The bitter side of sweet: the role of Galectin-9 in immunopathogenesis of viral infections

Galectin-9 Is Rapidly Released During Acute HIV-1 Infection and Remains Sustained at High Levels Despite Viral Suppression Even in Elite Controllers

(2014) Ravi Tandon et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Galectin-1 and -9 in angiogenesis: A sweet couple

(2014) V. L. Thijssen et al.   GLYCOBIOLOGY

Galectin-9-CD44 Interaction Enhances Stability and Function of Adaptive Regulatory T Cells

(2014) Chuan Wu et al.   IMMUNITY

Galectin-9 controls the therapeutic activity of 4-1BB–targeting antibodies

(2014) Shravan Madireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions

(2014) K. Nagahara et al.   JOURNAL OF IMMUNOLOGY

Human Cytomegalovirus Upregulates Expression of the Lectin Galectin 9 via Induction of Beta Interferon

(2014) B. P. McSharry et al.   JOURNAL OF VIROLOGY

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

(2014) Yu-Hwa Huang et al.   NATURE

Increased Levels of Plasma Galectin-9 in Patients with Influenza Virus Infection

(2014) Shigeki Katoh et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Liver-primed CD8+T cells suppress antiviral adaptive immunity through galectin-9-independent T-Cell immunoglobulin and mucin 3 engagement of high-mobility group box 1 in mice

(2013) Joseph S. Dolina et al.   HEPATOLOGY

Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection

(2013) Haorile Chagan-Yasutan et al.   JOURNAL OF CLINICAL VIROLOGY

Galectin-9 Functionally Impairs Natural Killer Cells in Humans and Mice

(2013) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Galectin-9 and IL-21 Mediate Cross-regulation between Th17 and Treg Cells during Acute Hepatitis C

(2013) Hassen Kared et al.   PLoS Pathogens

CD40 Activation Rescues Antiviral CD8+ T Cells from PD-1-Mediated Exhaustion

(2013) Masanori Isogawa et al.   PLoS Pathogens

Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity

(2012) L. C. Ndhlovu et al.   BLOOD

Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9

(2012) M. K. Gleason et al.   BLOOD

High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control

(2012) Z. M. Ndhlovu et al.   BLOOD

Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection

(2012) S. Elahi et al.   BLOOD

Association of HLA-alleles with the immune regulation of chronic viral infections

(2012) Shokrollah Elahi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Upregulation of the Tim-3/Galectin-9 Pathway of T Cell Exhaustion in Chronic Hepatitis B Virus Infection

(2012) Gaia Nebbia et al.   PLoS One

Rapid Decrease of Plasma Galectin-9 Levels in Patients with Acute HIV Infection after Therapy

(2012) Hiroki Saitoh et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal epithelial cells express galectin-9 in patients with food allergy that plays a critical role in sustaining allergic status in mouse intestine

(2011) X. Chen et al.   ALLERGY

Galectin-9 ameliorates herpes simplex virus-induced inflammation through apoptosis

(2011) Ju A. Shim et al.   IMMUNOBIOLOGY

T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy

(2011) Laura M. Snell et al.   IMMUNOLOGICAL REVIEWS

CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21

(2011) Huabiao Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Influence of Galectin-9/Tim-3 Interaction on Herpes Simplex Virus-1 Latency

(2011) P. B. J. Reddy et al.   JOURNAL OF IMMUNOLOGY

The Role of LAT in Increased CD8+ T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1

(2011) S. J. Allen et al.   JOURNAL OF VIROLOGY

A siege of hepatitis: Immune boost for viral hepatitis

(2011) Benoît Callendret et al.   NATURE MEDICINE

Protective HIV-specific CD8+ T cells evade Treg cell suppression

(2011) Shokrollah Elahi et al.   NATURE MEDICINE

T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses

(2011) S. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry

(2011) S. Bi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-9 induces osteoblast differentiation through the CD44/Smad signaling pathway

(2010) Rena Tanikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human cytomegalovirus latent infection and associated viral gene expression

(2010) Barry Slobedman et al.   Future Microbiology

Galectin-9 regulates T helper cell function independently of Tim-3

(2010) E. W. Su et al.   GLYCOBIOLOGY

Tim3 binding to galectin-9 stimulates antimicrobial immunity

(2010) Pushpa Jayaraman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor Necrosis Factor Receptor/Tumor Necrosis Factor Family Members in Antiviral CD8 T-Cell Immunity

(2010) Shahram Salek-Ardakani et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways

(2010) T Kobayashi et al.   LEUKEMIA

The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity

(2010) Yurong Li et al.   MOLECULAR IMMUNOLOGY

A Crucial Role for Kupffer Cell-Derived Galectin-9 in Regulation of T Cell Immunity in Hepatitis C Infection

(2010) John A. Mengshol et al.   PLoS One

Galectin-9/TIM-3 Interaction Regulates Virus-Specific Primary and Memory CD8+ T Cell Response

(2010) Sharvan Sehrawat et al.   PLoS Pathogens

Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions: A potent therapeutic tool for Th1- and/or Th17-mediated skin inflammation

(2009) Haruna Niwa et al.   CLINICAL IMMUNOLOGY

Dengue Virus Pathogenesis: an Integrated View

(2009) B. E. E. Martina et al.   CLINICAL MICROBIOLOGY REVIEWS

Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice

(2009) Feng-Cheng Chou et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Galectins in innate immunity: dual functions of host soluble β-galactoside-binding lectins as damage-associated molecular patterns (DAMPs) and as receptors for pathogen-associated molecular patterns (PAMPs)

(2009) Sachiko Sato et al.   IMMUNOLOGICAL REVIEWS

Galectin-9 Is a High Affinity IgE-binding Lectin with Anti-allergic Effect by Blocking IgE-Antigen Complex Formation

(2009) Toshiro Niki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Tim-3/Galectin-9 Inhibitory Interaction in Viral-Induced Immunopathology: Shifting the Balance toward Regulators

(2009) S. Sehrawat et al.   JOURNAL OF IMMUNOLOGY

The CDK Inhibitor p21Cip1/WAF1 Is Induced by Fc R Activation and Restricts the Replication of Human Immunodeficiency Virus Type 1 and Related Primate Lentiviruses in Human Macrophages

(2009) A. Bergamaschi et al.   JOURNAL OF VIROLOGY

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

Roles of galectins in infection

(2009) Gerardo R. Vasta   NATURE REVIEWS MICROBIOLOGY

Persistent Elevation of Plasma Osteopontin Levels in HIV Patients Despite Highly Active Antiretroviral Therapy

(2009) Haorile Chagan-Yasutan et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

The Galectin Profile of the Endothelium

(2008) Victor L. Thijssen et al.   AMERICAN JOURNAL OF PATHOLOGY

Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

(2008) Masako Seki et al.   CLINICAL IMMUNOLOGY

Tuning Microenvironments: Induction of Regulatory T Cells by Dendritic Cells

(2008) Yasmine Belkaid et al.   IMMUNITY

Structural Features of Galectin-9 and Galectin-1 That Determine Distinct T Cell Death Pathways

(2008) Shuguang Bi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protein-glycan interactions in the control of innate and adaptive immune responses

(2008) Yvette van Kooyk et al.   NATURE IMMUNOLOGY

Noncytotoxic Lytic Granule-Mediated CD8+ T Cell Inhibition of HSV-1 Reactivation from Neuronal Latency

(2008) J. E. Knickelbein et al.   SCIENCE