Review
Plant Sciences
Dania P. Lobaina, Roberto Tarazi, Tamara Castorino, Maite F. S. Vaslin
Summary: The ubiquitin-proteasome system (UPS) is crucial for maintaining cellular balance and plays a key role in DNA repair, gene transcription, and protein activation. Viruses often manipulate the UPS to maintain viral protein levels and evade host defenses. Understanding the mechanisms used by plant viruses to subvert host defenses is important for developing biotechnological approaches for viral resistance.
Article
Biochemistry & Molecular Biology
Zhongchen Ma, Ruirui Li, Ruirui Hu, Wei Zheng, Shuifa Yu, Kejian Cheng, Huan Zhang, Yangyang Xiao, Jihai Yi, Zhen Wang, Yong Wang, Chuangfu Chen
Summary: The study revealed that the effector protein AptA of Anaplasma phagocytophilum interacts with the host cell's proteasome assembly chaperone 3, enhancing proteasome activity and affecting ubiquitination and autophagy mechanisms, while also reducing the apoptotic efficiency of the host cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Dongun Lee, Jeong Hee Hong
Summary: This review discusses the relationship between the ubiquitin-proteasome system (UPS) and calcium (Ca2+) signaling, highlighting their critical roles in different tissue systems and the regulation between them.
Article
Oncology
Srirupa Bhattacharyya, Janet L. Oblinger, Roberta L. Beauchamp, Zhenzhen Yin, Serkan Erdin, Priya Koundinya, Anna D. Ware, Marc Ferrer, Justin T. Jordan, Scott R. Plotkin, Lei Xu, Long-Sheng Chang, Vijaya Ramesh
Summary: This study identifies a class of compounds targeting the ubiquitin-proteasome pathway (UPP) that have potent efficacy in treating NF2-associated tumors. These compounds reduce cell viability and induce apoptosis by downregulating c-KIT and PDGFR alpha expression and upregulating genes associated with endoplasmic reticulum stress-mediated activation of the unfolded protein response (UPR). In vivo models further demonstrate the therapeutic potential of these drugs.
Review
Oncology
Chee Wai Fhu, Azhar Ali
Summary: The UPS system regulates the non-lysosomal degradation of oxidized, damaged, or misfolded proteins through the activation and transfer of polyubiquitin chains to target proteins, which are then degraded by the 26S proteasome complex. UPS plays a crucial role in regulating protein levels to maintain fundamental cellular processes such as growth, division, signal transduction, and stress response. Dysregulation of UPS, resulting in loss of ability to maintain protein quality through proteolysis, is closely related to the development of various malignancies.
Review
Biochemistry & Molecular Biology
Dina Aweida, Shenhav Cohen
Summary: Protein degradation is essential for cellular integrity, with autophagy and the UPS being the main systems responsible for protein breakdown. Recent studies show that even complex protein structures can be efficiently degraded in vivo, with AAA-ATPases playing a crucial role in the disassembly process.
Article
Biochemistry & Molecular Biology
Radek Jorda, Veronika Molitorova, Eliska Pilarova, Veronika Vojackova, Eva Reznickova, Klara Svobodova, Karel Pauk, Ales Imramovsky, Vladimir Krystof
Summary: The comparative study examined new proteasome inhibitors based on salicylic acid-modified pseudo-tripeptides with aldehyde or vinylsulfone terminations. The study found that aldehydes were more effective than vinylsulfones in inhibiting proteasomes in cells, inducing the accumulation of polyubiquitinated proteins, GFP accumulation, and apoptotic cell death.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Anmol Sharma, Heena Khan, Thakur Gurjeet Singh, Amarjot Kaur Grewal, Agnieszka Najda, Malgorzata Kawecka-Radomska, Mohamed Kamel, Ahmed E. Altyar, Mohamed M. Abdel-Daim
Summary: The ubiquitin-proteasome pathway is crucial in regulating various biological functions and plays a significant role in tumor development. Inhibiting specific enzymes within this pathway can be an effective treatment for cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Fatemeh Aliabadi, Beheshteh Sohrabi, Ebrahim Mostafavi, Hamidreza Pazoki-Toroudi, Thomas J. Webster
Summary: Despite the potential of other cells to prevent cancer development, cancer cells can upregulate the ubiquitin-proteasome system (UPS) to degrade tumour suppressor proteins and avoid apoptosis. Understanding UPS inhibitors is crucial in controlling cancer development, with the need to improve inhibitors for more effective cancer therapy.
Article
Cell Biology
Lin Lyu, Zheng Chen, Nami McCarty
Summary: The study reveals TRIM44 as a novel link between the UPS system and autophagy pathway, which enhances aggregate protein clearance rate by promoting SQSTM1/p62 oligomerization and binding of K48 ubiquitin chains.
Article
Chemistry, Multidisciplinary
Zeqian Huang, Yong Luo, Tao Zhang, Yaqing Ding, Meixu Chen, Jie Chen, Qiuxing Liu, Yanjuan Huang, Chunshun Zhao
Summary: Selective activation of prodrugs is important for reducing the side effects of disease treatment. In this study, a metal-carrying prochelator concept was proposed, which can co-carry a metal ion and chelator within a small-molecule compound and synthesize a bioactive metal complex for targeted therapy. A H2O2-responsive small-molecule prochelator, DPBD, was designed and showed potent antitumor efficacy with low systemic toxicity by releasing chelator DTC and chelating Cu2+.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Cell Biology
Yanan Li, Shujing Li, Huijian Wu
Summary: Cells adapt to environmental stimuli by making changes to combat injury and increase stress tolerance. If the damage is too severe to repair, cells undergo apoptosis to protect the overall population. Protein aggregation can cause serious damage to the cells, but ubiquitin plays a crucial role in clearing these abnormal proteins. Dysregulation of ubiquitin-proteasome system and autophagy can lead to the development of diseases.
