, Kazuhisa Sugai, Kyohei Daigo, Shinya Goto, Kazuki Sato, Ken-ichi Yamada, Makoto Suematsu, Masaki Ieda, Motoaki Sano
Summary: This study found that glutathione release during ischemia-reperfusion (IR) is primarily dependent on the transporter MRP1, and its release induces ferroptosis. Suppression of glutathione release attenuates ferroptosis and reduces myocardial infarct size following IR.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Su Mon Shwe, Sivaprasath Prabu, Dapeng Jing, Kanglai He, Zhenying Wang
Summary: The Cry1Ah and Vip3Aa19 proteins have a synergistic interaction in controlling the Yellow peach moth. Cry1Ah has a higher binding affinity for midgut receptors compared to Vip3Aa19, and there is no competition between them.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Medicinal
Xing-Zi Li, Shi-You Jiang, Guo-Qiang Li, Qian-Ru Jiang, Jue-Wan Li, Chen-Chen Li, Yu-Qin Han, Bao-Liang Song, Xin-Ran Ma, Wei Qi, Wen-Wei Qiu
Summary: A series of novel HMG499 analogs were synthesized and one of the compounds, 29 (QH536), showed potent activity in promoting HMGCR degradation without inducing cholesterol accumulation in cells. Compound 29 also exhibited effects on lowering cholesterol levels and suppressing various related genes, making it a potential candidate for the treatment of CVD and NASH.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Je-Wen Liou, Hemalatha Mani, Jui-Hung Yen
Summary: Hepatitis is an inflammatory disease of the liver caused by viral infections, most commonly hepatitis B and hepatitis C. Host lipid metabolism, particularly cholesterol metabolism, is crucial for hepatitis viral infection and life cycle. Manipulating host cholesterol metabolism-related genes and proteins, such as using cholesterol-lowering drugs, has shown promising results in the treatment of viral hepatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jia-Li Feng, Suzanne C. Dixon-Suen, Susan J. Jordan, Penelope M. Webb
Summary: The use of statins may provide a survival benefit for women with ovarian cancer, particularly for those with endometrioid cancers. However, bias in observational studies poses challenges in conclusively establishing this association.
BRITISH JOURNAL OF CANCER
(2021)
Article
Gastroenterology & Hepatology
Claudia D. Fuchs, Gustav Paumgartner, Annika Wahlstrom, Philipp Schwabl, Thomas Reiberger, Nadja Leditznig, Tatjana Stojakovic, Nataliya Rohr-Udilova, Peter Chiba, Hanns-Ulrich Marschall, Michael Trauner
JOURNAL OF HEPATOLOGY
(2017)
Article
Pharmacology & Pharmacy
Muhammad Imran Sohail, Diethart Schmid, Katrin Wlcek, Matthias Spork, Gergely Szakacs, Michael Trauner, Thomas Stockner, Peter Chiba
MOLECULAR PHARMACOLOGY
(2017)
Article
Biophysics
Daniel Szoellosi, Gergely Szakacs, Peter Chiba, Thomas Stockner
BIOPHYSICAL JOURNAL
(2018)
Article
Oncology
Yueling Yuan, Peter Chiba, Tiange Cai, Richard Callaghan, Li Bai, Susan P. C. Cole, Yu Cai
Article
Multidisciplinary Sciences
Christine Wasinger, Alexandra Hofer, Oliver Spadiut, Martin Hohenegger
SCIENTIFIC REPORTS
(2018)
Article
Nanoscience & Nanotechnology
Yueling Yuan, Tiange Cai, Richard Callaghan, Qianwen Li, Yinghong Huang, Bingyue Wang, Qingqing Huang, Manling Du, Qianqian Ma, Peter Chiba, Yu Cai
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Review
Oncology
Qingqing Huang, Tiange Cai, Li Bai, Yinghong Huang, Qianwen Li, Qi Wang, Peter Chiba, Yu Cai
TRANSLATIONAL CANCER RESEARCH
(2019)
Article
Multidisciplinary Sciences
Daniel Szoellosi, Peter Chiba, Gergely Szakacs, Thomas Stockner
SCIENTIFIC REPORTS
(2020)
Article
Virology
I Goerzer, Ch Buchta, P. Chiba, B. Benka, J. Camp, H. Holzmann, E. Puchhammer-Stoeckl, S. W. Aberle
JOURNAL OF CLINICAL VIROLOGY
(2020)
Review
Oncology
Martin Hohenegger
Summary: Pharmacological anticancer therapy in elderly patients must consider age-related changes in organ function and disease-related alterations. While efficacy is maintained, plasma drug concentrations and adverse reactions may increase. Therapeutic drug monitoring, especially in novel targeted therapies, can help personalize treatment and enhance safety for elderly cancer patients in clinical practice.
MEMO-MAGAZINE OF EUROPEAN MEDICAL ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Fauzia Nasim, Diethart Schmid, Gergely Szakacs, Azmat Sohail, Harald H. Sitte, Peter Chiba, Thomas Stockner
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2020)
Meeting Abstract
Biophysics
D. Szoelloesi, S. Tarapcsak, G. Szaloki, P. Chiba, G. Szakacs, K. Goda, T. Stockner
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Felix Paul Mayer, Anthony W. Owens, Stefan Boehm, Ulrik Gether, Wouter Koek, Lynette C. Daws, Harald H. Sitte
Article
Chemistry, Medicinal
Dennis Haake, Peter Chiba, Gerhard F. Ecker
TRANSPORTERS AS DRUG TARGETS
(2017)
Article
Pharmacology & Pharmacy
Matthias Spork, Muhammad Imran Sohail, Diethart Schmid, Gerhard F. Ecker, Michael Freissmuth, Peter Chiba, Thomas Stockner
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2017)