Nanoparticle-Based Manipulation of Antigen-Presenting Cells for Cancer Immunotherapy

CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses

(2015) Rodney A. Rosalia et al.   BIOMATERIALS

Nanovaccine loaded with poly I:C and STAT3 siRNA robustly elicits anti-tumor immune responses through modulating tumor-associated dendritic cells in vivo

(2015) Zichao Luo et al.   BIOMATERIALS

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Infection-mimicking poly(γ-glutamic acid) as adjuvant material for effective anti-tumor immune response

(2015) Anushree Seth et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice

(2015) Matthias Obenaus et al.   NATURE BIOTECHNOLOGY

Immunomodulatory spherical nucleic acids

(2015) Aleksandar F. Radovic-Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T-Cell Activation

(2015) Randall A. Meyer et al.   Small

Nanoparticle-Delivered Transforming Growth Factor-β siRNA Enhances Vaccination against Advanced Melanoma by Modifying Tumor Microenvironment

(2014) Zhenghong Xu et al.   ACS Nano

Magnetic Field-Induced T Cell Receptor Clustering by Nanoparticles Enhances T Cell Activation and Stimulates Antitumor Activity

(2014) Karlo Perica et al.   ACS Nano

Final report of the phase I/II clinical trial of the E75 (nelipepimut-S) vaccine with booster inoculations to prevent disease recurrence in high-risk breast cancer patients

(2014) E. A. Mittendorf et al.   ANNALS OF ONCOLOGY

Cancer treatment and survivorship statistics, 2014

(2014) Carol E. DeSantis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Vaccination therapy for non-small-cell lung cancer

(2014) Kristof Cuppens et al.   CURRENT OPINION IN ONCOLOGY

Magnetic mesoporous silica nanoparticles for potential delivery of chemotherapeutic drugs and hyperthermia

(2014) Cuilian Tao et al.   DALTON TRANSACTIONS

The HER2 peptide nelipepimut-S (E75) vaccine (NeuVax™) in breast cancer patients at risk for recurrence: correlation of immunologic data with clinical response

(2014) Erika J Schneble et al.   Immunotherapy

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

(2014) Ronnie H. Fang et al.   NANO LETTERS

Therapeutic vaccines for cancer: an overview of clinical trials

(2014) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Enhancing immunomodulation on innate immunity by shape transition among RNA triangle, square and pentagon nanovehicles

(2014) Emil F. Khisamutdinov et al.   NUCLEIC ACIDS RESEARCH

Induction of Antigen-Specific Immunity with a Vaccine Targeting NY-ESO-1 to the Dendritic Cell Receptor DEC-205

(2014) M. V. Dhodapkar et al.   Science Translational Medicine

In vivo Gold Nanoparticle Delivery of Peptide Vaccine Induces Anti-Tumor Immune Response in Prophylactic and Therapeutic Tumor Models

(2014) Joao Paulo Mattos Almeida et al.   Small

Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

(2014) Petr O. Ilyinskii et al.   VACCINE

The right touch: design of artificial antigen-presenting cells to stimulate the immune system

(2014) Joep van der Weijden et al.   Chemical Science

pH-Responsive Nanoparticle Vaccines for Dual-Delivery of Antigens and Immunostimulatory Oligonucleotides

(2013) John T. Wilson et al.   ACS Nano

Programmed nanoparticles for combined immunomodulation, antigen presentation and tracking of immunotherapeutic cells

(2013) Min Beom Heo et al.   BIOMATERIALS

Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response

(2013) Susan N. Thomas et al.   BIOMATERIALS

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Adjuvant MAGE-A3 Immunotherapy in Resected Non–Small-Cell Lung Cancer: Phase II Randomized Study Results

(2013) Johan Vansteenkiste et al.   JOURNAL OF CLINICAL ONCOLOGY

Multifunctional nanoparticles co-delivering Trp2 peptide and CpG adjuvant induce potent cytotoxic T-lymphocyte response against melanoma and its lung metastasis

(2013) Zhenghong Xu et al.   JOURNAL OF CONTROLLED RELEASE

Bioreducible alginate-poly(ethylenimine) nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune responses

(2013) Ping Li et al.   JOURNAL OF CONTROLLED RELEASE

Colocalized Delivery of Adjuvant and Antigen Using Nanolipoprotein Particles Enhances the Immune Response to Recombinant Antigens

(2013) Nicholas O. Fischer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Phase I vaccine trial using dendritic cells pulsed with autologous oxidized lysate for recurrent ovarian cancer

(2013) Lana E Kandalaft et al.   Journal of Translational Medicine

Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-small-cell lung cancer (START): a randomised, double-blind, phase 3 trial

