Angiogenesis as a therapeutic target in arthritis in 2011: learning the lessons of the colorectal cancer experience

Work disability remains a major problem in rheumatoid arthritis in the 2000s: data from 32 countries in the QUEST-RA Study

(2012) Tuulikki Sokka et al.   ARTHRITIS RESEARCH & THERAPY

Synovial tissue hypoxia and inflammation in vivo

(2010) C. T. Ng et al.   ANNALS OF THE RHEUMATIC DISEASES

The vasculature in rheumatoid arthritis: cause or consequence?

(2010) Ewa M. Paleolog   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Clinical Significance of Serum Levels of Vascular Endothelial Growth Factor, Angiopoietin-1, and Angiopoietin-2 in Patients with Rheumatoid Arthritis

(2010) D. KUROSAKA et al.   JOURNAL OF RHEUMATOLOGY

Quantitative Power Doppler Ultrasonography Is a Sensitive Measure of Metacarpophalangeal Joint Synovial Vascularity in Rheumatoid Arthritis and Declines Significantly Following a 2-week Course of Oral Low-dose Corticosteroids

(2010) M. J. LARCHE et al.   JOURNAL OF RHEUMATOLOGY

Bevacizumab Increases Risk for Severe Proteinuria in Cancer Patients

(2010) S. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of the Angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritis

(2010) N. M. Malik et al.   RHEUMATOLOGY

Bevacizumab-Related Surgical Site Complication Despite Primary Tumor Resection in Colorectal Cancer Patients

(2009) Thierry Bège et al.   ANNALS OF SURGICAL ONCOLOGY

Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint

(2009) M. Biniecka et al.   ANNALS OF THE RHEUMATIC DISEASES

Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective french research axed on tolerance of biotherapies registry

(2009) F. Tubach et al.   ARTHRITIS AND RHEUMATISM

Inhibition of HIF-1α activity by BP-1 ameliorates adjuvant induced arthritis in rats

(2009) J. Shankar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model

(2009) Ken Matsumoto et al.   CANCER SCIENCE

A comparative study of arterial stiffness, flow-mediated vasodilation of the brachial artery, and the thickness of the carotid artery intima–media in patients with systemic autoimmune diseases

(2009) Pál Soltész et al.   CLINICAL RHEUMATOLOGY

Hypoxia-Inducible Factor-1 as Regulator of Angiogenesis in Rheumatoid Arthritis - Therapeutic Implications

(2009) J. Westra et al.   CURRENT MEDICINAL CHEMISTRY

Initial Safety Report of NSABP C-08: A Randomized Phase III Study of Modified FOLFOX6 With or Without Bevacizumab for the Adjuvant Treatment of Patients With Stage II or III Colon Cancer

(2009) Carmen J. Allegra et al.   JOURNAL OF CLINICAL ONCOLOGY

Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: a meta-analysis

(2009) Sanjaykumar Hapani et al.   LANCET ONCOLOGY

Correlation between synovial blood flow signals and serum vascular endothelial growth factor levels in patients with refractory rheumatoid arthritis

(2009) Daitaro Kurosaka et al.   Modern Rheumatology

Adverse effects of anticancer agents that target the VEGF pathway

(2009) Helen X. Chen et al.   Nature Reviews Clinical Oncology

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

(2009) Gregg L. Semenza   PHYSIOLOGY

Immature Blood Vessels in Rheumatoid Synovium Are Selectively Depleted in Response to Anti-TNF Therapy

(2009) Elena Izquierdo et al.   PLoS One

Characterization of synovial tissue from arthritis patients: a proton magnetic resonance spectroscopic investigation

(2009) Carol A. Hitchon et al.   RHEUMATOLOGY INTERNATIONAL

The Risk of Infections with Biologic Therapies for Rheumatoid Arthritis

(2009) Daniel E. Furst   SEMINARS IN ARTHRITIS AND RHEUMATISM

Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis

(2009) Mohammed A Akhavani et al.   ARTHRITIS RESEARCH & THERAPY

Etanercept therapy in rheumatoid arthritis and the risk of malignancies: a systematic review and individual patient data meta-analysis of randomised controlled trials

(2008) T Bongartz et al.   ANNALS OF THE RHEUMATIC DISEASES

Antagonism of the human epidermal growth factor receptor family controls disease severity in murine collagen-induced arthritis

(2008) Percy F. Sumariwalla et al.   ARTHRITIS AND RHEUMATISM

Cardiovascular, rheumatologic, and pharmacologic predictors of stroke in patients with rheumatoid arthritis: A nested, case-control study

(2008) Zurab Nadareishvili et al.   ARTHRITIS AND RHEUMATISM

High ten-year risk of cardiovascular disease in newly diagnosed rheumatoid arthritis patients: A population-based cohort study

(2008) Hilal Maradit Kremers et al.   ARTHRITIS AND RHEUMATISM

Hypoxia-inducible factor 1α is deregulated by the serum of rats with adjuvant-induced arthritis

(2008) Hye-Lim Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeted therapies in breast cancer: Where are we now?

(2008) Serena Di Cosimo et al.   EUROPEAN JOURNAL OF CANCER

The specific contribution of hypoxia-inducible factor-2α to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors

(2008) Christina Warnecke et al.   EXPERIMENTAL CELL RESEARCH

A pan-HER approach for cancer therapy: background, current status and future development

(2008) Zhongdong Huang et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Inhibition of histone deacetylase down-regulates the expression of hypoxia-induced vascular endothelial growth factor by rheumatoid synovial fibroblasts

(2008) H. Manabe et al.   INFLAMMATION RESEARCH

Risk of Venous Thromboembolism With the Angiogenesis Inhibitor Bevacizumab in Cancer Patients

(2008) Shobha Rani Nalluri et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Safety and Efficacy of Oxaliplatin and Fluoropyrimidine Regimens With or Without Bevacizumab As First-Line Treatment of Metastatic Colorectal Cancer: Results of the TREE Study

(2008) Howard S. Hochster et al.   JOURNAL OF CLINICAL ONCOLOGY

Synovial Hypoxia as a Cause of Tendon Rupture in Rheumatoid Arthritis

(2008) Branavan Sivakumar et al.   JOURNAL OF HAND SURGERY-AMERICAN VOLUME

Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients

(2008) Shoji Yamane et al.   Journal of Inflammation-London

An Angiogenesis Inhibitor, 2-Methoxyestradiol, Involutes Rat Collagen-Induced Arthritis and Suppresses Gene Expression of Synovial Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor

(2008) Ernest Brahn et al.   JOURNAL OF RHEUMATOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of hypoxia-inducible factor-1  in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes

(2008) J. K. Ahn et al.   RHEUMATOLOGY

Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis

(2008) Pei Jin et al.   ARTHRITIS RESEARCH & THERAPY

“Spontaneous,” delayed colon and rectal anastomotic complications associated with bevacizumab therapy

(2007) David A. August et al.   JOURNAL OF SURGICAL ONCOLOGY