Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 6, Issue 6, Pages 975-978Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b718766c
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- Biotechnology and Biological Sciences Research Council [BB/C507210/1, 36/B12126, BB/C503662, BB/C503662/1] Funding Source: Medline
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Feeding 5-hydroxy and 5-fluorotryptophan to a Streptomyces coelicolor Trp-auxotrophic strain WH101 results in the production of a number of new calcium-dependent antibiotics (CDAs) possessing modified Trp residues. It is anticipated that this method could be used to modulate the biological properties of Trp-containing nonribosomal peptide natural products, or to generate analogues with useful fluorescent properties for studying biological mechanisms of action.
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