Review
Oncology
Yonglin Mai, Zhihua Guo, Weiqiang Yin, Nanshan Zhong, Peter Dicpinigaitis, Ruchong Chen
Summary: Symptoms of lung cancer such as pain, cough, fatigue, and dyspnea are common, but their underlying mechanisms are unclear. Recent research has shown that extracellular ATP and its receptors play a crucial role in modulating tumor development and related symptoms.
FRONTIERS IN ONCOLOGY
(2021)
Review
Neurosciences
Wen -Jun Zhang, Dong-Xia Hu, Si-Jian Lin, Xiao-Qun Fang, Zhen-Feng Ye
Summary: This article discusses the role of P2X receptors in cerebral ischemic injury and the importance of regulating microglial activity. Activation of P2X receptors has been found to induce inflammatory responses and exacerbate neurological dysfunction, while inhibiting the activation of P2X receptors can help protect nerve function.
BRAIN RESEARCH BULLETIN
(2022)
Article
Neurosciences
Silvia Prades, Gregory Heard, Jonathan E. Gale, Tobias Engel, Robin Kopp, Annette Nicke, Katie E. Smith, Daniel J. Jagger
Summary: The P2X(7) receptors are primarily expressed by peripheral glial cells rather than afferent neurons in the auditory nerve. This finding contributes to a better understanding of the effects of ATP-dependent mechanisms on hearing loss and sensory neuropathies.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Medicine, Research & Experimental
Ji-peng Liu, Si-cheng Liu, Shi-qi Hu, Jia-feng Lu, Chang-lei Wu, Dong-xia Hu, Wen-jun Zhang
Summary: Multiple studies have shown that P2X purinergic receptors play a crucial role in inflammation. These receptors, when activated, release inflammatory cytokines and contribute to the progression of inflammatory diseases. In an inflammatory microenvironment, cells release ATP to activate P2X receptors, leading to the activation of various intracellular signaling pathways and the release of multiple inflammatory cytokines, thereby amplifying the inflammatory response. P2X4 and P2X7 receptors are especially important in the process of inflammation, mediating the activation of microglia and different inflammatory cells, respectively, and contributing to tissue-wide inflammation. This paper discusses the role of P2X receptors in mediating inflammation and describes the effects of various antagonists on inflammation relief by targeting P2X receptors.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Food Science & Technology
Jingqi Zhao, Yantong Sun, Li Ren, Shuqing Huang, Jie Zhang
Summary: Aloe-emodin, a novel androgen receptor (AR) antagonist, has been identified to inhibit AR signaling by promoting apoptosis, modulating AR protein levels, inhibiting AR downstream target genes, and preventing the nuclear translocation of AR. These findings suggest that aloe-emodin may play a crucial role in prostate cancer prevention and treatment.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Pharmacology & Pharmacy
Francesco Di Virgilio, Valentina Vultaggio-Poma, Alba Clara Sarti
Summary: Ion channels, especially P2X receptors, play crucial roles in tumor development, closely related to extracellular ATP, and could be key regulators of tumor growth.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jasmin Ballout, Rebecca Classen, Katrin Richter, Veronika Grau, Martin Diener
Summary: This study found that ionotropic P2X receptors are involved in the regulation of intestinal ion transport in rat colonic epithelia.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fang Yu, Nan Yu, Jie Peng, Yan Zhao, Lei Zhang, Xiaohui Wang, Xiaona Xu, Jian Zhou, Feng Wang
Summary: The study revealed that emodin inhibits obesity by promoting M2 macrophage polarization, thereby alleviating inflammation, improving insulin levels, and preventing fat accumulation in adipose tissue.
Review
Cell Biology
Anael Viana Pinto Alberto, Natiele Carla da Silva Ferreira, Andre Gustavo Calvano Bonavita, Oscar Kenji Nihei, Fernando Pires de Farias, Rodrigo da Cunha Bisaggio, Cristovao de Albuquerque, Wilson Savino, Robson Coutinho-Silva, Pedro Muanis Persechini, Luiz Anastacio Alves
Summary: Purinergic receptors play important roles in the immune system, particularly the P2 receptors that regulate leukocyte activity. This review examines the characteristics of P2 receptor subtypes in the immune system and their involvement in infectious diseases, inflammation, and pain.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Liyen K. Kan, Matthew Drill, Padmakrishnan C. Jayakrishnan, Richard P. Sequeira, Emily Galea, Marian Todaro, Paul G. Sanfilippo, Martin Hunn, David A. Williams, Terence J. O'Brien, Katharine J. Drummond, Mastura Monif
Summary: Activation of P2X7R promotes glioblastoma growth, and inhibition of P2X7R reduces tumor growth effectively. This discovery provides a new alternative therapeutic approach for the treatment of lethal glioblastomas.
