Pulmonary toxicity of nanomaterials: a critical comparison of published in vitro assays and in vivo inhalation or instillation studies

Influence of dispersive agent on nanomaterial agglomeration and implications for biological effects in vivo or in vitro

(2015) Ursula G. Sauer et al.   TOXICOLOGY IN VITRO

Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes

(2014) Linda M Sargent et al.   Particle and Fibre Toxicology

An integrated approach for the in vitro dosimetry of engineered nanomaterials

(2014) Joel M Cohen et al.   Particle and Fibre Toxicology

Physicochemical characteristics of nanomaterials that affect pulmonary inflammation

(2014) Hedwig M Braakhuis et al.   Particle and Fibre Toxicology

Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials

(2014) Robert Landsiedel et al.   Particle and Fibre Toxicology

Applicability of rat precision-cut lung slices in evaluating nanomaterial cytotoxicity, apoptosis, oxidative stress, and inflammation

(2014) Ursula G. Sauer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evaluation of cellular effects of silicon dioxide nanoparticles

(2014) Masanori Horie et al.   TOXICOLOGY MECHANISMS AND METHODS

Metrics, Dose, and Dose Concept: The Need for a Proper Dose Concept in the Risk Assessment of Nanoparticles

(2014) Myrtill Simkó et al.   International Journal of Environmental Research and Public Health

Silver and nanoparticles of silver in wound dressings: a review of efficacy and safety

(2014) L.J. Wilkinson et al.   Journal of Wound Care

A Multi-Stakeholder Perspective on the Use of Alternative Test Strategies for Nanomaterial Safety Assessment

(2013) Andre E. Nel et al.   ACS Nano

Physicochemical Properties of Nanoparticles Regulate Translocation across Pulmonary Surfactant Monolayer and Formation of Lipoprotein Corona

(2013) Guoqing Hu et al.   ACS Nano

Molecular modeling in structural nano-toxicology: Interactions of nano-particles with nano-machinery of cells

(2013) Naveena Yanamala et al.   ADVANCED DRUG DELIVERY REVIEWS

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

(2013) Freya Joris et al.   CHEMICAL SOCIETY REVIEWS

Cytotoxicity in the age of nano: The role of fourth period transition metal oxide nanoparticle physicochemical properties

(2013) Charles C. Chusuei et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Nanotoxicity: challenging the myth of nano-specific toxicity

(2013) Ken Donaldson et al.   CURRENT OPINION IN BIOTECHNOLOGY

Interlaboratory Evaluation of in Vitro Cytotoxicity and Inflammatory Responses to Engineered Nanomaterials: The NIEHS Nano GO Consortium

(2013) Tian Xia et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Relating nano-particle properties to biological outcomes in exposure escalation experiments

(2013) T. Patel et al.   ENVIRONMETRICS

Cytotoxicity and Genotoxicity of Ceria Nanoparticles on Different Cell Lines in Vitro

(2013) Laura De Marzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative Stress, Inflammatory Biomarkers, and Toxicity in Mouse Lung and Liver after Inhalation Exposure to 100% Biodiesel or Petroleum Diesel Emissions

(2013) Anna A. Shvedova et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

The Role of Iron Impurities in the Toxic Effects Exerted by Short Multiwalled Carbon Nanotubes (MWCNT) in Murine Alveolar Macrophages

(2013) E. Aldieri et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Concern-driven integrated approaches to nanomaterial testing and assessment – report of the NanoSafety Cluster Working Group 10

(2013) Agnes G. Oomen et al.   Nanotoxicology

Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

(2013) Wan-Seob Cho et al.   Particle and Fibre Toxicology

Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface carbon black

(2013) Lan Ma-Hock et al.   Particle and Fibre Toxicology

Exposure of silver-nanoparticles and silver-ions to lung cells in vitro at the air-liquid interface

(2013) Fabian Herzog et al.   Particle and Fibre Toxicology

Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation

(2013) Kyeong-Nam Yu et al.   TOXICOLOGY IN VITRO

Bio-active engineered 50nm silica nanoparticles with bone anabolic activity: Therapeutic index, effective concentration, and cytotoxicity profile in vitro

(2013) Shin-Woo Ha et al.   TOXICOLOGY IN VITRO

Mechanism of uptake of ZnO nanoparticles and inflammatory responses in macrophages require PI3K mediated MAPKs signaling

