Review
Food Science & Technology
Antoni Taraszkiewicz, Izabela Sinkiewicz, Agata Sommer, Hanna Staroszczyk
Summary: Prolyl oligopeptidase (POP) is a serine protease with enzymatic and non-enzymatic activity, involved in various biological processes and associated with neurodegenerative and neuropsychiatric disorders. This article discusses the physiological and pathological aspects of POP activity and explores the potential of peptide inhibitors derived from food proteins as cognition-enhancing agents. However, further evaluation, especially in clinical trials, is needed to determine the effectiveness of these peptides as natural procognitive nutraceuticals. The most promising POP-inhibiting peptides are characterized by their short sequence, high content of hydrophobic amino acids, and presence of proline residue.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Multidisciplinary Sciences
Mabel Deladem Tettey, Federico Rojas, Keith R. Matthews
Summary: This study identifies secreted peptidases released by trypanosomes and systematically assesses their role in stumpy formation in vivo. The results demonstrate the dominance of oligopeptidase B and metallocarboxypeptidase 1 in quorum sensing.
NATURE COMMUNICATIONS
(2022)
Review
Plant Sciences
Anis Baharin, Tiew-Yik Ting, Hoe-Han Goh
Summary: Proteases are essential enzymes that break down polypeptide chains into smaller peptide subunits. This review focuses on post-proline cleaving enzymes (PPCEs) and prolyl endoprotease/oligopeptidase (PEP/POP), discussing their catalytic mechanisms, specificity, and applications in various industries.
Article
Pharmacology & Pharmacy
Jasmin Gattringer, Olivier Eteme Ndogo, Bernhard Retzl, Carina Ebermann, Christian W. Gruber, Roland Hellinger
Summary: This study identified novel cyclotides from African plants, including alca 1 and alca 2, which showed inhibitory effects on the activity of the human protease POP.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
T. Etelainen, V Kulmala, R. Svarcbahs, M. Jantti, T. T. Myohanen
Summary: Oxidative stress is a common toxic feature in various neurodegenerative diseases, and reducing ROS production by inhibiting PREP can provide neuroprotection.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Neurosciences
Tony S. Etelainen, Tommi P. Kilpelainen, Adele Ignatius, Samuli Auno, Francesca De Lorenzo, Johanna K. Uhari-Vaananen, Ulrika H. Julku, Timo T. Myohanen
Summary: Our study demonstrates that the PREP inhibitor KYP-2047 relieves alpha Syn-induced toxicity in PD models by inducing autophagy and preventing alpha Syn aggregation. However, KYP-2047 has limited impact on soluble alpha Syn oligomers, indicating the importance of the whole alpha Syn aggregation process in the pathology of PD.
Article
Medicine, Research & Experimental
Laura Hellinen, Ali Koskela, Elina Vattulainen, Mikko Liukkonen, Christine Wegler, Andrea Treyer, Niklas Handin, Richard Svensson, Timo Myohanen, Antti Poso, Kai Kaarniranta, Per Artursson, Arto Urtti
Summary: Dry age-related macular degeneration (AMD) is a vision threatening disease with no current treatment. Inhibition of the cytosolic protease, prolyl oligopeptidase (PREP), has been identified as a potential pathway for treating dry AMD by inducing autophagy in retinal pigment epithelium (RPE) cells. Further exploration of PREP's role in autophagy is needed to develop more effective compounds for diseases requiring autophagy induction.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Norimichi Nagano, Yuki Ichihashi, Toru Komatsu, Hiroyuki Matsuzaki, Keisuke Hata, Toshiaki Watanabe, Yoshihiro Misawa, Misa Suzuki, Shingo Sakamoto, Yu Kagami, Ayumi Kashiro, Keiko Takeuchi, Yukihide Kanemitsu, Hiroki Ochiai, Rikiya Watanabe, Kazufumi Honda, Yasuteru Urano
Summary: In this study, a fluorogenic substrate probe was developed to analyze enzymatic activity changes in tissue and plasma samples. The probe was particularly useful for studying enzyme activities in a single-molecule enzyme assay platform. We detected the activity of neurolysin in plasma samples and found higher enzyme activity in the blood samples of colorectal tumor patients. The results suggest that single-molecule neurolysin activity could be a promising blood biomarker for colorectal cancer diagnosis.
