Gene expression profiling offers insights into the role of innate immune signaling in SSc

Gene expression changes reflect clinical response in a placebo-controlled randomized trial of abatacept in patients with diffuse cutaneous systemic sclerosis

(2015) Eliza F. Chakravarty et al.   ARTHRITIS RESEARCH & THERAPY

Nilotinib (Tasigna™) in the treatment of early diffuse systemic sclerosis: an open-label, pilot clinical trial

(2015) Jessica K. Gordon et al.   ARTHRITIS RESEARCH & THERAPY

Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms

(2015) J. Matthew Mahoney et al.   PLoS Computational Biology

Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic Sclerosis

(2015) Shervin Assassi et al.   Arthritis & Rheumatology

Myofibroblasts in Murine Cutaneous Fibrosis Originate From Adiponectin-Positive Intradermal Progenitors

(2015) Roberta Goncalves Marangoni et al.   Arthritis & Rheumatology

Experimentally-Derived Fibroblast Gene Signatures Identify Molecular Pathways Associated with Distinct Subsets of Systemic Sclerosis Patients in Three Independent Cohorts

(2015) Michael E. Johnson et al.   PLoS One

High Rhodotorula Sequences in Skin Transcriptome of Patients with Diffuse Systemic Sclerosis

(2014) Sarah T. Arron et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Global chemokine expression in systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin

(2013) Allison L Mathes et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetics of scleroderma: implications for personalized medicine?

(2013) Shervin Assassi et al.   BMC Medicine

Molecular Signatures in Skin Associated with Clinical Improvement during Mycophenolate Treatment in Systemic Sclerosis

(2013) Monique Hinchcliff et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epstein–Barr Virus Infection Induces Aberrant TLR Activation Pathway and Fibroblast–Myofibroblast Conversion in Scleroderma

(2013) Antonella Farina et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis

(2013) Lenny van Bon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association of Interferon- and Transforming Growth Factor β-Regulated Genes and Macrophage Activation With Systemic Sclerosis-Related Progressive Lung Fibrosis

(2013) Romy B. Christmann et al.   Arthritis & Rheumatology

Interspecies Comparison of Human and Murine Scleroderma Reveals IL-13 and CCL2 as Disease Subset-Specific Targets

(2012) Matthew B. Greenblatt et al.   AMERICAN JOURNAL OF PATHOLOGY

Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions

(2012) Alexis Mathian et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-6, IL-17 and STAT3: a holy trinity in auto-immunity?

(2012) Annalisa Camporeale   Frontiers in Bioscience-Landmark

Janus-like effects of type I interferon in autoimmune diseases

(2012) Robert C. Axtell et al.   IMMUNOLOGICAL REVIEWS

Intrinsic Gene Expression Subsets of Diffuse Cutaneous Systemic Sclerosis Are Stable in Serial Skin Biopsies

(2012) Sarah A. Pendergrass et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IMP: a multi-species functional genomics portal for integration, visualization and prediction of protein functions and networks

(2012) Aaron K. Wong et al.   NUCLEIC ACIDS RESEARCH

Plasmacytoid Dendritic Cells: Recent Progress and Open Questions

(2011) Boris Reizis et al.   Annual Review of Immunology

Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension

(2011) Romy B. Christmann et al.   ARTHRITIS AND RHEUMATISM

The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis

(2011) Carol M. Artlett et al.   ARTHRITIS AND RHEUMATISM

Th17 peripheral cells are increased in diffuse cutaneous systemic sclerosis compared with limited illness: a cross-sectional study

(2011) Tatiana S. Rodríguez-Reyna et al.   RHEUMATOLOGY INTERNATIONAL

Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease

(2011) Marie-Elise Truchetet et al.   ARTHRITIS RESEARCH & THERAPY

Type I interferon system activation and association with disease manifestations in systemic sclerosis

(2010) M.-L. Eloranta et al.   ANNALS OF THE RHEUMATIC DISEASES

Distinct evolution of TLR-mediated dendritic cell cytokine secretion in patients with limited and diffuse cutaneous systemic sclerosis

(2010) L. van Bon et al.   ANNALS OF THE RHEUMATIC DISEASES

Systemic sclerosis and lupus: Points in an interferon-mediated continuum

(2010) Shervin Assassi et al.   ARTHRITIS AND RHEUMATISM

Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension

(2010) Eileen Hsu et al.   ARTHRITIS AND RHEUMATISM

Alternatively activated alveolar macrophages in pulmonary fibrosis—mediator production and intracellular signal transduction

(2010) Dmitri V. Pechkovsky et al.   CLINICAL IMMUNOLOGY

Th17 cells in inflammation

(2010) Akihiro Kimura et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis

(2010) Nobuyo Higashi-Kuwata et al.   ARTHRITIS RESEARCH & THERAPY

Molecular framework for response to imatinib mesylate in systemic sclerosis

(2009) Lorinda Chung et al.   ARTHRITIS AND RHEUMATISM

B cell depletion with rituximab in patients with diffuse cutaneous systemic sclerosis

(2009) Robert Lafyatis et al.   ARTHRITIS AND RHEUMATISM

Alternatively activated macrophages (M2 macrophages) in the skin of patient with localized scleroderma

(2009) Nobuyo Higashi-Kuwata et al.   EXPERIMENTAL DERMATOLOGY

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

A TGFβ-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with Increased Disease Severity

(2009) Jennifer L. Sargent et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transforming growth factor β as a therapeutic target in systemic sclerosis

(2009) John Varga et al.   Nature Reviews Rheumatology

The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes

(2009) Timothy R. D. J. Radstake et al.   PLoS One

Induction of interferon‐α by scleroderma sera containing autoantibodies to topoisomerase I: Association of higher interferon‐α activity with lung fibrosis

(2008) Daniel Kim et al.   ARTHRITIS AND RHEUMATISM

Clinical association of serum interleukin-17 levels in systemic sclerosis: Is systemic sclerosis a Th17 disease?

(2008) Maki Murata et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

(2008) Ausra Milano et al.   PLoS One