Article
Food Science & Technology
Yoowha Jeon, Jieun Oh, Mi Sook Cho
Summary: The study aimed to define the optimal formulation of sucrose-free hard candy using D-optimal mixture design and examined the effects of polyol mixtures on physicochemical and sensory features of hard candies, recommending an appropriate ratio of xylitol for better quality characteristics.
Article
Biochemistry & Molecular Biology
Wonmin Ko, Nayeon Kim, Hwan Lee, Eun-Rhan Woo, Youn-Chul Kim, Hyuncheol Oh, Dong-Sung Lee
Summary: Compounds from the root bark of Cudrania tricuspidata have shown anti-inflammatory effects on HaCaT cells treated with tumor necrosis factor-alpha+interferon-gamma. Six compounds, including steppogenin, cudraflavone C, and macluraxanthone B, were found to be the most effective in reducing chemokine levels and inhibiting NF-KB p65 translocation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jintong Song, Ke Xu, Chunyu Liu, Tian Wang, Xiaoyi Luan, Lihua Zhu, Zhaojun Chu, Xiaojie Fu, Wenqiang Chang, Xiaoning Wang, Hongxiang Lou
Summary: Fourteen undescribed compounds, including five 2,5-diarylcyclopentenones xylariaones A1-B2, seven a-pyrone derivatives xylaripyones A G, one.-pyrone derivative xylaripyone H, one diketopiperazine cyclo-(L-Leu-N=ethyl-L-Glu), and two known diketopiperazines, were isolated from cultures of the endophytic fungus Xylaria sp., which was separated from Cudrania tricuspidata Bureau ex Lavall ' ee. Their structures were determined by analysing extensive spectroscopic data (HRESIMS and NMR) and electronic circular dichroism (ECD) calculations. Furthermore, these compounds were evaluated for potential antiproliferative activity against the human tumour cell lines PC3 and A549, and the results showed that xylaripyone D exhibited moderate inhibitory activity against the proliferation of PC3 cell lines with an IC50 value of 14.75 μM. Meanwhile, xylariaone A3 and xylaripyone F displayed weak inhibitory effects on NO production in RAW 264.7 murine macrophages with IC50 values of 49.76 and 69.68 μM, respectively.
Article
Medicine, Research & Experimental
Jeong In Seo, Jun Sang Yu, Eun Kyu Lee, Ki Baek Park, Hye Hyun Yoo
Summary: This study investigated the pharmacokinetic profiles of bioactive components in the Cudrania tricuspidata leaf extract using a molecular networking system. The results identified quercetin and kaempferol glucuronide metabolites as the major circulating species and suggested that molecular network-based approaches are potential and efficient methods for pharmacokinetic studies of herbal medicines.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Zikang Ding, Meng Zhao, Xinyue Li, Xiaomei Wang, Zhongshan Zhang
Summary: In this study, two polysaccharide fractions, ZGs-1 and ZGs-2, were purified hierarchically from the fruits of Cudrania tricuspidata. ZGs-2 exhibited strong antioxidant activity and scavenging effects on free radicals, indicating its potential as an antioxidant and hepatoprotective agent.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Si Young Ha, Ji Young Jung, Jae-Kyung Yang
Summary: The study examined the antioxidant effects of roasted Cudrania tricuspidata fruits compared to unroasted ones. The results indicated that roasted fruits exhibited significantly higher antioxidant activity, particularly in terms of anti-inflammatory effects. The color of the roasted fruit was found to be highly correlated with its antioxidant activity, and heating increased the flavonoid content, possibly due to disruption of cells and interference with plant metabolism. HPLC analysis showed that the increase in antioxidant activity was attributed to the increase in flavan-3-ols and phenolic acids in roasted fruits. This study is the first to investigate the antioxidant and anti-inflammatory properties of roasted C. tricuspidata fruits, highlighting their potential as a natural source of antioxidants for various applications.
