Article
Biochemistry & Molecular Biology
Somayyeh Heidary, Nagendra Awasthi, Nicole Page, Theo Allnutt, Rowena S. Lewis, Clifford Liongue, Alister C. Ward
Summary: This study aimed to generate a zebrafish model of growth hormone insensitivity syndrome with immune dysregulation 1 (GHISID1) by targeting the stat5.1 gene using CRISPR/Cas9. The zebrafish Stat5.1 mutants exhibited smaller size and increased adiposity, with dysregulation of growth and lipid metabolism genes. The mutants also showed impaired lymphopoiesis with reduced T cells throughout the lifespan, along with broader disruption of the lymphoid compartment in adulthood, including evidence of T cell activation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Immunology
Bonnie Douglas, Oyebola Oyesola, Martha M. Cooper, Avery Posey, Elia Tait Wojno, Paul R. Giacomin, De'Broski R. Herbert
Summary: In the past decade, significant progress has been made in the field of helminth immunology, from innate lymphoid cells to the emerging importance of neuroimmune connections. Future research may focus on genetic manipulation of parasites to study immunology and the use of engineered T cells for therapeutic options.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Article
Fisheries
Jie Song, Ling-Yao Li, Bing-Bing Chen, Ling-Ling Shan, Shuo-Ying Yuan, Hai-Rui Yu
Summary: A 12-week feeding trial determined the optimal dietary copper requirement for postlarval coho salmon to be 5.6 mg/kg, which significantly influenced growth and physiological parameters of the fish.
AQUACULTURE NUTRITION
(2021)
Article
Fisheries
Hai-Rui Yu, Ling-Yao Li, Ling-Ling Shan, Jing Gao, Cheng-Yu Ma, Xue Li
Summary: This study found that proper dietary zinc supplementation can improve growth performance and antioxidative enzyme activities in coho salmon alevins, but excess zinc in the diet may have negative effects.
AQUACULTURE REPORTS
(2021)
Article
Fisheries
Lian-cai Du, Hai-rui Yu, Ling-yao Li, Qin Zhang, Qi Tian, Jin-qian Liu, Ling-ling Shan
Summary: In a 12-week feeding trial, the impact of dietary selenium levels on coho salmon alevins showed varying growth and antioxidant enzyme activities. The optimal dietary selenium requirement for coho salmon alevins was determined to be in the range of 0.39-0.43 mg/kg.
AQUACULTURE INTERNATIONAL
(2021)
Review
Multidisciplinary Sciences
Hongliang Zhang, Jie Gao, Yujie Tang, Tengchuan Jin, Jinhui Tao
Summary: Inflammasomes play a crucial role in both the innate and adaptive immune systems, acting as a bridge between these two components to maintain a fine balance in immune responses. Understanding the function of inflammasomes in lymphocytes can provide new insights into the mechanisms and treatment of various diseases, including autoimmune diseases and tumors.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Hai-Rui Yu, Meng-Jie Guo, Le-Yong Yu, Ling-Yao Li, Qing-He Wang, Fang-Hui Li, Yu-Zhuo Zhang, Jia-Yi Zhang, Ji-Yun Hou
Summary: This study examined the effects of various dietary riboflavin levels on the growth performance, body composition, and antioxidant capacity of coho salmon post-smolts. The results showed that the diet with 31.81 mg/kg riboflavin significantly improved the specific growth rate and influenced muscle lipid content and various physiological indicators.
Article
Multidisciplinary Sciences
Lin Ling, Alexander S. Raikhel
Summary: Female mosquitoes feed on carbohydrates and proteins during each gonadotrophic cycle to become reproductively competent, with metabolism synchronized to support this process. The hormones juvenile hormone and ecdysteroids play key roles in female mosquito reproduction, while insulin-like peptides are critical for controlling metabolism. The JH and 20E pathways regulate protein levels of ILPs, establishing a regulatory axis for metabolism during gonadotrophic cycles.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Shalaleh Mousavi, Najmeh Sheikhzadeh, Gholamreza Hamidian, Karim Mardani, Ali Khani Oushani, Masoumeh Firouzamandi, Maria A. Esteban, Poulin Shohreh
Summary: The study revealed that dietary grape seed extract enhanced growth performance and mucosal immunity in rainbow trout fry, with lower dosage showing more pronounced effects.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Seyed Hossein Hoseinifar, Ghasem Rashidian, Hamed Ghafarifarsani, Mohammad Amin Jahazi, Mehdi Soltani, Hien Van Doan, Ehab El-Haroun, Marina Paolucci
Summary: The study investigated the dietary effects of apple pomace-derived pectin (APDP) in rainbow trout culture, showing promising improvements in growth performance and immune parameters. The results suggest APDA as a potential beneficial feed additive for rainbow trout.
Article
Agriculture, Dairy & Animal Science
Hairui Yu, Min Li, Leyong Yu, Xuejun Ma, Shuliang Wang, Ziyi Yuan, Lingyao Li
Summary: This study investigated the effects of poultry by-product meal (PBPM) as a substitute for fish meal (FM) on the growth, muscle composition, and tissue biochemical parameters of coho salmon. The results showed that high levels of PBPM negatively affected the growth performance, feed utilization, muscle composition, and liver antioxidant enzyme activities of coho salmon. Based on the evaluation of the specific growth rate, the optimal substitution level of PBPM was determined to be 16.63-17.50% of FM protein.
Article
Fisheries
Mohammad Hossein Khanjani, Gholamreza Ghaedi, Moslem Sharifinia
Summary: The study demonstrated that adding 0.2% beta-glucan to the diet of rainbow trout significantly improves growth performance, survival, and various haematological, immune, and biochemical parameters.
AQUACULTURE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Erfan Akbari Nargesi, Bahram Falahatkar
Summary: The present study investigated the effects of dietary probiotic supplementation on the feed efficiency, physiological parameters, and semen quality of male rainbow trout broodstock. The results showed that probiotic supplementation improved body weight increase, growth rate, and protein efficiency ratio, while decreasing feed conversion ratio. Probiotic supplementation also had positive effects on blood parameters, immune response, and spermatological features. Overall, multi-strain probiotics can be used as functional feed additives to enhance semen quality, improve physiological responses, and increase feed efficiency in male rainbow trout broodstock.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Christa C. van Bunderen, Rick I. Meijer, Paul Lips, Mark H. Kramer, Erik H. Serne, Madeleine L. Drent
Summary: The study found that increasing IGF-1 levels had a beneficial effect on body composition but was detrimental to insulin resistance. At the same time, the contribution of the neurogenic vasomotion domain also increased.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Takara L. Stanley, Lindsay T. Fourman, Lai Ping Wong, Ruslan Sadreyev, James M. Billingsley, Meghan N. Feldpausch, Isabel Zheng, Chelsea S. Pan, Autumn Boutin, Hang Lee, Kathleen E. Corey, Martin Torriani, David E. Kleiner, Raymond T. Chung, Colleen M. Hadigan, Steven K. Grinspoon
Summary: This study demonstrated that long-term treatment with a GHRH analog reduced markers of T-cell and monocyte/macrophage activity, suggesting that augmentation of the GH axis may ameliorate immune activation in an HIV population with metabolic dysregulation, systemic and end organ inflammation.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Jin-Hyoung Kim, Satid Chatchaiphan, Michelle T. Crown, Samantha L. White, Robert H. Devlin
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Biology
Eleni Mente, Eleni Nikouli, Efthimia Antonopoulou, Samuel A. M. Martin, Konstantinos A. Kormas
Article
Biochemical Research Methods
Dwight R. Causey, Jin-Hyoung Kim, David A. Stead, Samuel A. M. Martin, Robert H. Devlin, Daniel J. Macqueen
JOURNAL OF PROTEOMICS
(2019)
Article
Biotechnology & Applied Microbiology
Dwight R. Causey, Moritz A. N. Pohl, David A. Stead, Samuel A. M. Martin, Christopher J. Secombes, Daniel J. Macqueen
Article
Immunology
Carola E. Dehler, Katherine Lester, Giulia Della Pelle, Luc Jouneau, Armel Houel, Catherine Collins, Tatiana Dovgan, Radek Machat, Jun Zou, Pierre Boudinot, Samuel A. M. Martin, Bertrand Collet
JOURNAL OF IMMUNOLOGY
(2019)
Article
Fisheries
T. C. Clark, J. Tinsley, D. J. Macqueen, S. A. M. Martin
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Dwight R. Causey, Jin-Hyoung Kim, Robert H. Devlin, Samuel A. M. Martin, Daniel J. Macqueen
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
T. C. Clark, J. Tinsley, T. Sigholt, D. J. Macqueen, S. A. M. Martin
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2020)
Article
Fisheries
T. C. Clark, J. Tinsley, T. Sigholt, D. J. Macqueen, S. A. M. Martin
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Seunghyun Kang, Jin-Hyoung Kim, Euna Jo, Seung Jae Lee, Jihye Jung, Bo-Mi Kim, Jun Hyuck Lee, Tae-Jin Oh, Seungshic Yum, Jae-Sung Rhee, Hyun Park
MOLECULAR ECOLOGY RESOURCES
(2020)
Article
Biochemistry & Molecular Biology
Seulah Lee, Man Hyung Koo, Dong-Won Han, Il-Chan Kim, Jun Hyuck Lee, Jeong-Hoon Kim, Razia Sultana, Sun Yeou Kim, Ui Joung Youn, Jin-Hyoung Kim
Summary: This study analyzed the fatty acid composition of different organs of two Antarctic fish species (marbled rockcod and mackerel icefish) using GC-MS. The results showed variations in the fatty acid composition between the two fish species and differences in organ specificity. Additionally, extracts from the skin and liver of marbled rockcod exhibited significant inhibitory effects on matrix metalloproteinase-1.
Article
Food Science & Technology
Seongmin Lee, Mi-Ock Baek, Sana Abdul Khaliq, Amna Parveen, Sun Yeou Kim, Jin-Hyoung Kim, Il-Chan Kim, Mee-Sup Yoon
Summary: Sarcopenia is a degenerative disease characterized by decreased muscle mass and strength, for which there is currently no effective treatment. In this study, a new metabolite from Antarctic krill was isolated and found to promote muscle regeneration by enhancing mTOR signaling. This finding suggests that the metabolite may be a potential therapeutic target for sarcopenia.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Cell Biology
Ralfs Buks, Abdo Alnabulsi, Rodanthi Zindrili, Ayham Alnabulsi, Alex Wang, Tiehui Wang, Samuel A. M. Martin, Maria K. Dahle
Summary: The aim of this study is to characterize SAA protein levels in salmonids using a newly developed antibody specific to salmonid SAA. The presence of SAA protein was analyzed in rainbow trout macrophage cell line and rainbow trout challenged with Aeromonas salmonicida- or flagellin-stimulated Atlantic salmon. This study is the first to characterize SAA protein levels in salmonids in vivo and in vitro, and the newly developed salmonid SAA antibody has the potential to be developed into assays for monitoring and evaluating fish health.
Article
Fisheries
Hokyung Song, Seungyeon Lee, Dong-Won Han, Jin-Hyoung Kim
Summary: The gut microbiome of Antarctic mackerel icefish was characterized using next-generation sequencing for the first time in this study. The microbial community composition of the intestinal wall samples was found to be different from other sample types, with a higher relative abundance of Photobacterium in the intestinal content and potential pathogens such as Escherichia, Shigella, and Pseudomonas in the intestinal wall. Unlike other marine fish species, Vibrio and Lactobacillus were nearly absent in the gut microbiome of the mackerel icefish. Functional gene profiling predicted higher relative abundance of nutrient degradation-related genes in the intestinal content and higher relative abundance of important metabolite biosynthesis-related genes, such as menaquinols, in the intestinal wall. The difference in microbial community structure between the intestinal wall and intestinal content supports niche separation and highlights the importance of collecting intestinal wall samples to understand the complete picture of the gut microbiome.