Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation

Mature Dendritic Cells Express Functional Thrombin Receptors Triggering Chemotaxis and CCL18/Pulmonary and Activation-Regulated Chemokine Induction

(2014) X. Li et al.   JOURNAL OF IMMUNOLOGY

Neutrophil-mediated Activation of Epithelial Protease-Activated Receptors-1 and -2 Regulates Barrier Function and Transepithelial Migration

(2014) A. C. Chin et al.   JOURNAL OF IMMUNOLOGY

Protease Activity Enhances Production of Thymic Stromal Lymphopoietin and Basophil Accumulation in Flaky Tail Mice

(2013) Catharina S. Moniaga et al.   AMERICAN JOURNAL OF PATHOLOGY

Netherton syndrome: skin inflammation and allergy by loss of protease inhibition

(2013) Alain Hovnanian   CELL AND TISSUE RESEARCH

Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

(2013) Junxian Lim et al.   FASEB JOURNAL

Mast Cell Tryptase Induces Eosinophil Recruitment in the Pleural Cavity of Mice via Proteinase-Activated Receptor 2

(2013) Natália A. Matos et al.   INFLAMMATION

Thrombin promotes airway remodeling via protease-activated receptor-1 and transforming growth factor-β1 in ovalbumin-allergic rats

(2013) Weiwei Zhu et al.   INHALATION TOXICOLOGY

Protease-activated receptor-2 deficient mice have reduced house dust mite-evoked allergic lung inflammation

(2013) J Daan de Boer et al.   Innate Immunity

Activation of Protease-Activated Receptor 2-Mediated Signaling by Mast Cell Tryptase Modulates Cytokine Production in Primary Cultured Astrocytes

(2013) Xiaoning Zeng et al.   MEDIATORS OF INFLAMMATION

Neutrophil elastase induces MUC5AC secretion via protease-activated receptor 2

(2013) Jia Zhou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Expression, function and cooperating partners of protease-activated receptor type 3 in vascular endothelial cells and B lymphocytes studied with specific monoclonal antibody

(2013) Olena Kalashnyk et al.   MOLECULAR IMMUNOLOGY

Stimulation of Naïve Monocytes and PBMCs with Coagulation Proteases Results in Thrombin-Mediated and PAR-1-Dependent Cytokine Release and Cell Proliferation in PBMCs Only

(2013) L. Nieuwenhuizen et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Role of YKL-40 in Bronchial Smooth Muscle Remodeling in Asthma

(2012) Imane Bara et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Suppression of Connexin 26 is Related to Protease-Activated Receptor 2–Mediated Pathway in Patients with Allergic Rhinitis

(2012) Jing Zheng et al.   American Journal of Rhinology & Allergy

Modulation of PAR expression and tryptic enzyme induced IL-4 production in mast cells by IL-29

(2012) Huiyun Zhang et al.   CYTOKINE

An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

(2012) Rink-Jan Lohman et al.   FASEB JOURNAL

AlternariaFungus Induces the Production of GM-CSF, Interleukin-6 and Interleukin-8 and Calcium Signaling in Human Airway Epithelium through Protease-Activated Receptor 2

(2012) Yoshinori Matsuwaki et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Matrix Metalloproteinase-1-mediated Up-regulation of Vascular Endothelial Growth Factor-2 in Endothelial Cells

(2012) Rafi Mazor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Effector Function of CD8+ T Cells From Healthy Controls and HIV-Infected Patients Occurs Through Thrombin Activation of Protease-Activated Receptor 1

(2012) Amanda Hurley et al.   JOURNAL OF INFECTIOUS DISEASES

The role of protease-activated receptor-2 on pulmonary neutrophils in the innate immune response to cockroach allergen

(2012) Riad Lutfi et al.   Journal of Inflammation-London

Physiology, pharmacology, and therapeutic potential of protease-activated receptors in vascular disease

(2012) Hannah Lee et al.   PHARMACOLOGY & THERAPEUTICS

A novel function of FoxO transcription factors in thrombin-stimulated vascular smooth muscle cell proliferation

(2012) Shailaja Mahajan et al.   THROMBOSIS AND HAEMOSTASIS

Protease Activated Receptor-2 Mediates Activated Protein C–Induced Cutaneous Wound Healing via Inhibition of p38

