A Late-Stage Intermediate in Salinomycin Biosynthesis Is Revealed by Specific Mutation in the Biosynthetic Gene Cluster

Effects of Salinomycin on Cancer Stem Cell in Human Lung Adenocarcinoma A549 Cells

(2012) Yi Wang   Medicinal Chemistry

Salinomycin Selectively Targets ‘CD133+’ Cell Subpopulations and Decreases Malignant Traits in Colorectal Cancer Lines

(2011) Tao-Tao Dong et al.   ANNALS OF SURGICAL ONCOLOGY

Salinomycin inhibits osteosarcoma by targeting its tumor stem cells

(2011) Qing-Lian Tang et al.   CANCER LETTERS

Stereoselectivity of Isolated Dehydratase Domains of the Borrelidin Polyketide Synthase: Implications for cis Double Bond Formation

(2011) Olivia Vergnolle et al.   CHEMBIOCHEM

Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A

(2011) Hak Joong Kim et al.   NATURE

A twist in the tail

(2011) Kira J Weissman   Nature Chemical Biology

Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation

(2011) Shunji Takahashi et al.   Nature Chemical Biology

Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells

(2011) Desheng Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells

(2010) Dominik Fuchs et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Salinomycin sensitizes cancer cells to the effects of doxorubicin and etoposide treatment by increasing DNA damage and reducing p21 protein

(2010) Ju-Hwa Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Kitlow Stem Cells Cause Resistance to Kit/Platelet-Derived Growth Factor α Inhibitors in Murine Gastrointestinal Stromal Tumors

(2010) Michael R. Bardsley et al.   GASTROENTEROLOGY

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase

(2009) T. J. Erb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genes for the Biosynthesis of the Fungal Polyketides Hypothemycin from Hypomyces subiculosus and Radicicol from Pochonia chlamydosporia

(2008) C. D. Reeves et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Analysis of Specific Mutants in the Lasalocid Gene Cluster: Evidence for Enzymatic Catalysis of a Disfavoured Polyether Ring Closure

(2008) Luke Smith et al.   CHEMBIOCHEM

Analysis of the Tetronomycin Gene Cluster: Insights into the Biosynthesis of a Polyether Tetronate Antibiotic

(2008) Yuliya Demydchuk et al.   CHEMBIOCHEM

cis-Δ2,3-Double Bond of Phoslactomycins Is Generated by a Post-PKS Tailoring Enzyme

(2008) Nadaraj Palaniappan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Epoxide Hydrolase Lsd19 for Polyether Formation in the Biosynthesis of Lasalocid A: Direct Experimental Evidence on Polyene-Polyepoxide Hypothesis in Polyether Biosynthesis

(2008) Yoshihiro Shichijo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The biosynthesis of polyketide-derived polycyclic ethers

(2008) Andrew R. Gallimore   NATURAL PRODUCT REPORTS