Chemical language and warfare of bacterial natural products in bacteria–nematode–insect interactions

Identification and occurrence of the hydroxamate siderophores aerobactin, putrebactin, avaroferrin and ochrobactin C as virulence factors from entomopathogenic bacteria

(2017) Merle Hirschmann et al.   ENVIRONMENTAL MICROBIOLOGY

Biosynthesis and function of simple amides in Xenorhabdus doucetiae

(2017) Edna Bode et al.   ENVIRONMENTAL MICROBIOLOGY

A tricyclic pyrrolobenzodiazepine produced byKlebsiella oxytocais associated with cytotoxicity in antibiotic-associated hemorrhagic colitis

(2017) Herman Tse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stilbene epoxidation and detoxification in aPhotorhabdus luminescens-nematode symbiosis

(2017) Hyun Bong Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural products from myxobacteria: novel metabolites and bioactivities

(2017) J. Herrmann et al.   NATURAL PRODUCT REPORTS

Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases

(2017) Linda Lauinger et al.   Nature Chemical Biology

Biosynthesis of the Antibiotic Nematophin and Its Elongated Derivatives in Entomopathogenic Bacteria

(2017) Xiaofeng Cai et al.   ORGANIC LETTERS

Two symbiotic bacteria of the entomopathogenic nematode Heterorhabditis spp. against Galleria mellonella

(2017) Chunli Liao et al.   TOXICON

Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus

(2017) Nicholas J. Tobias et al.   Nature Microbiology

The native microbiome of the nematode Caenorhabditis elegans: gateway to a new host-microbiome model

(2016) Philipp Dirksen et al.   BMC BIOLOGY

Genome comparisons provide insights into the role of secondary metabolites in the pathogenic phase of the Photorhabdus life cycle

(2016) Nicholas J. Tobias et al.   BMC GENOMICS

Signaling in Host-Associated Microbial Communities

(2016) Michael A. Fischbach et al.   CELL

Pyrazinone protease inhibitor metabolites from Photorhabdus luminescens

(2016) Hyun Bong Park et al.   JOURNAL OF ANTIBIOTICS

SlyA regulates phytotoxin production and virulence inDickeya zeaeEC1

(2016) Jia-Nuan Zhou et al.   MOLECULAR PLANT PATHOLOGY

Activating and Attenuating the Amicoumacin Antibiotics

(2016) Hyun Park et al.   MOLECULES

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

(2016) Mingxun Wang et al.   NATURE BIOTECHNOLOGY

Structural basis of nonribosomal peptide macrocyclization in fungi

(2016) Jinru Zhang et al.   Nature Chemical Biology

Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design

(2016) Xiaofeng Cai et al.   Nature Chemistry

Quorum sensing signal–response systems in Gram-negative bacteria

(2016) Kai Papenfort et al.   NATURE REVIEWS MICROBIOLOGY

Microbes Drive Evolution of Animals and Plants: the Hologenome Concept

(2016) Eugene Rosenberg et al.   mBio

Getting the Hologenome Concept Right: an Eco-Evolutionary Framework for Hosts and Their Microbiomes

(2016) Kevin R. Theis et al.   mSystems

Structure Elucidation and Activity of Kolossin A, theD-/L-Pentadecapeptide Product of a Giant Nonribosomal Peptide Synthetase

(2015) Helge B. Bode et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids

(2015) Olivia Schimming et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioactive natural products from novel microbial sources

(2015) Victoria L. Challinor et al.   Annals of the New York Academy of Sciences

Biosynthesis and function of bacterial dialkylresorcinol compounds

(2015) Tim A. Schöner et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

APhotorhabdusNatural Product Inhibits Insect Juvenile Hormone Epoxide Hydrolase

(2015) Friederike I. Nollmann et al.   CHEMBIOCHEM

Simple “On-Demand” Production of Bioactive Natural Products

(2015) Edna Bode et al.   CHEMBIOCHEM

Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor

(2015) A. O. Brachmann et al.   CHEMICAL COMMUNICATIONS

Biological warfare: Microorganisms as drivers of host–parasite interactions

(2015) Nolwenn M. Dheilly et al.   INFECTION GENETICS AND EVOLUTION

Insect pathogens as biological control agents: Back to the future

(2015) L.A. Lacey et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

Lumiquinone A, an α-Aminomalonate-Derived Aminobenzoquinone from Photorhabdus luminescens

