Efficacy of serotonin inhibition in mouse models of bone loss

Emerging therapeutic opportunities for skeletal restoration

(2011) Masanobu Kawai et al.   NATURE REVIEWS DRUG DISCOVERY

Lithium chloride attenuates BMP-2 signaling and inhibits osteogenic differentiation through a novel WNT/GSK3- independent mechanism

(2010) Jingjing Li et al.   BONE

Genetic Analysis of Lrp5 Function in Osteoblast Progenitors

(2010) Vijay K. Yadav et al.   CALCIFIED TISSUE INTERNATIONAL

The direct examination of three-dimensional bone architecture in vitro by computed tomography

(2010) Lee A. Feldkamp et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin

(2010) Morten Frost et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

(2010) Vijay K Yadav et al.   NATURE MEDICINE

The Societal Burden of Osteoporosis

(2010) David J. Becker et al.   Current Rheumatology Reports

Anabolic Therapies

(2010) Nancy E. Lane et al.   Current Osteoporosis Reports

Lithium modulates tryptophan hydroxylase 2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons

(2009) Kathrin Scheuch et al.   BRAIN RESEARCH

A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure

(2009) Vijay K. Yadav et al.   CELL

Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia

(2009) Anne Saarinen et al.   CLINICAL ENDOCRINOLOGY

Future therapeutic targets in osteoporosis

(2009) Chad Deal   CURRENT OPINION IN RHEUMATOLOGY

Increasing Options for the Treatment of Osteoporosis

(2009) Sundeep Khosla   NEW ENGLAND JOURNAL OF MEDICINE

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

(2008) Vijay K. Yadav et al.   CELL

Modulation of Peripheral Serotonin Levels by Novel Tryptophan Hydroxylase Inhibitors for the Potential Treatment of Functional Gastrointestinal Disorders

(2008) Zhi-Cai Shi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Characterization of Novel Tryptophan Hydroxylase Inhibitors That Selectively Inhibit Serotonin Synthesis in the Gastrointestinal Tract

(2008) Q. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL