With or Without Sugar? (A)glycosylation of Therapeutic Antibodies

A phase II, double-blind, randomised, placebo-controlled study of BMS945429 (ALD518) in patients with rheumatoid arthritis with an inadequate response to methotrexate

(2012) P Mease et al.   ANNALS OF THE RHEUMATIC DISEASES

Cation exchange surface-mediated denaturation of an aglycosylated immunoglobulin (IgG1)

(2012) Ron Gillespie et al.   JOURNAL OF CHROMATOGRAPHY A

Aglycosylated antibodies and antibody fragments produced in a scalable in vitro transcription-translation system

(2012) Gang Yin et al.   mAbs

Marketed therapeutic antibodies compendium

(2012) Janice M. Reichert   mAbs

Generation and Comparative Characterization of Glycosylated and Aglycosylated Human IgG1 Antibodies

(2012) Dmitrij Hristodorov et al.   MOLECULAR BIOTECHNOLOGY

Microscale to manufacturing scale-up of cell-free cytokine production-a new approach for shortening protein production development timelines

(2011) James F. Zawada et al.   BIOTECHNOLOGY AND BIOENGINEERING

Bypassing glycosylation: engineering aglycosylated full-length IgG antibodies for human therapy

(2011) Sang Taek Jung et al.   CURRENT OPINION IN BIOTECHNOLOGY

Engineering of Therapeutic Proteins Production in Escherichia coli

(2011) Mariusz Kamionka   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Glycoengineered Pichia produced anti-HER2 is comparable to trastuzumab in preclinical study

(2011) Ningyan Zhang et al.   mAbs

Neonatal Fc receptor and IgG-based therapeutics

(2011) Timothy T. Kuo et al.   mAbs

Recombinant immunotherapeutics: current state and perspectives regarding the feasibility and market

(2010) Chung-Jr Huang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Acid-Induced Aggregation of Human Monoclonal IgG1 and IgG2: Molecular Mechanism and the Effect of Solution Composition

(2010) Sanjay B. Hari et al.   BIOCHEMISTRY

Influence of pH on Heat-Induced Aggregation and Degradation of Therapeutic Monoclonal Antibodies

(2010) Tomoyoshi Ishikawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Glycosylation influences on the aggregation propensity of therapeutic monoclonal antibodies

(2010) Veysel Kayser et al.   Biotechnology Journal

A Highly Controllable Reconstituted Cell-Free System -a Breakthrough in Protein Synthesis Research

(2010) Hiroyuki Ohashi et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass

(2010) B. Keymeulen et al.   DIABETOLOGIA

A Novel Role for the IgG Fc Glycan: The Anti-inflammatory Activity of Sialylated IgG Fcs

(2010) Robert M. Anthony et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Pharmacokinetics and Antibody Responses to the CD3 Antibody Otelixizumab Used in the Treatment of Type 1 Diabetes

(2010) Geoff Hale et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Engineering host cell lines to reduce terminal sialylation of secreted antibodies

(2010) Michael F. Naso et al.   mAbs

Certolizumab Pegol

(2010) Niti Goel et al.   mAbs

Antibodies to watch in 2010

(2010) Janice M. Reichert   mAbs

Stability of IgG isotypes in serum

(2010) Ivan Correia   mAbs

Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry

(2009) Damian Houde et al.   ANALYTICAL CHEMISTRY

Integrated solution to purification challenges in the manufacture of a soluble recombinant protein inE. coli

(2009) Maire H. Caparon et al.   BIOTECHNOLOGY AND BIOENGINEERING

Novel Therapeutic Inhibitors of the c-Met Signaling Pathway in Cancer

(2009) J. P. Eder et al.   CLINICAL CANCER RESEARCH

Pharmacokinetics and Pharmacodynamics of a Chimeric/Humanized Anti-CD3 Monoclonal Antibody, Otelixizumab (TRX4), in Subjects With Psoriasis and With Type 1 Diabetes Mellitus

(2009) Paweł Wiczling et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Structure of the Murine Unglycosylated IgG1 Fc Fragment

(2009) Matthias J. Feige et al.   JOURNAL OF MOLECULAR BIOLOGY

Impact of methionine oxidation on the binding of human IgG1 to FcRn and Fcγ receptors

(2009) Andrea Bertolotti-Ciarlet et al.   MOLECULAR IMMUNOLOGY

Species-independent translational leaders facilitate cell-free expression

(2009) Sergei Mureev et al.   NATURE BIOTECHNOLOGY

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Aglycosylated IgG variants expressed in bacteria that selectively bind Fc RI potentiate tumor cell killing by monocyte-dendritic cells

(2009) S. T. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

(2009) Hai Pan et al.   PROTEIN SCIENCE

Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

(2009) Royston Jefferis   TRENDS IN PHARMACOLOGICAL SCIENCES

Plants as biofactories

(2008) Vadim Mett et al.   BIOLOGICALS

Meeting report & News from academia

(2008) Sandrine Moutel et al.   Biotechnology Journal

Trends in Glycosylation, Glycoanalysis and Glycoengineering of Therapeutic Antibodies and Fc-Fusion Proteins

(2008) Alain Beck et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

(2008) Richard Strasser et al.   PLANT BIOTECHNOLOGY JOURNAL

Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors

(2008) S. L. Sazinsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE

Characterization of a complex glycoprotein whose variable metabolic clearance in humans is dependent on terminal N-acetylglucosamine content

(2007) Rodney Keck et al.   BIOLOGICALS

Effect of constant and variable domain glycosylation on pharmacokinetics of therapeutic antibodies in mice

(2007) Thomas A. Millward et al.   BIOLOGICALS

Glycosylation of Recombinant Antibody Therapeutics

(2005) Royston Jefferis   BIOTECHNOLOGY PROGRESS