New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells

The immunoproteasome β5i subunit is a key contributor to ictogenesis in a rat model of chronic epilepsy

(2015) Michele Mishto et al.   BRAIN BEHAVIOR AND IMMUNITY

Comparative study of the biochemical properties of proteasomes in domestic animals

(2015) Mary Raule et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Regulation of Immunoproteasome Function in the Lung

(2015) Ilona E. Keller et al.   Scientific Reports

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis

(2014) Michael Basler et al.   EMBO Molecular Medicine

Carfilzomib demonstrates broad anti-tumor activity in pre-clinical non-small cell and small cell lung cancer models

(2014) Amanda F Baker et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Dendritic cell maturation in HCV infection: Altered regulation of MHC class I antigen processing-presenting machinery

(2014) Patrizia Leone et al.   JOURNAL OF HEPATOLOGY

Interferon-γ Induces Immunoproteasomes and the Presentation of MHC I-Associated Peptides on Human Salivary Gland Cells

(2014) Martha E. Arellano-Garcia et al.   PLoS One

Immuno- and Constitutive Proteasomes Do Not Differ in Their Abilities to Degrade Ubiquitinated Proteins

(2013) James A. Nathan et al.   CELL

A New Infant Case of Nakajo-Nishimura Syndrome with a Genetic Mutation in the Immunoproteasome Subunit: An Overlapping Entity with JMP and CANDLE Syndrome Related toPSMB8Mutations

(2013) Kayo Kunimoto et al.   DERMATOLOGY

Identification of the Immunoproteasome as a Novel Regulator of Skeletal Muscle Differentiation

(2013) Z. Cui et al.   MOLECULAR AND CELLULAR BIOLOGY

Immunoproteasome Deficiency Modifies the Alternative Pathway of NFκB Signaling

(2013) Marcela Maldonado et al.   PLoS One

β5i Subunit Deficiency of the Immunoproteasome Leads to Reduced Th2 Response in OVA Induced Acute Asthma

(2013) Anton Volkov et al.   PLoS One

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice

(2012) M Wehenkel et al.   BRITISH JOURNAL OF CANCER

Prophylactic and therapeutic efficacies of a selective inhibitor of the immunoproteasome for Hashimoto's thyroiditis, but not for Graves' hyperthyroidism, in mice

(2012) Y. Nagayama et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunoproteasome Subunit LMP7 Deficiency and Inhibition Suppresses Th1 and Th17 but Enhances Regulatory T Cell Differentiation

(2012) K. W. Kalim et al.   JOURNAL OF IMMUNOLOGY

The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications

(2012) Idit Shachar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Adaptive immunity in obesity and insulin resistance

(2012) Henrike Sell et al.   Nature Reviews Endocrinology

Targeting monocytes/macrophages in the treatment of rheumatoid arthritis

(2012) J.-L. Davignon et al.   RHEUMATOLOGY

Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity

(2011) Yin Liu et al.   ARTHRITIS AND RHEUMATISM

LPS-Induced Formation of Immunoproteasomes: TNF-α and Nitric Oxide Production are Regulated by Altered Composition of Proteasome-Active Sites

(2011) Julia Reis et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans

(2011) Akiko Kitamura et al.   JOURNAL OF CLINICAL INVESTIGATION

The Antiviral Immune Response in Mice Devoid of Immunoproteasome Activity

(2011) M. Basler et al.   JOURNAL OF IMMUNOLOGY

Novel Proteasome Inhibitors to Overcome Bortezomib Resistance

(2011) Amy M. Ruschak et al.   JNCI-Journal of the National Cancer Institute

Mice completely lacking immunoproteasomes show major changes in antigen presentation

(2011) Eleanor Z Kincaid et al.   NATURE IMMUNOLOGY

Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome

(2011) K. Arima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impairment of Immunoproteasome Function by β5i/LMP7 Subunit Deficiency Results in Severe Enterovirus Myocarditis

(2011) Elisa Opitz et al.   PLoS Pathogens

PSMB8 Encoding the β5i Proteasome Subunit Is Mutated in Joint Contractures, Muscle Atrophy, Microcytic Anemia, and Panniculitis-Induced Lipodystrophy Syndrome

(2010) Anil K. Agarwal et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma

(2010) D. Chauhan et al.   BLOOD

PTEN Inhibition Improves Muscle Regeneration in Mice Fed a High-Fat Diet

(2010) Z. Hu et al.   DIABETES

An Autosomal Recessive Syndrome of Joint Contractures, Muscular Atrophy, Microcytic Anemia, and Panniculitis-Associated Lipodystrophy

(2010) Abhimanyu Garg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Unexpected Role for the Immunoproteasome Subunit LMP2 in Antiviral Humoral and Innate Immune Responses

(2010) S. E. Hensley et al.   JOURNAL OF IMMUNOLOGY

Prevention of Experimental Colitis by a Selective Inhibitor of the Immunoproteasome

(2010) M. Basler et al.   JOURNAL OF IMMUNOLOGY

Evidence for a role of immunoproteasomes in regulating cardiac muscle mass in diabetic mice

(2010) Lingyun Zu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome

(2009) F. Parlati et al.   BLOOD

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

Immunoproteasome Overexpression Underlies the Pathogenesis of Thyroid Oncocytes and Primary Hypothyroidism: Studies in Humans and Mice

(2009) Hiroaki J. Kimura et al.   PLoS One

The proteasome: Overview of structure and functions

(2009) Keiji TANAKA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

(2008) Deborah J. Kuhn et al.   BLOOD

Adipocytokines and the Metabolic Complications of Obesity

(2008) Neda Rasouli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM