The Biochemical and Cellular Basis for Nutraceutical Strategies to Attenuate Neurodegeneration in Parkinson’s Disease

Environmental and Familial Risk Factors of Parkinsons Disease: Case-Control Study

(2014) Jaya Sanyal et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Effect of N-methyl-D-aspartate (NMDA) receptor antagonists on α-synuclein-evoked neuronal nitric oxide synthase activation in the rat brain

(2014) Agata Adamczyk et al.   Pharmacological Reports

Updates of mTOR Inhibitors

(2012) Hongyu Zhou et al.   Anti-Cancer Agents in Medicinal Chemistry

Monoamine Oxidase Inhibitors as Neuroprotective Agents in Age-Dependent Neurodegenerative Disorders

(2012) Makoto Naoi et al.   CURRENT PHARMACEUTICAL DESIGN

Correlation between lactate and neuronal cell damage in the rat brain after focal ischemia: An in vivo 1H magnetic resonance spectroscopic (1H-MRS) study

(2010) Chul-Woong Woo et al.   ACTA RADIOLOGICA

Arginine-induced stimulation of protein synthesis and survival in IPEC-J2 cells is mediated by mTOR but not nitric oxide

(2010) Caroline Bauchart-Thevret et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1

(2010) Chuang-Rung Chang et al.   Annals of the New York Academy of Sciences

The regulatory role of α-synuclein and parkin in neuronal cell apoptosis; possible implications for the pathogenesis of Parkinson’s disease

(2010) Toru Yasuda et al.   APOPTOSIS

Presynaptic roles of intracellular Ca2+stores in signalling and exocytosis : Figure 1

(2010) Sohaib Nizami et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection

(2010) Andrew P. Halestrap   BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: Implications for mitochondrial dysfunction in Parkinson disease

(2010) Marco Bisaglia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Antibrowning potential of Brassicacaea processing water

(2010) Federico Zocca et al.   BIORESOURCE TECHNOLOGY

Riboflavin-responsive oxidative phosphorylation complex I deficiency caused by defective ACAD9: new function for an old gene

(2010) Mike Gerards et al.   BRAIN

Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats

(2010) Marwa M. Safar et al.   BRAIN RESEARCH

Characterizing iron deposition in Parkinson's disease using susceptibility-weighted imaging: An in vivo MR study

(2010) Jiuquan Zhang et al.   BRAIN RESEARCH

Inhibition of calpain prevents NMDA-induced cell death and β-amyloid-induced synaptic dysfunction in hippocampal slice cultures

(2010) V Nimmrich et al.   BRITISH JOURNAL OF PHARMACOLOGY

Suppression of mTOR via Akt-dependent and -independent mechanisms in selenium-treated colon cancer cells: involvement of AMPK 1

(2010) Y.-K. Lee et al.   CARCINOGENESIS

Variable toxicological response to the loss of OXPHOS through 1-methyl-4-phenylpyridinium-induced mitochondrial damage and anoxia in diverse neural immortal cell lines

(2010) Elizabeth A. Mazzio et al.   CELL BIOLOGY AND TOXICOLOGY

Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent

(2010) Hong Jiang et al.   CELL RESEARCH

Oxygen catalyzed mobilization of iron from ferritin by iron(iii) chelate ligands

(2010) Fadi Bou-Abdallah et al.   CHEMICAL COMMUNICATIONS

Nicotine- and caffeine-mediated changes in gene expression patterns of MPTP-lesioned mouse striatum: Implications in neuroprotection mechanism

(2010) Kavita Singh et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A Mitochondrial Myopathy in an Infant with Lactic Acidosis

(2010) Verena Griebel et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology

(2010) Ayse Ulusoy et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

α-Synuclein induced cell death in mouse hippocampal (HT22) cells is mediated by nitric oxide-dependent activation of caspase-3

(2010) Agata Adamczyk et al.   FEBS LETTERS

PPARγ agonist pioglitazone inhibits microglia inflammation by blocking p38 mitogen-activated protein kinase signaling pathways

(2010) Huoyan Ji et al.   INFLAMMATION RESEARCH

Long-Term Efficacy of Rasagiline in Early Parkinson's Disease

(2010) Mark F. Lew et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Consumption ofS-Allylcysteine Inhibits the Growth of Human Non-Small-Cell Lung Carcinoma in a Mouse Xenograft Model

(2010) Feng-Yao Tang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antioxidant and Anti-inflammatory Activities of Bean (Phaseolus vulgaris L.) Hulls

(2010) B. Dave Oomah et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Phosphorylated α-Synuclein at Ser-129 Is Targeted to the Proteasome Pathway in a Ubiquitin-independent Manner

(2010) Youhei Machiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases

(2010) Maurizio Renna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

Does autophagy take a front seat in lifespan extension?

