Influenza neuraminidase: A druggable target for natural products

Design, synthesis and biological activity of thiazolidine-4-carboxylic acid derivatives as novel influenza neuraminidase inhibitors

(2011) Yu Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase

(2011) Christopher John Vavricka et al.   CHINESE SCIENCE BULLETIN

Novel neuraminidase inhibitors: identification, biological evaluation and investigations of the binding mode

(2011) Johannes Kirchmair et al.   Future Medicinal Chemistry

Evaluation of the anti-neuraminidase activity of the traditional Chinese medicines and determination of the anti-influenza A virus effects of the neuraminidase inhibitory TCMs in vitro and in vivo

(2011) Li Tian et al.   JOURNAL OF ETHNOPHARMACOLOGY

Neuraminidase inhibitor susceptibility of swine influenza A viruses isolated in Germany between 1981 and 2008

(2011) Katja Bauer et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Identifying selective inhibitors against the human cytosolic sialidase NEU2 by substrate specificity studies

(2011) Yanhong Li et al.   Molecular BioSystems

Mechanism of 150-cavity formation in influenza neuraminidase

(2011) Rommie E. Amaro et al.   Nature Communications

Assessment of Pandemic and Seasonal Influenza A (H1N1) Virus Susceptibility to Neuraminidase Inhibitors in Three Enzyme Activity Inhibition Assays

(2010) H. T. Nguyen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activity of Melaleuca alternifolia (tea tree) oil on Influenza virus A/PR/8: Study on the mechanism of action

(2010) A. Garozzo et al.   ANTIVIRAL RESEARCH

Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro

(2010) Larisa V Gubareva et al.   ANTIVIRAL THERAPY

New stilbenoid with inhibitory activity on viral neuraminidases from Erythrina addisoniae

(2010) Phi Hung Nguyen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis

(2010) Young Bae Ryu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata

(2010) Trong Tuan Dao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potential drug-like inhibitors of Group 1 influenza neuraminidase identified through computer-aided drug design

(2010) Jacob D. Durrant et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Emerging Methods for Ensemble-Based Virtual Screening

(2010) Rommie Amaro et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

QSAR study of flavonoids and biflavonoids as influenza H1N1 virus neuraminidase inhibitors

(2010) Andrew G. Mercader et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mumefural and related HMF derivatives from Japanese apricot fruit juice concentrate show multiple inhibitory effects on pandemic influenza A (H1N1) virus

(2010) Nongluk Sriwilaijaroen et al.   FOOD CHEMISTRY

Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis

(2010) Thi Ngoc Anh Nguyen et al.   FOOD CHEMISTRY

Top Leads for Swine Influenza A/H1N1 Virus Revealed by Steered Molecular Dynamics Approach

(2010) Binh Khanh Mai et al.   Journal of Chemical Information and Modeling

Dual Resistance to Adamantanes and Oseltamivir Among Seasonal Influenza A(H1N1) Viruses: 2008–2010

(2010) Tiffany G. Sheu et al.   JOURNAL OF INFECTIOUS DISEASES

Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses

(2010) Aaron J. Oakley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Complexity in Influenza Virus Targeted Drug Design: Interaction with Human Sialidases

(2010) Leonard M. G. Chavas et al.   JOURNAL OF MEDICINAL CHEMISTRY

C-Methylated Flavonoids fromCleistocalyx operculatusand Their Inhibitory Effects on Novel Influenza A (H1N1) Neuraminidase

(2010) Trong-Tuan Dao et al.   JOURNAL OF NATURAL PRODUCTS

In SilicoIdentification of the Potential Drug Resistance Sites over 2009 Influenza A (H1N1) Virus Neuraminidase

(2010) Huanxiang Liu et al.   MOLECULAR PHARMACEUTICS

Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa

(2010) Li Zhang et al.   MOLECULES

Anti-influenza agents from Traditional Chinese Medicine

(2010) Hu Ge et al.   NATURAL PRODUCT REPORTS

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site

(2010) Qing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of influenza A proteins and insights into antiviral drug targets

(2010) Kalyan Das et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Emergence of a Multidrug-Resistant Pandemic Influenza A (H1N1) Virus

(2010) Erhard van der Vries et al.   NEW ENGLAND JOURNAL OF MEDICINE

In VitroAnti-influenza Viral Activities of Stilbenoids from the Lianas ofGnetum pendulum

(2010) Ai-Lin Liu et al.   PLANTA MEDICA

Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance

(2010) J. D. Bloom et al.   SCIENCE

Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase

(2010) Santosh Rudrawar et al.   Nature Communications

Different neuraminidase inhibitor susceptibilities of human H1N1, H1N2, and H3N2 influenza A viruses isolated in Germany from 2001 to 2005/2006

(2009) Katja Bauer et al.   ANTIVIRAL RESEARCH

Crystal structures of respiratory pathogen neuraminidases

(2009) Yu-Shan Hsiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata

(2009) Young Bae Ryu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities

(2009) Hyung Jae Jeong et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Evolution of Influenza Resistance and Treatment

(2009) David M. Weinstock   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pharmacophore Modeling, Quantitative Structure−Activity Relationship Analysis, and Shape-Complementedin SilicoScreening Allow Access to Novel Influenza Neuraminidase Inhibitors

(2009) Areej M. Abu Hammad et al.   Journal of Chemical Information and Modeling

A Novel Small-Molecule Inhibitor of the Avian Influenza H5N1 Virus Determined through Computational Screening against the Neuraminidase

