Aberrant Expression of RCAN1 in Alzheimer’s Pathogenesis: A New Molecular Mechanism and a Novel Drug Target

Working Memory Impairment in Calcineurin Knock-out Mice Is Associated with Alterations in Synaptic Vesicle Cycling and Disruption of High-Frequency Synaptic and Network Activity in Prefrontal Cortex

(2013) J. R. Cottrell et al.   JOURNAL OF NEUROSCIENCE

Overexpression of RCAN1 isoform 4 in mouse neurons leads to a moderate behavioral impairment

(2013) Devang L Bhoiwala et al.   NEUROLOGICAL RESEARCH

The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease

(2013) Y. Ihara et al.   Cold Spring Harbor Perspectives in Medicine

2012 Alzheimer’s disease facts and figures

(2012)   Alzheimers & Dementia

The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7

(2012) Jee Won Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein kinase A phosphorylates Down syndrome critical region 1 (RCAN1)

(2012) Seon Sook Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis

(2012) Wei Wang et al.   EMBO JOURNAL

Increased Expression of the Glucose-Responsive Gene,RCAN1, Causes Hypoinsulinemia, β-Cell Dysfunction, and Diabetes

(2012) Heshan Peiris et al.   ENDOCRINOLOGY

Regulation of RCAN1 translation and its role in oxidative stress-induced apoptosis

(2012) Yili Wu et al.   FASEB JOURNAL

Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory

(2012) Katherine R. Martin et al.   HUMAN MOLECULAR GENETICS

Chronic Expression of RCAN1-1L Protein Induces Mitochondrial Autophagy and Metabolic Shift from Oxidative Phosphorylation to Glycolysis in Neuronal Cells

(2012) Gennady Ermak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RCAN1 regulates vesicle recycling and quantal release kinetics via effects on calcineurin activity

(2012) Mark P. Zanin et al.   JOURNAL OF NEUROCHEMISTRY

Regulator of calcineurin 1 (Rcan1) has a protective role in brain ischemia/reperfusion injury

(2012) Mónica Sobrado et al.   Journal of Neuroinflammation

NR2B-Containing NMDA Receptors Expression and Their Relationship to Apoptosis in Hippocampus of Alzheimer’s Disease-Like Rats

(2012) Zhi’an Liu et al.   NEUROCHEMICAL RESEARCH

Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease

(2012) Latha Devi et al.   PLoS One

Over-Expression of DSCR1 Protects against Post-Ischemic Neuronal Injury

(2012) Vanessa H. Brait et al.   PLoS One

Covalent NEDD8 Conjugation Increases RCAN1 Protein Stability and Potentiates Its Inhibitory Action on Calcineurin

(2012) Eun Hye Noh et al.   PLoS One

GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

(2012) Chong Gao et al.   REVIEWS IN THE NEUROSCIENCES

p38α MAP kinase phosphorylates RCAN1 and regulates its interaction with calcineurin

(2012) Lei Ma et al.   Science China-Life Sciences

Kaposi's Sarcoma Herpesvirus K15 Protein Contributes to Virus-Induced Angiogenesis by Recruiting PLCγ1 and Activating NFAT1-dependent RCAN1 Expression

(2012) Kiran Bala et al.   PLoS Pathogens

Calcineurin may regulate multiple endocytic processes in C. elegans

(2011) Hyun-Ok Song et al.   BMB Reports

A Role for Calcineurin in Alzheimers Disease

(2011) Lindsay C. Reese et al.   Current Neuropharmacology

MicroRNA networks surrounding APP and amyloid-β metabolism — Implications for Alzheimer's disease

(2011) Nicole Schonrock et al.   EXPERIMENTAL NEUROLOGY

Do RCAN1 proteins link chronic stress with neurodegeneration?

(2011) Gennady Ermak et al.   FASEB JOURNAL

Regulation of RCAN1 Protein Activity by Dyrk1A Protein-mediated Phosphorylation

(2011) Min-Su Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulator of Calcineurin 1 (RCAN1) Facilitates Neuronal Apoptosis through Caspase-3 Activation

(2011) Xiulian Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcineurin Selectively Docks with the Dynamin Ixb Splice Variant to Regulate Activity-dependent Bulk Endocytosis

(2011) Jing Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of β-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer’s Disease

(2011) Xiulian Sun et al.   JOURNAL OF NEUROCHEMISTRY

Isoform-Specific Dephosphorylation of Dynamin1 by Calcineurin Couples Neurotrophin Receptor Endocytosis to Axonal Growth