SCIENTIFIC REPORTS
(2023)
Review
Pharmacology & Pharmacy
Marie-Louise T. Monaghan, Matthew A. Bailey, Robert J. Unwin
Summary: Historically, renal vascular and tubular function has been mainly controlled through neural and endocrine regulation. However, it is now acknowledged that complex humoral control systems exist within the kidney, complementing neuroendocrine regulation by fine-tuning renal function in response to rapid changes. The extracellular nucleotide/P2 receptor system plays a central role in intrinsic regulatory feedback loops within the kidney, contributing to the understanding and potential treatment of kidney disease.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Oncology
Jasmeet Kaur, Sanchit Dora
Summary: Cancer is a complex disease with diverse characteristics, and there is a need to discover new therapeutic targets to improve treatment outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biology
Ralf Schmauder, Thomas Eick, Eckhard Schulz, Guenther Sammler, Elmar Voigt, Guenter Mayer, Holger Ginter, Guenter Ditze, Klaus Benndorf
Summary: By using a microfluidic chip-based technique, we have developed a method for studying ion currents and fluorescence signals in order to measure the kinetics of channel activation and deactivation, as well as ligand binding and unbinding. This approach allows for the rapid generation of concentration-activation relationships and activation kinetics, while minimizing the effects of interference.
COMMUNICATIONS BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Nadine Mundt, Lina Kenzler, Marc Spehr
Summary: Adenosine triphosphate (ATP) is not only the essential source of cellular energy, but also functions as an extracellular signal that activates purinergic receptors. Purinergic signaling plays a crucial role in male reproductive system functions, particularly in spermatogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Matthias Ollivier, Juline Beudez, Nathalie Linck, Thomas Grutter, Vincent Compan, Francois Rassendren
Summary: Biosensors based on P2X receptors and GECIs have been developed, capable of detecting nanomolar ATP concentrations and tracking P2X receptor activity. These sensors have successfully dynamically tracked ATP release in mouse neurons.
Article
Biochemistry & Molecular Biology
Emily A. Caseley, Stephen P. Muench, Lin-Hua Jiang
Summary: The P2X7 receptor is a calcium-permeable cation channel activated by high concentrations of extracellular ATP, playing crucial roles in physiological and pathological processes. Investigation of the role of tyrosine at position 288 in the extracellular domain contributes to a deeper understanding of the structure-function relationships of the hP2X7R.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2022)
Article
Cell Biology
Kenny Man, Habib Joukhdar, Xue D. Manz, Mathieu Y. Brunet, Lin-Hua Jiang, Jelena Rnjak-Kovacina, Xuebin B. Yang
Summary: Epigenetic reprogramming and silk scaffolds were used to promote bone formation of human dental pulp stromal cells (hDPSCs). The study demonstrated that MI192 pre-treatment significantly enhanced hDPSCs alkaline phosphatase activity and promoted bone extracellular matrix deposition and mineralisation. The hDPSCs-silk scaffold constructs also enhanced vascularisation and extracellular matrix mineralisation in vivo.
CELL AND TISSUE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xiaoling Jia, Chao Gao, Xia Wang, Lin-Hua Jiang, Yubo Fan
Summary: This study found that mechanical stretch had different effects on the expressions of BKCa and L-VDCC channels in rat uterine smooth muscle cells, with stretch down-regulating BKCa channel expression but upregulating L-VDCC channel expression.
JOURNAL OF MEMBRANE BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stephanie Chadet, Jordan Allard, Lucie Brisson, Osbaldo Lopez-Charcas, Roxane Lemoine, Audrey Heraud, Stephanie Lerondel, Roseline Guibon, Gaelle Fromont, Alain Le Pape, Denis Angoulvant, Lin-Hua Jiang, Ruth Murrell-Lagnado, Sebastien Roger
Summary: The P2X4 purinergic receptor is upregulated in breast cancer patients and primarily localised in endolysosomes. It promotes breast cancer invasion, tumour growth, and metastasis by regulating lysosome acidity, promoting autophagy and cell survival. It is also associated with epithelial-to-mesenchymal transition and plays a more significant role under metabolic challenges.
Editorial Material
Physiology
Nady Braidy, Bilal Cig, Lin-Hua Jiang, Xinhua Shu
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Xiaoling Jia, Xinlan Chen, Chao Gao, Haikun Wang, Chengxi Yang, Lin-Hua Jiang, Yubo Fan
Summary: The cooperation between IKCa and TRPC1 channels in mediating calcium influx and activating the ERK1/2 pathway is critical for vascular smooth muscle cell (VSMC) proliferation. Inhibition or knockdown of IKCa or TRPC1 suppresses serum-induced cell proliferation and increases in intracellular calcium concentration. Additionally, extracellular calcium removal or TRPC1 knockdown significantly inhibits VSMC proliferation. These findings provide new insights into the mechanisms underlying VSMC proliferation.
CELL PROLIFERATION
(2023)
Article
Neurosciences
Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang
Summary: Microglial cell function and inflammation are regulated by the activation of Piezo1 channel. This study found that the activation of Piezo1 channel can inhibit the pro-inflammatory activation and production of pro-inflammatory cytokines in microglial cells by initiating intracellular Ca2+ signaling to inhibit the NF-kappa B inflammatory signaling pathway.
