Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

(2011) Walter L. Miller et al.   ENDOCRINE REVIEWS

Novel Therapeutic Strategies for Castration Resistant Prostate Cancer: Inhibition of Persistent Androgen Production and Androgen Receptor Mediated Signaling

(2011) Arturo Molina et al.   JOURNAL OF UROLOGY

Abiraterone and Increased Survival in Metastatic Prostate Cancer

(2011) Johann S. de Bono et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics

(2010) Pengxiang Huang et al.   Annual Review of Physiology

Clinical, Genetic and Functional Characteristics of Three NovelCYP17A1Mutations Causing Combined 17α-Hydroxylase/17,20-Lyase Deficiency

(2010) S. Rosa et al.   Hormone Research in Paediatrics

Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1

(2010) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Modeling on Inhibitor Complexes and Active-Site Dynamics of Cytochrome P450 C17, a Target for Prostate Cancer Therapy

(2010) Shozeb M. Haider et al.   JOURNAL OF MOLECULAR BIOLOGY

A single amino acid residue, Ala 105, confers 16α-hydroxylase activity to human cytochrome P450 17α-hydroxylase/17,20 lyase

(2010) Amanda C. Swart et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

CYP17 inhibitors for prostate cancer therapy

(2010) Tadas S. Vasaitis et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Antitumor Activity with CYP17 Blockade Indicates That Castration-Resistant Prostate Cancer Frequently Remains Hormone Driven

(2009) G. Attard et al.   CANCER RESEARCH

Key Residues Controlling Binding of Diverse Ligands to Human Cytochrome P450 2A Enzymes

(2009) N. M. DeVore et al.   DRUG METABOLISM AND DISPOSITION

Steroid 17α-Hydroxylase Deficiency: Functional Characterization of Four Mutations (A174E, V178D, R440C, L465P) in theCYP17A1Gene

(2009) Vivek Dhir et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Novel P450c17 Mutation H373D Causing Combined 17α-Hydroxylase/17,20-Lyase Deficiency

(2009) Taninee Sahakitrungruang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Novel CYP17A1 mutation in a Japanese patient with combined 17α-hydroxylase/17,20-lyase deficiency

(2009) Noriyuki Katsumata et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Structural basis for androgen specificity and oestrogen synthesis in human aromatase

(2009) Debashis Ghosh et al.   NATURE

Targeting CYP17: established and novel approaches in prostate cancer

(2008) Timothy A Yap et al.   CURRENT OPINION IN PHARMACOLOGY

Metabolic evidence for impaired 17α-hydroxylase activity in a kindred bearing the E305G mutation for isolate 17,20-lyase activity

(2008) Dov Tiosano et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Phase I Clinical Trial of a Selective Inhibitor of CYP17, Abiraterone Acetate, Confirms That Castration-Resistant Prostate Cancer Commonly Remains Hormone Driven

(2008) Gerhardt Attard et al.   JOURNAL OF CLINICAL ONCOLOGY

Androgen receptor inactivation contributes to antitumor efficacy of 17 -hydroxylase/17,20-lyase inhibitor 3 -hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer

(2008) T. Vasaitis et al.   MOLECULAR CANCER THERAPEUTICS

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

(2008) N. Mast et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Coffey Lecture: Steroidogenic enzyme inhibitors and hormone dependent cancer

(2008) Angela Brodie et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure

(2007) Carsten Jagusch et al.   BIOORGANIC & MEDICINAL CHEMISTRY