Article
Food Science & Technology
Marta Maria Calvo, Ana Belen Martin-Diana, Daniel Rico, Maria Elvira Lopez-Caballero, Oscar Martinez-Alvarez
Summary: This study found that a purified polyphenolic extract from the ice plant has strong antioxidant, antihypertensive, hypoglycaemic and nootropic activities. Flavones were identified as the major group responsible for the enzyme inhibition activity.
Article
Biochemistry & Molecular Biology
Elia Vila, Raquel Pinacho, Roger Prades, Teresa Tarrago, Elena Castro, Eva Munarriz-Cuezva, J. Javier Meana, Ania Eugui-Anta, Monica Roldan, America Vera-Montecinos, Belen Ramos
Summary: Cognitive impairment is a core feature of schizophrenia. Prolyl Oligopeptidase (POP) inhibition is an emerging strategy for compensating cognitive deficits in hypoglutamatergic states such as schizophrenia. The mitochondrial and nuclear protein Prohibitin 2 (PHB2) could be dysregulated in schizophrenia, and its link to N-methyl-D-aspartate receptor (NMDAR) activity and cognitive deficits is still unknown. This study found that PHB2 levels increased in the dorsolateral prefrontal cortex of chronic schizophrenia cases, and were associated with cognitive impairments. NMDAR antagonists also increased PHB2 levels in mice and rat astrocytes and neurons, and IPR19 restored PHB2 levels in acute NMDAR inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Minoru Sakaguchi, Ryota Nishiuchi, Mika Bando, Yui Yamada, Rie Kondo, Mika Mitsumori, Ai Shiokawa, Miyuki Kanazawa, Shiori Ikeguchi, Fumi Kikyo, Satoshi Tanaka
Summary: This study found that the anticancer effects of Ara-C not only include the commonly known antimetabolic effects, but also the induction of cell death by nuclear transfer of GAPDH through interaction with POP.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Lucie Cahlikova, Rudolf Vrabec, Filip Pidany, Rozalie Perinova, Negar Maafi, Abdullah Al Mamun, Aneta Ritomska, Viriyanata Wijaya, Gerald Blunden
Summary: Alzheimer's disease is a progressive age-related neurodegenerative disease, with the exact pathogenesis still remaining unclear and treatment currently limited to symptomatic relief. With increasing life expectancy worldwide, the rates of AD are predicted to rise significantly, highlighting an urgent need for new treatment drugs. Alkaloids, especially Amaryllidaceae alkaloids and isoquinoline alkaloids, show promise as potential candidates for AD treatment.
Article
Biochemistry & Molecular Biology
Dmitry E. Petrenko, David M. Karlinsky, Veronika D. Gordeeva, Georgij P. Arapidi, Elena V. Britikova, Vladimir V. Britikov, Alena Y. Nikolaeva, Konstantin M. Boyko, Vladimir I. Timofeev, Inna P. Kuranova, Anna G. Mikhailova, Eduard V. Bocharov, Tatiana V. Rakitina
Summary: The crystal structure of bacterial oligopeptidase B from Serratia proteamaculans in complex with a chloromethyl ketone inhibitor was determined, revealing a closed conformation in the active state. The structure showed that a single inhibitor molecule binds to the catalytic residues S532 and H652, mimicking a tetrahedral intermediate. Comparative analysis with a similar enzyme from Trypanosoma brucei revealed different interdomain interactions in bacterial OpBs, with a complementary oppositely charged surface in SpOpB instead of a salt bridge in TbOpB. Bioinformatics analysis and structural modeling classified bacterial OpBs into two groups based on the modes of D-loop stabilization in closed conformations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Laura Cucinotta, Deborah Mannino, Giovanna Casili, Alberto Repici, Lelio Crupi, Irene Paterniti, Emanuela Esposito, Michela Campolo
Summary: This study demonstrated the involvement of prolyl oligopeptidase (PREP) in the pathogenesis of pulmonary fibrosis and showed that its inhibition by KYP-2047 has a protective role in lung injury induced by bleomycin, suggesting PREP as a potential target therapy for pulmonary fibrosis. The protective mechanism of KYP-2047 may involve the modulation of JAK2/STAT3 and NF-kappa B pathways.