(2015) Hyun Bong Park et al.   JOURNAL OF NATURAL PRODUCTS

Myxochelins Target Human 5-Lipoxygenase

(2015) Sebastian Schieferdecker et al.   JOURNAL OF NATURAL PRODUCTS

Specificity of Signal-Binding via Non-AHL LuxR-Type Receptors

(2015) Sophie Brameyer et al.   PLoS One

Languages and dialects: bacterial communication beyond homoserine lactones

(2015) Sophie Brameyer et al.   TRENDS IN MICROBIOLOGY

A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics

(2015) Joleen Masschelein et al.   Chemical Science

Control of litchi downy blight by zeamines produced by Dickeya zeae

(2015) Lisheng Liao et al.   Scientific Reports

Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes

(2015) Seth R. Bordenstein et al.   PLOS BIOLOGY

Census of solo LuxR genes in prokaryotic genomes

(2015) Sanjarbek Hudaiberdiev et al.   Frontiers in Cellular and Infection Microbiology

The broad-spectrum antibiotic, zeamine, kills the nematode worm Caenorhabditis elegans

(2015) Josephine E. E. U. Hellberg et al.   Frontiers in Microbiology

Paenilamicin: Structure and Biosynthesis of a Hybrid Nonribosomal Peptide/Polyketide Antibiotic from the Bee PathogenPaenibacillus larvae

(2014) Sebastian Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Chimeric Siderophore Halts SwarmingVibrio

(2014) Thomas Böttcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Zeamine Antibiotics Affect the Integrity of Bacterial Membranes

(2014) Joleen Masschelein et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Specialized Metabolites from the Microbiome in Health and Disease

(2014) Gil Sharon et al.   Cell Metabolism

Rapid Determination of the Amino Acid Configuration of Xenotetrapeptide

(2014) Carsten Kegler et al.   CHEMBIOCHEM

Fabclavines: Bioactive Peptide-Polyketide-Polyamino Hybrids fromXenorhabdus

(2014) Sebastian W. Fuchs et al.   CHEMBIOCHEM

Yeast Homologous Recombination Cloning Leading to the Novel Peptides Ambactin and Xenolindicin

(2014) Olivia Schimming et al.   CHEMBIOCHEM

Biosynthesis of the Insecticidal Xenocyloins inXenorhabdus bovienii

(2014) Anna Proschak et al.   CHEMBIOCHEM

Biosynthetic Origin of the Antibiotic Cyclocarbamate Brabantamide A (SB-253514) in Plant-AssociatedPseudomonas.

(2014) Yvonne Schmidt et al.   CHEMBIOCHEM

Insect-Specific Production of New GameXPeptides inPhotorhabdus luminescensTTO1, Widespread Natural Products in Entomopathogenic Bacteria

(2014) Friederike I. Nollmann et al.   CHEMBIOCHEM

Characterisation of Taxlllaids A-G; Natural Products fromXenorhabdus indica

(2014) Max Kronenwerth et al.   CHEMISTRY-A EUROPEAN JOURNAL

Xenortide Biosynthesis by Entomopathogenic Xenorhabdus nematophila

(2014) Daniela Reimer et al.   JOURNAL OF NATURAL PRODUCTS

Antiparasitic Chaiyaphumines from Entomopathogenic Xenorhabdus sp. PB61.4

(2014) Florian Grundmann et al.   JOURNAL OF NATURAL PRODUCTS

Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome

(2014) Yury S. Polikanov et al.   MOLECULAR CELL

Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics

(2014) Bo Li et al.   NATURAL PRODUCT REPORTS

Enterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis

(2014) G. Schneditz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dialkylresorcinols as bacterial signaling molecules

(2014) Sophie Brameyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation of 1,3-Cyclohexanediones and Resorcinols Catalyzed by a Widely Occuring Ketosynthase

(2013) Sebastian W. Fuchs et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhabdopeptides as Insect-Specific Virulence Factors from Entomopathogenic Bacteria

(2013) Daniela Reimer et al.   CHEMBIOCHEM

Nonribosomal Assembly of Natural Lipocyclocarbamate Lipoprotein-Associated Phospholipase Inhibitors

(2013) Chad W. Johnston et al.   CHEMBIOCHEM

Structure and Biosynthesis of Fimsbactins A-F, Siderophores fromAcinetobacter baumanniiandAcinetobacter baylyi

(2013) Anna Proschak et al.   CHEMBIOCHEM

Structure and Biosynthesis of Xenoamicins from EntomopathogenicXenorhabdus

(2013) Qiuqin Zhou  et al.   CHEMISTRY-A EUROPEAN JOURNAL

From a Multipotent Stilbene to Soluble Epoxide Hydrolase Inhibitors with Antiproliferative Properties

(2013) Estel.la Buscató et al.   ChemMedChem

The Drosophila IMD pathway in the activation of the humoral immune response

(2013) Anni Kleino et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Cabanillasin, a new antifungal metabolite, produced by entomopathogenic Xenorhabdus cabanillasii JM26