(2009) Jianghong An et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antiviral Potential and Molecular Insight into Neuraminidase Inhibiting Diarylheptanoids fromAlpinia katsumadai

(2009) Ulrike Grienke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterizing Loop Dynamics and Ligand Recognition in Human- and Avian-Type Influenza Neuraminidases via Generalized Born Molecular Dynamics and End-Point Free Energy Calculations

(2009) Rommie E. Amaro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The human rhinovirus: human-pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery

(2009) Judith M. Rollinger et al.   MEDICINAL RESEARCH REVIEWS

Broad-spectrum antiviral effect ofAgrimonia pilosaextract on influenza viruses

(2009) Woo-Jin Shin et al.   MICROBIOLOGY AND IMMUNOLOGY

Emergence and pandemic potential of swine-origin H1N1 influenza virus

(2009) Gabriele Neumann et al.   NATURE

The Emergency Use Authorization of Peramivir for Treatment of 2009 H1N1 Influenza

(2009) Debra Birnkrant et al.   NEW ENGLAND JOURNAL OF MEDICINE

Global Transmission of Oseltamivir-Resistant Influenza

(2009) Anne Moscona   NEW ENGLAND JOURNAL OF MEDICINE

Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Elderberry flavonoids bind to and prevent H1N1 infection in vitro

(2009) Bill Roschek et al.   PHYTOCHEMISTRY

Pomegranate (Punica granatum) purified polyphenol extract inhibits influenza virus and has a synergistic effect with oseltamivir

(2009) Mehran Haidari et al.   PHYTOMEDICINE

In vitroAnti-Influenza Viral Activities of Constituents fromCaesalpinia sappan

(2009) Ai-Lin Liu et al.   PLANTA MEDICA

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

Emerging antiviral targets for influenza A virus

(2009) Robert M. Krug et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Structural basis for oseltamivir resistance of influenza viruses

(2009) P.J. Collins et al.   VACCINE

Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian Influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV)

(2009) Stephan Pleschka et al.   Virology Journal

Structure of the catalytic domain ofStreptococcus pneumoniaesialidase NanA

(2008) Guogang Xu et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

CS-8958, a Prodrug of the New Neuraminidase Inhibitor R-125489, Shows Long-Acting Anti-Influenza Virus Activity

(2008) M. Yamashita et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Limited Inhibitory Effects of Oseltamivir and Zanamivir on Human Sialidases

(2008) K. Hata et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Surveillance for Neuraminidase Inhibitor Resistance among Human Influenza A and B Viruses Circulating Worldwide from 2004 to 2008

(2008) T. G. Sheu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Inhibition of Human Influenza A Virus Infection by Fruit-Juice Concentrate of Japanese Plum (Prunus mume SIEB. et ZUCC)

(2008) Sangchai Yingsakmongkon et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Design, synthesis, inhibitory activity, and SAR studies of hydrophobic p-aminosalicylic acid derivatives as neuraminidase inhibitors

(2008) Jie Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure–activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities

(2008) Ai-Lin Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pterocarpans and flavanones from Sophora flavescens displaying potent neuraminidase inhibition

(2008) Young Bae Ryu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel Druggable Hot Spots in Avian Influenza Neuraminidase H5N1 Revealed by Computational Solvent Mapping of a Reduced and Representative Receptor Ensemble

(2008) Melissa R. Landon et al.   Chemical Biology & Drug Design

Pandemic and seasonal influenza: therapeutic challenges

(2008) Matthew J. Memoli et al.   DRUG DISCOVERY TODAY

The Structure ofClostridium perfringensNanI Sialidase and Its Catalytic Intermediates

(2008) Simon L. Newstead et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding Interaction Analysis of the Active Site and Its Inhibitors for Neuraminidase (N1 Subtype) of Human Influenza Virus by the Integration of Molecular Docking, FMO Calculation and 3D-QSAR CoMFA Modeling

(2008) Qingye Zhang et al.   Journal of Chemical Information and Modeling

Ensemble-Based Virtual Screening Reveals Potential Novel Antiviral Compounds for Avian Influenza Neuraminidase

(2008) Lily S. Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of the NanB Sialidase from Streptococcus pneumoniae

(2008) Guogang Xu et al.   JOURNAL OF MOLECULAR BIOLOGY

Developing a Drug-like Natural Product Library⊥

(2008) Ronald J. Quinn et al.   JOURNAL OF NATURAL PRODUCTS

Structural Characterization of the 1918 Influenza Virus H1N1 Neuraminidase

(2008) X. Xu et al.   JOURNAL OF VIROLOGY

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

(2008) Patrick J. Collins et al.   NATURE

Anti-Influenza Virus Activities of Flavonoids from the Medicinal PlantElsholtzia rugulosa

(2008) Ai-Lin Liu et al.   PLANTA MEDICA

Human-Like Receptor Specificity Does Not Affect the Neuraminidase-Inhibitor Susceptibility of H5N1 Influenza Viruses

(2008) Natalia A. Ilyushina et al.   PLoS Pathogens

Enzymatic Properties of the Neuraminidase of Seasonal H1N1 Influenza Viruses Provide Insights for the Emergence of Natural Resistance to Oseltamivir

(2008) Marie-Anne Rameix-Welti et al.   PLoS Pathogens

Natural Product-likeness Score and Its Application for Prioritization of Compound Libraries

(2007) Peter Ertl et al.   Journal of Chemical Information and Modeling