Article
Plant Sciences
Soraia I. Pedro, Tiago Rosado, Celina Barroca, Duarte Neiva, Vanesa Alonso-Herranz, Ana Gradillas, Antonia Garcia, Jorge Gominho, Eugenia Gallardo, Ofelia Anjos
Summary: Acacia spp. is an invasive species widely distributed in Portugal. It has been found that Acacia flowers contain high concentrations of phenolic compounds and flavonoids. The composition of these compounds varies among different species and flowering stages, and can be distinguished through analysis of FTIR-ATR spectra data of the extracts.
Article
Plant Sciences
Wasim Ahmad, Mohd Amir, Adil Ahmad, Abuzer Ali, Amena Ali, Shadma Wahab, Harshita Abul Barkat, Mohammad Azam Ansari, Mohammad Sarafroz, Ayaz Ahmad, Md. Abul Barkat, Prawez Alam
Summary: Aegle marmelos leaf extract exhibited strong cytotoxicity and antioxidant potential, with the ability to reduce ROS levels caused by high glucose and enhance glucose uptake. The study also identified significant inhibitory effects on alpha-amylase and alpha-glycosidase enzymes, suggesting potential as a therapeutic agent for diabetes and related diseases.
Article
Chemistry, Applied
Giuseppe Mannino, Graziella Serio, Cinzia Margherita Bertea, Roberto Chiarelli, Antonino Lauria, Carla Gentile
Summary: This study evaluated the phytochemical profile and antioxidative properties of the edible and non-edible portions of black sapote. Phytochemical analysis revealed the presence of various bioactive compounds in different parts of black sapote. The non-edible portions were found to have potential in the production of functional foods and supplements.
Article
Food Science & Technology
Swati B. Jadhav, Tejal Gaonkar, Abhijit Rathi
Summary: The study found that athletes tend to consume more protein than the daily recommended allowance, and supplementing their protein intake with external enzymes can enhance bioavailability. In vitro research showed that pepzymeAG assisted digestion had higher degree of hydrolysis and released bioactive peptides with enhanced antioxidant and antidiabetic properties. This enzyme may benefit athletes by increasing the rate of gastric emptying and aiding in better absorption of protein through the intestine.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Lazar D. Zarkovic, Ksenija S. Mileski, Jelena S. Matejic, Uros M. Gasic, Nemanja F. Rajcevic, Petar D. Marin, Ana M. Dzamic
Summary: This study analyzed the chemical composition, antioxidant, and hypoglycemic activity of Rosa arvensis Huds. leaves and fruits collected from different regions in Serbia. The results showed that leaf extracts had high antioxidant capacity and good alpha-glucosidase inhibitory potential, indicating their potential as novel food ingredients.
Article
Chemistry, Applied
Daniela D. Herrera-Balandrano, Trust Beta, Zhi Chai, Xiaoxiao Zhang, Ying Li, Wuyang Huang
Summary: The study demonstrated that the phenolic composition and antioxidant capacity of Burdock roots can be influenced by the harvest time, with changes observed during in vitro digestion.
Article
Biochemistry & Molecular Biology
Shaymaa Najm Abed, Sania Bibi, Marwa Jan, Muhammad Talha, Noor Ul Islam, Muhammad Zahoor, Fakhria A. Al-Joufi
Summary: Cydonia oblonga, a medicinal plant, has potential antibacterial, antioxidant, and anti-diabetic properties in its bark extracts. Methanolic extracts showed effective antibacterial activity, especially against Staphylococcus aureus and Streptococcus pneumonia. The phytochemical composition of the extracts may lead to new antibiotic discoveries.
Article
Food Science & Technology
Ji-Min Lv, Mostafa Gouda, Alaa El-Din Bekhit, Ya-Ke He, Xing-Qian Ye, Jian-Chu Chen
Summary: This study investigated the potential use of kiwifruit leaves waste as a source of proanthocyanidins (PAs). The results showed that kiwifruit leaves PAs exhibited higher phenolic content and antioxidant activity than other parts of the kiwifruit. Moreover, they showed dose-dependent anti-proliferation activity against HepG2 cells. This study highlights the importance of utilizing agro-wastes for valuable product production.