(2013) Ruchi Roy et al.   TOXICOLOGY IN VITRO

Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate

(2012) Motao Zhu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High-Throughput Screening

(2012) Andre Nel et al.   ACCOUNTS OF CHEMICAL RESEARCH

Microsomal Glutathione Transferase 1 Protects Against Toxicity Induced by Silica Nanoparticles but Not by Zinc Oxide Nanoparticles

(2012) Jingwen Shi et al.   ACS Nano

Hazard identification of inhaled nanomaterials: making use of short-term inhalation studies

(2012) Christoph L. Klein et al.   ARCHIVES OF TOXICOLOGY

Nanostructured calcium silicate hydrate seeds accelerate concrete hardening: a combined assessment of benefits and risks

(2012) Michael Bräu et al.   ARCHIVES OF TOXICOLOGY

Genotoxicity investigations on nanomaterials

(2012) Franz Oesch et al.   ARCHIVES OF TOXICOLOGY

Toxico-/biokinetics of nanomaterials

(2012) Robert Landsiedel et al.   ARCHIVES OF TOXICOLOGY

Interactions of silica nanoparticles with lung epithelial cells and the association to flotillins

(2012) Jennifer Kasper et al.   ARCHIVES OF TOXICOLOGY

The Dissolution Rates of SiO2 Nanoparticles As a Function of Particle Size

(2012) Tamara Diedrich et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Multi-walled carbon nanotubes induce cytotoxicity and genotoxicity in human lung epithelial cells

(2012) Delia Cavallo et al.   JOURNAL OF APPLIED TOXICOLOGY

Development of risk-based nanomaterial groups for occupational exposure control

(2012) E. D. Kuempel et al.   JOURNAL OF NANOPARTICLE RESEARCH

Recovery from silver-nanoparticle-exposure-induced lung inflammation and lung function changes in Sprague Dawley rats

(2012) Kyung Seuk Song et al.   Nanotoxicology

Screening of different metal oxide nanoparticles reveals selective toxicity and inflammatory potential of silica nanoparticles in lung epithelial cells and macrophages

(2012) A. Panas et al.   Nanotoxicology

In vitroassessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers

(2012) Ali Kermanizadeh et al.   Nanotoxicology

Anin vivoandin vitrotoxicological characterisation of realistic nanoscale CeO2inhalation exposures

(2012) Philip Demokritou et al.   Nanotoxicology

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Use of back-scatter electron signals to visualise cell/nanowires interactions in vitro and in vivo; frustrated phagocytosis of long fibres in macrophages and compartmentalisation in mesothelial cells in vivo

(2012) Anja Schinwald et al.   Particle and Fibre Toxicology

Use of silver nanowires to determine thresholds for fibre length-dependent pulmonary inflammation and inhibition of macrophage migration in vitro

(2012) Anja Schinwald et al.   Particle and Fibre Toxicology

The mechanism of pleural inflammation by long carbon nanotubes: interaction of long fibres with macrophages stimulates them to amplify pro-inflammatory responses in mesothelial cells

(2012) Fiona A Murphy et al.   Particle and Fibre Toxicology

Carbon Nanotubes Enhance Metastatic Growth of Lung Carcinoma via Up-Regulation of Myeloid-Derived Suppressor Cells

(2012) Anna A. Shvedova et al.   Small

The Threshold Length for Fiber-Induced Acute Pleural Inflammation: Shedding Light on the Early Events in Asbestos-Induced Mesothelioma

(2012) Anja Schinwald et al.   TOXICOLOGICAL SCIENCES

Assessing the relevance of in vitro studies in nanotoxicology by examining correlations between in vitro and in vivo data

(2012) Xianglu Han et al.   TOXICOLOGY

Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress

(2012) Anna A. Shvedova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Comparative cyto-genotoxicity assessment of functionalized and pristine multiwalled carbon nanotubes on human lung epithelial cells

(2012) Cinzia Lucia Ursini et al.   TOXICOLOGY IN VITRO

Mechanisms of toxicity by carbon nanotubes

(2012) Yury Rodriguez-Yañez et al.   TOXICOLOGY MECHANISMS AND METHODS

Inhalation studies for the safety assessment of nanomaterials: status quo and the way forward

