Article
Agronomy
Yu-Jung Cheng, Yun-Shan Tsai, Fang-Wei Lee, Yen-Chou Kuan
Summary: This study evaluated the antifungal actions of S. hygroscopicus metabolites tanespimycin and rapamycin against mango anthracnose. The results showed that these metabolites significantly inhibited fungal growth and enhanced plant resistance by regulating the expression of heat shock proteins in mango. Furthermore, tanespimycin and rapamycin extended the shelf life of mango without deteriorating fruit quality.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Review
Cell Biology
Xiude Ren, Tao Li, Wei Zhang, Xuejun Yang
Summary: Heat-shock protein 90 (HSP90) is an important molecule chaperone associated with tumorigenesis and malignancy. It plays a role in the malignant behaviors of cancer cells, but currently there are no effective single-agent treatments. Combining HSP90 inhibitors with other anticancer therapies may be a better strategy.
Article
Biochemistry & Molecular Biology
Iza Mirela Rodini Garcia-Princival, Jefferson Luiz Princival, Emmanuel Dias da Silva, Sandrine Maria de Arruda Lima, Jhonattas Carvalho Carregosa, Alberto Wisniewski Jr, Caio Cezar Oliveira de Lucena, Fernando Halwass, Jose Adonias Alves Franca, Luiz Felipe Gomes Rebello Ferreira, Marcelo Zaldini Hernandes, Karina Lidianne Alcantara Saraiva, Christina Alves Peixoto, Blandine Baratte, Thomas Robert, Stephane Bach, Dayene Correia Gomes, Patricia Maria Guedes Paiva, Pascal Marchand, Maria Desterro Rodrigues, Teresinha Goncalves da Silva
Summary: The study demonstrated cytotoxic activity of Nigericin against several cancer cell lines, especially HL-60 and HCT-116. Nigericin induced apoptosis and autophagy in HCT-116 cells. Additionally, Nigericin was able to inhibit JAK3 and GSK-3 beta kinases in vitro and its binding affinities were mapped through intermolecular interactions with each target in silico.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Applied
Ahmed S. Al-Janabi, Ahmed F. K. Al-Bayati, Omar Abdullah ALtaie, Amin O. Elzupir, Tarek A. Yousef
Summary: This study demonstrates the inhibitory effects of 4-methyl-2-(((5-methyl-1,3,4-oxadiazol-2-yl)amino)methyl)phenol and its complexes on Hsp90 protein in cancer, and shows excellent antibacterial properties.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Review
Oncology
Christian Tibor Josef Magyar, Yogesh K. Vashist, Deborah Stroka, Corina Kim-Fuchs, Martin D. Berger, Vanessa M. Banz
Summary: HSP90 inhibitors may have potential efficacy in the treatment of gastrointestinal cancers, but more research is needed to determine which patient subgroups and at what time point these inhibitors may be beneficial.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Ruben M. L. Colunga Biancatelli, Pavel Solopov, Christiana Dimitropoulou, Betsy Gregory, Tierney Day, John D. Catravas
Summary: The HSP90 inhibitor, AT13387, shows promising potential in preventing chronic lung injury induced by HCl and protecting the endothelial barrier. It reduces inflammation and fibrosis caused by HCl exposure and restores lung function.
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Vladislav A. Kalmykov, Nikolay A. Orekhov, Andrey V. Grechko, Alexander N. Orekhov
Summary: Cardiovascular diseases are a major cause of death worldwide, with molecular chaperones like HSP90 playing a crucial role in heart protection and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Enzo M. Scutigliani, Yongxin Liang, Marloes IJff, Hans Rodermond, Xionge Mei, Miriam P. Korver, Vaneesha S. Orie, Ron A. Hoebe, Daisy Picavet, Arlene Oei, Roland Kanaar, Przemek M. Krawczyk
Summary: Summary Hyperthermia can improve the effects of radio- and chemotherapy, but its efficacy is limited by the heat stress response (HSR). In this study, we evaluated the HSP90 inhibitor ganetespib in promoting the effects of radiotherapy or cisplatin combined with hyperthermia. Our results showed that ganetespib could enhance the efficacy of hyperthermia when combined with radiation.
Review
Biology
Xun Fu, Jiang Liu, Xin Yan, Michael E. DiSanto, Xinhua Zhang
Summary: Prostate cancer is the second most common cancer in aging men globally, but its exact pathogenesis is not fully understood. The heat shock protein (HSP) family plays a significant role in promoting tumor growth and protecting cancer cells from death. HSP molecules are closely involved in important biological processes such as cell differentiation, epithelial-mesenchymal transition, and fibrosis. Agents and inhibitors targeting the critical structure of HSP molecules have been developed for their potent antitumor effects. However, only a small number of them have been clinically tested. Further clinical studies are needed to establish the relationship between HSP70 family, HSP90 molecule, and prostate cancer treatment.
