Article
Medicine, Research & Experimental
Yong-Hyun Joo, Yeong-Geun Lee, Younghyun Lim, Hoyeon Jeon, In-Gu Lee, Yong -Bin Cho, So-Hee Hong, Eui Ho Kim, Soon Ho Choi, Jung-Woong Kim, Se Chan Kang, Young-Jin Seo
Summary: This study investigated the anti-influenza A virus (IAV) activity of an aqueous mixture of Agrimonia pilosa and Galla rhois extracts (APRG64). The results showed that APRG64 significantly reduced IAV-induced cytopathic effect, viral protein transcription/expression, and infectious viral particle production. The main component responsible for the anti-IAV activity was identified as apigenin. APRG64 and apigenin inhibited virus attachment, entry, and polymerase activity. Intranasal or oral administration of APRG64 reduced viral loads and protected mice from IAV-induced mortality by reducing viral RNA levels and pro-inflammatory cytokine expression in the lungs.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemical Research Methods
Nguyen Quang Hop, Ninh The Son
Summary: Hairy agrimony is a traditional medicinal plant used in Eastern Europe and Eastern Asia. It has various pharmacological activities and contains more than 160 secondary metabolites. The plant and its extracts have shown potential in treating cancer, microbial infections, inflammation, diabetes, and other health conditions.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Chemistry, Multidisciplinary
Jin Seok Lee, Yu Ran Nam, Su Jin Park, Ji Min Lee, Hyun Jong Kim, Woo Kyung Kim
Summary: In this experiment, a simple and rapid method of analyzing flavonoid glucuronides was developed and validated while developing topical formulations containing 0.1% Agrimonia pilosa extract. The physicochemical properties and stability of the flavonoid glucuronides were observed, and an optimized cream formulation was developed. Stability tests showed that both physicochemical and biological properties were stable during the test period.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Medicinal
Jia Zhang, Ya-Nan Yang, Zi-Ming Feng, Xiang Yuan, Xu Zhang, Jian-Shuang Jiang, Pei-Cheng Zhang
Summary: The phytochemical study of Agrimonia pilosa led to the discovery of two new nortriterpenoids, as well as a known triterpenoid with selective cytotoxicity against certain cancer cell lines. These findings provide valuable insights into the chemical constituents of Agrimonia pilosa and its potential pharmacological applications.
Article
Virology
Liping Sun, Xueqi Zhang, Shufa Xu, Chunsheng Hou, Jin Xu, Dongxiang Zhao, Yanping Chen
Summary: The study demonstrated the antiviral activity of Radix isatidis extract against Chinese Sacbrood virus (CSBV) infection in honey bees. The extract inhibited CSBV replication, alleviated impacts on larval growth and development, reduced mortality in infected larvae, and modulated immune gene expression in infected bees. This provides a potential strategy for controlling SBV infection.
Article
Biochemistry & Molecular Biology
Yeong-Geun Lee, Kyung Won Kang, Woojae Hong, Yeon Hwa Kim, Jen Taek Oh, Dae Won Park, Minsung Ko, Yun-Feng Bai, Young-Jin Seo, Sang-Myeong Lee, Hyunggun Kim, Se Chan Kang
Summary: Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle. Three components in APRG64 displayed strong antiviral activity, and molecular docking analysis showed their potent binding to the spike receptor-binding-domain of SARS-CoV-2 and its variant B.1.1.7. Overall, APRG64 is a potent drug candidate to treat SARS-CoV-2 and its variants.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Won-Kyung Cho, Jin Yeul Ma
Summary: Epimedium koreanum Nakai (EKN) has shown significant inhibitory effects on influenza A virus infection by directly blocking viral attachment and having a virucidal effect. It can potentially be developed as a natural viral inhibitor against influenza virus infection.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Jing-Hui Feng, Hyun-Yong Kim, Su-Min Sim, Guang-Lei Zuo, Jeon-Sub Jung, Seung-Hwan Hwang, Youn-Gil Kwak, Min-Jung Kim, Jeong-Hun Jo, Sung-Chan Kim, Soon-Sung Lim, Hong-Won Suh
Summary: The study demonstrated that the mixture extract from Agrimonia pilosa Ledeb. and Salvia miltiorrhiza Bunge showed significant anti-inflammatory and antinociceptive effects, indicating its potential as a therapeutic for arthritis treatment.
Article
Biochemistry & Molecular Biology
Su Yeon Eom, Moon-Moo Kim
Summary: The methanolic extract of Agrimonia Pilosa inhibits cancer cell invasion by suppressing the activities of ERK and JNK, reducing the activation and protein expression of MMP-2 and MMP-9, along with AKT-1. This suggests that APLME could be a potential alternative therapeutic agent for inhibiting metastasis.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Ayaka Nakashima, Yuka Horio, Kengo Suzuki, Yuji Isegawa
Summary: Euglena extract has shown strong inhibitory effects against various strains of influenza virus, including drug-resistant strains. It may work by activating host cell defense mechanisms rather than directly targeting the virus. Additionally, minerals in the extract, mainly zinc, were found to be involved in its antiviral activity.