(2011) Sohel M. Julovi et al.   AMERICAN JOURNAL OF PATHOLOGY

UV-B Radiation Induces Macrophage Migration Inhibitory Factor–Mediated Melanogenesis through Activation of Protease-Activated Receptor-2 and Stem Cell Factor in Keratinocytes

(2011) Akiko Enomoto et al.   AMERICAN JOURNAL OF PATHOLOGY

Alternaria alternata serine proteases induce lung inflammation and airway epithelial cell activation via PAR2

(2011) Scott Boitano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Role of Thrombin in Chronic Rhinosinusitis–associated Tissue Remodeling

(2011) Shino Shimizu et al.   American Journal of Rhinology & Allergy

Increased expression of protease-activated receptor 1 (PAR-1) in human leukemias

(2011) Camilla de S.B. Veiga et al.   BLOOD CELLS MOLECULES AND DISEASES

Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110)

(2011) JY Suen et al.   BRITISH JOURNAL OF PHARMACOLOGY

House dust mite potentiates capsaicin-evoked Ca2+transients in mouse pulmonary sensory neurons via activation of protease-activated receptor-2

(2011) Qihai Gu et al.   EXPERIMENTAL PHYSIOLOGY

Protease-activated receptor 2–dependent fluid secretion from airway submucosal glands by house dust mite extract

(2011) Hyung-Ju Cho et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

German Cockroach Proteases and Protease-Activated Receptor-2 Regulate Chemokine Production and Dendritic Cell Recruitment

(2011) Scottie B. Day et al.   Journal of Innate Immunity

Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activated feed-back loop in visceral inflammatory pain

(2011) A. Annaházi et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Protease activated receptor 4 status of mast cells in post infectious irritable bowel syndrome

(2011) W. Han et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Allergic sensitization enhances anion current responsiveness of murine trachea to PAR-2 activation

(2011) Juraj Rievaj et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through  -arrestin and dishevelled-2 scaffolds

(2011) U. J. K. Soh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Properties and Proinflammatory Functions of Cockroach Allergens Per a 1.01s

(2011) S. He et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The roles of thrombin and protease-activated receptors in inflammation

(2011) Liang Ma et al.   Seminars in Immunopathology

Differential expression of protease-activated receptors in monocytes from patients with primary antiphospholipid syndrome

(2010) Chary López-Pedrera et al.   ARTHRITIS AND RHEUMATISM

PAR1- and PAR2-induced innate immune markers are negatively regulated by PI3K/Akt signaling pathway in oral keratinocytes

(2010) Maryam G Rohani et al.   BMC IMMUNOLOGY

TNF Increases Expression of IL-4 and PARs in Mast Cells

(2010) Huiyun Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The role of protease-activated receptors PAR-1 and PAR-2 in the repair of 16HBE 14o−epithelial cell monolayersin vitro

(2010) D. Ewen et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Induction of IL-13 production and upregulated expression of protease activated receptor-1 by RANTES in a mast cell line

(2010) Huiyun Zhang et al.   CYTOKINE

House dust mite extract downregulates C/EBP  in asthmatic bronchial smooth muscle cells

(2010) N. Miglino et al.   EUROPEAN RESPIRATORY JOURNAL

Epidermal growth factor receptor signalling contributes to house dust mite-induced epithelial barrier dysfunction

(2010) I. H. Heijink et al.   EUROPEAN RESPIRATORY JOURNAL

Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice

(2010) Marta Dabek et al.   INFLAMMATORY BOWEL DISEASES

House dust mite extract activates apical Cl−channels through protease-activated receptor 2 in human airway epithelia

(2010) Hyung-Ju Cho et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Human cytomegalovirus increases HUVEC sensitivity to thrombin and modulates expression of thrombin receptors

(2010) Milan Popović et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Role of enteric nerves in immune-mediated changes in protease-activated receptor 2 effects on gut function

(2010) T. Shea-donohue et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Induction of IL-6 and IL-8 by House Dust Mite Allergen Der p1 in Cultured Human Nasal Epithelial Cells Is Associated with PAR/PI3K/NFĸB Signaling

(2010) Jianbo Shi et al.   ORL-Journal for Oto-Rhino-Laryngology Head and Neck Surgery

Thrombin receptors in vascular smooth muscle cells – function and regulation by vasodilatory prostaglandins

(2010) Ellen Bretschneider et al.   THROMBOSIS AND HAEMOSTASIS

Protease and Protease-Activated Receptor-2 Signaling in the Pathogenesis of Atopic Dermatitis

