Native roles of Baeyer–Villiger monooxygenases in the microbial metabolism of natural compounds

Hot spots for the protein engineering of Baeyer-Villiger monooxygenases

(2018) Kathleen Balke et al.   BIOTECHNOLOGY ADVANCES

VpStyA1/VpStyA2B of Variovorax paradoxus EPS: An Aryl Alkyl Sulfoxidase Rather than a Styrene Epoxidizing Monooxygenase

(2018) Dirk Tischler et al.   MOLECULES

Chemical language and warfare of bacterial natural products in bacteria–nematode–insect interactions

(2018) Yi-Ming Shi et al.   NATURAL PRODUCT REPORTS

Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

(2018) Gao-Qian Wang et al.   Nature Communications

The Viridin Biosynthesis Gene Cluster of Trichoderma virens and Its Conservancy in the Bat White-Nose Fungus Pseudogymnoascus destructans

(2018) Ravindra Bansal et al.   ChemistrySelect

Genome-wide identification and characterization of genes encoding cyclohexylamine degradation in a novel cyclohexylamine-degrading bacterial strain of Pseudomonas plecoglossicida NyZ12

(2017) Da-Zhong Yan et al.   JOURNAL OF BIOTECHNOLOGY

Pyrrolizidine alkaloids: occurrence, biology, and chemical synthesis

(2017) Jeremy Robertson et al.   NATURAL PRODUCT REPORTS

Biosynthetic pathway of aliphatic formates via a Baeyer–Villiger oxidation in mechanism present in astigmatid mites

(2017) Nobuhiro Shimizu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biocatalytic Characterization of Human FMO5: Unearthing Baeyer–Villiger Reactions in Humans

(2016) Filippo Fiorentini et al.   ACS Chemical Biology

Baeyer-Villiger oxidations: biotechnological approach

(2016) Marek Bučko et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characterization of a new Baeyer-Villiger monooxygenase and conversion to a solely N-or S-oxidizing enzyme by a single R292 mutation

(2016) Gianluca Catucci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Involvement of the Baeyer-Villiger Monooxygenase IfnQ in the Biosynthesis of Isofuranonaphthoquinone Scaffold of JBIR-76 and -77

(2016) Yohei Katsuyama et al.   CHEMBIOCHEM

JBIR-76 and JBIR-77, modified naphthoquinones from Streptomyces sp. RI-77

(2016) Keiichiro Motohashi et al.   JOURNAL OF ANTIBIOTICS

Heterocyclic Aromatic N-Oxidation in the Biosynthesis of Phenazine Antibiotics from Lysobacter antibioticus

(2016) Yangyang Zhao et al.   ORGANIC LETTERS

Structural and Catalytic Characterization of a Fungal Baeyer-Villiger Monooxygenase

(2016) Felix Martin Ferroni et al.   PLoS One

Improving Cancer Chemoradiotherapy Treatment by Dual Controlled Release of Wortmannin and Docetaxel in Polymeric Nanoparticles

(2015) Kin Man Au et al.   ACS Nano

Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins

(2015) Sheng Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids

(2015) Olivia Schimming et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Enzyme Cascade Synthesis of ε-Caprolactone and its Oligomers

(2015) Sandy Schmidt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Escherichia coli Overexpressing a Baeyer-Villiger Monooxygenase from Acinetobacter radioresistens Becomes Resistant to Imipenem

(2015) Daniela Minerdi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Bi-enzymatic Convergent Cascade for ε-Caprolactone Synthesis Employing 1,6-Hexanediol as a ‘Double-Smart Cosubstrate’

(2015) Amin Bornadel et al.   ChemCatChem

New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition

(2015) Karl A. P. Payne et al.   NATURE

The oxygenating constituent of 3,6-diketocamphane monooxygenase from the CAM plasmid of Pseudomonas putida: the first crystal structure of a type II Baeyer–Villiger monooxygenase

(2015) Michail N. Isupov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Origin and Evolution of Baeyer—Villiger Monooxygenases (BVMOs): An Ancestral Family of Flavin Monooxygenases

(2015) Maria Laura Mascotti et al.   PLoS One

Lactone-Bound Structures of Cyclohexanone Monooxygenase Provide Insight into the Stereochemistry of Catalysis

(2014) Brahm J. Yachnin et al.   ACS Chemical Biology

Arixanthomycins A–C: Phylogeny-Guided Discovery of Biologically Active eDNA-Derived Pentangular Polyphenols

