Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

(2014) Tarek M.A. Abdel-Fatah et al.   Molecular Oncology

DNA polymerase β deficiency is linked to aggressive breast cancer: A comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts

(2014) Tarek M.A. Abdel-Fatah et al.   Molecular Oncology

3-Aminobenzamide – a PARP inhibitor enhances the sensitivity of peripheral blood micronucleus and comet assays in mice

(2014) Kamran Shekh et al.   TOXICOLOGY MECHANISMS AND METHODS

Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer

(2014) S De Summa et al.   Cell Death & Disease

Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy

(2013) Tarek M. A. Abdel-Fatah et al.   BREAST CANCER RESEARCH AND TREATMENT

Promoter methylation of BRCA1 in the prognosis of breast cancer: a meta-analysis

(2013) Liang Wu et al.   BREAST CANCER RESEARCH AND TREATMENT

Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer

(2013) Tarek M. A. Abdel-Fatah et al.   BREAST CANCER RESEARCH AND TREATMENT

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis

(2013) Marie-France Langelier et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice

(2013) A. Schipler et al.   NUCLEIC ACIDS RESEARCH

Mammalian Base Excision Repair: the Forgotten Archangel

(2013) Grigory L. Dianov et al.   NUCLEIC ACIDS RESEARCH

Methylation of BRCA1 Promoter Region Is Associated with Unfavorable Prognosis in Women with Early-Stage Breast Cancer

(2013) Nicholas C. Hsu et al.   PLoS One

Interaction between DNA Polymerase β and BRCA1

(2013) Aya Masaoka et al.   PLoS One

Targeting XRCC1 Deficiency in Breast Cancer for Personalized Therapy

(2012) R. Sultana et al.   CANCER RESEARCH

The role of BRCA1 in DNA double-strand repair: Past and present

(2012) Kevin W. Caestecker et al.   EXPERIMENTAL CELL RESEARCH

Clinicopathological and functional significance of XRCC1 expression in ovarian cancer

(2012) Tarek Abdel-Fatah et al.   INTERNATIONAL JOURNAL OF CANCER

Enhancement of Synthetic Lethality via Combinations of ABT-888, a PARP Inhibitor, and Carboplatin In Vitro and In Vivo Using BRCA1 and BRCA2 Isogenic Models

(2012) C. C. Clark et al.   MOLECULAR CANCER THERAPEUTICS

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

Mechanisms of BRCA1 Tumor Suppression: Figure 1.

(2012) Daniel P. Silver et al.   Cancer Discovery

Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination

(2011) Michele Tavecchio et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways

(2011) Emil Mladenov et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Cytoscape 2.8: new features for data integration and network visualization

(2010) M. E. Smoot et al.   BIOINFORMATICS

Loss of BRCA1 function increases the antitumor activity of cisplatin against human breast cancer xenografts in vivo

(2010) Pierfrancesco Tassone et al.   CANCER BIOLOGY & THERAPY

BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair

(2010) P. J. O'Donovan et al.   CARCINOGENESIS

The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?

(2010) Richard Hill et al.   CELL CYCLE

Transcriptional Regulation of the Base Excision Repair Pathway by BRCA1

(2010) Tapas Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A validated gene expression profile for detecting clinical outcome in breast cancer using artificial neural networks

(2009) L. J. Lancashire et al.   BREAST CANCER RESEARCH AND TREATMENT

Defective Repair of Oxidative DNA Damage in Triple-Negative Breast Cancer Confers Sensitivity to Inhibition of Poly(ADP-Ribose) Polymerase

(2009) E. Alli et al.   CANCER RESEARCH

53BP1 promotes ATM activity through direct interactions with the MRN complex

(2009) Ji-Hoon Lee et al.   EMBO JOURNAL

DNA-Dependent Protein Kinase (DNA-PK)-Dependent Cisplatin-Induced Loss of Nucleolar Facilitator of Chromatin Transcription (FACT) and Regulation of Cisplatin Sensitivity by DNA-PK and FACT

(2009) J. Dejmek et al.   MOLECULAR CANCER RESEARCH

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

(2009) S. E. Golding et al.   MOLECULAR CANCER THERAPEUTICS

BRCA1 and its toolbox for the maintenance of genome integrity

(2009) Michael S.Y. Huen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeted therapy for cancer using PARP inhibitors

(2008) Christopher J Lord et al.   CURRENT OPINION IN PHARMACOLOGY