RESPIRATORY RESEARCH
(2023)
Article
Chemistry, Medicinal
Henri T. Patsi, Tommi P. Kilpelainen, Samuli Auno, Pyry M. J. Dillemuth, Khaled Arja, Maija K. Lahtela-Kakkonen, Timo T. Myohanen, Erik A. A. Wallen
Summary: 2-Imidazoles are found to be highly potent inhibitors of the proteolytic activity with a new putative noncovalent binding mode, while their inhibition of the proteolytic activity did not correlate with the modulating effect on other functions of PREP.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Oncology
Clara Matute-Blanch, Veronica Brito, Luciana Midaglia, Luisa M. Villar, Gerardo Garcia-Diaz Barriga, Alerie Guzman de la Fuente, Eva Borras, Sara Fernandez-Garcia, Laura Calvo-Barreiro, Andres Miguez, Lucienne Costa-Frossard, Rucsanda Pinteac, Eduard Sabido, Jordi Alberch, Denise C. Fitzgerald, Xavier Montalban, Manuel Comabella
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Environmental Sciences
Paula de Prado-Bert, Charline Warembourg, Audrius Dedele, Barbara Heude, Eva Borras, Eduard Sabido, Gunn Marit Aasvang, Johanna Lepeule, John Wright, Jose Urquiza, Kristine B. Gutzkow, Lea Maitre, Leda Chatzi, Maribel Casas, Marina Vafeiadi, Mark J. Nieuwenhuijsen, Montserrat de Castro, Regina Grazuleviciene, Rosemary R. C. McEachan, Xavier Basagana, Martine Vrijheid, Jordi Sunyer, Mariona Bustamante
Summary: This study explored the association between air pollution exposure and protein profiles, as well as their link with blood pressure in children. The findings suggest that certain air pollutants are positively associated with the levels of hepatocyte growth factor (HGF) and interleukin 8 (IL8), and home exposure to NO2 is related to higher systolic blood pressure.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Luis Ferrandez-Peral, Xiaoyu Zhan, Marina Alvarez-Estape, Cristina Chiva, Paula Esteller-Cucala, Raquel Garcia-Perez, Eva Julia, Esther Lizano, Oscar Fornas, Eduard Sabido, Qiye Li, Tomas Marques-Bonet, David Juan, Guojie Zhang
Summary: Transcriptomic diversity plays a significant role in disease, lineage-specific biology, and environmental adaptation. This study combines long- and short-read sequencing with mass spectrometry proteomics to analyze human, great apes, and rhesus macaque lymphoblastoid cell lines, resulting in the largest primate full-length isoform catalog to date. The findings reveal numerous transcriptomic innovations and isoform usage changes related to immune function and immunological disorders.
Article
Biochemistry & Molecular Biology
Neus Mestre-Farras, Santiago Guerrero, Nadine Bley, Ezequiel Rivero, Olga Coll, Eva Borras, Eduard Sabido, Alberto Indacochea, Carlos Casillas-Serra, Aino Jarvelin, Baldomero Oliva, Alfredo Castello, Stefan Huettelmaier, Fatima Gebauer
Summary: In this study, the melanoma RBPome was characterized using RNA interactome capture (RIC), leading to the discovery of novel RBPs involved in melanoma progression. Functional validation revealed unexpected roles of RBPs in melanoma malignancy. PDIA6, an ER-lumen chaperone, was identified as one of the RBPs involved in metastatic progression and its RNA-binding activity was found to be required for its tumorigenic properties. These findings demonstrate the potential of RIC technologies in uncovering novel vulnerabilities of cancer cells.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Ecology
Xavier Grau-Bove, Cristina Navarrete, Cristina Chiva, Thomas Pribasnig, Meritxell Anto, Guifre Torruella, Luis Javier Galindo, Bernd Franz Lang, David Moreira, Purificacion Lopez-Garcia, Inaki Ruiz-Trillo, Christa Schleper, Eduard Sabido, Arnau Sebe-Pedros
Summary: This study combines comparative proteomics and genomics analysis to explore the evolutionary history of eukaryotic chromatin in archaea and eukaryotes. The research reveals the existence of histone post-translational modifications in archaea, though they are scarce compared to the highly conserved and abundant marks found in eukaryotes. The study also suggests that chromatin-associated catalytic functions have pre-eukaryotic origins, while histone mark readers and chaperones are innovations in eukaryotes.