(2014) Hahk-Soo Kang et al.   ACS Chemical Biology

Introducing an In Situ Capping Strategy in Systems Biocatalysis To Access 6-Aminohexanoic acid

(2014) Johann H. Sattler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gene Discovery for Enzymes Involved in Limonene Modification or Utilization by the Mountain Pine Beetle-Associated Pathogen Grosmannia clavigera

(2014) Ye Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification, Cloning and Biochemical Characterization of Pseudomonas putida A (ATCC 12633) Monooxygenase Enzyme necessary for the Metabolism of Tetradecyltrimethylammonium Bromide

(2014) Andrés S. Liffourrena et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Comparative genome sequencing reveals chemotype-specific gene clusters in the toxigenic black mold Stachybotrys

(2014) Jeremy Semeiks et al.   BMC GENOMICS

Biosynthetic Origin of the Antibiotic Cyclocarbamate Brabantamide A (SB-253514) in Plant-AssociatedPseudomonas.

(2014) Yvonne Schmidt et al.   CHEMBIOCHEM

One-pot Conversion of Cycloalkanes to Lactones

(2014) Alizé Pennec et al.   ChemCatChem

Functional divergence between closely related Baeyer-Villiger monooxygenases from Aspergillus flavus

(2014) F.M. Ferroni et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Complete Biosynthetic Pathway of Anditomin: Nature’s Sophisticated Synthetic Route to a Complex Fungal Meroterpenoid

(2014) Yudai Matsuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aflatoxin and deconstruction of type I, iterative polyketide synthase function

(2014) Craig A. Townsend   NATURAL PRODUCT REPORTS

Pyrrolizidine alkaloids

(2014) Jeremy Robertson et al.   NATURAL PRODUCT REPORTS

A carbonate-forming Baeyer-Villiger monooxygenase

(2014) Youcai Hu et al.   Nature Chemical Biology

Molecular Insight into Substrate Recognition and Catalysis of Baeyer–Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent Mithramycin

(2013) Mary A. Bosserman et al.   ACS Chemical Biology

Camphor Pathway Redux: Functional Recombinant Expression of 2,5- and 3,6-Diketocamphane Monooxygenases of Pseudomonas putida ATCC 17453 with Their Cognate Flavin Reductase Catalyzing Baeyer-Villiger Reactions

(2013) Hiroaki Iwaki et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Flavin dependent monooxygenases

(2013) Mieke M.E. Huijbers et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Type II Flavin-Containing Monooxygenases: A New Class of Biocatalysts that Harbors Baeyer-Villiger Monooxygenases with a Relaxed Coenzyme Specificity

(2013) Anette Riebel et al.   ChemCatChem

Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone

(2013) Svenja Staudt et al.   ENZYME AND MICROBIAL TECHNOLOGY

Discovery of Baeyer–Villiger monooxygenases from photosynthetic eukaryotes

(2013) Elisa Beneventi et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Baeyer–Villiger Oxidation of Acyl Carrier Protein-Tethered Thioester to Acyl Carrier Protein-Linked Thiocarbonate Catalyzed by a Monooxygenase Domain in FR901464 Biosynthesis

(2013) Man-Cheng Tang et al.   ACS Catalysis

Cloning, Baeyer-Villiger Biooxidations, and Structures of the Camphor Pathway 2-Oxo-Δ3-4,5,5-Trimethylcyclopentenylacetyl-Coenzyme A Monooxygenase of Pseudomonas putida ATCC 17453

(2012) Hannes Leisch et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Two Enzymes of a Complete Degradation Pathway for Linear Alkylbenzenesulfonate (LAS) Surfactants: 4-Sulfoacetophenone Baeyer-Villiger Monooxygenase and 4-Sulfophenylacetate Esterase in Comamonas testosteroni KF-1

(2012) Michael Weiss et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Completing the series of BVMOs involved in camphor metabolism of Pseudomonas putida NCIMB 10007 by identification of the two missing genes, their functional expression in E. coli, and biochemical characterization

(2012) Maria Kadow et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Expanding the set of rhodococcal Baeyer–Villiger monooxygenases by high-throughput cloning, expression and substrate screening

(2012) A. Riebel et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Unveiling the Post-PKS Redox Tailoring Steps in Biosynthesis of the Type II Polyketide Antitumor Antibiotic Xantholipin

(2012) Weike Zhang et al.   CHEMISTRY & BIOLOGY

Diversity of flavin-binding monooxygenase genes (almA) in marine bacteria capable of degradation long-chain alkanes