Article
Biochemistry & Molecular Biology
Ji-Min Lv, Mostafa Gouda, Yan-Yun Zhu, Xing-Qian Ye, Jian-Chu Chen
Summary: The use of ultrasound in the extraction of proanthocyanidins has shown potential in enhancing the functionality of bioactive compounds. This study demonstrated the optimal conditions for extracting PAs from kiwifruit leaves using ultrasound and showed that the purified PAs exhibited significant antioxidant activity. These findings suggest that ultrasound-assisted extraction has promising applications in maximizing phytochemical functionality in various fields.
Article
Biochemistry & Molecular Biology
Xin Li, Jingling Liu, Qinxiang Chang, Ziyun Zhou, Ruilian Han, Zongsuo Liang
Summary: This study identified the rhizome of Fagopyrum dibotrys as a rich source of proanthocyanidins with high antioxidant and antidiabetic activities. The purified proanthocyanidins showed better antidiabetic activity compared to grape seed proanthocyanidins. The detailed structural analysis revealed the presence of 72 proanthocyanidins with catechin and epicatechin as the dominant monomers. These findings suggest the potential development of F. dibotrys proanthocyanidins as antioxidant and hypoglycemic products.
Article
Biochemistry & Molecular Biology
Francesco Maioli, Luigi Sanarica, Lorenzo Cecchi, Bruno Zanoni, Nadia Mulinacci, Valentina Canuti
Summary: In this study, 21 oenotannins from different botanical origins were investigated in a model wine solution. The reactivity against proteins and antioxidant properties were found to be influenced by the chemical structure and botanical origin of the oenotannins. The highest turbidity values were observed for gallic hydrolysable tannins. Based on the findings, two formulations were prepared to increase and decrease the oxidation-reduction potential of the model wine.
Article
Food Science & Technology
Zhendong Ding, Weiming Chen, Fengyu Jiang, Mengmiao Mo, Yongguang Bi, Fansheng Kong
Summary: Folic acid decorated chitosan nanoparticles were designed to improve the stability and bioavailability of proanthocyanidins. The nanoparticles exhibited good morphology and distribution characteristics, and showed a protective effect against oxidative hemolysis.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Michelle Cheung, Julie A. Robinson, Phillip Greenspan, Ronald B. Pegg
Summary: Crude extracts from raw and roasted Georgia pecans were digested in vitro, and the digested and undigested extracts were separated into low- and high-molecular-weight fractions. The LMW fraction contained primarily flavan-3-ols and ellagic acid derivatives, while the HMW fraction contained procyanidins with different degrees of polymerization. Following digestion, there was a loss in phenolics and an increase in dimers in the LMW fraction, and a decrease in higher oligomeric procyanidins in the HMW fraction. The loss of phenolics after digestion was reflected in reduced total phenolics content and antioxidant capacity.
Article
Chemistry, Applied
Justyna Siegien, Tina Buchholz, Dominik Popowski, Sebastian Granica, Ewa Osinska, Matthias F. Melzig, Monika E. Czerwinska
Summary: The study evaluated inhibitory effects of fractions obtained from Chaenomeles japonica and Hippophae rhamnoides extracts on pancreatic lipase and α-amylase activities after artificial gastrointestinal digestion. The main active constituents were procyanidins and isorhamnetin derivatives in the extracts, correlating with significant inhibitory activity.
