Article
Clinical Neurology
Jose Vina, Joaquin Escudero, Miquel Baquero, Monica Cebrian, Juan Antonio Carbonell-Asins, Jose Enrique Munoz, Encarnacion Satorres, Juan Carlos Melendez, Jose Ferrer-Rebolleda, Ma del Puig Cozar-Santiago, Jose Manuel Santabarbara-Gomez, Mariona Jove, Reinald Pamplona, Francisco Jose Tarazona-Santabalbina, Consuelo Borras
Summary: This study suggests that genistein may have a therapeutic role in delaying the onset of dementia in patients with prodromal Alzheimer's disease.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Environmental Sciences
Anjum Hajat, Christina Park, Claire Adam, Annette L. Fitzpatrick, Sindana D. Ilango, Cindy Leary, Tanya Libby, Oscar Lopez, Erin O. Semmens, Joel D. Kaufman
Summary: Air pollution is associated with Alzheimer's disease and related dementias (ADRD), possibly due to oxidative stress, neuroinflammation, and the deposition of beta-amyloid in the brain. A study found that exposure to fine particulate matter (PM2.5), particulate matter (PM10), and nitrogen dioxide (NO2) was positively associated with higher levels of beta-amyloid, indicating a link between air pollution and ADRD.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Food Science & Technology
Su-Yan Wang, Yun-Jiao Zhang, Gui-Yang Zhu, Xin-Chi Shi, Xin Chen, Daniela D. Herrera-Balandrano, Feng-Quan Liu, Pedro Laborda
Summary: Sprouting is a common strategy to enhance the nutritional value of seeds. This review covers the occurrence of isoflavones in soybean sprouts for the first time, highlighting the concentrations and factors affecting their levels. The review also discusses different treatments to enhance isoflavone contents. It provides a better understanding of the current research on soybean sprouts and their potential health benefits.
JOURNAL OF FOOD SCIENCE
(2022)
Review
Cell Biology
Emma L. Twait, Britt Min, Magdalena Beran, Jet M. J. Vonk, Mirjam I. Geerlings
Summary: This systematic review and meta-analysis investigated the relationship between amyloid burden and white matter hyperintensities (WMH) in older adults without cognitive impairment. The findings revealed an association between amyloid pathology and WMH in cerebrospinal fluid (CSF) and positron emission tomography (PET), but the relationship in plasma remains unclear. Further studies should explore the relationship between plasma amyloid-beta and WMH to identify at-risk individuals in preclinical stages.
AGEING RESEARCH REVIEWS
(2023)
Review
Medicine, Research & Experimental
Francisco Sergio Lopes Vasconcelos-Filho, Lucas Christyan da Rocha Oliveira, Tereza Brenda Clementino de Freitas, Pedro Alberto Diogenes Saldanha de Pontes, Roberta Cristina Da Rocha-E-Silva, Edna Maria Camelo Chaves, Claudio Gleidiston Lima da Silva, Paula Matias Soares, Vania Marilande Ceccatto
Summary: This study examined the impact of chronic exercise on the production of Aβ in Alzheimer's disease models, finding that exercise reduces Aβ production and contributes to improvements in physiological aspects related to AD.
Article
Radiology, Nuclear Medicine & Medical Imaging
Brian J. Burkett, Jeffrey C. Babcock, Val J. Lowe, Jonathan Graff-Radford, Rathan M. Subramaniam, Derek R. Johnson
Summary: PET imaging plays an essential role in the earlier and more specific diagnoses of dementia syndromes, especially with the development of pathology-specific disease-modifying therapy for Alzheimer disease. Amyloid and tau PET techniques have entered clinical use, making nuclear medicine physicians and radiologists crucial members of the care team. This review discusses recent changes in the understanding of dementia and examines the roles of nuclear medicine imaging in clinical practice.