Article
Plant Sciences
Dong-Hwan Lee, Yong-Hwan Son, Jun-Hyuk Jang, Sun-Young Lee, Hyun-Jun Kim
Summary: This study aimed to investigate the relationship between the growth of Cudrania tricuspidata and environmental factors, as well as the compounds present in the plant. Samples of fruit and soil were collected from 28 cultivation sites and analyzed for growth characteristics, soil properties, meteorological data, and active compounds. An optimized UPLC method was developed and validated for quantifying the active compounds. The results of this study can be used for standard cultural practices and quality control of C. tricuspidata fruits.
Article
Endocrinology & Metabolism
Jae Yeon Joung, Whasun Lim, Yeon Jeong Seo, Jiyeon Ham, Nam Su Oh, Sae Hun Kim
Summary: This study investigated the effects of a synbiotic combination on the hypothalamic-pituitary-gonadal axis in mice under chronic stress. The results showed that the synbiotic combination suppressed the increase in corticosterone induced by UCMS, repaired testicular damage, and regulated the expression of genes related to gonadal function.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eui-Baek Byun, Ha-Yeon Song, Woo Sik Kim, Jeong Moo Han, Ho Seong Seo, Sang-Hyun Park, Kwangwook Kim, Eui-Hong Byun
Summary: The study revealed that Cudrania tricuspidata fruit-derived polysaccharides could protect cells from cisplatin-induced cytotoxicity, reduce apoptotic and necrotic events, and mitigate the damage caused by chemotherapy drugs to both cells and tumors in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Ju Kyoung Oh, Robie Vasquez, In-Chan Hwang, Ye Na Oh, Sang Hoon Kim, Shin Ho Kang, Jae Yeon Joung, Nam Su Oh, Sejeong Kim, Yohan Yoon, Dae-Kyung Kang
Summary: The study demonstrated that the synbiotic administration of L. rhamnosus 4B15 and C. tricuspidata extract significantly reduced fat mass, serum triglyceride, and ALT levels in obese mice. The treatment also modulated gut microbiota abundance and upregulated metabolic pathways associated with improved metabolic health. Further research is needed to understand the mechanisms behind this synbiotic effect.
Article
Medicine, General & Internal
Jinyoung Shin, Tae-Hoon Oh, Joo-Yun Kim, Jae-Jung Shim, Jung-Lyoul Lee
Summary: The study found that Cudrania tricuspidata extract is effective for alleviating gastrointestinal symptoms in patients with functional dyspepsia, with no significant adverse events observed.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Jeong Yoon Lee, Hyung Gu Son, Yejin Koo, Seung Hee Jung, Soo-Dong Park, Jae-Jung Shim, Jung-Lyoul Lee, Yoo-Hyun Lee
Summary: This study investigated the effect of Cudrania tricuspidata on Helicobacter pylori infection in mice. Results showed that C. tricuspidata significantly reduced H. pylori-induced inflammation, suggesting its potential as an effective functional food material against H. pylori.
JOURNAL OF MEDICINAL FOOD
(2023)
Article
Chemistry, Multidisciplinary
Inkyu Kim, Hansol Kim, Eunjoo H. Lee, Geonung Jo, Chun Soo Na, Kyungtae Kang, Tae Hoon Lee
Summary: Our study demonstrated that both Cudrania tricuspidata extracts (CTE) and a mixture of CTE/Stewartia koreana extracts (CTE mix) have significant anti-inflammatory effects, especially in managing rheumatoid arthritis and related symptoms.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Jitendra Shrestha, Dong-Jae Baek, Yoon-Sin Oh, Sam-Seok Cho, Sung-Hwan Ki, Eun-Young Park
Summary: Cudrania tricuspidata (CT) has been shown to have a significant ameliorative effect on nonalcoholic fatty liver disease, reducing hepatic fat accumulation and decreasing oxidative stress and inflammation.
Article
Chemistry, Medicinal
Li Nan, Hyeon-Hwa Nam, Byung-Kil Choo
Summary: In this study, fermented C. tricuspidata fruit extract (FCt) was evaluated for its role in improving reflux esophagitis (RE). The results showed that FCt inhibited inflammation, improved esophageal tissue damage caused by acid reflux, and increased the barrier function of cell tissues.