(2010) Sang Eun Lee et al.   YONSEI MEDICAL JOURNAL

Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes

(2009) T. Kato et al.   ALLERGY

Luminal Cathepsin G and Protease-Activated Receptor 4

(2009) Marta Dabek et al.   AMERICAN JOURNAL OF PATHOLOGY

Participation of Proteinase-Activated Receptor-2 in Passive Cutaneous Anaphylaxis-Induced Scratching Behavior and the Inhibitory Effect of Tacrolimus

(2009) Yu Zhu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Downregulation of protease activated receptor expression and cytokine production in P815 cells by RNA interference

(2009) Liya Qiao et al.   BMC CELL BIOLOGY

Regulation of protease-activated receptor-2 expression in gingival fibroblasts and Jurkat T cells byPorphyromonas gingivalis

(2009) Georgios N Belibasakis et al.   CELL BIOLOGY INTERNATIONAL

Induction of IL-4 release and upregulated expression of protease activated receptors by GM-CSF in P815 cells

(2009) Huiyun Zhang et al.   CYTOKINE

Endosomal Deubiquitinating Enzymes Control Ubiquitination and Down-regulation of Protease-activated Receptor 2

(2009) Burcu Hasdemir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of blood coagulation factors on monocytes after exposure to TNF-treated endothelium in a novel whole blood model of arterial flow

(2009) Marion G. Macey et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Recognition of Fungal Protease Activities Induces Cellular Activation and Eosinophil-Derived Neurotoxin Release in Human Eosinophils

(2009) Y. Matsuwaki et al.   JOURNAL OF IMMUNOLOGY

Pravastatin prevents miscarriages in antiphospholipid antibody-treated mice

(2009) Guillermina Girardi   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Cleavage of protease-activated receptors on an immortalized oral epithelial cell line by Porphyromonas gingivalis gingipains

(2009) R. A. Giacaman et al.   MICROBIOLOGY-SGM

Protease-activated receptor-4 (PAR4): a role as inhibitor of visceral pain and hypersensitivity

(2009) c. augé et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice

(2009) Anita Annaházi et al.   PAIN

Chitinase Activates Protease-Activated Receptor-2 in Human Airway Epithelial Cells

(2008) Jeong Hee Hong et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Plasmin is involved in inflammation via protease-activated receptor-1 activation in human dental pulp

(2008) Naoto Kamio et al.   BIOCHEMICAL PHARMACOLOGY

Effects of Topical Application of Tacrolimus on Acute Itch-Associated Responses in Mice

(2008) Tasuku Nakano et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

PKC isoenzymes differentially modulate the effect of thrombin on MAPK-dependent RPE proliferation

(2008) Jose P. Palma-Nicolas et al.   BIOSCIENCE REPORTS

Downregulation of protease-activated receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin E2 receptor EP2 through cAMP elevation and protein kinase A

(2008) Elena Sokolova et al.   FEBS Journal

Coordinate Activation of Human Platelet Protease-activated Receptor-1 and -4 in Response to Subnanomolar α-Thrombin

(2008) Frederick A. Ofosu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CUX1 Transcription Factor Is a Downstream Effector of the Proteinase-activated Receptor 2 (PAR2)

(2008) Brian J. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potential role of protease-activated receptor-2-stimulated activation of cytosolic phospholipase A2 in intestinal myofibroblast proliferation: Implications for stricture formation in Crohn's disease

(2008) Ulrika Christerson et al.   Journal of Crohns & Colitis

Mite and Cockroach Allergens Activate Protease-Activated Receptor 2 and Delay Epidermal Permeability Barrier Recovery

(2008) Se Kyoo Jeong et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration

(2008) Milan Popovic et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Protease-activated receptor 2 and gut permeability: a review

(2008) l. bueno et al.   NEUROGASTROENTEROLOGY AND MOTILITY

THE p38 MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY PLAYS A CRITICAL ROLE IN PAR2-INDUCED ENDOTHELIAL IL-8 PRODUCTION AND LEUKOCYTE ADHESION

(2008) Shiow L. Pan et al.   SHOCK

INDUCTION OF INFLAMMATORY CYTOKINE RELEASE FROM HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS BY AGONISTS OF PROTEINASE-ACTIVATED RECEPTOR-2

(2007) Qing-Xia Niu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY