Polyketide biosynthesis in dinoflagellates: what makes it different?

A Dioxane Template for Highly Selective Epoxy Alcohol Cyclizations

(2013) James J. Mousseau et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biosynthetic machinery of ionophore polyether lasalocid: enzymatic construction of polyether skeleton

(2013) Atsushi Minami et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

First report of the toxin profile of Dinophysis sacculus Stein from LC–MS analysis of laboratory cultures

(2013) P. Riobó et al.   TOXICON

Origins of Oxygen Atoms in a Marine Ladder-Frame Polyether: Evidence of Monooxygenation by 18O-Labeling and Using Tandem Mass Spectrometry

(2012) Masatoshi Yamazaki et al.   JOURNAL OF ORGANIC CHEMISTRY

Sequential Enzymatic Epoxidation Involved in Polyether Lasalocid Biosynthesis

(2012) Atsushi Minami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthetic Studies on Water-Soluble Derivative 5c (DTX5c)

(2012) Tamara Vilches et al.   Marine Drugs

Electrophilic and nucleophilic enzymatic cascade reactions in biosynthesis

(2012) Barbara T. Ueberbacher et al.   NATURAL PRODUCT REPORTS

Flavoenzymes: Versatile catalysts in biosynthetic pathways

(2012) Christopher T. Walsh et al.   NATURAL PRODUCT REPORTS

Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis

(2012) Kinya Hotta et al.   NATURE

Insights into Lasalocid A Ring Formation by Chemical Chain Termination In Vivo

(2011) Manuela Tosin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cloning and Characterization of the Polyether Salinomycin Biosynthesis Gene Cluster of Streptomyces albus XM211

(2011) Chunyan Jiang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Mupirocin: biosynthesis, special features and applications of an antibiotic from a Gram-negative bacterium

(2011) Rachel Gurney et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A Late-Stage Intermediate in Salinomycin Biosynthesis Is Revealed by Specific Mutation in the Biosynthetic Gene Cluster

(2011) Marie E. Yurkovich et al.   CHEMBIOCHEM

Enzymatic Epoxide-Opening Cascades Catalyzed by a Pair of Epoxide Hydrolases in the Ionophore Polyether Biosynthesis

(2011) Atsushi Minami et al.   ORGANIC LETTERS

Occurrence of 12-methylgymnodimine in a spirolide-producing dinoflagellate Alexandrium peruvianum and the biogenetic implications

(2011) Ryan M. Van Wagoner et al.   TETRAHEDRON LETTERS

Marine huge molecules: the longest carbon chains in natural products

(2010) Masaki Kita et al.   CHEMICAL RECORD

Production of pinnatoxins by a peridinoid dinoflagellate isolated from Northland, New Zealand

(2010) L. Rhodes et al.   HARMFUL ALGAE

Structure and Relative Potency of Several Karlotoxins fromKarlodinium veneficum

(2010) Ryan M. Van Wagoner et al.   JOURNAL OF NATURAL PRODUCTS

Structure and Biosynthesis of Amphidinol 17, a Hemolytic Compound fromAmphidinium carterae⊥

(2010) Yanhui Meng et al.   JOURNAL OF NATURAL PRODUCTS

Absolute Configuration of Brevisamide and Brevisin: Confirmation of a Universal Biosynthetic Process forKarenia brevisPolyethers

(2010) Ryan M. Van Wagoner et al.   JOURNAL OF NATURAL PRODUCTS

Induced Biosynthesis of Cryptic Polyketide Metabolites in a Burkholderia thailandensis Quorum Sensing Mutant

(2010) Keishi Ishida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and Absolute Configuration of Karlotoxin-2, an Ichthyotoxin from the Marine DinoflagellateKarlodinium veneficum

(2010) Jiangnan Peng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis and Molecular Genetics of Polyketides in Marine Dinoflagellates

(2010) Ralf Kellmann et al.   Marine Drugs

Polyketides from Marine Dinoflagellates of the Genus Prorocentrum, Biosynthetic Origin and Bioactivity of Their Okadaic Acid Analogues

(2010) Weimin Hu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Biosynthesis of ethers: Unusual or common natural events?