Article
Plant Sciences
Mohd Amir, Ameeduzzafar Zafar, Rizwan Ahmad, Wasim Ahmad, Mohammad Sarafroz, Mohammad Khalid, Mohammed M. Ghoneim, Sultan Alshehri, Shadma Wahab, Sayeed Ahmad, Mohd Mujeeb
Summary: The increase in the use of herbal medicines has led to more stringent regulations for quality variation and standardization. This study aimed to standardize Prunus domestica Linn. using various evaluation techniques, advanced instrumental analysis, and biological and toxicological techniques. The results showed that the fruit met quality requirements and did not contain harmful substances beyond the permissible limits.
Review
Nutrition & Dietetics
Kristine L. Kay, Renee C. Strauch, Cheryl D. Granillo, Megan W. Bame, Jia Xiong, Aubrey C. Mast, Britt Burton-Freeman, Colin D. Kay, Mary Ann Lila
Summary: Consumption of berries is associated with various health benefits, but there are still questions about the mechanism of action, dosage effectiveness, and optimal intake duration and frequency. A systematic assessment of current research is needed to inform future study designs and fill knowledge gaps. The development of tools to organize this information can also aid in consumer messaging, targeted nutritional health initiatives, and dietary guidelines.
Article
Chemistry, Multidisciplinary
Xun Wang, Longjie Xiao, Xinyi Zhang, Jia Zhang, Yu Zhang, Fei Wang, Xun Li
Summary: The study demonstrated that the bioderivatization strategy effectively alleviated the toxicity of terpenoid products and enhanced productivity. By converting geraniol to less toxic geranyl acetate, the engineered system achieved a high concentration and purity of the desired compound. The combination of bioderivatization and engineering approaches is a promising method to address the challenges of toxic terpenoid accumulation in microbial factories.
Article
Chemistry, Multidisciplinary
Xun Wang, Xinyi Zhang, Jia Zhang, Longjie Xiao, Yujunjie Zhou, Yu Zhang, Fei Wang, Xun Li
Summary: This study reports a microbial cell factory that achieves selective and high-level production of geranyl acetate in Escherichia coli. The combination of genetic and bioprocess engineering provides a promising strategy for improving yield and selectivity, with potential applications in the synthesis of other monoterpene esters in E. coli.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Agriculture, Multidisciplinary
Jia Zhang, Xun Wang, Xinyi Zhang, Yu Zhang, Fei Wang, Xun Li
Summary: This study presents the engineering of a biosynthetic pathway for alpha-santalene in Escherichia coli, resulting in high production levels of this natural compound. By amplifying the precursor flux and mutating the synthase enzyme, the titer of alpha-santalene was significantly increased, reaching one of the highest levels reported in E. coli as a host.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Agriculture, Multidisciplinary
Mary Ann Lila, Roberta Targino Hoskin, Mary H. Grace, Jia Xiong, Renee Strauch, Mario Ferruzzi, Massimo Iorizzo, Colin Kay
Summary: Protein-polyphenol aggregate particles can enhance the health effects of functional food products. Evidence suggests that the complexation of polyphenolic compounds can protect them during transit in the gastrointestinal tract, allowing them to exert their health benefits in the colon.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Jia Xiong, Sierra Bonney, Reggiani Vilela Goncalves, Debora Esposito
Summary: In this study, the effects of BRs on wound repair were analyzed. It was found that certain BRs compounds can reduce inflammation and promote migration of skin cells. Furthermore, BRs have positive effects on mitochondrial metabolism, contributing to skin health.
