Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding

Recognition and Binding of Human Telomeric G-Quadruplex DNA by Unfolding Protein 1

(2014) Jason S. Hudson et al.   BIOCHEMISTRY

The effect of pyridyl substituents on the thermodynamics of porphyrin binding to G-quadruplex DNA

(2013) Gerald B. Rowland et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural characterization of quadruplex DNA with in-cell EPR approaches

(2013) Isabelle T. Holder et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Solution Structure of an Intramolecular (3 + 1) Human Telomeric G-Quadruplex Bound to a Telomestatin Derivative

(2013) Wan Jun Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure–Activity Relationship for FDA Approved Drugs As Inhibitors of the Human Sodium Taurocholate Cotransporting Polypeptide (NTCP)

(2013) Zhongqi Dong et al.   MOLECULAR PHARMACEUTICS

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes

(2013) Prashansa Agrawal et al.   NUCLEIC ACIDS RESEARCH

Minor groove binders as anti-infective agents

(2013) Michael P. Barrett et al.   PHARMACOLOGY & THERAPEUTICS

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents

(2013) Peter B. Madrid et al.   PLoS One

Bcl-2 Promoter Sequence G-Quadruplex Interactions with Three Planar and Non-Planar Cationic Porphyrins: TMPyP4, TMPyP3, and TMPyP2

(2013) Vu H. Le et al.   PLoS One

Modeling complex equilibria in isothermal titration calorimetry experiments: Thermodynamic parameters estimation for a three-binding-site model

(2012) Vu H. Le et al.   ANALYTICAL BIOCHEMISTRY

Intracellular Conformations of Human Telomeric Quadruplexes Studied by Electron Paramagnetic Resonance Spectroscopy

(2012) Mykhailo Azarkh et al.   CHEMPHYSCHEM

Searching Drug-Like Anti-cancer Compound(s) Based on G-Quadruplex Ligands

(2012) Qian Li et al.   CURRENT PHARMACEUTICAL DESIGN

G-Quadruplex Binding Ligands: from Naturally Occurring to Rationally Designed Molecules

(2012) Tuong Vy Thi Le et al.   CURRENT PHARMACEUTICAL DESIGN

G-quadruplexes: targets and tools in anticancer drug design

(2012) Markus Düchler   JOURNAL OF DRUG TARGETING

Shooting for Selective Druglike G-Quadruplex Binders: Evidence for Telomeric DNA Damage and Tumor Cell Death

(2012) Sandro Cosconati et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Model of Smart G-Quadruplex Ligand

(2012) Romain Haudecoeur et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1

(2012) Carla Bazzicalupi et al.   NUCLEIC ACIDS RESEARCH

Interaction of G-Quadruplexes with Nonintercalating Duplex-DNA Minor Groove Binding Ligands

(2011) Akash K. Jain et al.   BIOCONJUGATE CHEMISTRY

Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP

(2011) Ilana Kelsey et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

DSC Deconvolution of the Structural Complexity of c-MYC P1 Promoter G-Quadruplexes

(2011) Jamie M. Dettler et al.   BIOPHYSICAL JOURNAL

Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA

(2011) Yan Xu   CHEMICAL SOCIETY REVIEWS

The application of DNA and RNA G-quadruplexes to therapeutic medicines

(2011) Gavin W. Collie et al.   CHEMICAL SOCIETY REVIEWS

G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulatec-KITExpression in Human Gastric Carcinoma Cells

(2011) Keith I. E. McLuckie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Complexity in the binding of minor groove agents: netropsin has two thermodynamically different DNA binding modes at a single site

(2011) Edwin A. Lewis et al.   NUCLEIC ACIDS RESEARCH

Studies on the Site and Mode of TMPyP4 Interactions with Bcl-2 Promoter Sequence G-Quadruplexes

(2010) Narayana Nagesh et al.   BIOPHYSICAL JOURNAL

Making sense of G-quadruplex and i-motif functions in oncogene promoters

(2010) Tracy A. Brooks et al.   FEBS Journal

Structural and Conformational Requisites in DNA Quadruplex Groove Binding: Another Piece to the Puzzle

(2010) Sandro Cosconati et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex

(2010) Gavin W. Collie et al.   NUCLEIC ACIDS RESEARCH

5'-UTR G-quadruplex structures acting as translational repressors

(2010) J.-D. Beaudoin et al.   NUCLEIC ACIDS RESEARCH

Guanidinium-Modified Phthalocyanines as High-Affinity G-Quadruplex Fluorescent Probes and Transcriptional Regulators

(2009) Jawad Alzeer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: I. Recognizing mixed G-quadruplex in human telomeres

(2009) Qianfan Yang et al.   CHEMICAL COMMUNICATIONS

Targeting Human Gastrointestinal Stromal Tumor Cells with a Quadruplex-Binding Small Molecule

(2009) Mekala Gunaratnam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigation of mRNA quadruplex formation in Escherichia coli

(2009) Markus Wieland et al.   Nature Protocols

Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: II. The binding characterization with specific intramolecular G-quadruplex and the recognizing mechanism

(2009) Qianfan Yang et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplexes: Targets in Anticancer Drug Design

(2008) Tian-miao Ou et al.   ChemMedChem

The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents

(2008) D. Sun et al.   MOLECULAR CANCER THERAPEUTICS