Article
Biochemistry & Molecular Biology
Vasudha Tandon, Rita Moreno, Kira Allmeroth, Jean Quinn, Sandra E. Wiley, Lynden G. Nicely, Martin S. Denzel, Joanne Edwards, Laureano de la Vega, Sourav Banerjee
Summary: Preserving proteostasis is a crucial survival mechanism for cancer, and targeting the kinase DYRK2 and its substrate HSF1 can induce apoptosis faster than individual targeting. This study suggests that cotargeting DYRK2 and HSF1 could be a promising strategy in suppressing cancer.
BIOSCIENCE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Tanya Ju-Ngam, Nichanun McMillan, Mamoru Yoshimizu, Hisae Kasai, Ratree Wongpanya, Prapansak Srisapoome
Summary: This research conducted molecular characterization and biofunctional analyses of Hsp40 and Hsp90 genes in giant river prawns under various stress conditions. The highest similarity scores of these genes were found with crustaceans. Expression patterns of Mr-hsp40 and Mr-hsp90 were different under Aeromonas hydrophila challenge and heat-cold shock conditions, highlighting their significant roles in stress responses.
Review
Biochemistry & Molecular Biology
Stefan Tukaj, Krzysztof Sitko
Summary: Over a hundred different autoimmune diseases have been described to date, affecting various organs including the skin. The loss of immune tolerance in autoimmune diseases leads to chronic inflammation and tissue damage. Current treatments focus on immunosuppression but may cause serious adverse effects. Heat shock proteins Hsp90 and Hsp70 have been identified as potential therapeutic targets for autoimmune skin diseases.
Article
Environmental Sciences
Luciana C. Furtado, Anelize Bauermeister, Rafael de Felicio, Raquel Ortega, Francisco das Chagas L. Pinto, Joao Agostinho Machado-Neto, Daniela B. B. Trivella, Otilia D. L. Pessoa, Diego V. Wilke, Norberto P. Lopes, Paula C. Jimenez, Leticia V. Costa-Lotufo
Summary: The study showed that cytotoxic extracts produced by marine bacteria recovered from the Brazilian endemic ascidian Euherdmania sp. have potential as proteasome inhibitors, with the extract from marine Streptomyces sp. BRA-346 displaying potent proteasome inhibitory activity. Both the extract and its dihydroeponemycin compound exhibited high cytotoxicity in glioma cell lines, suggesting potential for further development in targeted cancer therapy.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Medicine, Research & Experimental
Ho Jin Lee, Hye-Young Min, Young-Sik Yong, Jihyae Ann, Cong Truong Nguyen, Minh Thanh La, Seung Yeob Hyun, Huong Thuy Le, Hyewon Kim, Hyukjin Kwon, Gibeom Nam, Hyun-Ju Park, Jeewoo Lee, Ho-Young Lee
Summary: This study revealed that Hsp90 inhibitors that block the N-terminal ATP-binding pocket activate STAT3, leading to the transcriptional upregulation of Wnt ligands and promoting cell survival in NSCLC. NCT-80 effectively reduced NSCLC cell viability, migration, and CSC-like phenotypes, and inhibited the growth of patient-derived xenograft tumors.
Article
Parasitology
Desmond O. Agwunobi, Tongxuan Wang, Meng Zhang, Tianhong Wang, Qingying Jia, Miao Zhang, Xinyue Shi, Zhijun Yu, Jingze Liu
Summary: In this study, genes of hsp70 and hsp90 cDNA were cloned and characterized from the tick Dermacentor silvarum, and their functions in cold stress were evaluated. Results showed that Dshsp70 and Dshsp90 play essential roles in the low-temperature adaptation of ticks. This study contributes to understanding the survival and acclimatization of overwintering ticks.