Article
Biochemistry & Molecular Biology
Jia Zhang, Ya-Nan Yang, Jian-Shuang Jiang, Zi-Ming Feng, Xiang Yuan, Xu Zhang, Pei-Cheng Zhang
Summary: Five new dimeric phloroglucinol derivatives, agrimones A-E (1-5), were isolated from Agrimonia pilosa. Their structures and absolute configurations were determined through a series of spectroscopic data, and compounds 1 and 2 exhibited a unique highly oxidized tricyclic ring skeleton. Additionally, compounds 1a, 4, and 5 showed moderate hepatoprotective activities against APAP-induced HepG2 cell injury.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Hong-Rui Li, Yu-Kui Li, Jian Xiao, Cui Yang, Meng-Yuan Jiang, Kai Tian, Wei Wang, Yan-Hong Li, Xiang-Zhong Huang
Summary: A pilot study on the ethanol extracts of Agrimonia pilosa revealed anti-α-glucosidase and anti-inflammatory activities, with a new phenylethyl isocoumarin glycoside (1) and eight known compounds (2-9) being isolated. Compound 1 showed modest α-glucosidase inhibitory activity, while most compounds exhibited weak anti-inflammatory effects, except for compounds 3 and 6 which were inactive.
NATURAL PRODUCT RESEARCH
(2022)
Article
Veterinary Sciences
Chengzhi Yu, Yayu Huang, Xin Ren, Leqiang Sun
Summary: In this study, antiviral active ingredients were extracted from medicinal and edible plants to prepare a drug called Ren's oligopeptide through biotransformation and enzymatic hydrolysis. The analysis showed that Ren's oligopeptide could inhibit the replication of influenza virus and SARS-CoV-2 virus with high antiviral activities. In vitro experiments demonstrated that the antiviral activity of Ren's oligopeptide mainly targeted the replication process after virus enters the cell. Therefore, Ren's oligopeptide is a promising drug against influenza and COVID-19.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Plant Sciences
Yong-Hyun Joo, Yeong-Geun Lee, Younghyun Lim, Hoyeon Jeon, Eui Ho Kim, Joongyeon Choi, Woojae Hong, Hyelin Jeon, Michael Ahrweiler, Hyunggun Kim, Se Chang Kang, Young-Jin Seo
Summary: The study found that the extract of Elaeocarpus sylvestris has strong antiviral activity against influenza A virus infection, which could lead to the development of new plant-based medicine to treat influenza virus infection.
Article
Chemistry, Medicinal
E. A. Krasnov, V. I. Otmakhov, T. A. Zamoshchina, Ya. E. Reshetov, I. S. Kuskova, E. V. Petrova
Summary: Individual fractions with significant lithium content were obtained from an aqueous extract of Agrimonia pilosa; tannin fractions exhibited marked rhythm-modulating activity.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2021)
Article
Oncology
Woo-Jin Shin, Ky-Youb Nam, Nam-Doo Kim, Sei-Hwan Kim, Kyoung-Tai No, Baik-Lin Seong
Review
Pharmacology & Pharmacy
Woo-Jin Shin, Baik Lin Seong
EXPERT OPINION ON DRUG DISCOVERY
(2017)
Article
Multidisciplinary Sciences
Gil Ju Seo, Charlotte Kim, Woo-Jin Shin, Ella H. Sklan, Hyungjin Eoh, Jae U. Jung
NATURE COMMUNICATIONS
(2018)
Review
Pharmacology & Pharmacy
Woo-Jin Shin, Baik L. Seong
EXPERT OPINION ON DRUG DISCOVERY
(2019)
Article
Microbiology
Woo-Jin Shin, Daiki Hara, Francisca Gbormittah, Hana Chang, Byeong S. Chang, Jae U. Jung
Article
Microbiology
Su-Jin Park, Young-Il Kim, Angela Park, Hyeok-Il Kwon, Eun-Ha Kim, Young-Jae Si, Min-Suk Song, Chul-Ho Lee, Kyle Jung, Woo-Jin Shin, Jianxiong Zeng, Younho Choi, Jae U. Jung, Young Ki Choi
NATURE MICROBIOLOGY
(2019)
Article
Microbiology
Younho Choi, Su-Jin Park, Yinyan Sun, Ji-Seung Yoo, Raghavendra Sumanth Pudupakam, Suan-Sin Foo, Woo-Jin Shin, Sally B. Chen, Philip N. Tsichlis, Won-Ja Lee, Jong-Soo Lee, Wenhui Li, Benjamin Brennan, Young-Ki Choi, Jae U. Jung
NATURE MICROBIOLOGY
(2019)
Article
Microbiology
Huan Yan, Suan-Sin Foo, Weiqiang Chen, Ji-Seung Yoo, Woo-Jin Shin, Christine Wu, Jae U. Jung
Article
Virology
Younho Choi, Zhongyi Jiang, Woo-Jin Shin, Jae U. Jung