(2012) Robert Landsiedel et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

The contributions of metal impurities and tube structure to the toxicity of carbon nanotube materials

(2012) Cuicui Ge et al.   NPG Asia Materials

The Evolution of the Protein Corona around Nanoparticles: A Test Study

(2011) Martin Lundqvist et al.   ACS Nano

Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles

(2011) Boon Chin Heng et al.   ARCHIVES OF TOXICOLOGY

Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses

(2011) Hisao Haniu et al.   International Journal of Nanomedicine

Cytotoxicity and Uptake of Zinc Oxide Nanoparticles Leading to Enhanced Inflammatory Cytokines Levels in Murine Macrophages: Comparison with Bulk Zinc Oxide

(2011) Ruchi Roy et al.   Journal of Biomedical Nanotechnology

Physical−Chemical Aspects of Protein Corona: Relevance toin Vitroandin VivoBiological Impacts of Nanoparticles

(2011) Marco P. Monopoli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genotoxic effects of silver nanoparticles stimulated by oxidative stress in human normal bronchial epithelial (BEAS-2B) cells

(2011) Ha Ryong Kim et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Amorphous silica nanoparticles do not induce cytotoxicity, cell transformation or genotoxicity in Balb/3T3 mouse fibroblasts

(2011) Chiara Uboldi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Nanomaterial cell interactions: are currentin vitrotests reliable?

(2011) Cordula Hirsch et al.   Nanomedicine

No time to lose—high throughput screening to assess nanomaterial safety

(2011) R. Damoiseaux et al.   Nanoscale

Independent cytotoxic and inflammatory responses to zinc oxide nanoparticles in human monocytes and macrophages

(2011) Bryce N. Feltis et al.   Nanotoxicology

Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ionsin vitroandin vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs

(2011) Wan-Seob Cho et al.   Nanotoxicology

Cytotoxicity screening of 23 engineered nanomaterials using a test matrix of ten cell lines and three different assays

(2011) Alexandra Kroll et al.   Particle and Fibre Toxicology

Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes

(2011) Wan-Seob Cho et al.   Particle and Fibre Toxicology

Effects of various physicochemical characteristics on the toxicities of ZnO and TiO2 nanoparticles toward human lung epithelial cells

(2011) I-Lun Hsiao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Zinc Oxide Nanoparticles Interfere With Zinc Ion Homeostasis to Cause Cytotoxicity

(2011) Yi-Yun Kao et al.   TOXICOLOGICAL SCIENCES

Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro

(2011) Stephan Hackenberg et al.   TOXICOLOGY IN VITRO

Evaluation of apoptosis induced by nanoparticles and fine particles in RAW 264.7 macrophages: Facts and artefacts

(2011) Verena Wilhelmi et al.   TOXICOLOGY IN VITRO

Acute inhalation toxicity of cerium oxide nanoparticles in rats

(2011) A. Srinivas et al.   TOXICOLOGY LETTERS

Toward toxicity testing of nanomaterials in the 21st century: a paradigm for moving forward

(2011) David Y. Lai   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Testing Metal-Oxide Nanomaterials for Human Safety

(2010) Robert Landsiedel et al.   ADVANCED MATERIALS

Cytotoxicity of zinc oxide (ZnO) nanoparticles is influenced by cell density and culture format

(2010) Boon Chin Heng et al.   ARCHIVES OF TOXICOLOGY

Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549

(2010) Rasmus Foldbjerg et al.   ARCHIVES OF TOXICOLOGY

A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity

(2010) Helinor J. Johnston et al.   CRITICAL REVIEWS IN TOXICOLOGY

Metal Oxide Nanoparticles Induce Unique Inflammatory Footprints in the Lung: Important Implications for Nanoparticle Testing

(2010) Wan-Seob Cho et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Comparative Cytotoxicity of Al2O3, CeO2, TiO2 and ZnO Nanoparticles to Human Lung Cells

(2010) In-Sun Kim et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Concept of Assessing Nanoparticle Hazards Considering Nanoparticle Dosemetric and Chemical/Biological Response Metrics

(2010) Erik K. Rushton et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

A critical review of the biological mechanisms underlying thein vivoandin vitrotoxicity of carbon nanotubes: The contribution of physico-chemical characteristics

(2010) Helinor J. Johnston et al.   Nanotoxicology

A theoretical framework for predicting the oxidative stress potential of oxide nanoparticles