(2010) Goran Petrovski et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ameliorative and neuroprotective effect in MPTP model of Parkinson's disease by Zhen-Wu-Tang (ZWT), a traditional Chinese medicine

(2010) Xiu-Min Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Vesicular monoamine transporter 2 mRNA levels are reduced in platelets from patients with Parkinson’s disease

(2010) Gessica Sala et al.   JOURNAL OF NEURAL TRANSMISSION

Proteasome inhibition modeling nigral neuron degeneration in Parkinson’s disease

(2010) Wenjie Xie et al.   JOURNAL OF NEUROCHEMISTRY

Imaging Approaches to Parkinson Disease

(2010) D. J. Brooks   JOURNAL OF NUCLEAR MEDICINE

Leucine Supplementation of a Low-Protein Meal Increases Skeletal Muscle and Visceral Tissue Protein Synthesis in Neonatal Pigs by Stimulating mTOR-Dependent Translation Initiation

(2010) Roberto Murgas Torrazza et al.   JOURNAL OF NUTRITION

Metalloproteomics and metal toxicology of α-synuclein

(2010) Aaron Santner et al.   Metallomics

Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain

(2010) Dominic J. Hare et al.   Metallomics

Redox Reactions Induced by Nitrosative Stress Mediate Protein Misfolding and Mitochondrial Dysfunction in Neurodegenerative Diseases

(2010) Zezong Gu et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2

(2010) H. Mortiboys et al.   NEUROLOGY

Neuroprotective effects of pyruvate following NMDA-mediated excitotoxic insults in hippocampal slices

(2010) Yukitoshi Izumi et al.   NEUROSCIENCE LETTERS

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

Brain fuel metabolism, aging, and Alzheimer’s disease

(2010) Stephen Cunnane et al.   NUTRITION

Genetic variation of the mitochondrial complex I subunit NDUFV2 and Parkinson’s disease

(2010) Kenya Nishioka et al.   PARKINSONISM & RELATED DISORDERS

S-allylcysteine reduces the MPTP-induced striatal cell damage via inhibition of pro-inflammatory cytokine tumor necrosis factor-α and inducible nitric oxide synthase expressions in mice

(2010) Esperanza García et al.   PHYTOMEDICINE

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

Rasagiline: A novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity

(2010) Orly Weinreb et al.   PROGRESS IN NEUROBIOLOGY

Critical role of transglutaminase and other stress proteins during neurodegenerative processes

(2009) Daniela Caccamo et al.   AMINO ACIDS

Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps

(2009) Oren A. Levy et al.   APOPTOSIS

Occupation and Risk of Parkinsonism

(2009) Caroline M. Tanner et al.   ARCHIVES OF NEUROLOGY

Involvement of NMDA receptors in both MPTP-induced neuroinflammation and deficits in episodic-like memory in Wistar rats

(2009) An-Li Wang et al.   BEHAVIOURAL BRAIN RESEARCH

Controlling aggregation propensity in A53T mutant of alpha-synuclein causing Parkinson’s disease

(2009) Sonu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein Targets of Oxidative Damage in Human Neurodegenerative Diseases with Abnormal Protein Aggregates

(2009) Anna Martínez et al.   BRAIN PATHOLOGY

Impaired glutamate homeostasis and programmed cell death in a chronic MPTP mouse model of Parkinson's disease

(2009) G.E. Meredith et al.   EXPERIMENTAL NEUROLOGY

Dopamine (DA) induced irreversible proteasome inhibition via DA derived quinones

(2009) Zhi Dong Zhou et al.   FREE RADICAL RESEARCH

Parkinson's disease: from monogenic forms to genetic susceptibility factors

(2009) S. Lesage et al.   HUMAN MOLECULAR GENETICS

Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells

(2009) Mordhwaj S. Parihar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial quality control: insights on how Parkinson’s disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Phosphorylation of Synucleins by Members of the Polo-like Kinase Family

(2009) Martial K. Mbefo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathologic Modifications of α-Synuclein in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Treated Squirrel Monkeys

(2009) Alison L. McCormack et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Statin's Excitoprotection Is Mediated by sAPP and the Subsequent Attenuation of Calpain-Induced Truncation Events, Likely via Rho-ROCK Signaling

(2009) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Ionic flow enhances low-affinity binding: a revised mechanistic view into Mg2+block of NMDA receptors

(2009) Ya-Chin Yang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents

(2009) Anupom Borah et al.   JOURNAL OF PINEAL RESEARCH

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Evidence that folic acid deficiency is a major determinant of hyperhomocysteinemia in Parkinson´s disease

(2009) Eliseu Felippe dos Santos et al.   METABOLIC BRAIN DISEASE

MPTP intoxication in mice: a useful model of Leigh syndrome to study mitochondrial diseases in childhood

(2009) E. Lagrue et al.   METABOLIC BRAIN DISEASE

Treatment of mitochondrial electron transport chain disorders: A review of clinical trials over the past decade

(2009) Douglas S. Kerr   MOLECULAR GENETICS AND METABOLISM

Protective Actions of the Vesicular Monoamine Transporter 2 (VMAT2) in Monoaminergic Neurons

(2009) Thomas S. Guillot et al.   MOLECULAR NEUROBIOLOGY

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Blockade of the translocation and activation of c-Jun N-terminal kinase 3 (JNK3) attenuates dopaminergic neuronal damage in mouse model of Parkinson's disease

(2009) Jing Pan et al.   NEUROCHEMISTRY INTERNATIONAL

Covalent arylation of metallothionein by oxidized dopamine products: A possible mechanism for zinc-mediated enhancement of dopaminergic neuron survival

(2009) Michelle A. Gauthier et al.   NEUROTOXICITY RESEARCH

Mechanisms of amino acid sensing in mTOR signaling pathway

(2009) Eunjung Kim   Nutrition Research and Practice

Iron transport in Parkinson's disease

(2009) E.C. Hirsch   PARKINSONISM & RELATED DISORDERS

Modeling sporadic Parkinson's disease by silencing the ubiquitin E3 ligase component, SKP1A

(2009) Silvia A. Mandel et al.   PARKINSONISM & RELATED DISORDERS

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

(2009) Aruna D. Balgi et al.   PLoS One

The pattern of neuronal loss and survival may reflect differential expression of proteasome activators in Parkinson's disease

(2009) Kevin St.P. Mcnaught et al.   SYNAPSE

Monoamine oxidase inactivation: From pathophysiology to therapeutics☆

(2008) Marco Bortolato et al.   ADVANCED DRUG DELIVERY REVIEWS

Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†

(2008) Daniel Sevlever et al.   BIOCHEMISTRY

Imaging neurodegeneration in Parkinson's disease

(2008) Nicola Pavese et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations

(2008) Pierre Maurois et al.   BRITISH JOURNAL OF NUTRITION

Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions

(2008) Wolfgang Reindl et al.   CHEMISTRY & BIOLOGY

Pathophysiology of Parkinsonism

(2008) Adriana Galvan et al.   CLINICAL NEUROPHYSIOLOGY

Metals in Alzheimer's and Parkinson's Diseases

(2008) Kevin J Barnham et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Broad neuroprotective profile of nicotinamide in different mouse models of MPTP-induced parkinsonism

(2008) D. W. Anderson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mechanism of metal-mediated DNA damage and apoptosis induced by 6-hydroxydopamine in neuroblastoma SH-SY5Y cells

(2008) Hatasu Kobayashi et al.   FREE RADICAL RESEARCH

Vesicular Monoamine Transporter Substrate/Inhibitor Activity of MPTP/MPP+Derivatives: A Structure–Activity Study

(2008) D. Shyamali Wimalasena et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regional distribution of tetrahydroisoquinoline derivatives in rodent, human, and parkinson’s disease brain

(2008) Michael DeCuypere et al.   JOURNAL OF NEUROCHEMISTRY

MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation – relevance in a mouse model of Parkinson’s disease

(2008) Tobias Thomas et al.   JOURNAL OF NEUROCHEMISTRY

Concomitant supplementation of lycopene and eicosapentaenoic acid inhibits the proliferation of human colon cancer cells

(2008) Feng-Yao Tang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Synergistic anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model

(2008) Haiqun Jia et al.   NEUROBIOLOGY OF AGING

Alteration of dopamine uptake into rat striatal vesicles and synaptosomes caused by an in vitro exposure to atrazine and some of its metabolites

(2008) Muhammad M. Hossain et al.   TOXICOLOGY

Catalpol protects mesencephalic neurons against MPTP induced neurotoxicity via attenuation of mitochondrial dysfunction and MAO-B activity

(2008) Jing Bi et al.   TOXICOLOGY IN VITRO

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

(2008) Claire Henchcliffe et al.   Nature clinical practice. Neurology

Deficiency of Inducible Nitric Oxide Synthase Protects Against MPTP Toxicity In Vivo

(2003) Thomas Dehmer et al.   JOURNAL OF NEUROCHEMISTRY

Analysis of VMAT2 Binding After Methamphetamine or MPTP Treatment

(2003) Kelly A. Hogan et al.   JOURNAL OF NEUROCHEMISTRY