A Unified Model of the GABAA Receptor Comprising Agonist and Benzodiazepine Binding Sites

Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands

(2012) Lars Richter et al.   Nature Chemical Biology

The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor

(2012) Andrew J. Thompson et al.   NEUROPHARMACOLOGY

A Structure-based QSAR and Docking Study on Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4,]benzodiazepines as Selective GABAAα5 Inverse Agonists

(2011) Sajjad Gharaghani et al.   Chemical Biology & Drug Design

Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine α4β2 Receptors

(2011) Line Aagot Hede Rohde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

Unraveling the High- and Low-Sensitivity Agonist Responses of Nicotinic Acetylcholine Receptors

(2011) K. Harpsoe et al.   JOURNAL OF NEUROSCIENCE

Different Residues in the GABAA Receptor Benzodiazepine Binding Pocket Mediate Benzodiazepine Efficacy and Binding

(2011) E. V. Morlock et al.   MOLECULAR PHARMACOLOGY

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

New insights into the GABAA receptor structure and orthosteric ligand binding: Receptor modeling guided by experimental data

(2011) Tommy Sander et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Homology modeling and atomic level binding study of GABAA receptor with novel enaminone amides

(2010) Jin Cheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophore models for GABAAmodulators: implications in CNS drug discovery

(2010) Nanda Ghoshal et al.   Expert Opinion on Drug Discovery

Allosteric activation mechanism of the cys-loop receptors

(2009) Yong-chang Chang et al.   ACTA PHARMACOLOGICA SINICA

Synthesis, pharmacological studies and molecular modeling of some tetracyclic 1,3-diazepinium chlorides

(2009) Julie-Ann A. Grant et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Modeling Neuronal Nicotinic and GABA Receptors: Important Interface Salt-Links and Protein Dynamics

(2009) Richard J. Law et al.   BIOPHYSICAL JOURNAL

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

(2009) Ryan E Hibbs et al.   EMBO JOURNAL

Identification of Anxiolytic/Nonsedative Agents among Indol-3-ylglyoxylamides Acting as Functionally Selective Agonists at the γ-Aminobutyric Acid-A (GABAA) α2Benzodiazepine Receptor

(2009) Sabrina Taliani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABAAreceptors

(2009) Kelly R. Tan et al.   JOURNAL OF NEUROCHEMISTRY

Docking of 1,4-Benzodiazepines in the  1/ 2 GABAA Receptor Modulator Site

(2009) D. Berezhnoy et al.   MOLECULAR PHARMACOLOGY

Structural Requirements for Eszopiclone and Zolpidem Binding to the γ-Aminobutyric Acid Type-A (GABAA) Receptor Are Different

(2008) Susan M. Hanson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of GABAAReceptor Agonists and Evaluation of their α-Subunit Selectivity and Orientation in the GABA Binding Site

(2008) Michaela Jansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Homology modeling and dynamics of the extracellular domain of rat and human neuronal nicotinic acetylcholine receptor subtypes α4β2 and α7

(2008) William H. Bisson et al.   JOURNAL OF MOLECULAR MODELING

Individually Monitoring Ligand-Induced Changes in the Structure of the GABAA Receptor at Benzodiazepine Binding Site and Non-Binding-Site Interfaces

(2008) L. M. Sharkey et al.   MOLECULAR PHARMACOLOGY

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

A conserved salt bridge critical for GABAA receptor function and loop C dynamics

(2008) S. P. Venkatachalan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Very fast prediction and rationalization of pKa values for protein-ligand complexes

(2008) Delphine C. Bas et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Mechanism of action of benzodiazepines on GABAA receptors

(2006) Claudia Campo-Soria et al.   BRITISH JOURNAL OF PHARMACOLOGY