NATURE ECOLOGY & EVOLUTION
(2022)
Article
Biochemical Research Methods
Melisa Gualdron-Lopez, Miriam Diaz-Varela, Gigliola Zanghi, Iris Aparici-Herraiz, Ryan W. J. Steel, Carola Schafer, Pol Cusco, Vorada Chuenchob, Niwat Kangwangransan, Zachary P. Billman, Tayla M. Olsen, Juan R. Gonzalez, Wanlapa Roobsoong, Jetsumon Sattabongkot, Sean C. Murphy, Sebastian A. Mikolajczak, Eva Borras, Eduard Sabido, Carmen Fernandez-Becerra, Erika L. Flannery, Stefan H. Kappe, Hernando A. del Portillo
Summary: This study identified parasite and human proteins associated with extracellular vesicles (EVs) secreted from in vivo infections exclusively containing hypnozoites. This provides a foundation for understanding the biological features of hypnozoite infection and identifying associated biomarkers.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Biochemical Research Methods
Devon Kohler, Maanasa Kaza, Cristina Pasi, Ting Huang, Mateusz Staniak, Dhaval Mohandas, Eduard Sabido, Meena Choi, Olga Vitek
Summary: Liquid chromatography coupled with bottom-up mass spectrometry (LC-MS/MS)-based proteomics is a versatile technology for identifying and quantifying proteins in complex biological mixtures. To make the statistical methods in MSstats accessible to users with limited programming and statistical background, an R-Shiny graphical user interface (GUI) called MSstatsShiny has been created, providing a point and click analysis pipeline applicable to a wide variety of proteomics experimental types.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Medicine, Research & Experimental
Melissa Bradbury, Eva Borras, Marta Vilar, Josep Castellvi, Jose Luis Sanchez-Iglesias, Assumpcio Perez-Benavente, Antonio Gil-Moreno, Anna Santamaria, Eduard Sabido
Summary: A new strategy has been established in this study, combining molecular and clinical parameters to predict the response to first-line treatment in high-grade serous carcinoma (HGSC) patients at the time of diagnosis. This strategy can improve therapeutic decision-making and assess alternative treatment strategies, contributing to the advancement of patient outcomes and personalized care for HGSC patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biology
Evelyn Andrades, Agusti Toll, Gustavo Deza, Sonia Segura, Ramon Gimeno, Guadalupe Espadas, Eduard Sabido, Noemi Haro, Oscar Pozo, Marta Bodalo, Paloma Torres, Ramon M. Pujol, Inmaculada Hernandez-Munoz
Summary: This study analyzed the role of extracellular matrix and intravascular non-coding small RNAs in the metastasis of cutaneous squamous cell carcinoma (cSCC). The study found that metastatic cSCCs showed reduced expression of small nucleolar RNAs and progressive loss of Dyskerin, which triggered disruption of lipid metabolism and acquisition of metastatic traits. Treatment of Dyskerin-depleted cells with Shimastatin, an inhibitor of the mevalonate pathway, blocked the expression of proteins related to epithelial-to-mesenchymal transition. These findings highlight the importance of mevalonate metabolism in cSCC metastasis and suggest potential therapeutic approaches.
