Modulation of apoptosis-related cell signalling pathways by curcumin as a strategy to inhibit tumor progression

INCB16562, a JAK1/2 Selective Inhibitor, Is Efficacious against Multiple Myeloma Cells and Reverses the Protective Effects of Cytokine and Stromal Cell Support

(2015) Jun Li et al.   NEOPLASIA

Jak-Stat signaling pathway may play a role in the pathogenesis of cholesteatoma

(2013) Görkem Eskiizmir et al.   AMERICAN JOURNAL OF OTOLARYNGOLOGY

Molecular mechanisms of curcumin action: Signal transduction

(2013) Adeeb Shehzad et al.   BIOFACTORS

Inhibition of the PI3K/AKT-NF-κB Pathway With Curcumin Enhanced Radiation-Induced Apoptosis in Human Burkitt’s Lymphoma

(2013) Qiao Qiao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells

(2013) Yun-Hee Bae et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK Pathways

(2012) Chu-Wen Yang et al.   BMC Complementary and Alternative Medicine

Prolonged Biologically Active Colonic Tissue Levels of Curcumin Achieved After Oral Administration--A Clinical Pilot Study Including Assessment of Patient Acceptability

(2012) G. R. B. Irving et al.   Cancer Prevention Research

Deguelin, an Akt Inhibitor, Down-Regulates NF-κB Signaling and Induces Apoptosis in Colon Cancer Cells and Inhibits Tumor Growth in Mice

(2012) Hyoun Woo Kang et al.   DIGESTIVE DISEASES AND SCIENCES

Curcumin induces apoptosis in tumor necrosis factor-alpha-treated HaCaT cells

(2012) Jun Sun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Perifosine sensitizes curcumin-induced anti-colorectal cancer effects by targeting multiple signaling pathways bothin vivoandin vitro

(2012) Min-Bin Chen et al.   INTERNATIONAL JOURNAL OF CANCER

Anti-inflammatory Mechanism of 15,16-Epoxy-3α-hydroxylabda-8,13(16),14-trien-7-one via Inhibition of LPS-Induced Multicellular Signaling Pathways

(2012) Salman Khan et al.   JOURNAL OF NATURAL PRODUCTS

Curcumin enhances the anticancer effects of trichostatin a in breast cancer cells

(2012) Guang Yan et al.   MOLECULAR CARCINOGENESIS

Curcumin attenuates rat thoracic aortic aneurysm formation by inhibition of the c-Jun N-terminal kinase pathway and apoptosis

(2012) Jun Fan et al.   NUTRITION

Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1

(2012) A Fassl et al.   ONCOGENE

Curcumin Induces Cell Death in Esophageal Cancer Cells through Modulating Notch Signaling

(2012) Dharmalingam Subramaniam et al.   PLoS One

Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways

(2011) S. Prakobwong et al.   CARCINOGENESIS

Curcumin Induces Small Cell Lung Cancer NCI-H446 Cell Apoptosis via the Reactive Oxygen Species-Mediated Mitochondrial Pathway and Not the Cell Death Receptor Pathway

(2011) Cheng-Liang Yang et al.   DNA AND CELL BIOLOGY

Inhibition of PP2A and the consequent activation of JNK/c-Jun are involved in tributyltin-induced apoptosis in human amnionic cells

(2011) Yali Zhang et al.   ENVIRONMENTAL TOXICOLOGY

Notch-1 and Notch-4 Biomarker Expression in Triple-Negative Breast Cancer

(2011) Jodi Speiser et al.   INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

Inhibitory effect of curcumin on oral carcinoma CAL-27 cells via suppression of Notch-1 and NF-κB signaling pathways

(2011) Shengkai Liao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think: Table I.