(2010) Enrico Burello et al.   Nanotoxicology

Rapid translocation of nanoparticles from the lung airspaces to the body

(2010) Hak Soo Choi et al.   NATURE BIOTECHNOLOGY

The nanosilica hazard: another variable entity

(2010) Dorota Napierska et al.   Particle and Fibre Toxicology

Asbestos, carbon nanotubes and the pleural mesothelium: a review and the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma

(2010) Ken Donaldson et al.   Particle and Fibre Toxicology

Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation

(2010) Ilse Gosens et al.   Particle and Fibre Toxicology

ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies

(2010) Paul M Hinderliter et al.   Particle and Fibre Toxicology

Acute inhalation toxicity of silver nanoparticles

(2010) Jae Hyuck Sung et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

A Predictive Toxicological Paradigm for the Safety Assessment of Nanomaterials

(2009) Huan Meng et al.   ACS Nano

Development ofin vitrosystems for nanotoxicology: methodological considerations

(2009) Vicki Stone et al.   CRITICAL REVIEWS IN TOXICOLOGY

Comparative pulmonary response to inhaled nanostructures: considerations on test design and endpoints

(2009) Jürgen Pauluhn   INHALATION TOXICOLOGY

Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs

(2009) Wolfgang G. Kreyling et al.   INHALATION TOXICOLOGY

Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology

(2009) G. Oberdörster   JOURNAL OF INTERNAL MEDICINE

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics

(2009) Helinor J Johnston et al.   Particle and Fibre Toxicology

Size-Dependent Cytotoxicity of Monodisperse Silica Nanoparticles in Human Endothelial Cells

(2009) Dorota Napierska et al.   Small

Subchronic 13-Week Inhalation Exposure of Rats to Multiwalled Carbon Nanotubes: Toxic Effects Are Determined by Density of Agglomerate Structures, Not Fibrillar Structures

(2009) Jürgen Pauluhn   TOXICOLOGICAL SCIENCES

Inhalation Toxicity of Multiwall Carbon Nanotubes in Rats Exposed for 3 Months

(2009) Lan Ma-Hock et al.   TOXICOLOGICAL SCIENCES

Absence of Carcinogenic Response to Multiwall Carbon Nanotubes in a 2-Year Bioassay in the Peritoneal Cavity of the Rat

(2009) Julie Muller et al.   TOXICOLOGICAL SCIENCES

Engineered nanomaterials cause cytotoxicity and activation on mouse antigen presenting cells

(2009) J. Palomäki et al.   TOXICOLOGY

Oxidative stress of CeO2 nanoparticles via p38-Nrf-2 signaling pathway in human bronchial epithelial cell, Beas-2B

(2009) Hyun-Jeong Eom et al.   TOXICOLOGY LETTERS

Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties

(2008) Tian Xia et al.   ACS Nano

Geeignete Methoden zur Prüfung der Sicherheit von Nanomaterialien

(2008) R. Landsiedel et al.   CHEMIE INGENIEUR TECHNIK

Concordance BetweenInVitroandInVivoDosimetry in the Proinflammatory Effects of Low-Toxicity, Low-Solubility Particles: The Key Role of the Proximal Alveolar Region

(2008) K. Donaldson et al.   INHALATION TOXICOLOGY

Development of a Short-Term Inhalation Test in the Rat Using Nano-Titanium Dioxide as a Model Substance

(2008) Lan Ma-Hock et al.   INHALATION TOXICOLOGY

Not ready to use – overcoming pitfalls when dispersing nanoparticles in physiological media

(2008) Christine Schulze et al.   Nanotoxicology

Optimized dispersion of nanoparticles for biological in vitro and in vivo studies

(2008) Peter Bihari et al.   Particle and Fibre Toxicology

Subchronic Inhalation Toxicity of Silver Nanoparticles

(2008) Jae Hyuck Sung et al.   TOXICOLOGICAL SCIENCES

Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells

(2008) Eun-Jung Park et al.   TOXICOLOGY

Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells

(2008) Eun-Jung Park et al.   TOXICOLOGY LETTERS

Comparing fate and effects of three particles of different surface properties: Nano-TiO2, pigmentary TiO2 and quartz

(2008) Ben van Ravenzwaay et al.   TOXICOLOGY LETTERS