Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species

Evidence for a Functionally Relevant Rocaglamide Binding Site on the eIF4A–RNA Complex

(2013) Heather Sadlish et al.   ACS Chemical Biology

Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential

(2013) Frédéric Thuaud et al.   CHEMISTRY & BIOLOGY

The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints

(2013) Jennifer Neumann et al.   INTERNATIONAL JOURNAL OF CANCER

Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia

(2013) Houda Alachkar et al.   Journal of Hematology & Oncology

Bioactive Flavaglines and Other Constituents Isolated from Aglaia perviridis

(2013) Li Pan et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis of Biotinylated Episilvestrol: Highly Selective Targeting of the Translation Factors eIF4AI/II

(2013) Jennifer M. Chambers et al.   ORGANIC LETTERS

Prohibitin, an essential protein for Colorado potato beetle larval viability, is relevant to Bacillus thuringiensis Cry3Aa toxicity

(2013) Camila Ochoa-Campuzano et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Therapeutic Potential of the Translation Inhibitor Silvestrol in Hepatocellular Cancer

(2013) Takayuki Kogure et al.   PLoS One

Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation

(2013) H. A. Meijer et al.   SCIENCE

Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State

(2013) S. Santagata et al.   SCIENCE

The Natural Anticancer Compounds Rocaglamides Inhibit the Raf-MEK-ERK Pathway by Targeting Prohibitin 1 and 2

(2012) Gernot Polier et al.   CHEMISTRY & BIOLOGY

Dual Targeting of the Cyclin/Rb/E2F and Mitochondrial Pathways in Mantle Cell Lymphoma with the Translation Inhibitor Silvestrol

(2012) L. Alinari et al.   CLINICAL CANCER RESEARCH

Flavaglines as Potent Anticancer and Cytoprotective Agents

(2012) Nigel Ribeiro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Silvestrol Analogues as Potent and Selective Protein Synthesis Inhibitors

(2012) Tao Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis of (±)-Rocaglamide via Oxidation-Initiated Nazarov Cyclization

(2012) John A. Malona et al.   JOURNAL OF ORGANIC CHEMISTRY

Formal Synthesis of (±)-Methyl Rocaglate Using an Unprecedented Acetyl Bromide Mediated Nazarov Reaction

(2012) Philip Magnus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Photocycloaddition of 3-Hydroxyflavones: Total Syntheses and Absolute Configuration Assignments of (+)-Ponapensin and (+)-Elliptifoline

(2012) Neil J. Lajkiewicz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein

(2012) C Jin et al.   ONCOGENE

Two new rocaglamide derivatives from twigs of Aglaia odorata var. microphyllina

(2012) Shuai Liu et al.   Phytochemistry Letters

A cellular response linking eIF4AI activity to eIF4AII transcription

(2012) G. Galicia-Vazquez et al.   RNA

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

(2012) L M Lindqvist et al.   Cell Death & Disease

Resistance to the Translation Initiation Inhibitor Silvestrol is Mediated by ABCB1/P-Glycoprotein Overexpression in Acute Lymphoblastic Leukemia Cells

(2011) Sneha V. Gupta et al.   AAPS Journal

Characterization of Silvestrol Pharmacokinetics in Mice Using Liquid Chromatography–Tandem Mass Spectrometry

(2011) U. V. R. Vijaya Saradhi et al.   AAPS Journal

Recent advances in the biology and chemistry of the flavaglines

(2011) Nigel Ribeiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeted cancer therapy

(2011) Jonathan H. Schatz et al.   CELL CYCLE

Synthesis of Rocaglamide Hydroxamates and Related Compounds as Eukaryotic Translation Inhibitors: Synthetic and Biological Studies

(2011) Christina M. Rodrigo et al.   JOURNAL OF MEDICINAL CHEMISTRY

The biological and therapeutic relevance of mRNA translation in cancer

(2011) Sarah P. Blagden et al.   Nature Reviews Clinical Oncology

mRNA helicases: the tacticians of translational control

(2011) Armen Parsyan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27

(2011) Yohann Bernard et al.   PLoS One

Biomimetic Photocycloaddition of 3-Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation

(2010) Stéphane P. Roche et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression

(2010) M Bleumink et al.   CELL DEATH AND DIFFERENTIATION

Potential of Plant-Derived Natural Products in the Treatment of Leukemia and Lymphoma

(2010) David M. Lucas et al.   CURRENT DRUG TARGETS

The role of prohibitin in cell signaling

(2010) Suresh Mishra et al.   FEBS Journal

Novel Flavaglines Displaying Improved Cytotoxicity

(2010) Frédéric Thuaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Isolation and Characterization of Minor Analogues of Silvestrol and Other Constituents from a Large-Scale Re-collection ofAglaia foveolata

(2010) Li Pan et al.   JOURNAL OF NATURAL PRODUCTS

Constituents of Amoora cucullata with TRAIL resistance-overcoming activity

(2010) Firoj Ahmed et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

(2009) David M. Lucas et al.   BLOOD

Inhibiting the transcription factor HSF1 as an anticancer strategy

(2009) Luke Whitesell et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Synthetic Analogue of Rocaglaol Displays a Potent and Selective Cytotoxicity in Cancer Cells: Involvement of Apoptosis Inducing Factor and Caspase-12

(2009) Frédéric Thuaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nazarov Cyclization Initiated by Peracid Oxidation: The Total Synthesis of (±)-Rocaglamide

(2009) John A. Malona et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells

(2009) Regina Cencic et al.   LEUKEMIA RESEARCH

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

(2009) Regina Cencic et al.   PLoS One

Amide-esters from Aglaia tenuicaulis – First representatives of a class of compounds structurally related to bisamides and flavaglines

(2007) Harald Greger et al.   PHYTOCHEMISTRY

Flavaglines and triterpenoids from the leaves of Aglaia forbesii

(2007) Nantiya Joycharat et al.   PHYTOCHEMISTRY