LIFE SCIENCE ALLIANCE
(2023)
Article
Environmental Sciences
Lorenzo Fabbri, Ronan Garlantezec, Karine Audouze, Mariona Bustamante, Angel Carracedo, Leda Chatzi, Juan Ramon Gonzalez, Regina Grazuleviciene, Hector Keun, Chung-Ho E. Lau, Eduard Sabido, Alexandros P. Siskos, Remy Slama, Cathrine Thomsen, John Wright, Wen Lun Yuan, Maribel Casas, Martin Vrijheid, Lea Maitre
Summary: This study aimed to identify multi-omic signatures associated with childhood exposure to non-persistent endocrine disrupting chemicals (EDCs). By using a repeated sampling strategy and integrating multiple omics data, a total of 950 reproducible associations were found, including 23 direct associations between EDCs and omics. These associations can help us understand the effects of EDCs on neurological and metabolic outcomes.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Plant Sciences
Silvia Proietti, Gaia Salvatore Falconieri, Laura Bertini, Alberto Pascale, Elisabetta Bizzarri, Julia Morales-Sanfrutos, Eduard Sabido, Michelina Ruocco, Maurilia M. Monti, Assunta Russo, Kinga Dziurka, Marcello Ceci, Francesco Loreto, Carla Caruso
Summary: This study reveals that the interaction between tomato and the beneficial fungus Beauveria bassiana leads to changes in molecular pathways, metabolism, growth and defense hormones, and can effectively prevent necrotrophic infection. These findings are important for understanding the beneficial role of B. bassiana in tomato plants.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Chemistry, Medicinal
Jenniffer Linares, Monica Varese, Anna Sallent-Aragay, Ana Mendez, Sergio Palomo-Ponce, Mar Iglesias, Eduard Batlle, Jorge Pisonero, Clara Montagut, Ernest Giralt, Daniele Lo Re, Alexandre Calon
Summary: We report the synthesis of a novel Pt(IV) cell-penetrating peptide conjugate, C-POC, with reduced impact on nonmalignant cells. In vitro and in vivo evaluation showed that C-POC maintains robust anticancer efficacy while reducing accumulation in healthy organs and adverse toxicity compared to standard Pt-based therapy. Our findings highlight the importance of considering the off-target impact of anticancer treatment on normal cells for improved drug development and patient care.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Devon Kohler, Mateusz Staniak, Tsung-Heng Tsai, Ting Huang, Nicholas Shulman, Oliver M. Bernhardt, Brendan X. MacLean, Alexey I. Nesvizhskii, Lukas Reiter, Eduard Sabido, Meena Choi, Olga Vitek
Summary: The MSstats R-Bioconductor family of packages, particularly the new version MSstats v4.0, is widely used for statistical analyses of quantitative proteomic experiments. It provides improved usability, versatility, and accuracy of statistical methodology, as well as better memory use and computation speed. Empirical comparisons have demonstrated the stronger performance and better usability of MSstats v4.0 compared to existing methods.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ivan Milenkovic, Helaine Graziele Santos Vieira, Morghan C. Lucas, Jorge Ruiz-Orera, Giannino Patone, Scott Kesteven, Jianxin Wu, Michael Feneley, Guadalupe Espadas, Eduard Sabido, Norbert Huebner, Sebastiaan van Heesch, Mirko Voelkers, Eva Maria Novoa
Summary: The study investigates the existence of ribosome heterogeneity and its potential impact on specialized ribosomes. Through analyzing a knockout mouse strain, the researchers find that the depletion of RPL3L leads to an up-regulation of RPL3, resulting in the formation of RPL3-containing ribosomes in cardiomyocytes. Additionally, they discover that RPL3L depletion increases interactions between ribosomes and mitochondria, leading to elevated ATP levels.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Chemistry, Analytical
Cristina Chiva, Zahra Elhamraoui, Amanda Sole, Marc Serret, Mathias Wilhelm, Eduard Sabido
Summary: Mass spectrometry coupled to liquid chromatography is a powerful technology for proteome quantification in biomedical samples. However, the identification of all potential peptides for a given protein is challenging, and proteomics experiments often focus on a subset of peptides for protein quantitation. This study evaluated the stability of human proteotypic peptides and developed a deep learning model to predict peptide stability from tryptic sequences, providing a valuable resource for peptide selection in proteome quantification experiments.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
