Inhibition of NEDD8-conjugation pathway by novel molecules: Potential approaches to anticancer therapy

Biochemical and cellular effects of inhibiting Nedd8 conjugation

(2010) Yee Chin Leck et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF- B-dependent lymphoma

(2010) M. A. Milhollen et al.   BLOOD

Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia

(2010) R. T. Swords et al.   BLOOD

NUB1, an interferon-inducible protein, mediates anti-proliferative actions and apoptosis in renal cell carcinoma cells through cell-cycle regulation

(2010) T Hosono et al.   BRITISH JOURNAL OF CANCER

A Dual E3 Mechanism for Rub1 Ligation to Cdc53

(2010) Daniel C. Scott et al.   MOLECULAR CELL

miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression

(2010) T Murata et al.   PROSTATE CANCER AND PROSTATIC DISEASES

SnapShot: F Box Proteins I

(2009) Jeffrey R. Skaar et al.   CELL

Resolving the CSN and CAND1 Paradoxes

(2009) Wolfgang Dubiel   MOLECULAR CELL

CUL4A Abrogation Augments DNA Damage Response and Protection against Skin Carcinogenesis

(2009) Liren Liu et al.   MOLECULAR CELL

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Chemotherapy induces NEDP1-mediated destabilization of MDM2

(2009) I R Watson et al.   ONCOGENE

CRL4s: the CUL4-RING E3 ubiquitin ligases

(2009) Sarah Jackson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Function and regulation of protein neddylation. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Gwénaël Rabut et al.   EMBO REPORTS

WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase

(2008) J. Hu et al.   GENES & DEVELOPMENT

DEN1 deneddylates non-cullin proteins in vivo

(2008) Y. Chan et al.   JOURNAL OF CELL SCIENCE

Targeted inactivation of the COP9 signalosome impairs multiple stagesof T cell development

(2008) Martina Panattoni et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular mechanisms of Nrf2-mediated antioxidant response

(2008) Wenge Li et al.   MOLECULAR CARCINOGENESIS

Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation

(2008) Thimo Kurz et al.   MOLECULAR CELL

The CUL7 E3 Ubiquitin Ligase Targets Insulin Receptor Substrate 1 for Ubiquitin-Dependent Degradation

(2008) Xinsong Xu et al.   MOLECULAR CELL

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

(2008) Thomas F. Westbrook et al.   NATURE

Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma

(2008) Jesús F. San Miguel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of SCF Ubiquitin Ligase Substrates by Global Protein Stability Profiling

(2008) H.-C. S. Yen et al.   SCIENCE

Cullin-RING ubiquitin ligases: global regulation and activation cycles

(2008) Dimple R Bosu et al.   Cell Division