JOURNAL OF VIROLOGY
(2020)
Article
Cell Biology
Wenjie Wang, Woo-Jin Shin, Bojie Zhang, Younho Choi, Ji-Seung Yoo, Maxwell I. Zimmerman, Thomas E. Frederick, Gregory R. Bowman, Michael L. Gross, Daisy W. Leung, Jae U. Jung, Gaya K. Amarasinghe
Article
Microbiology
Su-Jin Park, Kwang-Min Yu, Young-Il Kim, Se-Mi Kim, Eun-Ha Kim, Seong-Gyu Kim, Eun Ji Kim, Mark Anthony B. Casel, Rare Rollon, Seung-Gyu Jang, Min-Hyeok Lee, Jae-Hyung Chang, Min-Suk Song, Hye Won Jeong, Younho Choi, Weiqiang Chen, Woo-Jin Shin, Jae U. Jung, Young Ki Choi
Article
Chemistry, Medicinal
Sang Hoon Han, Christopher M. Goins, Tarun Arya, Woo-Jin Shin, Joshua Maw, Alice Hooper, Dhiraj P. Sonawane, Matthew R. Porter, Breyanne E. Bannister, Rachel D. Crouch, A. Abigail Lindsey, Gabriella Lakatos, Steven R. Martinez, Joseph Alvarado, Wendell S. Akers, Nancy S. Wang, Jae U. Jung, Jonathan D. Macdonald, Shaun R. Stauffer
Summary: Starting from ML300, a structure-based optimization campaign was conducted against the SARS-CoV-2 main protease, resulting in the discovery of compound 41 with antiviral activity. This study provides important insights for the development of antiviral drugs in combating SARS-like coronavirus outbreaks.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Microbiology
Xin Wu, Tian Xia, Woo-Jin Shin, Kwang-Min Yu, Wooram Jung, Alexandra Herrmann, Suan-Sin Foo, Weiqiang Chen, Pengfei Zhang, Jong-Soo Lee, Haryoung Poo, Suzy A. A. Comhair, Lara Jehi, Young Ki Choi, Armin Ensser, Jae U. Jung
Summary: Patients infected with SARS-CoV-2 variants lacking open reading frame 8 (ORF8) have milder infection and disease outcome. The study reveals that secreted ORF8 protein mimics host IL-17 to activate IL-17 receptors A and C, inducing a stronger inflammatory response than host IL-17A. This provides molecular insights into the role of ORF8 in COVID-19 pathogenesis and serves as a potential therapeutic target.
Letter
Multidisciplinary Sciences
Woo-Jin Shin, Dat P. Ha, Keigo Machida, Amy S. Lee
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Suan-Sin Foo, Mary Catherine Cambou, Thalia Mok, Viviana M. Fajardo, Kyle L. Jung, Trevon Fuller, Weiqiang Chen, Tara Kerin, Jenny Mei, Debika Bhattacharya, Younho Choi, Xin Wu, Tian Xia, Woo-Jin Shin, Jessica Cranston, Grace Aldrovandi, Nicole Tobin, Deisy Contreras, Francisco J. Ibarrondo, Otto Yang, Shangxin Yang, Omai Garner, Ruth Cortado, Yvonne Bryson, Carla Janzen, Shubhamoy Ghosh, Sherin Devaskar, Brenda Asilnejad, Maria Elisabeth Moreira, Zilton Vasconcelos, Priya R. Soni, L. Caroline Gibson, Patricia Brasil, Suzy A. A. Comhair, Vaithilingaraja Arumugaswami, Serpil C. Erzurum, Rashmi Rao, Jae U. Jung, Karin Nielsen-Saines
Summary: Pregnancy increases the risk for severe COVID-19, but the effects of COVID-19 on maternal-fetal health are still unknown. Research shows that prenatal SARS-CoV-2 infection triggers immune activation, severe COVID-19 patients exhibit heightened inflammation, and COVID-19 affects maternal immunity and newborns differently.
CELL REPORTS MEDICINE
(2021)
Article
Immunology
Carlos Henrique Camargo, Amanda Yaeko Yamada, Andreia Rodrigues de Souza, Claudio Tavares Sacchi, Alex Domingos Reis, Marlon Benedito Nascimento Santos, Denise Brandao de Assis, Eneas de Carvalho, Elizabeth Harummyy Takagi, Marcos Paulo Vieira Cunha, Monique Ribeiro Tiba-Casas
Summary: This study reveals the silent spread of New Delhi metallo-beta-lactamase (NDM) carbapenemase in Brazil, particularly in Enterobacterales other than Klebsiella spp. It highlights the diverse species and coexistence of important resistance genes in these NDM-producing strains. Prompt detection and effective measures are crucial to mitigate the further dissemination of NDM carbapenemase and preserve antimicrobial therapy options in hospital settings.
MICROBIOLOGY AND IMMUNOLOGY
(2024)