Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules

New and Unexpected Insights into the Modulation of LuxR-Type Quorum Sensing by Cyclic Dipeptides

(2009) Jennifer Campbell et al.   ACS Chemical Biology

Novel compound with potential of an antibacterial drug targets FtsZ protein

(2009) Dipak Dasgupta   BIOCHEMICAL JOURNAL

Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position

(2009) Stanislaw F. Wnuk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery and structure–activity relationship analysis of Staphylococcus aureus sortase A inhibitors

(2009) Nuttee Suree et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of Pseudomonas aeruginosa quorum sensing by AI-2 analogs

(2009) Hadas Ganin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A naturally occurring brominated furanone covalently modifies and inactivates LuxS

(2009) Tianzhu Zang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology

(2009) Tsai-Tien Tseng et al.   BMC MICROBIOLOGY

LsrR-binding site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing

(2009) Ting Xue et al.   CELL RESEARCH

Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

(2009) Jacqueline A. I. Smith et al.   CHEMICAL COMMUNICATIONS

Efforts towards the Identification of Simpler Platensimycin Analogues-The Total Synthesis of Oxazinidinyl Platensimycin

(2009) Jingxin Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biological activity and identification of a peptide inhibitor of LuxS fromStreptococcus suisserotype 2

(2009) Xiangan Han et al.   FEMS MICROBIOLOGY LETTERS

Selective Toxin Sequestrants for the Treatment of Bacterial Infections

(2009) Levi S. Simpson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Syntheses of (±)-Platencin and (−)-Platencin

(2009) K. C. Nicolaou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiostrepton Biosynthesis: Prototype for a New Family of Bacteriocins

(2009) Wendy L. Kelly et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Quorum-Sensing Antagonist Targets Both Membrane-Bound and Cytoplasmic Receptors and Controls Bacterial Pathogenicity

(2009) Lee R. Swem et al.   MOLECULAR CELL

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

(2009) Sophie Brinster et al.   NATURE

The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA

(2009) Robert C Kelly et al.   Nature Chemical Biology

Transition state analogs of 5′-methylthioadenosine nucleosidase disrupt quorum sensing

(2009) Jemy A Gutierrez et al.   Nature Chemical Biology

2008 FDA drug approvals

(2009) Bethan Hughes   NATURE REVIEWS DRUG DISCOVERY

Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge

(2009) Cesar A. Arias et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis and Antibacterial Properties of (−)-nor-Platencin

(2009) Olga V. Barykina et al.   ORGANIC LETTERS

A synthesis of sulfonamide analogs of platensimycin employing a palladium-mediated carbonylation strategy

(2009) James McNulty et al.   TETRAHEDRON LETTERS

Connecting Quorum Sensing, c-di-GMP, Pel Polysaccharide, and Biofilm Formation in Pseudomonas aeruginosa through Tyrosine Phosphatase TpbA (PA3885)

(2009) Akihiro Ueda et al.   PLoS Pathogens

Construction and Screening of a 2‐Aminoimidazole Library Identifies a Small Molecule Capable of Inhibiting and Dispersing Bacterial Biofilms across Order, Class, and Phylum

(2008) Steven A. Rogers et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Brominated Furanones Inhibit Biofilm Formation by Salmonella enterica Serovar Typhimurium

(2008) J. C. A. Janssens et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa

(2008) Zhirui Zeng et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

LuxS-independent formation of AI-2 from ribulose-5-phosphate

(2008) Timothy J Tavender et al.   BMC MICROBIOLOGY

Inhibition and dispersion of proteobacterial biofilms

(2008) Justin J. Richards et al.   CHEMICAL COMMUNICATIONS

Towards quorum-quenching catalytic antibodies

(2008) Prashant B. Kapadnis et al.   CHEMICAL COMMUNICATIONS

Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria

(2008) Grant D. Geske et al.   CHEMICAL SOCIETY REVIEWS

The type VI secretion toolkit

(2008) Eric Cascales   EMBO REPORTS

Quorum Sensing Controls Biofilm Formation in Vibrio cholerae through Modulation of Cyclic Di-GMP Levels and Repression of vpsT

(2008) C. M. Waters et al.   JOURNAL OF BACTERIOLOGY

A Fatty Acid Messenger Is Responsible for Inducing Dispersion in Microbial Biofilms

(2008) D. G. Davies et al.   JOURNAL OF BACTERIOLOGY

β-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors ofStaphylococcus aureus

(2008) Thomas Böttcher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Unexpected Switch in the Modulation of AI-2-Based Quorum Sensing Discovered through Synthetic 4,5-Dihydroxy-2,3-pentanedione Analogues

(2008) Colin A. Lowery et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Probing the Catalytic Mechanism ofS-Ribosylhomocysteinase (LuxS) with Catalytic Intermediates and Substrate Analogues

(2008) Bhaskar Gopishetty et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibitors and antagonists of bacterial quorum sensing

(2008) Nanting Ni et al.   MEDICINAL RESEARCH REVIEWS

A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues

(2008) Irene Kiburu et al.   Molecular BioSystems

Discovery of a Quorum-Sensing Inhibitor of Drug-Resistant Staphylococcal Infections by Structure-Based Virtual Screening

(2008) M. D. Kiran et al.   MOLECULAR PHARMACOLOGY

2007 FDA drug approvals: a year of flux

(2008) Bethan Hughes   NATURE REVIEWS DRUG DISCOVERY

Inter-kingdom signalling: communication between bacteria and their hosts

(2008) David T. Hughes et al.   NATURE REVIEWS MICROBIOLOGY

Targeting QseC Signaling and Virulence for Antibiotic Development

(2008) D. A. Rasko et al.   SCIENCE