HIV-2 and SIVmac Accessory Virulence Factor Vpx Down-regulates SAMHD1 Enzyme Catalysis Prior to Proteasome-dependent Degradation

Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

(2013) Junpeng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction

(2013) Natalia Beloglazova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals

(2013) Hangxing Yu et al.   Retrovirology

Restriction of diverse retroviruses by SAMHD1

(2013) Thomas Gramberg et al.   Retrovirology

SAMHD1 Joins the Red Queen's Court

(2012) Vicente Planelles   Cell Host & Microbe

Innate Immune Sensing of HIV-1 by Dendritic Cells

(2012) Jeremy Luban   Cell Host & Microbe

Evolutionary and Functional Analyses of the Interaction between the Myeloid Restriction Factor SAMHD1 and the Lentiviral Vpx Protein

(2012) Nadine Laguette et al.   Cell Host & Microbe

The Ability of Primate Lentiviruses to Degrade the Monocyte Restriction Factor SAMHD1 Preceded the Birth of the Viral Accessory Protein Vpx

(2012) Efrem S. Lim et al.   Cell Host & Microbe

A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest

(2012) Wei Wei et al.   CELLULAR MICROBIOLOGY

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations

(2012) Adriana Goncalves et al.   HUMAN MUTATION

Tight Interplay among SAMHD1 Protein Level, Cellular dNTP Levels, and HIV-1 Proviral DNA Synthesis Kinetics in Human Primary Monocyte-derived Macrophages

(2012) Baek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV/Simian Immunodeficiency Virus (SIV) Accessory Virulence Factor Vpx Loads the Host Cell Restriction Factor SAMHD1 onto the E3 Ubiquitin Ligase Complex CRL4DCAF1

(2012) Jinwoo Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMHD1 Restricts HIV-1 Cell-to-Cell Transmission and Limits Immune Detection in Monocyte-Derived Dendritic Cells

(2012) I. Puigdomenech et al.   JOURNAL OF VIROLOGY

The Vpx Lentiviral Accessory Protein Targets SAMHD1 for Degradation in the Nucleus

(2012) H. Hofmann et al.   JOURNAL OF VIROLOGY

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

SAMHD1 does it again, now in resting T cells

(2012) Nan Yan et al.   NATURE MEDICINE

SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

(2012) Hanna-Mari Baldauf et al.   NATURE MEDICINE

Co-Evolution of Primate SAMHD1 and Lentivirus Vpx Leads to the Loss of the vpx Gene in HIV-1 Ancestor

(2012) Chiyu Zhang et al.   PLoS One

SAMHD1: a new contributor to HIV-1 restriction in resting CD4+ T-cells

(2012) Li Wu   Retrovirology

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

(2012) Corine St Gelais et al.   Retrovirology

Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac

(2012) Alberto Brandariz-Nuñez et al.   Retrovirology

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+ T-cells

(2012) Benjamin Descours et al.   Retrovirology

HIV Interplay with SAMHD1

(2012) T. Schaller et al.   SCIENCE

Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1

(2012) Tommy E. White et al.   VIROLOGY

Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein fromEnterococcus faecalisand Crystal Structure of the Activator-Substrate Complex

(2011) Ivan I. Vorontsov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

(2011) Rebecca D. Powell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifaceted Counter-APOBEC3G Mechanisms Employed by HIV-1 Vif

(2011) Elena Britan-Rosich et al.   JOURNAL OF MOLECULAR BIOLOGY

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

SAMHD1-Deficient CD14+ Cells from Individuals with Aicardi-Goutières Syndrome Are Highly Susceptible to HIV-1 Infection

(2011) André Berger et al.   PLoS Pathogens

HIV-1 Vpr Loads Uracil DNA Glycosylase-2 onto DCAF1, a Substrate Recognition Subunit of a Cullin 4A-RING E3 Ubiquitin Ligase for Proteasome-dependent Degradation

(2010) Jinwoo Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human Immunodeficiency Virus Type 2 Vpx Protein Usurps the CUL4A-DDB1DCAF1 Ubiquitin Ligase To Overcome a Postentry Block in Macrophage Infection

(2009) A. Bergamaschi et al.   JOURNAL OF VIROLOGY

Evidence for an Activation Domain at the Amino Terminus of Simian Immunodeficiency Virus Vpx

(2009) T. Gramberg et al.   JOURNAL OF VIROLOGY

Detection of sequential polyubiquitylation on a millisecond timescale

(2009) Nathan W. Pierce et al.   NATURE

Primate Lentiviral Vpx Commandeers DDB1 to Counteract a Macrophage Restriction

(2008) Natalia Sharova et al.   PLoS Pathogens

Lentiviral Vpx Accessory Factor Targets VprBP/DCAF1 Substrate Adaptor for Cullin 4 E3 Ubiquitin Ligase to Enable Macrophage Infection

(2008) Smita Srivastava et al.   PLoS Pathogens