Translating Tumor Antigens into Cancer Vaccines

Distinct CD8+ T Cell Repertoires Primed with Agonist and Native Peptides Derived from a Tumor-Associated Antigen

(2014) Y. Hou et al.   JOURNAL OF IMMUNOLOGY

Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines

(2010) Siina Junnila et al.   BMC CANCER

A new era in anticancer peptide vaccines

(2010) Sonia A. Perez et al.   CANCER

Cancer Vaccine by Fusions of Dendritic and Cancer Cells

(2010) Shigeo Koido et al.   Clinical & Developmental Immunology

Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients

(2010) J. F. M. Jacobs et al.   CLINICAL CANCER RESEARCH

Use of GM-CSF as an adjuvant with cancer vaccines: beneficial or detrimental?

(2010) Kevin S Clive et al.   Expert Review of Vaccines

APC Activation by IFN-  Decreases Regulatory T Cell and Enhances Th Cell Functions

(2010) L. Pace et al.   JOURNAL OF IMMUNOLOGY

Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders

(2010) Luigi Buonaguro et al.   Journal of Translational Medicine

Automated Network Analysis Identifies Core Pathways in Glioblastoma

(2010) Ethan Cerami et al.   PLoS One

Peptide vaccines prevent tumor growth by activating T cells that respond to native tumor antigens

(2010) K. R. Jordan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole tumor antigen vaccines

(2010) Cheryl Lai-Lai Chiang et al.   SEMINARS IN IMMUNOLOGY

Characterization of Antibodies Directed against the Immunoglobulin Light κ Chain Variable Chain Region (VK) of Hepatitis C Virus-Related Type-II Mixed Cryoglobulinemia and B-Cell Proliferations

(2009) Valli De Re et al.   Annals of the New York Academy of Sciences

Clinical Use of Anti-CD25 Antibody Daclizumab to Enhance Immune Responses to Tumor Antigen Vaccination by Targeting Regulatory T cells

(2009) Andrew J. Rech et al.   Annals of the New York Academy of Sciences

T-regulatory cell modulation: the future of cancer immunotherapy?

(2009) S Nizar et al.   BRITISH JOURNAL OF CANCER

Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer

(2009) Celestia S. Higano et al.   CANCER

Cancer Genome Sequencing--An Interim Analysis

(2009) E. J. Fox et al.   CANCER RESEARCH

Increasing the Antigenicity of Synthetic Tumor-Associated Carbohydrate Antigens by Targeting Toll-Like Receptors

(2009) Sampat Ingale et al.   CHEMBIOCHEM

Induction of a Melanoma-Specific Antibody Response by a Monovalent, but not a Divalent, Synthetic GM2 Neoglycopeptide

(2009) S. Bay et al.   ChemMedChem

CD4+CD25+CD127low/− regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression

(2009) Li-Song Shen et al.   CLINICAL IMMUNOLOGY

Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner

(2009) Xiang-Liang Yuan et al.   CLINICAL IMMUNOLOGY

Recent development in carbohydrate-based cancer vaccines

(2009) Zhongwu Guo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Targeting the Immune System in Cancer

(2009) Devyani Chaudhuri et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Treating human cancers with heat shock protein-peptide complexes: the road ahead

(2009) Pramod K Srivastava et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Vitespen: a preclinical and clinical review

(2009) Christopher G Wood et al.   Future Oncology

Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasia

(2009) Koenraad Van Doorslaer et al.   GYNECOLOGIC ONCOLOGY

Anti-tumor immunity in a model of acute myeloid leukemia

(2009) Adam T. C. Cheuk et al.   LEUKEMIA & LYMPHOMA

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Cyclophosphamide and cancer: golden anniversary

(2009) Ashkan Emadi et al.   Nature Reviews Clinical Oncology

Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes

(2009) Adnan S. Syed et al.   NUCLEIC ACIDS RESEARCH

Biological Convergence of Cancer Signatures

(2009) Xavier Solé et al.   PLoS One

Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia

(2009) I. Radtke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Vaccines Consisting of Tumor-Associated MUC1 Glycopeptide Antigens and a T-Cell Epitope for the Induction of a Highly Specific Humoral Immune Response

(2008) Ulrika Westerlind et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hepatitis C virus (HCV)-driven stimulation of subfamily-restricted natural IgM antibodies in mixed cryoglobulinemia

(2008) Mario Perotti et al.   AUTOIMMUNITY REVIEWS

Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines

(2008) M. A. Morse et al.   BLOOD

Vaccination of metastatic renal cell carcinoma patients with autologous tumour-derived vitespen vaccine: clinical findings

(2008) E Jonasch et al.   BRITISH JOURNAL OF CANCER

Antitumor activity of a self-adjuvanting glyco-lipopeptide vaccine bearing B cell, CD4+ and CD8+ T cell epitopes

(2008) Ilham Bettahi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine

(2008) M. J.P. Welters et al.   CLINICAL CANCER RESEARCH

Phase I Immunotherapeutic Trial with Long Peptides Spanning the E6 and E7 Sequences of High-Risk Human Papillomavirus 16 in End-Stage Cervical Cancer Patients Shows Low Toxicity and Robust Immunogenicity

(2008) G. G. Kenter et al.   CLINICAL CANCER RESEARCH

Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation

(2008) Martijn S. Bijker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Heat-shock proteins as powerful weapons in vaccine development

(2008) Azam Bolhassani et al.   Expert Review of Vaccines

Heat-shock proteins in cancer vaccines: agents of antigen cross-presentation

(2008) Ayesha Murshid et al.   Expert Review of Vaccines

Reengineering dendritic cell-based anti-cancer vaccines

(2008) Gary K. Koski et al.   IMMUNOLOGICAL REVIEWS

Enhancing the clinical activity of granulocyte-macrophage colony-stimulating factor-secreting tumor cell vaccines

(2008) Masahisa Jinushi et al.   IMMUNOLOGICAL REVIEWS

Toll-like receptor signalling on Tregs: to suppress or not to suppress?

(2008) Wendy W. C. van Maren et al.   IMMUNOLOGY

Designer adjuvants for enhancing the efficacy of infectious disease and cancer vaccines based on suppression of regulatory T cell induction

(2008) Kingston H.G. Mills   IMMUNOLOGY LETTERS

Phase III Comparison of Vitespen, an Autologous Tumor-Derived Heat Shock Protein gp96 Peptide Complex Vaccine, With Physician's Choice of Treatment for Stage IV Melanoma: The C-100-21 Study Group

(2008) Alessandro Testori et al.   JOURNAL OF CLINICAL ONCOLOGY

An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised phase III trial

(2008) Christopher Wood et al.   LANCET

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

Toll-like receptor 9 (TLR9) agonists in the treatment of cancer

(2008) A M Krieg   ONCOGENE

TLR ligand suppression or enhancement of Treg cells? A double-edged sword in immunity to tumours

(2008) H Conroy et al.   ONCOGENE

Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells

(2008) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Age-dependent tolerance to an endogenous tumor-associated antigen

(2008) Jennifer A. McWilliams et al.   VACCINE