Review
Chemistry, Medicinal
Yaling Yin, Linyu Wei, Emily A. Caseley, Osbaldo Lopez-Charcas, Yingjuan Wei, Dongliang Li, Steve P. Muench, Sebastian Roger, Lu Wang, Lin-Hua Jiang
Summary: This review discusses the role and mechanisms of the P2X7 receptor in mediating neuroinflammation and other pathogenic events in the central nervous system, as well as its relationship with traumatic CNS damage and related complications. The article raises the perspective on the steady progress in developing CNS-penetrant P2X7 receptor-specific antagonists that leverage the ATP-P2X7 receptor signaling axis as a potential therapeutic strategy.
MEDICINAL RESEARCH REVIEWS
(2023)
Editorial Material
Cell Biology
Mo Zhang, Philippa Malko, Lin-Hua Jiang
NEURAL REGENERATION RESEARCH
(2023)
Article
Neurosciences
Han-Wei Liu, Li-Na Gong, Ke Lai, Xia-Fei Yu, Zhen-Qi Liu, Ming-Xian Li, Xin-Lu Yin, Min Liang, Hao-Song Shi, Lin-Hua Jiang, Wei Yang, Hai-Bo Shi, Lu-Yang Wang, Shan-Kai Yin
Summary: Stroke prognosis is negatively affected by elevated levels of serum bilirubin, but the mechanism of how bilirubin worsens outcomes is still unknown. This study found that post-stroke bilirubin levels, but not pre-stroke levels, are associated with infarct volume in hospitalized patients. Mouse models showed that bilirubin increases neuronal excitability and ischemic infarct size, and ischemic insults trigger the release of endogenous bilirubin, which activates TRPM2 channels. Knockout or antagonization of the TRPM2 channel attenuates these effects. These findings suggest a vicious cycle of stroke injury involving the release of endogenous bilirubin and activation of TRPM2 channels, exacerbating Ca2+-dependent brain injury.
Editorial Material
Cell Biology
Lin-Hua Jiang, Xiaoqiang Yao, Bilal cig
Article
Gastroenterology & Hepatology
Xiaobo Cai, Xiazhen Yu, Jiawen Yang, Lin Lu, Ning Hua, Xin Duan, Peiwu Ye, Lei Ni, Linhua Jiang, Wei Yang, Tingbo Liang, Peilin Yu
Summary: In this study, it was found that the TRPM2 channel plays a crucial role in the development and progression of HCC. Inhibition or silencing of TRPM2, as well as inhibition of the downstream signaling pathway, significantly suppressed the proliferation of HCC cells. Furthermore, inhibition or depletion of TRPM2 also slowed down the growth of HCC xenografts in mice, indicating its potential as a therapeutic target for HCC.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Neurosciences
Lu Wang, Yingjuan Wei, Zhenzhou Sun, Lin-Hua Jiang, Yaling Yin, Panpan Zheng, Yun Fu, Hongwei Wang, Changzheng Li, Jian-Zhi Wang
Summary: Tau protein hyperphosphorylation and NFTs formation are key features of AD, and DpdtpA can attenuate these processes by regulating the PI3K/AKT/GSK-36 signaling pathway. DpdtpA also reduces microglial activation and inflammatory responses induced by Tau, offering a potential treatment option for AD-associated neuroinflammation.
Article
Multidisciplinary Sciences
Cheng Zhong, Jing Yang, Yiyin Zhang, Xiaoxiao Fan, Yang Fan, Ning Hua, Duguang Li, Shengxi Jin, Yirun Li, Peng Chen, Yongle Chen, Xiaobo Cai, Yi Zhang, Linhua Jiang, Wei Yang, Peilin Yu, Hui Lin
Summary: This study found that TRPM2 deficiency could alleviate liver dysfunction, inflammation, and cell death caused by hepatic ischemia-reperfusion (IR) injury. Further research indicated that TRPM2 mediates hepatic IR injury through ferroptosis-related pathways. Animal experiments and in vitro studies showed that inhibition of TRPM2 and calcium depletion could significantly attenuate IR-induced ferroptosis. These findings reveal the crucial role of TRPM2-mediated ferroptosis in hepatic IR injury and suggest that pharmacological inhibition of TRPM2 may be an effective therapeutic strategy for hepatic IR injury-related diseases, such as during liver resection and transplantation.
Article
Engineering, Biomedical
Kenny Man, Cesar Alcala, Naveen V. Mekhileri, Khoon S. Lim, Lin-Hua Jiang, Tim B. F. Woodfield, Xuebin B. Yang
Summary: This study investigated a GelMA hydrogel reinforced with a 3D printed scaffold to support MI192-induced hBMSCs for bone formation. The results demonstrated that the GelMA-PEGT/PBT construct provides enhanced mechanical strength and facilitates the delivery of epigenetically-activated MSCs for bone augmentation strategies.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