(2013) Charles Butts et al.   LANCET ONCOLOGY

Nanoengineering approaches to the design of artificial antigen-presenting cells

(2013) Joel C Sunshine et al.   Nanomedicine

Combinational delivery of lipid-enveloped polymeric nanoparticles carrying different peptides for anti-tumor immunotherapy

(2013) Songwei Tan et al.   Nanomedicine

Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

(2013) Ronnie H. Fang et al.   Nanoscale

Gold Nanoparticle Delivery of Modified CpG Stimulates Macrophages and Inhibits Tumor Growth for Enhanced Immunotherapy

(2013) Adam Yuh Lin et al.   PLoS One

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

(2013) A. de Titta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Nanomedicine: From Drug Delivery to Imaging

(2013) E. K.-H. Chow et al.   Science Translational Medicine

The endocytosis and intracellular fate of nanomedicines: Implication for rational design

(2013) Longfa Kou et al.   Asian Journal of Pharmaceutical Sciences

Imageable Antigen-Presenting Gold Nanoparticle Vaccines for Effective Cancer Immunotherapy In Vivo

(2012) In-Hyun Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Increasing the efficacy of tumor cell vaccines by enhancing cross priming

(2012) Brian M. Andersen et al.   CANCER LETTERS

Exploiting the Mutanome for Tumor Vaccination

(2012) J. C. Castle et al.   CANCER RESEARCH

Particle-mediated delivery of cytokines for immunotherapy

(2012) David A Christian et al.   Immunotherapy

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

The big picture on nanomedicine: the state of investigational and approved nanomedicine products

(2012) Michael L. Etheridge et al.   Nanomedicine-Nanotechnology Biology and Medicine

Combinatorial drug therapy for cancer in the post-genomic era

(2012) Bissan Al-Lazikani et al.   NATURE BIOTECHNOLOGY

Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

(2012) Jason Park et al.   NATURE MATERIALS

Antibody-Antigen-Adjuvant Conjugates Enable Co-Delivery of Antigen and Adjuvant to Dendritic Cells in Cis but Only Have Partial Targeting Specificity

(2012) Martin Kreutz et al.   PLoS One

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

(2012) J. Hrkach et al.   Science Translational Medicine

Cellular Cancer Vaccines: an Update on the Development of Vaccines Generated from Cell Surface Antigens

(2012) Petr G. Lokhov et al.   Journal of Cancer

Natural Innate and Adaptive Immunity to Cancer

(2011) Matthew D. Vesely et al.   Annual Review of Immunology

Nanoparticle Delivery of Cancer Drugs

(2011) Andrew Z. Wang et al.   Annual Review of Medicine

Dimercaptosuccinic acid-coated magnetite nanoparticles for magnetically guided in vivo delivery of interferon gamma for cancer immunotherapy

(2011) Raquel Mejías et al.   BIOMATERIALS

Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery

(2011) Zhiping Zhang et al.   BIOMATERIALS

PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine

(2011) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Comparison of two CD40-ligand/interleukin-2 vaccines in patients with chronic lymphocytic leukemia

(2011) Fatma Visal Okur et al.   CYTOTHERAPY

CpG DNA as a vaccine adjuvant

(2011) Christian Bode et al.   Expert Review of Vaccines

Effective Melanoma Immunotherapy with Interleukin-2 Delivered by a Novel Polymeric Nanoparticle

(2011) H. Yao et al.   MOLECULAR CANCER THERAPEUTICS

Nanoparticle PEGylation for imaging and therapy

(2011) Jesse V Jokerst et al.   Nanomedicine

Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging

(2011) Suphiya Parveen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses

(2011) James J. Moon et al.   NATURE MATERIALS

Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response

(2011) Haiyan Li et al.   Nature Nanotechnology

gp100 Peptide Vaccine and Interleukin-2 in Patients with Advanced Melanoma

(2011) Douglas J. Schwartzentruber et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development of Effective Cancer Vaccine Using Targeting System of Antigen Protein to APCs

(2011) Tomoaki Kurosaki et al.   PHARMACEUTICAL RESEARCH

Targeted antigen delivery and activation of dendritic cells in vivo: Steps towards cost effective vaccines

(2011) Paul J. Tacken et al.   SEMINARS IN IMMUNOLOGY

Antigen shedding and metastasis of tumour cells

(2010) S. K. A. LAW   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Translating Tumor Antigens into Cancer Vaccines

(2010) Luigi Buonaguro et al.   Clinical and Vaccine Immunology

Efficient In vivo Priming by Vaccination with Recombinant NY-ESO-1 Protein and CpG in Antigen Naive Prostate Cancer Patients

