The Neddylation-Cullin 2-RBX1 E3 Ligase Axis Targets Tumor Suppressor RhoB for Degradation in Liver Cancer

Induction of p21-Dependent Senescence by an NAE Inhibitor, MLN4924, as a Mechanism of Growth Suppression

(2015) Lijun Jia et al.   NEOPLASIA

Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis

(2014) Hua Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Overactivated Neddylation Pathway as a Therapeutic Target in Lung Cancer

(2014) Lihui Li et al.   JNCI-Journal of the National Cancer Institute

Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases

(2013) Weihua Zhou et al.   CELL RESEARCH

Negative Regulation of NEDD8 Conjugation Pathway by Novel Molecules and Agents for Anticancer Therapy

(2013) Tomoaki Tanaka et al.   CURRENT PHARMACEUTICAL DESIGN

A Fast Workflow for Identification and Quantification of Proteomes

(2013) Chen Ding et al.   MOLECULAR & CELLULAR PROTEOMICS

Expression Loss and Revivification of RhoB Gene in Ovary Carcinoma Carcinogenesis and Development

(2013) Yingwei Liu et al.   PLoS One

Intratumoral IL-17+ Cells and Neutrophils show Strong Prognostic Significance in Intrahepatic Cholangiocarcinoma

(2012) Fang-Ming Gu et al.   ANNALS OF SURGICAL ONCOLOGY

Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells

(2012) Zhongguang Luo et al.   Autophagy

RhoB Differentially Controls Akt Function in Tumor Cells and Stromal Endothelial Cells during Breast Tumorigenesis

(2012) S. Kazerounian et al.   CANCER RESEARCH

The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth

(2012) Z. Luo et al.   CANCER RESEARCH

Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells

(2012) D Yang et al.   CELL DEATH AND DIFFERENTIATION

MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy

(2012) Steffan T Nawrocki et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A Strategy for Large-Scale Phosphoproteomics and SRM-Based Validation of Human Breast Cancer Tissue Samples

(2012) Ryohei Narumi et al.   JOURNAL OF PROTEOME RESEARCH

Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents

(2012) Y. Kee et al.   MOLECULAR CANCER RESEARCH

Inhibition of NEDD8-conjugation pathway by novel molecules: Potential approaches to anticancer therapy

(2012) Tomoaki Tanaka et al.   Molecular Oncology

WEE1 accumulation and deregulation of S-phase proteins mediate MLN4924 potent inhibitory effect on Ewing sarcoma cells

(2012) C Mackintosh et al.   ONCOGENE

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Targeting protein neddylation: a novel therapeutic strategy for the treatment of cancer

(2011) Meng Wang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation

(2011) Nieves Embade et al.   HEPATOLOGY

Stereoselective Synthesis of MLN4924, an Inhibitor of NEDD8-Activating Enzyme

(2011) Hyuk Woo Lee et al.   JOURNAL OF ORGANIC CHEMISTRY

DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy

(2011) Yongchao Zhao et al.   MOLECULAR CELL

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF- B-dependent lymphoma

(2010) M. A. Milhollen et al.   BLOOD

A distinct role of RhoB in gastric cancer suppression

(2010) Jitao Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Simultaneous analysis of relative protein expression levels across multiple samples using iTRAQ isobaric tags with 2D nano LC–MS/MS

(2010) Richard D Unwin et al.   Nature Protocols

Reactivation of Suppressed RhoB is a Critical Step for the Inhibition of Anaplastic Thyroid Cancer Growth

(2009) Laura A. Marlow et al.   CANCER RESEARCH

ROC1/RBX1 E3 Ubiquitin Ligase Silencing Suppresses Tumor Cell Growth via Sequential Induction of G2-M Arrest, Apoptosis, and Senescence

(2009) L. Jia et al.   CANCER RESEARCH

Loss of RhoB Expression Promotes Migration and Invasion of Human Bronchial Cells Via Activation of AKT1

(2009) E. Bousquet et al.   CANCER RESEARCH

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

(2009) Ji Luo et al.   CELL

E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification

(2009) Danny T. Huang et al.   MOLECULAR CELL

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

The C-Terminal Sequence of RhoB Directs Protein Degradation through an Endo-Lysosomal Pathway

(2009) Dolores Pérez-Sala et al.   PLoS One

Novel substrates and functions for the ubiquitin-like molecule NEDD8: Figure 1

(2008) Dimitris P. Xirodimas   BIOCHEMICAL SOCIETY TRANSACTIONS

In vivo restoration of RhoB expression leads to ovarian tumor regression

(2008) B Couderc et al.   CANCER GENE THERAPY

Structural Insights into E1-Catalyzed Ubiquitin Activation and Transfer to Conjugating Enzymes

(2008) Imsang Lee et al.   CELL

Function and regulation of protein neddylation. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Gwénaël Rabut et al.   EMBO REPORTS