(2012) Wanpeng Wang et al.   FEMS MICROBIOLOGY ECOLOGY

Exploring the Structural Basis of Substrate Preferences in Baeyer-Villiger Monooxygenases

(2012) Stefano Franceschini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the Product of Toxoflavin Lyase: Degradation via a Baeyer–Villiger Oxidation

(2012) Benjamin Philmus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Baeyer–Villiger C–C Bond Cleavage Reaction in Gilvocarcin and Jadomycin Biosynthesis

(2012) Nidhi Tibrewal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Substrate-Bound Crystal Structure of a Baeyer–Villiger Monooxygenase Exhibits a Criegee-like Conformation

(2012) Brahm J. Yachnin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two Separate Gene Clusters Encode the Biosynthetic Pathway for the Meroterpenoids Austinol and Dehydroaustinol in Aspergillus nidulans

(2012) Hsien-Chun Lo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Flavoenzymes: Versatile catalysts in biosynthetic pathways

(2012) Christopher T. Walsh et al.   NATURAL PRODUCT REPORTS

Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

(2012) Natasha M. DeVore et al.   NATURE

A specialized ABC efflux transporter GcABC-G1 confers monoterpene resistance toGrosmannia clavigera, a bark beetle-associated fungal pathogen of pine trees

(2012) Ye Wang et al.   NEW PHYTOLOGIST

Identification of a novel Baeyer-Villiger monooxygenase fromAcinetobacter radioresistens: close relationship to theMycobacterium tuberculosisprodrug activator EtaA

(2012) Daniela Minerdi et al.   Microbial Biotechnology

Catalytic and Structural Features of Flavoprotein Hydroxylases and Epoxidases

(2011) Stefania Montersino et al.   ADVANCED SYNTHESIS & CATALYSIS

Metabolites from Pseudomonas brassicacearum with activity against the pink snow mould causing pathogen Microdochium nivale

(2011) Pierre F. Andersson et al.   BIOCONTROL

Baeyer−Villiger Monooxygenases: More Than Just Green Chemistry

(2011) Hannes Leisch et al.   CHEMICAL REVIEWS

Cloning and Elucidation of the FR901464 Gene Cluster Revealing a Complex Acyltransferase-less Polyketide Synthase Using Glycerate as Starter Units

(2011) Feng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis

(2011) Madan K. Kharel et al.   NATURAL PRODUCT REPORTS

Natural functions of mycotoxins and control of their biosynthesis in fungi

(2010) Massimo Reverberi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Isolation of the lysolipin gene cluster of Streptomyces tendae Tü 4042

(2010) Patricio Lopez et al.   GENE

Cloning of the biosynthetic gene cluster for naphthoxanthene antibiotic FD-594 from Streptomyces sp. TA-0256

(2010) Fumitaka Kudo et al.   JOURNAL OF ANTIBIOTICS

A Biosynthetic Pathway for BE-7585A, a 2-Thiosugar-Containing Angucycline-Type Natural Product

(2010) Eita Sasaki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal Structure of the Bacterial Luciferase/Flavin Complex Provides Insight into the Function of the β Subunit

(2009) Zachary T. Campbell et al.   BIOCHEMISTRY

Genome Mining inStreptomyces avermitilis: A Biochemical Baeyer−Villiger Reaction and Discovery of a New Branch of the Pentalenolactone Family Tree

(2009) Jiaoyang Jiang et al.   BIOCHEMISTRY

Crystal Structure of Baeyer−Villiger Monooxygenase MtmOIV, the Key Enzyme of the Mithramycin Biosynthetic Pathway,

(2009) Miranda P. Beam et al.   BIOCHEMISTRY

Degradation of alkanes by bacteria

(2009) Fernando Rojo   ENVIRONMENTAL MICROBIOLOGY

Cleavage of Four Carbon−Carbon Bonds during Biosynthesis of the Griseorhodin A Spiroketal Pharmacophore

(2009) Zeynep Yunt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal Structures of Cyclohexanone Monooxygenase Reveal Complex Domain Movements and a Sliding Cofactor

(2009) I. Ahmad Mirza et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Meroterpenoids produced by fungi

(2009) Regina Geris et al.   NATURAL PRODUCT REPORTS

Sequential Action of Two Flavoenzymes, PgaE and PgaM, in Angucycline Biosynthesis: Chemoenzymatic Synthesis of Gaudimycin C

(2008) Pauli Kallio et al.   CHEMISTRY & BIOLOGY