(2013) Jessica Houard et al.   JOURNAL OF ANTIBIOTICS

Pyrones as bacterial signaling molecules

(2013) Alexander O Brachmann et al.   Nature Chemical Biology

A PKS/NRPS/FAS Hybrid Gene Cluster from Serratia plymuthica RVH1 Encoding the Biosynthesis of Three Broad Spectrum, Zeamine-Related Antibiotics

(2013) Joleen Masschelein et al.   PLoS One

Animals in a bacterial world, a new imperative for the life sciences

(2013) Margaret McFall-Ngai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure determination of the bioactive depsipeptide xenobactin from Xenorhabdus sp. PB30.3

(2013) Florian Grundmann et al.   RSC Advances

Immune Signaling and Antimicrobial Peptide Expression in Lepidoptera

(2013) Ángel Casanova-Torres et al.   Insects

Chemical Detoxification of Small Molecules by Caenorhabditis elegans

(2012) Gregory S. Stupp et al.   ACS Chemical Biology

Neutral Loss Fragmentation Pattern Based Screening for Arginine-Rich Natural Products in Xenorhabdus and Photorhabdus

(2012) Sebastian W. Fuchs et al.   ANALYTICAL CHEMISTRY

Reciprocal Cross Talk between Fatty Acid and Antibiotic Biosynthesis in a Nematode Symbiont

(2012) Alexander O. Brachmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phospholipase A2Inhibitors Synthesized by Two Entomopathogenic Bacteria, Xenorhabdus nematophila and Photorhabdus temperata subsp. temperata

(2012) Samyeol Seo et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Synthesis of szentiamide, a depsipeptide from entomopathogenicXenorhabdus szentirmaiiwith activity againstPlasmodium falciparum

(2012) Friederike I Nollmann et al.   Beilstein Journal of Organic Chemistry

Heterologous Expression and Structural Characterisation of a Pyrazinone Natural Product Assembly Line

(2012) Morgan A. Wyatt et al.   CHEMBIOCHEM

Histone acetylation mediates epigenetic regulation of transcriptional reprogramming in insects during metamorphosis, wounding and infection

(2012) Krishnendu Mukherjee et al.   Frontiers in Zoology

Luminmycins A–C, Cryptic Natural Products from Photorhabdus luminescens Identified by Heterologous Expression in Escherichia coli

(2012) Xiaoying Bian et al.   JOURNAL OF NATURAL PRODUCTS

Xentrivalpeptides A–Q: Depsipeptide Diversification in Xenorhabdus

(2012) Qiuqin Zhou et al.   JOURNAL OF NATURAL PRODUCTS

Heterologous expression of a Photorhabdus luminescens syrbactin-like gene cluster results in production of the potent proteasome inhibitor glidobactin A

(2012) Alexey Dudnik et al.   MICROBIOLOGICAL RESEARCH

Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting

(2012) Jun Fu et al.   NATURE BIOTECHNOLOGY

Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain

(2012) Xue Gao et al.   Nature Chemical Biology

Mass spectral molecular networking of living microbial colonies

(2012) J. Watrous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecule perimeter defense in entomopathogenic bacteria

(2012) J. M. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor

(2012) M. L. Stein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Single Promoter Inversion Switches Photorhabdus Between Pathogenic and Mutualistic States

(2012) V. S. Somvanshi et al.   SCIENCE

Validation of the Intact Zwittermicin A Biosynthetic Gene Cluster and Discovery of a Complementary Resistance Mechanism in Bacillus thuringiensis

(2011) Yi Luo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cytotoxic Fatty Acid Amides from Xenorhabdus

(2011) Anna Proschak et al.   CHEMBIOCHEM

Bacterial symbionts and natural products

(2011) Jason M. Crawford et al.   CHEMICAL COMMUNICATIONS

Dihydrophenylalanine: A Prephenate-Derived Photorhabdus luminescens Antibiotic and Intermediate in Dihydrostilbene Biosynthesis

(2011) Jason M. Crawford et al.   CHEMISTRY & BIOLOGY

Ralfuranone Biosynthesis in Ralstonia solanacearum Suggests Functional Divergence in the Quinone Synthetase Family of Enzymes

(2011) Barbara Wackler et al.   CHEMISTRY & BIOLOGY

HdfR is a regulator in Photorhabdus luminescens that modulates metabolism and symbiosis with the nematode Heterorhabditis