CLINICAL NUCLEAR MEDICINE
(2022)
Review
Andrology
Vittorio Emanuele Bianchi
Summary: Alzheimer's disease is a neurodegenerative disease influenced by sex hormones. Animal models have shown that testosterone can protect neurons by reducing amyloid-beta production, improving synaptic signaling, and preventing neuronal death. Studies have found that prostate cancer patients receiving androgen deprivation therapy have a higher incidence of dementia and Alzheimer's disease. Testosterone therapy in hypogonadal men with Alzheimer's disease and cognitive impairment has shown some positive results.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Anesthesiology
Thomas Payne, Jennifer Taylor, Cameron Casey, David Kunkel, Maggie Parker, Kaj Blennow, Henrik Zetterberg, Robert A. Pearce, Richard C. Lennertz, Robert D. Sanders
Summary: The study aimed to investigate the relationship between surgery, delirium, and changes in amyloid pathways. Results showed that the increase in plasma A(3R was not associated with delirium incidence or severity. Additionally, the change in plasma A(3R was not related to intraoperative variables.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Clinical Neurology
Bridget Teevan Burke, Caitlin Latimer, C. Dirk Keene, Joshua A. Sonnen, Wayne McCormick, James D. Bowen, Susan M. McCurry, Eric B. Larson, Paul K. Crane
Summary: The AT(N) research framework categorizes eight biomarker profiles using amyloid (A), tauopathy (T), and neurodegeneration (N). Clinical trials would incur substantial expense to characterize AT(N) profiles, with A+T+(N)+ being the most common profile.
ALZHEIMERS & DEMENTIA
(2021)
Article
Biochemistry & Molecular Biology
Gajendra Choudhary, Manisha Prajapat, Gurjeet Kaur, Harvinder Singh, Saniya Mahendiratta, Ajay Prakash, Bikash Medhi
Summary: This study found that Panobinostat can inhibit HDAC6, enhance NEP levels, and reduce Aβ accumulation in neuronal cells. These findings suggest the potential therapeutic role of Panobinostat in Alzheimer's disease.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Cell Biology
Scott Ayton, Ashley Bush
Summary: Alzheimer's disease is a major disease without preventative or disease modifying therapy, and current drugs targeting amyloid beta have been unsuccessful in slowing cognitive decline. Debate is ongoing about whether to continue anti-A beta therapy or pursue alternative targets. The need for disease modifying AD therapies has become one of the highest priorities in all of medicine due to the growing burden of the disease on patients, families, and healthcare budgets.
AGEING RESEARCH REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Shima Tajahmadi, Hossein Molavi, Farhad Ahmadijokani, Amir Shamloo, Akbar Shojaei, Mohammad Sharifzadeh, Mashallah Rezakazemi, Ali Fatehizadeh, Tejraj M. Aminabhavi, Mohammad Arjmand
Summary: Beta-amyloid (Al3) peptide is a key biomarker of Alzheimer's disease (AD), and monitoring its levels is crucial for early diagnosis, prevention, and treatment. Recent attention has focused on the potential of metal-organic frameworks (MOFs) for AD diagnosis and treatment. This review discusses the latest advances in using MOFs for early detection of AD biomarkers, detection of metal ions in the brain, and imaging of Al3 plaques.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Cell Biology
Abubakar Wani, Sweilem B. Al Rihani, Ankita Sharma, Brenna Weadick, Rajgopal Govindarajan, Sameer U. Khan, Parduman R. Sharma, Ashish Dogra, Utpal Nandi, Chilakala N. Reddy, Sonali S. Bharate, Gurdarshan Singh, Sandip B. Bharate, Ram A. Vishwakarma, Amal Kaddoumi, Ajay Kumar
Summary: This study found that crocetin can induce autophagy in Alzheimer's disease, helping to clear Aβ and improve memory function.
Review
Cell Biology
Chantal Vidal, Li Zhang
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by amyloid beta plaques, neurofibrillary tangles, and neuronal loss. Despite decades of research, there is no effective treatment for AD. Recent studies suggest that dysfunctional heme metabolism may play a crucial role in the development of AD.
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques for identifying early stage Alzheimer's disease, with mass spectrometry plasma measures performing significantly better than other measures.
