The mitochondrial unfolded protein response in mammalian physiology

The Protein Import Machinery of Mitochondria—A Regulatory Hub in Metabolism, Stress, and Disease

(2014) Angelika B. Harbauer et al.   Cell Metabolism

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers

(2014) A Sheth et al.   Cell Death & Disease

Molecular mechanisms underlying genotype-dependent responses to dietary restriction

(2013) Jennifer Schleit et al.   AGING CELL

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

(2013) Seok Min Jin et al.   Autophagy

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation

(2013) T. Kelly Rainbolt et al.   Cell Metabolism

NAD+metabolism: A therapeutic target for age-related metabolic disease

(2013) Laurent Mouchiroud et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

A Mitochondrial Ribosomal and RNA Decay Pathway Blocks Cell Proliferation

(2013) Uwe Richter et al.   CURRENT BIOLOGY

Loss of Prohibitin Induces Mitochondrial Damages Altering  -Cell Function and Survival and Is Responsible for Gradual Diabetes Development

(2013) S. Supale et al.   DIABETES

Leptin regulation of Hsp60 impacts hypothalamic insulin signaling

(2013) André Kleinridders et al.   JOURNAL OF CLINICAL INVESTIGATION

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster

(2012) I Pimenta de Castro et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial quality control: a matter of life and death for neurons

(2012) Elena I Rugarli et al.   EMBO JOURNAL

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Mitochondrial quality control: an integrated network of pathways

(2012) Fabian Fischer et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2011) Marko Škrtić et al.   CANCER CELL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation

(2011) Eva Rath et al.   GUT

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

(2011) L. Papa et al.   JOURNAL OF CELL SCIENCE

FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study

(2011) Anu Suomalainen et al.   LANCET NEUROLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans

(2010) Cole M. Haynes et al.   MOLECULAR CELL

Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms

(2010) Alexander Buchberger et al.   MOLECULAR CELL

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Mitochondrial Quality Control and Parkinson’s Disease: A Pathway Unfolds

(2010) Inês Pimenta de Castro et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reduction of Protein Translation and Activation of Autophagy Protect against PINK1 Pathogenesis in Drosophila melanogaster

(2010) Song Liu et al.   PLoS Genetics

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Signalling Pathways in the Unfolded Protein Response: Development from Yeast to Mammals

(2009) K. Mori   JOURNAL OF BIOCHEMISTRY

Mitochondrial Protein Quality Control by the Proteasome Involves Ubiquitination and the Protease Omi

(2008) Susanne Radke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced cytosolic protein synthesis suppresses mitochondrial degeneration

(2008) Xiaowen Wang et al.   NATURE CELL BIOLOGY