(2011) Catherine A. Easom et al.   ENVIRONMENTAL MICROBIOLOGY

Characterization of Photorhabdus luminescens Growth for the Rearing of the Beneficial Nematode Heterorhabditis bacteriophora

(2011) Sunita Singh et al.   INDIAN JOURNAL OF MICROBIOLOGY

ClbP Is a Prototype of a Peptidase Subgroup Involved in Biosynthesis of Nonribosomal Peptides

(2011) Damien Dubois et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triggering the production of the cryptic blue pigment indigoidine from Photorhabdus luminescens

(2011) Alexander O. Brachmann et al.   JOURNAL OF BIOTECHNOLOGY

The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)

(2011) Daniel Krahn et al.   NATURAL PRODUCT REPORTS

A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis

(2011) Tom Bretschneider et al.   Nature Chemical Biology

A natural prodrug activation mechanism in nonribosomal peptide synthesis

(2011) Daniela Reimer et al.   Nature Chemical Biology

Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus nematophila

(2011) Sebastian W. Fuchs et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Unknown

(2011) Eyaulem Abebe et al.   Virulence

Prostaglandins and Their Receptors in Insect Biology

(2011) David Stanley et al.   Frontiers in Endocrinology

Exploiting a Global Regulator for Small Molecule Discovery inPhotorhabdus luminescens

(2010) Renee Kontnik et al.   ACS Chemical Biology

A concise, total synthesis and antibacterial evaluation of 2-hydroxy-1-(1H-indol-3-yl)-4-methylpentan-3-one

(2010) Son T. Nguyen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Family of Pyrazinone Natural Products from a Conserved Nonribosomal Peptide Synthetase in Staphylococcus aureus

(2010) Michael Zimmermann et al.   CHEMISTRY & BIOLOGY

Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Second-generation environmental sequencing unmasks marine metazoan biodiversity

(2010) Vera G. Fonseca et al.   Nature Communications

Characterization of the ‘pristinamycin supercluster’ of Streptomyces pristinaespiralis

(2010) Yvonne Mast et al.   Microbial Biotechnology

Photorhabdusand a Host of Hosts

(2009) Nick R. Waterfield et al.   Annual Review of Microbiology

Octopamine and 5-hydroxytryptamine mediate hemocytic phagocytosis and nodule formation via eicosanoids in the beet armyworm,Spodoptera exigua

(2009) Geun Seob Kim et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

A New Type of Pyrrolidine Biosynthesis Is Involved in the Late Steps of Xenocoumacin Production inXenorhabdus nematophila

(2009) Daniela Reimer et al.   CHEMBIOCHEM

13CLabeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibioticzeamine from Dickeya zeae

(2009) Jien Wu et al.   CHEMICAL COMMUNICATIONS

Regulating Alternative Lifestyles in Entomopathogenic Bacteria

(2009) Jason M. Crawford et al.   CURRENT BIOLOGY

Entomopathogenic bacteria as a source of secondary metabolites

(2009) Helge B Bode   CURRENT OPINION IN CHEMICAL BIOLOGY

Identification of a new antimicrobial lysine-rich cyclolipopeptide family from Xenorhabdus nematophila

(2009) Maxime Gualtieri et al.   JOURNAL OF ANTIBIOTICS

Eicosanoid Actions in Insect Immunity

(2009) David Stanley et al.   Journal of Innate Immunity

Insecticidal activity of Bacillus thuringiensis crystal proteins

(2009) Kees van Frankenhuyzen   JOURNAL OF INVERTEBRATE PATHOLOGY

Genetic analysis of xenocoumacin antibiotic production in the mutualistic bacteriumXenorhabdus nematophila

(2009) Dongjin Park et al.   MOLECULAR MICROBIOLOGY

Bacterial Biosynthesis of a Multipotent Stilbene

(2008) Susan A. Joyce et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell Invasion and Matricide during Photorhabdus luminescens Transmission by Heterorhabditis bacteriophora Nematodes

(2008) T. A. Ciche et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of the Complete Zwittermicin A Biosynthesis Gene Cluster from Bacillus cereus

(2008) B. M. Kevany et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Joining the Army of Proteasome Inhibitors

(2008) Alexei F. Kisselev   CHEMISTRY & BIOLOGY

Linear and Cyclic Peptides from the Entomopathogenic BacteriumXenorhabdus nematophilus

(2008) Gerhard Lang et al.   JOURNAL OF NATURAL PRODUCTS

A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

(2008) Michael Groll et al.   NATURE

The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism

(2008) Christoph Dieterich et al.   NATURE GENETICS

Plastic architecture of bacterial genome revealed by comparative genomics of Photorhabdus variants

(2008) Sophie Gaudriault et al.   GENOME BIOLOGY