PARASITES & VECTORS
(2021)
Article
Biotechnology & Applied Microbiology
Florencia Eberhardt, Andres Aguirre, Hugo G. Menzella, Salvador Peiru
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Claudia Elena, Sebastian Cerminati, Pablo Ravasi, Rodolfo Rasia, Salvador Peiru, Hugo G. Menzella, Maria Eugenia Castelli
PROCESS BIOCHEMISTRY
(2017)
Article
Biotechnology & Applied Microbiology
Sebastian Cerminati, Luciana Paoletti, Salvador Peiru, Hugo G. Menzella, Maria Eugenia Castelli
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Florencia Eberhardt, Andres Aguirre, Luciana Paoletti, Guillermo Hails, Mauricio Braia, Pablo Ravasi, Salvador Peiru, Hugo G. Menzella
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2018)
Review
Biotechnology & Applied Microbiology
Andres Aguirre, Florencia Eberhardt, Guillermo Hails, Sebastian Cerminati, Maria Eugenia Castelli, Rodolfo M. Rasia, Luciana Paoletti, Hugo G. Menzella, Salvador Peiru
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2018)
Review
Biotechnology & Applied Microbiology
Sebastian Cerminati, Luciana Paoletti, Andres Aguirre, Salvador Peiru, Hugo G. Menzella, Maria Eugenia Castelli
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Guillermo Hails, Sebastian Cerminati, Luciana Paoletti, Rodolfo Cabrera, Salvador Peiru, Andres Aguirre, Maria E. Castelli, Hugo G. Menzella
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Sebastian Cerminati, Melanie Leroux, Pablo Anselmi, Salvador Peiru, Juan C. Alonso, Bernard Priem, Hugo G. Menzella
Summary: Hyaluronic acid, a valuable glycosaminoglycan, is widely used in health and cosmetic fields. Research shows that Bacillus subtilis could be a cost-effective host for HA production with potential economic benefits.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Correction
Biotechnology & Applied Microbiology
Sebastian Cerminati, Melanie Leroux, Pablo Anselmi, Salvador Peiru, Juan C. Alonso, Bernard Priem, Hugo G. Menzella
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ines Armendariz, Pablo A. Ferrari, Daniel Fraiman, Jose M. Martinez, Hugo G. Menzella, Silvina Ponce Dawson
Summary: The use of droplet digital PCR has been shown to be more sensitive than RT-qPCR, allowing for direct quantification of RNA content and optimizing strategies for better identification of infected individuals.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Fiorela Marchisio, Luisina Di Nardo, Diego Sebastian Val, Sebastian Cerminati, Martin Espariz, Rodolfo Maximiliano Rasia, Hugo Gabriel Menzella, Maria Eugenia Castelli
Summary: The implementation of cleaner technologies that reduce environmental pollution caused by conventional industrial processes is a global trend. Enzymatic alternatives have replaced traditional chemicals in various industrial processes, including oil refining. By using enzymatic oil degumming, the volume of gums is reduced and the overall oil yield is increased. A thermostable phospholipase from Thermococcus kodakarensis has been found to effectively remove phospholipids from crude soybean oil at high temperatures, making it a promising candidate for industrial-scale enzymatic oil degumming.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sofia Heckel, Antonella Pacini, Franco Paredes, Ma Victoria Petreli, Marilina Perez, Natalia Adriani, Guadalupe Ibarra, Hugo Menzella, Alejandro Colaneri, Juliana Sesma
Summary: The detection of SARS-CoV-2 through pool testing is a cost-effective strategy that can save time in laboratory testing. This study demonstrates the feasibility and effectiveness of pool testing in nasopharyngeal samples, even with a low virus load. The study also highlights the potential of using saliva for pool testing, which reduces the risk for healthcare personnel.
Article
Food Science & Technology
Guillermo H. Peralta, Andres Aguirre, Maria D. Milagros Burgi, Luciano J. Martinez, Virginia H. Albarracin, Hugo G. Menzella, Leila Pozza, Erica R. Hynes, Carina Bergamini
Summary: The effect of high-pressure homogenisation (HPH) at 100 MPa on Lacticaseibacillus paracasei 90 (L90) was investigated both in vitro and in situ (fermented milk and cheese). HPH treatment led to cell lysis and injury, resulting in the release of intracellular enzymes and changes in metabolic activity. In fermented milk, HPH treatment increased lactic acid content, decreased pH and pyruvic acid levels. The microbiological and peptide profiles of cheeses were altered by using L90 cells or cell-free extracts. This study also suggests that L90 may release bioactive peptides.
INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Diego S. Val, Fiorela Marchisio, Luisina Di Nardo, Salvador Peiru, Andres Aguirre, Luciano A. Abriata, Luis E. Palacios, Rodolfo M. Rasia, Maria E. Castelli, Hugo G. Menzella
Summary: The increasing demand in the vegetable oil industry has led to the development of novel refining methods. One such method is degumming with type C phospholipases (PLCs), although natural PLCs are not active under the harsh conditions used in oil refining plants. This hindrance is overcome by using ChPLC, a synthetic PLC with superior thermal stability and catalytic properties. The implementation of ChPLC reduces overall costs and brings potential annual benefits in the billion-dollar range for the global economy.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Sebastian Cerminati, Florencia Eberhardt, Claudia E. Elena, Salvador Peiru, Maria E. Castelli, Hugo G. Menzella
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2017)