(2010) Pablo Domínguez de María et al.   NATURAL PRODUCT REPORTS

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria

(2010) Adam C. Jones et al.   NATURAL PRODUCT REPORTS

Characterization of thelnmKLMGenes Unveiling Key Intermediates for β-Alkylation in Leinamycin Biosynthesis

(2010) Yong Huang et al.   ORGANIC LETTERS

Complete 13C-labeling pattern of yessotoxin a marine ladder-frame polyether

(2010) Masatoshi Yamazaki et al.   TETRAHEDRON

Synthesis of a proposed biosynthetic intermediate of a marine cyclic ether brevisamide for study on biosynthesis of marine ladder-frame polyethers

(2010) Tomohiro Shirai et al.   TETRAHEDRON LETTERS

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of a Gene Cluster of Polyether Antibiotic Lasalocid fromStreptomyces lasaliensis

(2009) Akira MIGITA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria

(2009) Adam C Jones et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Azadinium spinosumgen. et sp. nov. (Dinophyceae) identified as a primary producer of azaspiracid toxins

(2009) Urban Tillmann et al.   EUROPEAN JOURNAL OF PHYCOLOGY

DSP toxin production de novo in cultures of Dinophysis acuminata (Dinophyceae) from North America

(2009) Jeremiah D. Hackett et al.   HARMFUL ALGAE

Amphidinolides and Its Related Macrolides from Marine Dinoflagellates

(2009) Jun'ichi Kobayashi   JOURNAL OF ANTIBIOTICS

iso-Migrastatin, Migrastatin, and Dorrigocin Production in Streptomyces platensis NRRL 18993 Is Governed by a Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase

(2009) Si-Kyu Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a Dispiroketal Spirolide Subclass fromAlexandrium ostenfeldii

(2009) Joy S. Roach et al.   JOURNAL OF NATURAL PRODUCTS

Synthetic Studies on Gambieric Acids, Potent Antifungal Polycyclic Ether Natural Products: Reassignment of the Absolute Configuration of the Nonacyclic Polyether Core by NMR Analysis of Model Compounds

(2009) Haruhiko Fuwa et al.   JOURNAL OF ORGANIC CHEMISTRY

Brevisin: An Aberrant Polycyclic Ether Structure from the DinoflagellateKarenia brevisand Its Implications for Polyether Assembly

(2009) Masayuki Satake et al.   JOURNAL OF ORGANIC CHEMISTRY

Water Overcomes Methyl Group Directing Effects in Epoxide-Opening Cascades

(2009) Christopher J. Morten et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bifunctional Acyltransferase/Decarboxylase LnmK as the Missing Link for β-Alkylation in Polyketide Biosynthesis

(2009) Tao Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Continuing Saga of the Marine Polyether Biotoxins

(2008) K. C. Nicolaou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A brief tour of myxobacterial secondary metabolism

(2008) Kira J. Weissman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Analysis of Specific Mutants in the Lasalocid Gene Cluster: Evidence for Enzymatic Catalysis of a Disfavoured Polyether Ring Closure

(2008) Luke Smith et al.   CHEMBIOCHEM

Analysis of the Tetronomycin Gene Cluster: Insights into the Biosynthesis of a Polyether Tetronate Antibiotic

(2008) Yuliya Demydchuk et al.   CHEMBIOCHEM

Belizeanic Acid: A Potent Protein Phosphatase 1 Inhibitor Belonging to the Okadaic Acid Class, with an Unusual Skeleton

(2008) Patricia G. Cruz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Production of dinophysistoxin-1 and pectenotoxin-2 by a culture of Dinophysis acuminata (Dinophyceae)

(2008) Takashi Kamiyama et al.   HARMFUL ALGAE

Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin

(2008) K. C. Nicolaou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Epoxide Hydrolase Lsd19 for Polyether Formation in the Biosynthesis of Lasalocid A: Direct Experimental Evidence on Polyene-Polyepoxide Hypothesis in Polyether Biosynthesis

(2008) Yoshihiro Shichijo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolution of polyketides: post-PKS processing in the formation of spiroketals

(2008) Jeanette Young et al.   NATURAL PRODUCT REPORTS

Isoprenoid-like alkylations in polyketide biosynthesis

(2008) Christopher T. Calderone   NATURAL PRODUCT REPORTS

The biosynthesis of polyketide-derived polycyclic ethers

(2008) Andrew R. Gallimore   NATURAL PRODUCT REPORTS

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY

Stereocontrolled Synthesis of the A/B-Ring Fragment of Gambieric Acid B: Reassignment of the Absolute Configuration of the Polycyclic Ether Region

(2008) Haruhiko Fuwa et al.   ORGANIC LETTERS

Brevisamide: An Unprecedented Monocyclic Ether Alkaloid from the DinoflagellateKarenia brevisThat Provides a Potential Model for Ladder-Frame Initiation

(2008) Masayuki Satake et al.   ORGANIC LETTERS

Isolation and characterization of karlotoxin 1, a new amphipathic toxin from Karlodinium veneficum

(2008) Ryan M. Van Wagoner et al.   TETRAHEDRON LETTERS