Article
Food Science & Technology
Yonghong Ye, Songyan Zheng, Yuanxing Wang
Summary: In this study, the changes of aroma components in Gannan navel orange during growth were systematically studied using HS-SPME-GC-MS. Key aroma components and markers were identified. These findings contribute to a better understanding of the dynamic variation of aroma compounds during navel orange growth and have potential for industrial applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Jia Xu, Yayuan Zhang, Mengke Zhang, Xinlin Wei, Yiming Zhou
Summary: This study evaluated the effects of glucosamine selenium on summer-autumn tea, showing that it can enhance nutritional quality, improve sensory characteristics, and increase plant adaptation to environmental changes and abiotic stresses.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yuanming Chu, Zhaoyang Ding, Jing Xie
Summary: This study investigated the use of ice glazing containing D-sodium erythorbate (DSE) and vacuum packaging to maintain the quality of large yellow croaker during frozen storage. The results showed that vacuum packaging effectively inhibited ice crystal growth and minimized water loss, while the combination of vacuum packaging and 0.3% DSE-infused ice glazing maintained freshness indicators at low levels throughout the 300-day storage period. This combination was considered the most effective in preserving the quality of the fish.
FOOD RESEARCH INTERNATIONAL
(2024)
Review
Food Science & Technology
Md. Ashikur Rahman, Shirin Akter, Md. Ashrafudoulla, Md. Anamul Hasan Chowdhury, A. G. M. Sofi Uddin Mahamud, Si Hong Park, Sang-Do Ha
Summary: This comprehensive review aims to provide insights into the mechanisms and key factors influencing biofilm formation by A. hydrophila in the food industry. It explores the molecular processes involved in various stages of biofilm formation and investigates the impact of intrinsic factors and environmental conditions on biofilm architecture and resilience. The article also highlights the potential of bibliometric analysis in conceptualizing the research landscape and identifying knowledge gaps in A. hydrophila biofilm research.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Chujing Wang, Wenni Tian, Zengliu Song, Qun Wang, Yong Cao, Jie Xiao
Summary: Solid lipid ratio in emulsions has significant effects on colloidal stability, mucus permeability, and bioavailability in vivo. Higher solid lipid ratio improves intestinal stability but reduces mucus permeability.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Dacai Zhong, Liping Kang, Juan Liu, Xiang Li, Li Zhou, Luqi Huang, Zidong Qiu
Summary: In this study, a novel online extraction electrospray ionization mass spectrometry method was developed to comprehensively characterize complex foods. Meanwhile, a characteristic marker screening method and chemometrics modeling were used for the accurate authentication of highly-similar foods. This research has significant implications for ensuring food quality and safety.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yanyun Cao, Qingling Wang, Jinou Lin, Yin-Yi Ding, Jianzhong Han
Summary: This study investigated the effects of gallic acid (GA) and epigallocatechin gallate (EGCG) at different ratios on the gel properties of calcium induced-whey protein emulsion gel. It was found that GA and EGCG could promote gel formation, increase gel strength, and delay the release of emulsified oil droplets.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Monique Martins Strieder, Vitor Lacerda Sanches, Mauricio Ariel Rostagno
Summary: This study proposed an integrated and automated procedure for extracting, separating, and quantifying bioactive compounds from coffee co-products. By optimizing the extraction, separation, and analysis method, real-time analysis was achieved. The results suggest that coupling different techniques can efficiently extract, separate, and analyze phenolic compounds, providing an integrated method to produce high-added value ingredients for various applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Kyu Sang Sim, Hyoyoung Kim, Suel Hye Hur, Tae Woong Na, Ji Hye Lee, Ho Jin Kim
Summary: Geographical origin plays a crucial role in determining the quality and safety of agricultural products. In this study, ICP analysis was used to determine the inorganic elemental content of onions and identify their geographical origin. Chemometric methods were applied to analyze the ICP results, and the accuracy of distinguishing between Korean and Chinese onions was found to be excellent. The findings suggest that this method can be beneficial for identifying agricultural products.
FOOD RESEARCH INTERNATIONAL
(2024)