Article
Integrative & Complementary Medicine
Jia Xiong, Mary H. Grace, Hideka Kobayashi, Mary Ann Lila
Summary: This study aimed to investigate the skin-protective properties of saffron in human dermal fibroblasts. The results showed that saffron extract exhibited tyrosinase and collagenase inhibition activities, antioxidant activity, and promoted collagen and hyaluronic acid synthesis. Additionally, saffron extract also enhanced cell migration activity, indicating potential benefits for skin resilience.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Food Science & Technology
Roberta Targino Hoskin, Mary H. H. Grace, Jia Xiong, Mary Ann Lila
Summary: This study investigates the performance of buckwheat protein (BK) and chia seed protein (CP) as drying carriers for the microencapsulation of polyphenols extracted from blackcurrant pomace and cocoa powder. It shows that nonconventional protein sources like chia/pea protein blend and buckwheat protein can efficiently produce functional microparticles with desirable physicochemical attributes and antioxidant activity. These protein-polyphenol microparticles have high polyphenol content and bioaccessibility, making them suitable for the development of protein-rich plant-based food products.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Materials Science, Biomaterials
Chen Ning, Yixin Dong, Kun Yang, Xun Li, Fei Wang, Yu Zhang
Summary: The biocompatible protein nanocarrier with homogeneous particle size is a promising candidate for delivering targeted drugs to tumors. By compatible with ursolic acid (UA), the dose of doxorubicin (DOX) can be reduced to decrease its side effects. The loaded ferritin can specifically enter breast cancer cells MCF-7 and non-small-cell lung cancer cells A549, enhancing their therapeutic effects.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biophysics
Kun Yang, Yixin Dong, Xun Li, Fei Wang, Yu Zhang
Summary: The development of a biocompatible nanoplatform containing indocyanine green (ICG) and paclitaxel (PTX) significantly enhances the effectiveness of combined chemo/photothermal/photodynamic therapy against tumors. The nanoplatform effectively delivers both drugs to the target site, and under near-infrared (NIR) light irradiation, it enhances the photothermal effect and internalization of ICG, as well as the production of reactive oxygen species in cancer cells. This study demonstrates the potential application of the dual-targeting HAS1411 nanocarrier in cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Like Ning, Chaoqun You, Yuxin Jia, Jingqian Chen, Yu Zhang, Xun Li, Orlando J. Rojas, Fei Wang
Summary: The development of a pesticide carrier system based on plant-derived cellulose nanocrystals modified with beta-cyclodextrin and tannic acid is investigated. The carrier enables pH-controlled delivery of the pesticide fenitrothion through hydrophobic and hydrogen bonding interactions and Cu2+ coordination. The system shows efficient antifungal and insecticidal effects along with excellent biosafety, making it a promising approach for pesticide delivery.
Article
Chemistry, Multidisciplinary
Cuihua Wu, Lingxiao He, Yu Zhang, Chaoqun You, Xun Li, Ping Jiang, Fei Wang
Summary: This study separated and purified myricitrin (W3) and myricetin-3-O-glucoside (W1) from Acacia mearnsii leaves, and evaluated their antioxidant and hypoglycemic activities. The results showed that A. mearnsii leaves can serve as a potential source for producing antioxidants and type II diabetes inhibitors.
Meeting Abstract
Horticulture
Hideka Kobayashi, Mary Ann Lila, Leigh Whittinghill, Shawn Lucas, Jia Xiong, Mary Grace
Article
Chemistry, Organic
Ji-Yu Tao, Qing-Hong Zhang, Tong-Hao Zhu, Xin-Wen Xu, Kun Ni, Qiao Zhao, Zheng-Bao Qin, Yu Zhang, Lili Zhao, Kai Zhao
Summary: This study reveals a visible-light-induced stereo- and regioselective phosphorylation reaction, which can deliver synthetically and pharmaceutically appealing beta-phosphorylated enamides with broad substrate scopes and excellent functional group tolerance under transition-metal-free conditions.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Ting Guan, Jing-Yu Guo, Qing-Hong Zhang, Xin-Wen Xu, Xiao-Yu Yu, Yu Zhang, Kai Zhao
Summary: A photoredox-catalyzed regio- and stereoselective Heck-type cyanoalkylation reaction was developed to incorporate synthetically versatile and pharmaceutically appealing distal cyanoalkyl moieties into enamide scaffolds under mild conditions. The methodology exhibited broad substrate scopes, satisfying functional group compatibilities, excellent regio- and stereoselectivities, and versatile synthetic applications of beta-cyanoalkylated enamides.