(2011) Daniel Bodmer et al.   NEURON

Behavioral Characterization of a Mouse Model Overexpressing DSCR1/ RCAN1

(2011) Mara Dierssen et al.   PLoS One

miR-107 Regulates Granulin/Progranulin with Implications for Traumatic Brain Injury and Neurodegenerative Disease

(2010) Wang-Xia Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

The CCAAT/Enhancer Binding Protein β (C/EBPβ) Cooperates with NFAT to Control Expression of the Calcineurin Regulatory ProteinRCAN1–4

(2010) Misook Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A hidden incoherent switch regulates RCAN1 in the calcineurin-NFAT signaling network

(2010) S.-Y. Shin et al.   JOURNAL OF CELL SCIENCE

The Role of Calcium/Calmodulin-Activated Calcineurin in Rapid and Slow Endocytosis at Central Synapses

(2010) T. Sun et al.   JOURNAL OF NEUROSCIENCE

Knockdown of RCAN1.4 Increases Susceptibility to FAS-mediated and DNA-damage-induced Apoptosis by Upregulation of p53 Expression

(2010) Young Sun Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Inflammatory, Apoptotic, and Survival Gene Signaling in Alzheimer’s Disease

(2010) Walter J. Lukiw et al.   MOLECULAR NEUROBIOLOGY

Neuronal Apoptosis in Alzheimer's Disease

(2009) Carlo Bertoni-Freddari et al.   Annals of the New York Academy of Sciences

Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin

(2009) Ji-Eun Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways

(2009) Heng Liu et al.   FASEB JOURNAL

RCAN1-4 knockdown attenuates cell growth through the inhibition of Ras signaling

(2009) Hong Joon Lee et al.   FEBS LETTERS

Regulator of Calcineurin (RCAN1-1L) Is Deficient in Huntington Disease and Protective against Mutant Huntingtin Toxicityin Vitro

(2009) Gennady Ermak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcineurin dephosphorylates glycogen synthase kinase-3 beta at serine-9 in neuroblast-derived cells

(2009) Yeni Kim et al.   JOURNAL OF NEUROCHEMISTRY

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

(2009) Kwan-Hyuck Baek et al.   NATURE

Interaction between TAK1–TAB1–TAB2 and RCAN1–calcineurin defines a signalling nodal control point

(2009) Qinghang Liu et al.   NATURE CELL BIOLOGY

Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: Implications for Down syndrome

(2009) K. T. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling

(2008) Hyun Jin Cho et al.   AGING CELL

Tau binds both subunits of calcineurin, and binding is impaired by calmodulin

(2008) Da-yu Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Infusion of FK506, a specific inhibitor of calcineurin, induces potent tau hyperphosphorylation in mouse brain

(2008) Jing Luo et al.   BRAIN RESEARCH BULLETIN

Inverse association of cortisol serum levels with T-tau, P-tau 181 and P-tau 231 peptide levels and T-tau/Aβ 1–42 ratios in CSF in patients with mild Alzheimer’s disease dementia

(2008) Christoph Laske et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

c-Jun Inhibits Thapsigargin-Induced ER Stress Through Up-Regulation of DSCR1/Adapt78

(2008) Peng Zhao et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Upregulation of DSCR1 (RCAN1 or Adapt78) in the peri-infarct cortex after experimental stroke

(2008) Kyung-Ok Cho et al.   EXPERIMENTAL NEUROLOGY

CREB activates proteasomal degradation of DSCR1/RCAN1

(2008) Su Ryeon Seo et al.   FEBS LETTERS

Calcium/calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes

(2008) Andrea Canellada et al.   GLIA

DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease

(2008) Damien J. Keating et al.   HUMAN MOLECULAR GENETICS

Transcription Enhancer Factor 3 (TEF3) Mediates the Expression of Down Syndrome Candidate Region 1 Isoform 1 (DSCR1-1L) in Endothelial Cells

(2008) Xin Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination of Growth and Endoplasmic Reticulum Stress Signaling by Regulator of Calcineurin 1 (RCAN1), a Novel ATF6-inducible Gene

(2008) Peter J. Belmont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

(2008) Hong Qing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Seasonal effects on cortisol secretion in normal aging, mild cognitive impairment and Alzheimer's disease

(2008) Genevieve Arsenault-Lapierre et al.   NEUROBIOLOGY OF AGING

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA