Review
Pharmacology & Pharmacy
Si-Min Qi, Jinyun Dong, Zhi-Yuan Xu, Xiang-Dong Cheng, Wei-Dong Zhang, Jiang-Jiang Qin
Summary: PROTAC technology is an effective method for degrading target proteins through the ubiquitin-proteasome system, with promising applications in cancer treatment. The first oral PROTACs have shown encouraging results in clinical trials, sparking greater enthusiasm for PROTAC research.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Nobumichi Ohoka, Masanori Suzuki, Takuya Uchida, Genichiro Tsuji, Yoshinori Tsukumo, Masayuki Yoshida, Takao Inoue, Yosuke Demizu, Hitoshi Ohki, Mikihiko Naito
Summary: In this study, novel FLT3 degraders were developed by introducing an FDA-approved FLT3 inhibitor, gilteritinib, into targeted protein degradation technology. The most active compound, CRBN(FLT3)-8, potently degraded FLT3-ITD via the ubiquitin-proteasome system and effectively inhibited the proliferation of AML cells.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Oncology
Moyang Lv, Weichao Hu, Shengwei Zhang, Lijiao He, Changjiang Hu
Summary: Proteolysis-targeting chimeras (PROTACs) are a promising class of drugs that can effectively target undruggable proteins and have potential applications in cancer therapy. This review provides an overview of PROTAC technology and highlights recent clinical trials, as well as novel findings and strategies to enhance PROTAC antitumor activity.
Review
Biochemistry & Molecular Biology
Carolyn Allain Breckel, Mark Hochstrasser
Summary: The proper folding of proteins is vital for their diverse functions, and misfolded proteins can potentially harm cells by forming aggregates. Protein quality control pathways are responsible for repairing or degrading abnormal proteins, with the ubiquitin-proteasome system being commonly employed.
Review
Biochemistry & Molecular Biology
David C. Hughes, Leslie M. Baehr, David S. Waddell, Adam P. Sharples, Sue C. Bodine
Summary: The development and prevalence of diseases associated with aging have a global health burden on society. One hallmark of aging is the loss of proteostasis, partly caused by alterations to the ubiquitin-proteasome system and lysosome-autophagy system, leading to impaired function and maintenance of mass in tissues such as skeletal muscle. In skeletal muscle, functional impairment occurs early in the aging process and depends on proteostatic mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tommaso Palomba, Massimo Baroni, Simon Cross, Gabriele Cruciani, Lydia Siragusa
Summary: Proteolysis-targeting chimeras (PROTACs) are novel therapeutics that utilize E3 ligases to degrade target proteins. Existing databases on E3 ligases have limited information on their structures and ligands. This study presents an accurate and comprehensive platform, ELIOT, to navigate and select new E3 ligases and ligands for the design of new PROTACs.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Multidisciplinary Sciences
Yawei Ru, Xiaojie Yan, Bing Zhang, Lili Song, Qiqi Feng, Chen Ye, Zhili Zhou, Zhenzhen Yang, Yao Li, Zhenjian Zhang, Qianqian Li, Wenyi Mi, Cheng Dong
Summary: In this study, a new C-degron pathway, called the Gln/C-degron pathway, was discovered. The B30.2 domain of TRIM7 mediates the recognition of proteins with a C-terminal glutamine. The C-terminal residues of the substrate play a crucial role in C-degron recognition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Lydia Qian, Laura J. Sharpe, Akira Gokool, Irina Voineagu, Andrew J. Brown
Summary: Circular RNAs (circRNAs) have various functions, and the MARCHF6 circRNA plays a crucial role in cholesterol homeostasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Review
Biochemistry & Molecular Biology
Na Yang, Bo Kong, Zhaohong Zhu, Fei Huang, Liliang Zhang, Tao Lu, Yadong Chen, Yanmin Zhang, Yulei Jiang
Summary: Targeted protein degradation (TPD) technology, such as PROTACs, has become widespread in the past 20 years and greatly accelerates the development of disease treatment. Unlike small inhibitors, targeted protein degraders can target undruggable targets and overcome drug resistance through ubiquitin-proteasome pathway (UPP) and lysosome pathway. This review discusses different degradation technologies and provides a basis for future research.
MOLECULAR DIVERSITY
(2023)
Review
Cell Biology
Yosup Kim, Eun-Kyung Kim, Yoona Chey, Min-Jeong Song, Ho Hee Jang
Summary: The proteasome is a multi-catalytic protease complex that regulates protein quality control. It selectively degrades cellular proteins through ubiquitination and plays a critical role in maintaining protein homeostasis. This article summarizes the proteasome's structure, regulatory mechanisms, proteins that control its activity, and its involvement in various diseases, chemoresistant cells, and cancer stem cells. Potential therapeutic modalities that target the ubiquitin-proteasome system are also discussed.
Review
Cell Biology
Emanuela Senatore, Rosa Iannucci, Francesco Chiuso, Rossella Delle Donne, Laura Rinaldi, Antonio Feliciello
Summary: Primary cilia are microtubule-based sensory organelles that receive and transmit external signals to control cell growth, differentiation, and development. The formation and disassembly of primary cilia are finely regulated during the cell cycle. The ubiquitin-proteasome system and autophagy machinery play essential roles in cilia dynamics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yulemi Gonzalez Quesada, Luc DesGroseillers
Summary: This study investigates the degradation mechanism of RNA-binding protein STAU1 in cancer cells. The research reveals that STAU1 degradation is related to the FPL-motif protein family and inflammation-related protein MAP4K1. Through experiments, it is confirmed that TRIM25 is the E3 ubiquitin ligase responsible for the degradation of STAU1 and MAP4K1. These findings are significant for further exploration of the inflammation mechanisms associated with cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Samuel Smalley, Hanjo Hellmann
Summary: This review provides an overview of how ubiquitin and similar proteins modify target proteins in plants to rapidly change their stability and activity, with a focus on their contribution to stress tolerance. The study also explores the potential use of these pathways for generating more robust crop plants to cope with stress situations.
Article
Cell Biology
Nikol Dibus, Vladimir Korinek, Lukas Cermak
Summary: The gene encoding FBXO38, an E3 ubiquitin ligase substrate receptor, has been found to be associated with various diseases. The study shows that FBXO38 controls the stability of ZXDA/B proteins through ubiquitination and proteasome-dependent degradation. These ZXDA/B proteins are involved in the regulation of chromatin-associated CENP-B protein levels, and their inappropriate stabilization leads to upregulation of CENP-A and CENP-B in centromeric chromatin.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Linke Zou, Xinyan Wang, Feifan Zhao, Keke Wu, Xiaowen Li, Zhaoyao Li, Yuwan Li, Wenxian Chen, Sen Zeng, Xiaodi Liu, Mingqiu Zhao, Lin Yi, Shuangqi Fan, Jinding Chen
Summary: Endoplasmic reticulum-associated degradation (ERAD) is a highly conserved mechanism in eukaryotic cells, and it plays a crucial role in maintaining endoplasmic reticulum (ER) homeostasis. Viruses have evolved mechanisms to exploit ERAD for their replication and transmission, but the host's use of ERAD to respond to viral infection and how viruses evade host immune clearance through ERAD are still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Abdullah Alzaid, Jin-Hyoung Kim, Robert H. Devlin, Samuel A. M. Martin, Daniel J. Macqueen
JOURNAL OF EXPERIMENTAL BIOLOGY
(2018)
Article
Biology
Eleni Mente, Eleni Nikouli, Efthimia Antonopoulou, Samuel A. M. Martin, Konstantinos A. Kormas
Article
Biochemical Research Methods
Dwight R. Causey, Jin-Hyoung Kim, David A. Stead, Samuel A. M. Martin, Robert H. Devlin, Daniel J. Macqueen
JOURNAL OF PROTEOMICS
(2019)
Article
Biotechnology & Applied Microbiology
Dwight R. Causey, Moritz A. N. Pohl, David A. Stead, Samuel A. M. Martin, Christopher J. Secombes, Daniel J. Macqueen
Article
Biochemistry & Molecular Biology
Tamsyn M. Uren Webster, Deiene Rodriguez-Barreto, Samuel A. M. Martin, Cock Van Oosterhout, Pablo Orozco-terWengel, Joanne Cable, Alastair Hamilton, Carlos Garcia De Leaniz, Sofia Consuegra
Article
Multidisciplinary Sciences
Moritz A. N. Pohl, Tiehui Wang, Thitiya Pohl, John Sweetman, Samuel A. M. Martin, Christopher J. Secombes
Article
Immunology
Carola E. Dehler, Katherine Lester, Giulia Della Pelle, Luc Jouneau, Armel Houel, Catherine Collins, Tatiana Dovgan, Radek Machat, Jun Zou, Pierre Boudinot, Samuel A. M. Martin, Bertrand Collet
JOURNAL OF IMMUNOLOGY
(2019)
Article
Fisheries
T. C. Clark, J. Tinsley, D. J. Macqueen, S. A. M. Martin
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Dwight R. Causey, Jin-Hyoung Kim, Robert H. Devlin, Samuel A. M. Martin, Daniel J. Macqueen
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
T. C. Clark, J. Tinsley, T. Sigholt, D. J. Macqueen, S. A. M. Martin
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2020)
Article
Fisheries
T. C. Clark, J. Tinsley, T. Sigholt, D. J. Macqueen, S. A. M. Martin
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Cell Biology
Ralfs Buks, Abdo Alnabulsi, Rodanthi Zindrili, Ayham Alnabulsi, Alex Wang, Tiehui Wang, Samuel A. M. Martin, Maria K. Dahle
Summary: The aim of this study is to characterize SAA protein levels in salmonids using a newly developed antibody specific to salmonid SAA. The presence of SAA protein was analyzed in rainbow trout macrophage cell line and rainbow trout challenged with Aeromonas salmonicida- or flagellin-stimulated Atlantic salmon. This study is the first to characterize SAA protein levels in salmonids in vivo and in vitro, and the newly developed salmonid SAA antibody has the potential to be developed into assays for monitoring and evaluating fish health.
Article
Nutrition & Dietetics
Sam J. S. Houston, Vasileios Karalazos, John Tinsley, Monica B. Betancor, Samuel A. M. Martin, Douglas R. Tocher, Oscar Monroig
BRITISH JOURNAL OF NUTRITION
(2017)
Article
Fisheries
Samuel A. M. Martin, Elzbieta Krol
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Fiona M. Robertson, Manu Kumar Gundappa, Fabian Grammes, Torgeir R. Hvidsten, Anthony K. Redmond, Sigbjorn Lien, Samuel A. M. Martin, Peter W. H. Holland, Simen R. Sandve, Daniel J. Macqueen