Glycoengineered Pichia produced anti-HER2 is comparable to trastuzumab in preclinical study

Plant-Made Trastuzumab (Herceptin) Inhibits HER2/Neu+ Cell Proliferation and Retards Tumor Growth

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Research and development of next generation of antibody-based therapeutics

(2010) Jing Li et al.   ACTA PHARMACOLOGICA SINICA

Enhancement of DNA uptake in FUT8-deleted CHO cells for transient production of afucosylated antibodies

(2010) Athena W. Wong et al.   BIOTECHNOLOGY AND BIOENGINEERING

Analysis of Fcγ Receptor IIA & IIIA Polymorphisms: Correlation with Outcome in Trastuzumab-Treated HER2/Neu Amplified Early and Metastatic Breast Cancer Patients.

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Superior In vivo Efficacy of Afucosylated Trastuzumab in the Treatment of HER2-Amplified Breast Cancer

(2010) Teemu T. Junttila et al.   CANCER RESEARCH

A defucosylated anti-CD317 antibody exhibited enhanced antibody-dependent cellular cytotoxicity against primary myeloma cells in the presence of effectors from patients

(2010) Takahiro Ishiguro et al.   CANCER SCIENCE

Plant-Produced Trastuzumab Inhibits the Growth of HER2 Positive Cancer Cells

(2010) Brittany M. Grohs et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

High-throughput screening and selection of yeast cell lines expressing monoclonal antibodies

(2010) Gavin C. Barnard et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Industrialization of mAb production technology: The bioprocessing industry at a crossroads

(2010) Brian Kelley   mAbs

Production of therapeutic antibodies with controlled fucosylation

(2010) Naoko Yamane-Ohnuki et al.   mAbs

Purification process development of a recombinant monoclonal antibody expressed in glycoengineered Pichia pastoris

(2010) Youwei Jiang et al.   PROTEIN EXPRESSION AND PURIFICATION

N-glycosylation Engineering of Biopharmaceutical Expression Systems

(2009) P. Jacobs et al.   CURRENT MOLECULAR MEDICINE

Short-hairpin-RNA-mediated silencing of fucosyltransferase 8 in Chinese-hamster ovary cells for the production of antibodies with enhanced antibody immune effector function

(2008) Vincent Beuger et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Engineered Antibodies of IgG1/IgG3 Mixed Isotype with Enhanced Cytotoxic Activities

(2008) A. Natsume et al.   CANCER RESEARCH

Production of monoclonal antibodies by glycoengineered Pichia pastoris

(2008) Thomas I. Potgieter et al.   JOURNAL OF BIOTECHNOLOGY

In Reply

(2008) Antonino Musolino et al.   JOURNAL OF CLINICAL ONCOLOGY