(2010) J. Karbach et al.   CLINICAL CANCER RESEARCH

Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trial

(2010) Redas Trepiakas et al.   CYTOTHERAPY

Strategies for Cancer Vaccine Development

(2010) Matteo Vergati et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Induction of CD8+ T-Cell Responses Against Novel Glioma–Associated Antigen Peptides and Clinical Activity by Vaccinations With α-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma

(2010) Hideho Okada et al.   JOURNAL OF CLINICAL ONCOLOGY

Polymer nanoparticles containing tumor lysates as antigen delivery vehicles for dendritic cell–based antitumor immunotherapy

(2010) Shashi Prasad et al.   Nanomedicine-Nanotechnology Biology and Medicine

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

(2010) R. A. Sperling et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Rate, molecular spectrum, and consequences of human mutation

(2010) M. Lynch   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adjuvants for cancer vaccines

(2010) Thomas W. Dubensky et al.   SEMINARS IN IMMUNOLOGY

Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation

(2010) Sachiko Hirosue et al.   VACCINE

Co-encapsulation of antigen and Toll-like receptor ligand in cationic liposomes affects the quality of the immune response in mice after intradermal vaccination

(2010) Suzanne M. Bal et al.   VACCINE

MAGRIT: The Largest-Ever Phase III Lung Cancer Trial Aims to Establish a Novel Tumor-Specific Approach to Therapy

(2009) Preeta Tyagi et al.   Clinical Lung Cancer

Timed Sequential Treatment With Cyclophosphamide, Doxorubicin, and an Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Breast Tumor Vaccine: A Chemotherapy Dose-Ranging Factorial Study of Safety and Immune Activation

(2009) Leisha A. Emens et al.   JOURNAL OF CLINICAL ONCOLOGY

Immunotherapy for Prostate Cancer: Walk, Don't Run

(2009) Charles G. Drake   JOURNAL OF CLINICAL ONCOLOGY

Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation

(2009) Satwinder Kaur Singh et al.   MOLECULAR IMMUNOLOGY

Immunostimulatory properties and enhanced TNF- α mediated cellular immunity for tumor therapy by C60(OH)20nanoparticles

(2009) Ying Liu et al.   NANOTECHNOLOGY

Design considerations for tumour-targeted nanoparticles

(2009) Hak Soo Choi et al.   Nature Nanotechnology

Development of amphiphilic γ-PGA-nanoparticle based tumor vaccine: Potential of the nanoparticulate cytosolic protein delivery carrier

(2008) Tomoaki Yoshikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vaccination greatly reduces disease, disability, death and inequity worldwide

(2008) FE Andre et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Phase 1/2 dose-escalation study of a GM-CSF-secreting, allogeneic, cellular immunotherapy for metastatic hormone-refractory prostate cancer

(2008) Celestia S. Higano et al.   CANCER

Allogeneic Granulocyte Macrophage Colony-Stimulating Factor-Secreting Tumor Immunotherapy Alone or in Sequence with Cyclophosphamide for Metastatic Pancreatic Cancer: A Pilot Study of Safety, Feasibility, and Immune Activation

(2008) D. Laheru et al.   CLINICAL CANCER RESEARCH

Therapeutic Nanoparticles for Drug Delivery in Cancer

(2008) K. Cho et al.   CLINICAL CANCER RESEARCH

Systemic Cancer Treatment Related Side Effects: Are We Changing the Promethean Experience With Molecularly Targeted Therapies?

(2008) Carlo De Angelis   Current Oncology

Delivery of antigen using a novel mannosylated dendrimer potentiates immunogenicityin vitro andin vivo

(2008) Kuo-Ching Sheng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cytokine adsorption/release on uniform magnetic nanoparticles for localized drug delivery

(2008) Raquel Mejías et al.   JOURNAL OF CONTROLLED RELEASE

Antitumor Activity of G3139 Lipid Nanoparticles (LNPs)

(2008) Xiaogang Pan et al.   MOLECULAR PHARMACEUTICS

Enabling personalized cancer medicine through analysis of gene-expression patterns

(2008) Laura J. van 't Veer et al.   NATURE

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY

Tumor-Inhibitory Effect and Immunomodulatory Activity of Fullerol C60(OH)x

(2008) Jiadan Zhu et al.   Small

Nanoparticles built by self-assembly of amphiphilic γ-PGA can deliver antigens to antigen-presenting cells with high efficiency: A new tumor-vaccine carrier for eliciting effector T cells

(2008) Tomoaki Yoshikawa et al.   VACCINE

Co-delivery of cancer-associated antigen and Toll-like receptor 4 ligand in PLGA nanoparticles induces potent CD8+ T cell-mediated anti-tumor immunity

(2008) Samar Hamdy et al.   VACCINE

TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses

(2008) Eva Schlosser et al.   VACCINE