PHARMACOGNOSY MAGAZINE
(2022)
Review
Biochemistry & Molecular Biology
Xuyu Liu, Marcus J. C. Long, Yimon Aye
TRENDS IN BIOCHEMICAL SCIENCES
(2019)
Correction
Chemistry, Multidisciplinary
Saba Parvez, Marcus J. C. Long, Jesse R. Poganik, Yimon Aye
Article
Chemistry, Multidisciplinary
Hem Raj Khatri, Bijay Bhattarai, Will Kaplan, Zhongzheng Li, Marcus John Curtis Long, Yimon Aye, Pavel Nagorny
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Review
Biochemistry & Molecular Biology
Marcus J. C. Long, Xuyu Liu, Yimon Aye
CURRENT OPINION IN CHEMICAL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Marcus J. C. Long, Lingxi Wang, Yimon Aye
ANTIOXIDANTS & REDOX SIGNALING
(2020)
Review
Biochemistry & Molecular Biology
Marcus J. C. Long, Alexandra Van Hall-Beauvais, Yimon Aye
CURRENT OPINION IN CHEMICAL BIOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Jesse R. Poganik, Alexandra K. Van Hall-Beauvais, Marcus J. C. Long, Michael T. Disare, Yi Zhao, Yimon Aye
HELVETICA CHIMICA ACTA
(2020)
Article
Chemistry, Multidisciplinary
Xuyu Liu, Marcus J. C. Long, Benjamin D. Hopkins, Chaosheng Luo, Lingxi Wang, Yimon Aye
ACS CENTRAL SCIENCE
(2020)
Review
Chemistry, Multidisciplinary
Marcus J. C. Long, Chloe Rogg, Yimon Aye
Summary: The article provides a personal account of the innovation and design principles behind REX technologies, which aim to interrogate precision electrophile signaling in cells and organisms. By developing methods like T-REX and G-REX, the researchers have been able to gain new insights into target engagement and design of covalent medicines.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yi Zhao, Pierre A. Miranda Herrera, Dalu Chang, Romain Hamelin, Marcus J. C. Long, Yimon Aye
Summary: Enzyme-assisted posttranslational modifications (PTMs) play a major role in signaling across cellular compartments. However, the impact of nonenzymatic PTMs on cross-compartment signaling is not well understood. This study establishes a quantitative platform to assess the responsivity of compartmentalized subproteomes to nonenzymatic PTMs, revealing that a significant number of protein sensors respond in compartments of nonprimary origin or where their canonical activity is inoperative.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Jesse R. Poganik, Kuan-Ting Huang, Saba Parvez, Yi Zhao, Sruthi Raja, Marcus J. C. Long, Yimon Aye
Summary: The study investigates the mechanism of action of dimethyl fumarate on innate immune cell toxicity, revealing that it modifies Keap1 to trigger mitochondrial-targeted neutrophil/macrophage apoptosis. Despite the importance of reactive electrophilic drugs, deconvolution of their principal targets remains difficult due to lack of genetic tractability and interference by non-specific compounds during validation.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Marcus J. C. Long, Phillippe Ly, Yimon Aye
Summary: Covalent drugs have re-emerged as a promising approach in drug discovery and design due to their ability to prolong target engagement and target shallower binding sites. Development of covalent drugs involves frameworks like identifying electrophile-sensing residues and studying innate signaling by endogenous molecules to predict drug mechanism and behavior.
RSC MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Marcus J. C. Long, Kuan-Ting Huang, Yimon Aye
Summary: This tutorial review compares and contrasts the chemical mechanisms of electrophile/oxidant sensing and the molecular mechanisms of signal propagation. It critically analyzes biological systems where these pathways are believed to be present and discusses the implications of the data. Finally, it explores the applications of this knowledge in disease treatment and drug development.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Marcus J. C. Long, Yi Zhao, Yimon Aye
RSC CHEMICAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Marcus J. C. Long, Yi Zhao, Yimon Aye
CELL CHEMICAL BIOLOGY
(2020)