Review
Oncology
Grazia R. Tundo, Diego Sbardella, Francesco Oddone, Anna A. Kudriaeva, Pedro M. Lacal, Alexey A. Belogurov, Grazia Graziani, Stefano Marini
Summary: The immunoproteasome plays a crucial role in antigen presentation and its modulation presents promising research opportunities. Immunotherapy has shown significant advancements, however, a broader understanding of cancer cell antigen processing dynamics is still required for further improvements.
Review
Cell Biology
Satyendra Chandra Tripathi, Disha Vedpathak, Edwin Justin Ostrin
Summary: Cell-mediated immunity is driven by antigenic peptide presentation on major histocompatibility complex (MHC) molecules. Immunoproteasomes, with inducible activity by inflammatory stimuli, play central roles in cancer, autoimmunity, and inflammation by altering the catalytic activity of the proteasome.Understanding the roles of immunoproteasome in different cancers offers insights into developing targeted therapies.
Review
Pharmacology & Pharmacy
Jiabin Lu, He Zhao, Caini Yu, Yuanyuan Kang, Xiaochun Yang
Summary: Chemoresistance is a major challenge in tumor treatment, requiring further research on the mechanisms of tumor resistance. Deubiquitinases play a crucial role in preventing protein degradation and could be a potential target to overcome drug resistance in cancer therapies.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maricela Viola-Rhenals, Kush R. Patel, Laura Jaimes-Santamaria, Guojun Wu, Jinbao Liu, Q. Ping Dou
CURRENT MEDICINAL CHEMISTRY
(2018)
Review
Biochemistry & Molecular Biology
Hui Wang, Qingzhu Yang, Q. Ping Dou, Huanjie Yang
CURRENT PROTEIN & PEPTIDE SCIENCE
(2018)
Article
Chemistry, Medicinal
Valentina Gambini, Martina Tilio, Eunice Wairimu Maina, Cristina Andreani, Caterina Bartolacci, Junbiao Wang, Manuela Iezzi, Stefano Ferraro, Anna Teresa Ramadori, Oumarou Camille Simon, Stefania Pucciarelli, Guojun Wu, Q. Ping Dou, Cristina Marchini, Rossana Galassi, Augusto Amici
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Ling Wu, Fanyan Meng, Lun Dong, C. James Block, Allison V. Mitchell, Jason Wu, Hyejeong Jang, Wei Chen, Lisa Polin, Qifeng Yang, Q. Ping Dou, Guojun Wu
SCIENTIFIC REPORTS
(2019)
Editorial Material
Pharmacology & Pharmacy
Feng Li, Yongli Wang, Dapeng Li, Yilun Chen, Q. Ping Dou
EXPERT OPINION ON DRUG DISCOVERY
(2019)
Review
Oncology
Elmira Ekinci, Sagar Rohondia, Raheel Khan, Qingping P. Dou
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
(2019)
Editorial Material
Nutrition & Dietetics
Q. Ping Dou
Article
Biochemistry & Molecular Biology
Isel Castro, Elmira Ekinci, Xuemei Huang, Hassan Ali Cheaito, Young-Hoon Ahn, Jesus Olivero-Verbel, Q. Ping Dou
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Review
Pharmacology & Pharmacy
Qingzhu Yang, Yao Yao, Kai Li, Lin Jiao, Jiazhen Zhu, Cheng Ni, Mengmeng Li, Q. Ping Dou, Huanjie Yang
CURRENT PHARMACEUTICAL DESIGN
(2019)
Article
Oncology
Xiaohong Xia, Yuning Lioa, Chuyi Huang, Yuan Liu, Jinchan He, Zhenlong Shao, Lin Jiang, Q. Ping Dou, Jinbao Liu, Hongbiao Huang
Article
Oncology
Liling Jiang, Yuening Sun, Jinxiang Wang, Qingyan He, Xinmei Chen, Xiaoying Lan, Jinghong Chen, Q. Ping Dou, Xianping Shi, Jinbao Liu
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Review
Oncology
Raheel Khan, Harras Khan, Yassen Abdullah, Q. Ping Dou
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
(2020)
Review
Oncology
Huanjie Yang, Xin Chen, Kai Li, Hassan Cheaito, Qianqian Yang, Guojun Wu, Jinbao Liu, Q. Ping Dou
Summary: The ubiquitin-proteasome system (UPS) is crucial in cellular protein degradation, and targeted protein degradation has been proven effective in cancer therapy. 20S proteasome inhibitors have been FDA-approved for multiple myeloma treatment, but face limitations like drug resistance. Repurposing old drugs with UPS-inhibitory properties as new anticancer agents is a strategy to improve current cancer treatment methods.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Liling Jiang, Chuangyu Wen, Qingyan He, Yuening Sun, Jinxiang Wang, Xiaoying Lan, Sagar Rohondia, Q. Ping Dou, Xianping Shi, Jinbao Liu
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Review
Pharmacology & Pharmacy
Feng Li, Yongli Wang, Dapeng Li, Yilun Chen, Xuguang Qiao, Rania Fardous, Ashton Lewandowski, Jinbao Liu, Tak-Hang Chan, Q. Ping Dou
EXPERT OPINION ON DRUG DISCOVERY
(2018)