(2011) Camille Lobry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Curcumin potentiates antitumor activity ofl-asparaginase via inhibition of the AKT signaling pathway in acute lymphoblastic leukemia

(2011) Hua Wang et al.   LEUKEMIA & LYMPHOMA

Multitargeting by curcumin as revealed by molecular interaction studies

(2011) Subash C. Gupta et al.   NATURAL PRODUCT REPORTS

Targeting the PI3K/AKT/mTOR Pathway in Non-Hodgkin’s Lymphoma: Results, Biology, and Development Strategies

(2011) Jonathan H. Schatz   Current Oncology Reports

Modulatory effect of curcumin on survival of irradiated human intestinal microvascular endothelial cells: role of Akt/mTOR and NF-κB

(2010) Parvaneh Rafiee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals

(2010) Subash C. Gupta et al.   CANCER AND METASTASIS REVIEWS

Curcumin Inhibits Constitutive STAT3 Phosphorylation in Human Pancreatic Cancer Cell lines and Downregulation of Survivin/BIRC5 Gene Expression

(2010) W. Glienke et al.   CANCER INVESTIGATION

A novel effect of DNA methyltransferase and histone deacetylase inhibitors : NFκB inhibition in malignant myeloblasts

(2010) Claire Fabre et al.   CELL CYCLE

Lesson Learned from Nature for the Development of Novel Anti-Cancer Agents: Implication of Isoflavone, Curcumin, and their Synthetic Analogs

(2010) Fazlul H. Sarkar et al.   CURRENT PHARMACEUTICAL DESIGN

Akt mediates 17β-estradiol and/or estrogen receptor-α inhibition of LPS-induced tumor necresis factor-α expression and myocardial cell apoptosis by suppressing the JNK1/2-NFκB pathway

(2010) Chung-Jung Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cellular repressor of E1A-stimulated genes inhibits human vascular smooth muscle cell apoptosis via blocking P38/JNK MAP kinase activation

(2010) Yaling Han et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

(2010) Matthew A Bill et al.   Molecular Cancer

Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?

(2009) Jayaraj Ravindran et al.   AAPS Journal

Alterations in Aortic Cellular Constituents during Thoracic Aortic Aneurysm Development

(2009) Jeffrey A. Jones et al.   AMERICAN JOURNAL OF PATHOLOGY

Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: Their inhibition by curcumin

(2009) Ji Hye Seo et al.   CANCER LETTERS

Curcumin Potentiates the Antitumor Effects of Bacillus Calmette-Guerin against Bladder Cancer through the Downregulation of NF- B and Upregulation of TRAIL Receptors

(2009) A. M. Kamat et al.   CANCER RESEARCH

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Curcumin as an Anti-Cancer Agent: Review of the Gap Between Basic and Clinical Applications

(2009) G. Bar-Sela et al.   CURRENT MEDICINAL CHEMISTRY

Notch signaling contributes to the pathogenesis of human osteosarcomas

(2009) F. Engin et al.   HUMAN MOLECULAR GENETICS

Determining the Effects of Lipophilic Drugs on Membrane Structure by Solid-State NMR Spectroscopy: The Case of the Antioxidant Curcumin

(2009) Jeffrey Barry et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells

(2009) Hui-Fang Li et al.   Radiation Oncology

TRAIL and cancer therapy

(2008) Frank A.E. Kruyt   CANCER LETTERS

Mammalian target of rapamycin (mTOR) pathway signalling in lymphomas

(2008) Elias Drakos et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-κB and STAT3 pathways in Hodgkin's lymphoma cells

(2008) Gerardo G. Mackenzie et al.   INTERNATIONAL JOURNAL OF CANCER

Ligand-Based Targeting of Apoptosis in Cancer: The Potential of Recombinant Human Apoptosis Ligand 2/Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (rhApo2L/TRAIL)

(2008) Avi Ashkenazi et al.   JOURNAL OF CLINICAL ONCOLOGY

Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism

(2008) S. Yu et al.   MOLECULAR CANCER THERAPEUTICS

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE

Therapeutic Efficacy of Curcumin/TRAIL Combination Regimen for Hormone-Refractory Prostate Cancer

(2008) Tanja Andrzejewski et al.   ONCOLOGY RESEARCH

Inteferons pen the JAK–STAT pathway

(2008) Christian Schindler et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY