The protein arginine deiminases: Structure, function, inhibition, and disease

Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils

(2014) I. Neeli et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

Regulation of histone modification and chromatin structure by the p53–PADI4 pathway

(2012) Chizu Tanikawa et al.   Nature Communications

Kinase Consensus Sequences: A Breeding Ground for Crosstalk

(2011) Heather L. Rust et al.   ACS Chemical Biology

Synthesis and Screening of a Haloacetamidine Containing Library To Identify PAD4 Selective Inhibitors

(2011) Justin E. Jones et al.   ACS Chemical Biology

Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor

(2011) Alexander A. Chumanevich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis

(2011) Erika Darrah et al.   ANNALS OF THE RHEUMATIC DISEASES

Autodeimination of Protein Arginine Deiminase 4 Alters Protein–Protein Interactions but Not Activity

(2011) Jessica L. Slack et al.   BIOCHEMISTRY

Protein deiminases: New players in the developmentally regulated loss of neural regenerative ability

(2011) Sigrun Lange et al.   DEVELOPMENTAL BIOLOGY

Citrullination of Inhibitor of Growth 4 (ING4) by Peptidylarginine Deminase 4 (PAD4) Disrupts the Interaction between ING4 and p53

(2011) Qin Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-l-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

(2011) Van C. Willis et al.   JOURNAL OF IMMUNOLOGY

The Development ofN-α-(2-Carboxyl)benzoyl-N5-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) andN-α-(2-Carboxyl)benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors

(2011) Corey P. Causey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Subcellular Localization of Peptidylarginine Deiminase 2 and Citrullinated Proteins in Brains of Scrapie-Infected Mice: Nuclear Localization of PAD2 and Membrane Fraction-Enriched Citrullinated Proteins

(2011) Byungki Jang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

On the Mechanism of Dimethylarginine Dimethylaminohydrolase Inactivation by 4-Halopyridines

(2011) Corey M. Johnson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2

(2011) Qin Guo et al.   Molecular BioSystems

Neutrophils in the pathogenesis and manifestations of SLE

(2011) Mariana J. Kaplan   Nature Reviews Rheumatology

Long pentraxin 3 (PTX3) expression and release by neutrophils in vitro and in ulcerative colitis

(2011) Alexander S. Savchenko et al.   PATHOLOGY INTERNATIONAL

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection

(2011) Saskia Hemmers et al.   PLoS One

Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation

(2010) Felipe Andrade et al.   ARTHRITIS AND RHEUMATISM

Substrate Specificity and Kinetic Studies of PADs 1, 3, and 4 Identify Potent and Selective Inhibitors of Protein Arginine Deiminase 3

(2010) Bryan Knuckley et al.   BIOCHEMISTRY

Protein arginine deiminase 4: a target for an epigenetic cancer therapy

(2010) Jessica L. Slack et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Arginine Metabolising Enzymes as Therapeutic Tools for Alzheimer’s Disease: Peptidyl Arginine Deiminase Catalyses Fibrillogenesis of β-amyloid Peptides

(2010) Peter Mohlake et al.   MOLECULAR NEUROBIOLOGY

Potential Role for Peptidylarginine Deiminase 2 (PAD2) in Citrullination of Canine Mammary Epithelial Cell Histones

(2010) Brian D. Cherrington et al.   PLoS One

Global turnover of histone post-translational modifications and variants in human cells

(2010) Barry M Zee et al.   Epigenetics & Chromatin

Increased PADI4 expression in blood and tissues of patients with malignant tumors

(2009) Xiaotian Chang et al.   BMC CANCER

Haloacetamidine-Based Inactivators of Protein Arginine Deiminase 4 (PAD4): Evidence that General Acid Catalysis Promotes Efficient Inactivation

(2009) Bryan Knuckley et al.   CHEMBIOCHEM

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Born−Oppenheimer ab Initio QM/MM Molecular Dynamics Simulations of the Hydrolysis Reaction Catalyzed by Protein Arginine Deiminase 4

(2009) Zhihong Ke et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Active Site Cysteine Is Protonated in the PAD4 Michaelis Complex: Evidence from Born−Oppenheimer Ab Initio QM/MM Molecular Dynamics Simulations

(2009) Zhihong Ke et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis

(2008) Andrew Kinloch et al.   ARTHRITIS AND RHEUMATISM

Histone Arg Modifications and p53 Regulate the Expression ofOKL38, a Mediator of Apoptosis

(2008) Hongjie Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of p53 Target Gene Expression by Peptidylarginine Deiminase 4

(2008) P. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Profiling Protein Arginine Deiminase 4 (PAD4): A novel screen to identify PAD4 inhibitors

(2007) Bryan Knuckley et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Haplotypes of PADI4 susceptible to rheumatoid arthritis are also associated with ulcerative colitis in the Japanese population

(2007) Chun Chuan Chen et al.   CLINICAL IMMUNOLOGY