Journal
FEBS LETTERS
Volume 583, Issue 15, Pages 2557-2564Publisher
WILEY
DOI: 10.1016/j.febslet.2009.07.023
Keywords
RCAN1/DSCR1; Cell growth; Ras; ERK/MAPK; Translation; eIF4E
Funding
- MRC [R13-2002-005-04002-0]
- Korea Science and Engineering Foundation (KOSEF)
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Forced changes in the expression of regulator of calcineurin 1 (RCAN1) affects cell growth. This has been linked to the suppression of calcineurin-nuclear factor of activated T cells signaling by RCAN1. Here, we describe a novel role of RCAN1 isoform 4 in proper expression of Ras protein and its signaling. RCAN1 isoform 4 knockdown attenuated growth factor-induced extracellular signal-regulated kinase activation and cell growth; reduced Ras levels and its translation rate; and led to a reduction of eukaryotic initiation factor 4E in the initiation complex and a slight repression of global protein synthesis. Experiments utilizing activity-modified mutants of calcineurin A demonstrated that these effects were calcineurin-independent. Our findings reveal a previously unknown role of RCAN1-4 in protein synthesis, which may be relevant to cell growth. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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