Electrophilic and nucleophilic enzymatic cascade reactions in biosynthesis

Squalene-Hopene Cyclases

(2011) Gabriele Siedenburg et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Electrostatic effects on (di)terpene synthase product outcome

(2011) Ke Zhou et al.   CHEMICAL COMMUNICATIONS

Evidence That Epoxide-Opening Cascades Promoted by Water Are Stepwise and Become Faster and More Selective After the First Cyclization

(2011) Christopher J. Morten et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Probing Eudesmane Cation−π Interactions in Catalysis by Aristolochene Synthase with Non-canonical Amino Acids

(2011) Juan A. Faraldos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis via carbocations: Theoretical studies on terpene formation

(2011) Dean J. Tantillo   NATURAL PRODUCT REPORTS

Cascade polycyclisations in natural product synthesis

(2011) Edward A. Anderson   ORGANIC & BIOMOLECULAR CHEMISTRY

Enzymatic Epoxide-Opening Cascades Catalyzed by a Pair of Epoxide Hydrolases in the Ionophore Polyether Biosynthesis

(2011) Atsushi Minami et al.   ORGANIC LETTERS

How Many Secondary Carbocations Are Involved in the Biosynthesis of Avermitilol?

(2011) Young J. Hong et al.   ORGANIC LETTERS

Structure of Epi-Isozizaene Synthase fromStreptomyces coelicolorA3(2), a Platform for New Terpenoid Cyclization Templates,

(2010) Julie A. Aaron et al.   BIOCHEMISTRY

The carbocation continuum in terpene biosynthesis—where are the secondary cations?

(2010) Dean J. Tantillo   CHEMICAL SOCIETY REVIEWS

Absolute Configuration of Brevisamide and Brevisin: Confirmation of a Universal Biosynthetic Process forKarenia brevisPolyethers

(2010) Ryan M. Van Wagoner et al.   JOURNAL OF NATURAL PRODUCTS

Genome Mining inStreptomyces avermitilis: Cloning and Characterization of SAV_76, the Synthase for a New Sesquiterpene, Avermitilol

(2010) Wayne K. W. Chou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Challenges Posed to Bornyl Diphosphate Synthase: Diverging Reaction Mechanisms in Monoterpenes

(2010) Michal Weitman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of ethers: Unusual or common natural events?

(2010) Pablo Domínguez de María et al.   NATURAL PRODUCT REPORTS

Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis

(2010) Mustafa Köksal et al.   NATURE

Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases

(2010) Takayuki Itoh et al.   Nature Chemistry

Intriguing Substrate Tolerance of Epoxide Hydrolase Lsd19 Involved in Biosynthesis of the Ionophore Antibiotic Lasalocid A

(2010) Yusuke Matsuura et al.   ORGANIC LETTERS

Diterpene cyclases and the nature of the isoprene fold

(2010) Rong Cao et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Epoxide-Opening Cascades in the Synthesis of Polycyclic Polyether Natural Products

(2009) Ivan Vilotijevic et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Epoxide-Hydrolase-Initiated Hydrolysis/Rearrangement Cascade of a Methylene-Interrupted Bis-Epoxide Yields Chiral THF Moieties without Involvement of a “Cyclase”

(2009) Barbara T. Ueberbacher et al.   CHEMBIOCHEM

The development of endo-selective epoxide-opening cascades in water

(2009) Christopher J. Morten et al.   CHEMICAL SOCIETY REVIEWS

The art of total synthesis through cascade reactions

(2009) K. C. Nicolaou et al.   CHEMICAL SOCIETY REVIEWS

The economies of synthesis

(2009) Timothy Newhouse et al.   CHEMICAL SOCIETY REVIEWS

Brevisin: An Aberrant Polycyclic Ether Structure from the DinoflagellateKarenia brevisand Its Implications for Polyether Assembly

(2009) Masayuki Satake et al.   JOURNAL OF ORGANIC CHEMISTRY

Water Overcomes Methyl Group Directing Effects in Epoxide-Opening Cascades

(2009) Christopher J. Morten et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Consequences of Conformational Preorganization in Sesquiterpene Biosynthesis: Theoretical Studies on the Formation of the Bisabolene, Curcumene, Acoradiene, Zizaene, Cedrene, Duprezianene, and Sesquithuriferol Sesquiterpenes

(2009) Young J. Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A potential energy surface bifurcation in terpene biosynthesis

(2009) Young J. Hong et al.   Nature Chemistry

Analysis of Specific Mutants in the Lasalocid Gene Cluster: Evidence for Enzymatic Catalysis of a Disfavoured Polyether Ring Closure

(2008) Luke Smith et al.   CHEMBIOCHEM

Unearthing the roots of the terpenome

(2008) David W Christianson   CURRENT OPINION IN CHEMICAL BIOLOGY

Epoxide Hydrolase Lsd19 for Polyether Formation in the Biosynthesis of Lasalocid A: Direct Experimental Evidence on Polyene-Polyepoxide Hypothesis in Polyether Biosynthesis

(2008) Yoshihiro Shichijo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The biosynthesis of polyketide-derived polycyclic ethers

(2008) Andrew R. Gallimore   NATURAL PRODUCT REPORTS

Brevisamide: An Unprecedented Monocyclic Ether Alkaloid from the DinoflagellateKarenia brevisThat Provides a Potential Model for Ladder-Frame Initiation

(2008) Masayuki Satake et al.   ORGANIC LETTERS

Chemical wizardry? The generation of diversity in terpenoid biosynthesis

(2008) Rudolf K. Allemann   PURE AND APPLIED CHEMISTRY