Liver-primed CD8+T cells suppress antiviral adaptive immunity through galectin-9-independent T-Cell immunoglobulin and mucin 3 engagement of high-mobility group box 1 in mice

IL-10: The Master Regulator of Immunity to Infection

(2014) Kevin N. Couper et al.   JOURNAL OF IMMUNOLOGY

Human Circulating CD4+CD25highFoxp3+ Regulatory T Cells Kill Autologous CD8+ but Not CD4+ Responder Cells by Fas-Mediated Apoptosis

(2014) L. Strauss et al.   JOURNAL OF IMMUNOLOGY

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

(2013) Clifford S Guy et al.   NATURE IMMUNOLOGY

Tim-3 Pathway Controls Regulatory and Effector T Cell Balance during Hepatitis C Virus Infection

(2012) J. P. Moorman et al.   JOURNAL OF IMMUNOLOGY

Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

(2012) Shigeki Chiba et al.   NATURE IMMUNOLOGY

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion

(2012) Manu Rangachari et al.   NATURE MEDICINE

Galectin-9 and T Cell Immunoglobulin Mucin-3 Pathway Is a Therapeutic Target for Type 1 Diabetes

(2011) Motoko Kanzaki et al.   ENDOCRINOLOGY

Granzyme B Regulates Antiviral CD8+ T Cell Responses

(2011) S. M. Salti et al.   JOURNAL OF IMMUNOLOGY

Hepatitis C Virus Infection Is Blocked by HMGB1 Released from Virus-Infected Cells

(2011) J. H. Jung et al.   JOURNAL OF VIROLOGY

A siege of hepatitis: Immune boost for viral hepatitis

(2011) Benoît Callendret et al.   NATURE MEDICINE

CD8+T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice

(2011) Hye-Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Liver as a Lymphoid Organ

(2009) Ian Nicholas Crispe   Annual Review of Immunology

The costimulatory role of TIM molecules

(2009) Roselynn Rodriguez-Manzanet et al.   IMMUNOLOGICAL REVIEWS

Immune tolerance: What is unique about the liver

(2009) Gisa Tiegs et al.   JOURNAL OF AUTOIMMUNITY

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

(2009) Brian T Fife et al.   NATURE IMMUNOLOGY

Liver Is Able to Activate Naïve CD8+ T Cells with Dysfunctional Anti-Viral Activity in the Murine System

(2009) John R. Lukens et al.   PLoS One

High mobility group box chromosomal protein 1 acts as a proliferation signal for activated T lymphocytes

(2008) Erik Sundberg et al.   IMMUNOBIOLOGY

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(2008) John Klune et al.   MOLECULAR MEDICINE